LOCUS       NM_001081043            5384 bp    mRNA    linear   ROD 10-FEB-2025
DEFINITION  Mus musculus protein tyrosine phosphatase, non-receptor type 23
            (Ptpn23), mRNA.
ACCESSION   NM_001081043 XM_001005289
VERSION     NM_001081043.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5384)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 5384)
  AUTHORS   Budzinska,M.I., Villarroel-Campos,D., Golding,M., Weston,A.,
            Collinson,L., Snijders,A.P. and Schiavo,G.
  TITLE     PTPN23 binds the dynein adaptor BICD1 and is required for endocytic
            sorting of neurotrophin receptors
  JOURNAL   J Cell Sci 133 (6) (2020)
   PUBMED   32079660
  REMARK    GeneRIF: PTPN23 binds the dynein adaptor BICD1 and is required for
            endocytic sorting of neurotrophin receptors.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5384)
  AUTHORS   Gingras,M.C., Kazan,J.M. and Pause,A.
  TITLE     Role of ESCRT component HD-PTP/PTPN23 in cancer
  JOURNAL   Biochem Soc Trans 45 (3), 845-854 (2017)
   PUBMED   28620046
  REMARK    GeneRIF: The role of HD-PTP/PTPN23 in cancer and tumorigenesis is
            reviewed.
            Review article
REFERENCE   4  (bases 1 to 5384)
  AUTHORS   Dickinson,M.E., Flenniken,A.M., Ji,X., Teboul,L., Wong,M.D.,
            White,J.K., Meehan,T.F., Weninger,W.J., Westerberg,H., Adissu,H.,
            Baker,C.N., Bower,L., Brown,J.M., Caddle,L.B., Chiani,F., Clary,D.,
            Cleak,J., Daly,M.J., Denegre,J.M., Doe,B., Dolan,M.E., Edie,S.M.,
            Fuchs,H., Gailus-Durner,V., Galli,A., Gambadoro,A., Gallegos,J.,
            Guo,S., Horner,N.R., Hsu,C.W., Johnson,S.J., Kalaga,S., Keith,L.C.,
            Lanoue,L., Lawson,T.N., Lek,M., Mark,M., Marschall,S., Mason,J.,
            McElwee,M.L., Newbigging,S., Nutter,L.M., Peterson,K.A.,
            Ramirez-Solis,R., Rowland,D.J., Ryder,E., Samocha,K.E.,
            Seavitt,J.R., Selloum,M., Szoke-Kovacs,Z., Tamura,M., Trainor,A.G.,
            Tudose,I., Wakana,S., Warren,J., Wendling,O., West,D.B., Wong,L.,
            Yoshiki,A., MacArthur,D.G., Tocchini-Valentini,G.P., Gao,X.,
            Flicek,P., Bradley,A., Skarnes,W.C., Justice,M.J., Parkinson,H.E.,
            Moore,M., Wells,S., Braun,R.E., Svenson,K.L., de Angelis,M.H.,
            Herault,Y., Mohun,T., Mallon,A.M., Henkelman,R.M., Brown,S.D.,
            Adams,D.J., Lloyd,K.C., McKerlie,C., Beaudet,A.L., Bucan,M. and
            Murray,S.A.
  CONSRTM   International Mouse Phenotyping Consortium; Jackson Laboratory;
            Infrastructure Nationale PHENOMIN, Institut Clinique de la Souris
            (ICS); Charles River Laboratories; MRC Harwell; Toronto Centre for
            Phenogenomics; Wellcome Trust Sanger Institute; RIKEN BioResource
            Center
  TITLE     High-throughput discovery of novel developmental phenotypes
  JOURNAL   Nature 537 (7621), 508-514 (2016)
   PUBMED   27626380
  REMARK    Erratum:[Nature. 2017 Nov 16;551(7680):398. doi:
            10.1038/nature24643.. PMID: 29144450]
REFERENCE   5  (bases 1 to 5384)
  AUTHORS   Manteghi,S., Gingras,M.C., Kharitidi,D., Galarneau,L., Marques,M.,
            Yan,M., Cencic,R., Robert,F., Paquet,M., Witcher,M., Pelletier,J.
            and Pause,A.
  TITLE     Haploinsufficiency of the ESCRT Component HD-PTP Predisposes to
            Cancer
  JOURNAL   Cell Rep 15 (9), 1893-1900 (2016)
   PUBMED   27210750
  REMARK    GeneRIF: HD-PTP/PTPN23 as a prominent haploinsufficient tumor
            suppressor gene preventing tumor progression through control of
            integrin trafficking.
REFERENCE   6  (bases 1 to 5384)
  AUTHORS   Okazaki,N., F-Kikuno,R., Ohara,R., Inamoto,S., Koseki,H.,
            Hiraoka,S., Saga,Y., Seino,S., Nishimura,M., Kaisho,T., Hoshino,K.,
            Kitamura,H., Nagase,T., Ohara,O. and Koga,H.
  TITLE     Prediction of the coding sequences of mouse homologues of KIAA
            gene: IV. The complete nucleotide sequences of 500 mouse
            KIAA-homologous cDNAs identified by screening of terminal sequences
            of cDNA clones randomly sampled from size-fractionated libraries
  JOURNAL   DNA Res 11 (3), 205-218 (2004)
   PUBMED   15368895
REFERENCE   7  (bases 1 to 5384)
  AUTHORS   Andersen,J.N., Jansen,P.G., Echwald,S.M., Mortensen,O.H.,
            Fukada,T., Del Vecchio,R., Tonks,N.K. and Moller,N.P.
  TITLE     A genomic perspective on protein tyrosine phosphatases: gene
            structure, pseudogenes, and genetic disease linkage
  JOURNAL   FASEB J 18 (1), 8-30 (2004)
   PUBMED   14718383
  REMARK    Review article
REFERENCE   8  (bases 1 to 5384)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   9  (bases 1 to 5384)
  AUTHORS   Tanaka,K., Tamura,H., Tanaka,H., Katoh,M., Futamata,Y., Seki,N.,
            Nishimune,Y. and Hara,T.
  TITLE     Spermatogonia-dependent expression of testicular genes in mice
  JOURNAL   Dev Biol 246 (2), 466-479 (2002)
   PUBMED   12051830
REFERENCE   10 (bases 1 to 5384)
  AUTHORS   Piao,Y., Ko,N.T., Lim,M.K. and Ko,M.S.
  TITLE     Construction of long-transcript enriched cDNA libraries from
            submicrogram amounts of total RNAs by a universal PCR amplification
            method
  JOURNAL   Genome Res 11 (9), 1553-1558 (2001)
   PUBMED   11544199
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY008138.1, CF538443.1, CF734421.1, CA325506.1 and BC059902.1.
            
            On Feb 7, 2007 this sequence version replaced XM_001005289.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMN00849374, SAMN00849375
                              [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-39                BY008138.1         2-40
            40-649              CF538443.1         1-610
            650-1134            CF734421.1         149-633
            1135-1879           CA325506.1         5-749
            1880-5384           BC059902.1         609-4113
FEATURES             Location/Qualifiers
     source          1..5384
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 59.92 cM"
     gene            1..5384
                     /gene="Ptpn23"
                     /gene_synonym="PTP-TD14"
                     /note="protein tyrosine phosphatase, non-receptor type 23"
                     /db_xref="GeneID:104831"
                     /db_xref="MGI:MGI:2144837"
     exon            1..177
                     /gene="Ptpn23"
                     /gene_synonym="PTP-TD14"
                     /inference="alignment:Splign:2.1.0"
     CDS             94..5172
                     /gene="Ptpn23"
                     /gene_synonym="PTP-TD14"
                     /EC_number="3.1.3.48"
                     /codon_start=1
                     /product="tyrosine-protein phosphatase non-receptor type
                     23"
                     /protein_id="NP_001074512.1"
                     /db_xref="CCDS:CCDS40780.1"
                     /db_xref="GeneID:104831"
                     /db_xref="MGI:MGI:2144837"
                     /translation="MEAVPRMPMIWLDLKEAGDFHFQSAVKKFVLKNYGENPEAYNEE
                     LKKLELLRQNAIRVARDFEGCSVLRKYLGQLHYLQSRVPMGSGQEAAVAVTWTEIFSG
                     KSVSHEDIKYEQACILYNLGALHSMLGAMDKRVSEEGMKVSCTHFQCAAGAFAYLREH
                     FPQAFSVDMSRQILTLNVNLMLGQAQECLLEKSMLDNRKSFLVARISAQVVDYYKEAC
                     RALENPDTASLLGRIQKDWKKLVQMKIYYFAAVAHLHMGKQAEEQQKFGERVAYFQSA
                     LDKLNEAIKLAKGQPDTVQDALRFAMDVIGGKYNSAKKDNDFIYHEAVPALDTLQPVK
                     GAPLVKPLPVNPTDPAVTGPDIFAKLVPMAAHEASSLYSEEKAKLLREMLAKIEDKNE
                     VLDQFMDSMQLDPETVDNLDAYNHIPPQLMEKCAALSVRPDTVKNLVQSMQVLSGVFT
                     DVEASLKDIRDLLEEDELQEQKLQETLGQAGAGPGPSVAKAELAEVRREWAKYMEVHE
                     KASFTNSELHRAMNLHVGNLRLLSGPLDQVRAALPTPALTPEDKAVLQNLKRILAKVQ
                     EMRDQRVSLEQQLRELIQKDDITASLVTTDHSEMKKLFEEQLKKYDQLKVYLEQNLAA
                     QDNVLRALTEANVQYAAVRRVLSELDQKWNSTLQTLVASYEAYEDLMKKSQEGKDFYA
                     DLESKVATLLERAQSICRAQEAARQQLLDRELKKKAPPPRPTAPKPLLSRREEGEAVE
                     AGDTPEELRSLPPDMMVGPRLPDPFLGTTAPLHFSPGPFPSSTGPATHYLSGPLPPGT
                     YSGPTQLMQPRAAVPMAPATVLYPAPAYTSELGLVPRSSPQHGIVSSPYAGVGPPQPV
                     VGLPSAPPPQLSGPELAMTVRPATTTVDSVQAPISSHTAPRPNPTPALPQPCFPVPQP
                     VPQSVPQPQPLPVPYTYSIGTKQPLPAPYTYSIGTKQHLTGPLPQHQFPPGIPTGFPV
                     PRTGPQAQAQPQPQPQPQPQPQPQPQPQPQPQSQSQPQPQPQPQPQRPAFGPQPTQQP
                     LPFQHPHLFPSQAPGILPPPPPTPYHFTPQPGVLGQPPPTLHTQLYPGPSQDPLPPHS
                     GALPFPSPGPPHPHPTLAYGPAPSPRPLGPQATPVSIRGPPPASQPTPSPHLVPSPAP
                     SPGPGPVPSRPPTAEPPPCLRRGAAAADLLSSSPESQHGGTQPPGGGQPLLQPTKVDA
                     AEGRRPQALRLIEQDPYEHPERLQQLQQELEAFRGQLGDAGALDAIWRELQEAQEHDA
                     RGRSIAIARCYSLKNRHQDVMPYDSNRVVLRSGKDDYINASCVEGLSPYCPPLVATQA
                     PLPGTAADFWLMVHEQKVSVIVMLVSEAEMEKQKVARYFPTERGQPMVHGALSVALSS
                     IRTTETHVERVLSLQFRDQSLKRSLVHLHFPTWPELGLPDSPGNLLRFIQEVHAHYLH
                     QRPLHTPIVVHCSSGVGRTGAFALLYAAVQEVEAGNGIPELPQLVRRMRQQRKHMLQE
                     KLHLKFCHEALVRHVEQVLQRHGVPPPGKPVASVNISQKNHLPQDSQDLVLGGDVPIS
                     SIQATIAKLSIRPLGGLDSPAASLPGLVEPPGLPPASLPESTPVPSSSPPPLSSPLPE
                     APQPEEEPSVPEAPSLGPPSSSLELLASLTPEAFSLDSSLRGKQRMSKQNFLQAHNGQ
                     GLRAAQPTDDPLSLLDPLWTLNKT"
     exon            178..252
                     /gene="Ptpn23"
                     /gene_synonym="PTP-TD14"
                     /inference="alignment:Splign:2.1.0"
     exon            253..380
                     /gene="Ptpn23"
                     /gene_synonym="PTP-TD14"
                     /inference="alignment:Splign:2.1.0"
     exon            381..457
                     /gene="Ptpn23"
                     /gene_synonym="PTP-TD14"
                     /inference="alignment:Splign:2.1.0"
     exon            458..507
                     /gene="Ptpn23"
                     /gene_synonym="PTP-TD14"
                     /inference="alignment:Splign:2.1.0"
     exon            508..639
                     /gene="Ptpn23"
                     /gene_synonym="PTP-TD14"
                     /inference="alignment:Splign:2.1.0"
     exon            640..720
                     /gene="Ptpn23"
                     /gene_synonym="PTP-TD14"
                     /inference="alignment:Splign:2.1.0"
     exon            721..852
                     /gene="Ptpn23"
                     /gene_synonym="PTP-TD14"
                     /inference="alignment:Splign:2.1.0"
     exon            853..900
                     /gene="Ptpn23"
                     /gene_synonym="PTP-TD14"
                     /inference="alignment:Splign:2.1.0"
     exon            901..957
                     /gene="Ptpn23"
                     /gene_synonym="PTP-TD14"
                     /inference="alignment:Splign:2.1.0"
     exon            958..1016
                     /gene="Ptpn23"
                     /gene_synonym="PTP-TD14"
                     /inference="alignment:Splign:2.1.0"
     exon            1017..1096
                     /gene="Ptpn23"
                     /gene_synonym="PTP-TD14"
                     /inference="alignment:Splign:2.1.0"
     exon            1097..1211
                     /gene="Ptpn23"
                     /gene_synonym="PTP-TD14"
                     /inference="alignment:Splign:2.1.0"
     exon            1212..1277
                     /gene="Ptpn23"
                     /gene_synonym="PTP-TD14"
                     /inference="alignment:Splign:2.1.0"
     exon            1278..1423
                     /gene="Ptpn23"
                     /gene_synonym="PTP-TD14"
                     /inference="alignment:Splign:2.1.0"
     exon            1424..1741
                     /gene="Ptpn23"
                     /gene_synonym="PTP-TD14"
                     /inference="alignment:Splign:2.1.0"
     exon            1742..1896
                     /gene="Ptpn23"
                     /gene_synonym="PTP-TD14"
                     /inference="alignment:Splign:2.1.0"
     exon            1897..2048
                     /gene="Ptpn23"
                     /gene_synonym="PTP-TD14"
                     /inference="alignment:Splign:2.1.0"
     exon            2049..2228
                     /gene="Ptpn23"
                     /gene_synonym="PTP-TD14"
                     /inference="alignment:Splign:2.1.0"
     exon            2229..4149
                     /gene="Ptpn23"
                     /gene_synonym="PTP-TD14"
                     /inference="alignment:Splign:2.1.0"
     exon            4150..4334
                     /gene="Ptpn23"
                     /gene_synonym="PTP-TD14"
                     /inference="alignment:Splign:2.1.0"
     exon            4335..4439
                     /gene="Ptpn23"
                     /gene_synonym="PTP-TD14"
                     /inference="alignment:Splign:2.1.0"
     exon            4440..4578
                     /gene="Ptpn23"
                     /gene_synonym="PTP-TD14"
                     /inference="alignment:Splign:2.1.0"
     exon            4579..4692
                     /gene="Ptpn23"
                     /gene_synonym="PTP-TD14"
                     /inference="alignment:Splign:2.1.0"
     exon            4693..5336
                     /gene="Ptpn23"
                     /gene_synonym="PTP-TD14"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ttccggcgtg gaggggcggg gttgcgcgcg cggctgaagc agctgctgga cctgggaggg
       61 gagcggccct agggccgcta ggcgctaccc gcgatggagg ccgtgccccg gatgcccatg
      121 atctggctgg acctgaagga ggccggtgac tttcacttcc agtctgcggt gaagaagttt
      181 gtcctgaaga attatggaga gaacccagaa gcctacaacg aggaactaaa gaagctggaa
      241 ttactcagac agaatgctat tcgcgttgcc cgggactttg agggctgcag tgttcttcga
      301 aagtaccttg gccagctaca ctacctacag agtcgggtgc ccatgggctc aggccaggag
      361 gctgctgtag ctgtcacctg gactgagatc ttctcgggca agtctgtgtc ccatgaagac
      421 atcaagtacg agcaggcctg tattctctac aacctcggtg cactgcactc catgctgggg
      481 gctatggaca agcgggtgtc tgaggagggc atgaaagtct cctgcaccca cttccagtgt
      541 gcagcaggcg cctttgccta cctgcgtgaa cacttcccac aggccttcag tgtggacatg
      601 agtcgccaga tccttacgct caatgtcaac ctcatgctgg gccaggctca ggagtgcctg
      661 ttggagaagt ccatgttgga caaccggaag agctttctag tggcccgcat cagcgcacag
      721 gtggtagatt actataagga ggcatgccgg gccttggaaa accctgatac tgcctccctg
      781 ctgggccgta tccagaaaga ctggaagaaa cttgtccaaa tgaagatcta ctactttgcg
      841 gctgtggctc atctacacat ggggaagcag gctgaggagc aacagaaatt tggggaacgg
      901 gtggcctact tccagagtgc cctggacaag cttaatgaag ccatcaagtt ggccaagggc
      961 cagcccgaca ctgtgcaaga tgcacttcgc tttgctatgg atgtcatcgg gggcaaatat
     1021 aattctgcca agaaggacaa tgactttatc taccatgagg ctgtgccagc actggataca
     1081 ctccagcctg tgaaaggagc tcccttggtg aagcccttgc cagtaaaccc cacagaccca
     1141 gctgttacag gtcctgacat ctttgccaag ttggtgccca tggctgccca tgaggcctca
     1201 tcactgtaca gtgaggagaa ggccaaactg cttcgggaga tgctggccaa aattgaagat
     1261 aagaatgagg tcctagatca gttcatggac tccatgcagc tggaccctga gacagtggac
     1321 aacttggatg cctacaacca tatccccccc cagctcatgg agaagtgtgc ggcactcagc
     1381 gtccggcctg acactgtcaa gaaccttgtc cagtctatgc aggtgctgtc aggggtgttc
     1441 acggatgtgg aggcctccct gaaggacatc agggatctac tggaggaaga tgagctgcaa
     1501 gagcagaaat tgcaggagac cctgggccag gccggggctg gccctggccc ctctgttgcc
     1561 aaggctgagc ttgcagaggt gaggcgagaa tgggccaagt acatggaagt gcatgaaaag
     1621 gcttccttca ccaacagtga gctgcatcgt gctatgaacc tgcatgttgg taacttgcgc
     1681 ctgctcagtg gaccactgga ccaggtgcgg gctgccctac ccacaccagc cctcacccca
     1741 gaggacaaag ccgtgctgca aaacctaaag cgcatcctcg ccaaggtgca ggagatgcgg
     1801 gaccagcgtg tgtccttgga acagcagctc cgagagctga tccagaagga tgacatcact
     1861 gcctctctgg tcaccactga ccactcagag atgaagaaac tgtttgagga gcagctgaag
     1921 aagtatgacc agctgaaggt ctacctggag cagaacctgg ccgcccagga caatgtcctc
     1981 cgtgccctga ctgaggccaa cgtgcagtat gcagccgtgc ggcgggtgct tagtgagctg
     2041 gaccaaaagt ggaactccac actacagacc ctggtagcat cctatgaggc ctatgaggac
     2101 ctgatgaaga agtcccaaga aggcaaggac ttttatgcag acttggaaag caaggtagct
     2161 acccttctgg aacgggcaca atccatctgt cgtgcccaag aggccgctcg ccagcagctc
     2221 ctggacagag agctgaagaa gaaggcacca ccacctcggc ctacagcccc aaagccattg
     2281 ctgtcccgcc gtgaggaggg ggaggcagtg gaggctggag acacacctga ggagctgcgc
     2341 agcttgcccc ctgacatgat ggttggccca cggctacctg acccattcct aggaactact
     2401 gcccctctcc acttttctcc tggccccttc cctagttcca caggcccagc aacccactat
     2461 ctctcaggac ccttaccccc tggaacttat tcaggcccca ctcaactgat gcagcctagg
     2521 gctgcagttc ccatggcacc tgcaacggtc ctctacccag cccctgccta tacatcggag
     2581 ttgggcctcg tacccagatc ctctccccag catggaattg taagcagtcc ctatgcaggg
     2641 gtagggccac cccaaccagt tgtaggtctt ccctctgctc cacctcccca gctctcagga
     2701 cccgagttag ccatgacagt tcggccagct accaccacag tagatagtgt ccaagcccct
     2761 atctctagcc acacggcacc acggccaaac cctacccctg ctcttcccca gccctgcttt
     2821 ccagtgcctc agcctgtacc tcaatctgtt ccccaaccac agcctctgcc tgtaccctat
     2881 acttattcta tagggaccaa gcagcctctg cctgcaccct atacttactc tatagggacc
     2941 aagcagcacc tcactggccc tctaccacag catcagtttc ctcctgggat ccccacaggc
     3001 tttccagtcc ccaggactgg gccccaggcc caggcccagc cccaacccca gccccagccc
     3061 cagcctcagc ctcagcccca gccccagccc cagccccagc cccagtccca gtcccagccc
     3121 cagccccagc cccagcctca gccccaacgg ccagcatttg ggccacaacc cacacaacag
     3181 ccccttccat tccagcatcc acatctcttc ccatctcagg ccccagggat tcttccacca
     3241 ccaccaccaa caccctacca ttttactcct cagcctggtg tcttgggaca accaccaccc
     3301 accctacaca cccagctcta tccaggccca tctcaagacc ctcttccccc acattcaggg
     3361 gctctgcctt tccccagccc tgggccccct catcctcacc ccaccctggc atatggccct
     3421 gccccttccc ctaggcccct tggtcctcag gcaacccctg tctccattcg aggcccccca
     3481 ccagccagtc agcccacccc tagtccacac ttggtgcctt cacctgcccc atcaccaggg
     3541 cctggcccag taccttcaag acctccaaca gccgagccac caccttgttt gcgccgaggt
     3601 gctgcagctg cagaccttct gtcttctagc cctgagagcc agcatggagg tacccagcct
     3661 cctgggggtg ggcagccctt gctacagcct accaaggtag atgcagctga gggccgtcgg
     3721 ccacaggccc tgcggctaat tgagcaggac ccctatgaac atcccgagag gctgcagcag
     3781 ttgcagcagg agctggaggc ctttcggggc cagctggggg atgcaggagc actggatgcc
     3841 atctggagag agttgcaaga ggcacaggaa cacgatgccc gaggtcgatc cattgccatt
     3901 gcccgctgct actccctgaa gaaccggcac caggatgtca tgccgtatga cagcaaccgt
     3961 gtggtgctgc gctcaggcaa agatgattat attaatgcta gctgtgtgga ggggctctcg
     4021 ccatactgtc cacccttagt ggccacccag gctccgctgc ctggcacagc tgcagatttc
     4081 tggctcatgg tgcatgaaca gaaagtgtca gtcattgtca tgctggtgtc tgaggctgag
     4141 atggaaaagc aaaaggtggc gcgttacttc cccacagaga ggggccagcc catggtgcat
     4201 ggagccctga gcgtggcact gagcagtatt cgtactactg agacccatgt ggagcgagtg
     4261 ctgagtctgc agttccggga tcagagcctc aagcgctctc ttgtgcacct ccatttccct
     4321 acttggcctg agttaggcct gccagacagc cctggcaatc tgctgcgctt catccaggag
     4381 gtgcatgcac attatttgca ccagcgaccc ctgcacacac ctattgtcgt acactgcagc
     4441 tctggggtgg gccgcacagg agccttcgcg ttgctctatg cagccgtgca ggaggtggag
     4501 gctgggaatg ggattccaga gctgccccag ctggtgaggc ggatgcggca gcagaggaaa
     4561 cacatgctgc aggaaaaact tcacctcaag ttctgccatg aggcgttggt gagacatgtg
     4621 gagcaggtcc tacagcgcca tggtgtgcct cctcctggca agcctgtggc cagtgtgaac
     4681 atcagccaga agaaccacct tcctcaggac tcccaggatc tggtccttgg tggagacgtg
     4741 cccatcagct ccattcaggc taccattgcc aagctcagca tccggcccct aggtggcttg
     4801 gattccccag ctgccagcct cccaggcctt gtagaacccc caggtcttcc accagctagc
     4861 cttccagagt ctacccctgt cccatcttcc tcgcctcccc cactctcttc acctctgcct
     4921 gaagcccccc agccagagga ggagccgtca gtgcctgaag cccccagctt agggcccccc
     4981 tcgtcatccc tggagctgtt ggcctctctg actccagaag cattttcact ggacagttct
     5041 ttacggggaa agcagcggat gagcaagcag aactttctgc aggcccacaa cgggcagggt
     5101 ctaagggctg cccagcctac ggatgacccc ctcagcctcc tggatccact ctggacactc
     5161 aacaagacct gaaaaggctt tgcctatctg atccttacac tacacctccc atccctgctg
     5221 ccttcagctc tgccagatgg agatgcactg caggcctcag atcaggctct gctcccttga
     5281 ggaacctgac atttttccag ccctgggctg ctgaaataat aaacttattc tgtggcaaaa
     5341 aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaa
//
