LOCUS       NM_008979               2745 bp    mRNA    linear   ROD 15-OCT-2024
DEFINITION  Mus musculus protein tyrosine phosphatase, non-receptor type 22
            (lymphoid) (Ptpn22), transcript variant 1, mRNA.
ACCESSION   NM_008979
VERSION     NM_008979.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2745)
  AUTHORS   Cai,H., Chen,S., Jiang,Z., Chen,L. and Yang,X.
  TITLE     PTPN22 through the regulation of Th17/Treg balance acts as a
            potential target for the treatment of Graves' disease
  JOURNAL   Tissue Cell 90, 102502 (2024)
   PUBMED   39083881
  REMARK    GeneRIF: PTPN22 through the regulation of Th17/Treg balance acts as
            a potential target for the treatment of Graves' disease.
REFERENCE   2  (bases 1 to 2745)
  AUTHORS   Lee,J., Yurkovetskiy,L.A., Reiman,D., Frommer,L., Strong,Z.,
            Chang,A., Kahaly,G.J., Khan,A.A. and Chervonsky,A.V.
  TITLE     Androgens contribute to sex bias of autoimmunity in mice by T
            cell-intrinsic regulation of Ptpn22 phosphatase expression
  JOURNAL   Nat Commun 15 (1), 7688 (2024)
   PUBMED   39227386
  REMARK    GeneRIF: Androgens contribute to sex bias of autoimmunity in mice
            by T cell-intrinsic regulation of Ptpn22 phosphatase expression.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2745)
  AUTHORS   Orozco,R.C., Marquardt,K., Pratumchai,I., Shaikh,A.F., Mowen,K.,
            Domissy,A., Teijaro,J.R. and Sherman,L.A.
  TITLE     Autoimmunity-associated allele of tyrosine phosphatase gene PTPN22
            enhances anti-viral immunity
  JOURNAL   PLoS Pathog 20 (3), e1012095 (2024)
   PUBMED   38512979
  REMARK    GeneRIF: Autoimmunity-associated allele of tyrosine phosphatase
            gene PTPN22 enhances anti-viral immunity.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2745)
  AUTHORS   Li,S., Luo,Z., Su,S., Wen,L., Xian,G., Zhao,J., Xu,X., Xu,D. and
            Zeng,Q.
  TITLE     Targeted inhibition of PTPN22 is a novel approach to alleviate
            osteogenic responses in aortic valve interstitial cells and aortic
            valve lesions in mice
  JOURNAL   BMC Med 21 (1), 252 (2023)
   PUBMED   37443055
  REMARK    GeneRIF: Targeted inhibition of PTPN22 is a novel approach to
            alleviate osteogenic responses in aortic valve interstitial cells
            and aortic valve lesions in mice.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2745)
  AUTHORS   Wang,X., Wei,G., Ding,Y., Gui,X., Tong,H., Xu,X., Zhang,S., Sun,Z.,
            Ju,W., Li,Y., Yao,R., Wu,Q., Lu,Z., Fu,C., Li,Z., Zhang,S.,
            Gardiner,E.E., Andrews,R.K., Hu,H., Zeng,L., Xu,K. and Qiao,J.
  TITLE     Protein tyrosine phosphatase PTPN22 negatively modulates platelet
            function and thrombus formation
  JOURNAL   Blood 140 (9), 1038-1051 (2022)
   PUBMED   35767715
  REMARK    GeneRIF: Protein tyrosine phosphatase PTPN22 negatively modulates
            platelet function and thrombus formation.
REFERENCE   6  (bases 1 to 2745)
  AUTHORS   Kannan,K., Kaminski,N., Rechavi,G., Jakob-Hirsch,J., Amariglio,N.
            and Givol,D.
  TITLE     DNA microarray analysis of genes involved in p53 mediated
            apoptosis: activation of Apaf-1
  JOURNAL   Oncogene 20 (26), 3449-3455 (2001)
   PUBMED   11423996
REFERENCE   7  (bases 1 to 2745)
  AUTHORS   Gjorloff-Wingren,A., Saxena,M., Han,S., Wang,X., Alonso,A.,
            Renedo,M., Oh,P., Williams,S., Schnitzer,J. and Mustelin,T.
  TITLE     Subcellular localization of intracellular protein tyrosine
            phosphatases in T cells
  JOURNAL   Eur J Immunol 30 (8), 2412-2421 (2000)
   PUBMED   10940933
REFERENCE   8  (bases 1 to 2745)
  AUTHORS   Gregorieff,A., Cloutier,J.F. and Veillette,A.
  TITLE     Sequence requirements for association of protein-tyrosine
            phosphatase PEP with the Src homology 3 domain of inhibitory
            tyrosine protein kinase p50(csk)
  JOURNAL   J Biol Chem 273 (21), 13217-13222 (1998)
   PUBMED   9582365
REFERENCE   9  (bases 1 to 2745)
  AUTHORS   Cloutier,J.F. and Veillette,A.
  TITLE     Association of inhibitory tyrosine protein kinase p50csk with
            protein tyrosine phosphatase PEP in T cells and other hemopoietic
            cells
  JOURNAL   EMBO J 15 (18), 4909-4918 (1996)
   PUBMED   8890164
REFERENCE   10 (bases 1 to 2745)
  AUTHORS   Matthews,R.J., Bowne,D.B., Flores,E. and Thomas,M.L.
  TITLE     Characterization of hematopoietic intracellular protein tyrosine
            phosphatases: description of a phosphatase containing an SH2 domain
            and another enriched in proline-, glutamic acid-, serine-, and
            threonine-rich sequences
  JOURNAL   Mol Cell Biol 12 (5), 2396-2405 (1992)
   PUBMED   1373816
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC124698.4.
            
            On Jul 22, 2022 this sequence version replaced NM_008979.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: M90388.1, BC055377.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849380
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-211               AC124698.4         76960-77170
            212-320             AC124698.4         90325-90433
            321-397             AC124698.4         90661-90737
            398-493             AC124698.4         90860-90955
            494-532             AC124698.4         91345-91383
            533-604             AC124698.4         92413-92484
            605-664             AC124698.4         92586-92645
            665-807             AC124698.4         93275-93417
            808-874             AC124698.4         93985-94051
            875-952             AC124698.4         96258-96335
            953-1039            AC124698.4         98730-98816
            1040-1116           AC124698.4         102002-102078
            1117-1931           AC124698.4         102207-103021
            1932-2015           AC124698.4         105192-105275
            2016-2137           AC124698.4         105415-105536
            2138-2165           AC124698.4         106936-106963
            2166-2243           AC124698.4         118794-118871
            2244-2359           AC124698.4         120050-120165
            2360-2390           AC124698.4         121836-121866
            2391-2468           AC124698.4         126061-126138
            2469-2745           AC124698.4         128656-128932
FEATURES             Location/Qualifiers
     source          1..2745
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 45.52 cM"
     gene            1..2745
                     /gene="Ptpn22"
                     /gene_synonym="70zpep; PEP; Ptpn8"
                     /note="protein tyrosine phosphatase, non-receptor type 22
                     (lymphoid)"
                     /db_xref="GeneID:19260"
                     /db_xref="MGI:MGI:107170"
     exon            1..211
                     /gene="Ptpn22"
                     /gene_synonym="70zpep; PEP; Ptpn8"
                     /inference="alignment:Splign:2.1.0"
     CDS             125..2533
                     /gene="Ptpn22"
                     /gene_synonym="70zpep; PEP; Ptpn8"
                     /EC_number="3.1.3.48"
                     /note="isoform 1 is encoded by transcript variant 1;
                     protein tyrosine phosphatase, non-receptor type 8; PEST
                     domain-enriched tyrosine phosphatase; tyrosine-protein
                     phosphatase non-receptor type 22; hematopoietic cell
                     protein-tyrosine phosphatase 70Z-PEP"
                     /codon_start=1
                     /product="tyrosine-protein phosphatase non-receptor type
                     22 isoform 1"
                     /protein_id="NP_033005.1"
                     /db_xref="CCDS:CCDS38577.1"
                     /db_xref="GeneID:19260"
                     /db_xref="MGI:MGI:107170"
                     /translation="MDQREILQQLLKEAQKKKLNSEEFASEFLKLKRQSTKYKADKIY
                     PTTVAQRPKNIKKNRYKDILPYDHSLVELSLLTSDEDSSYINASFIKGVYGPKAYIAT
                     QGPLSTTLLDFWRMIWEYRILVIVMACMEFEMGKKKCERYWAEPGETQLQFGPFSISC
                     EAEKKKSDYKIRTLKAKFNNETRIIYQFHYKNWPDHDVPSSIDPILQLIWDMRCYQED
                     DCVPICIHCSAGCGRTGVICAVDYTWMLLKDGIIPKNFSVFNLIQEMRTQRPSLVQTQ
                     EQYELVYSAVLELFKRHMDVISDNHLGREIQAQCSIPEQSLTVEADSCPLDLPKNAMR
                     DVKTTNQHSKQGAEAESTGGSSLGLRTSTMNAEEELVLHSAKSSPSFNCLELNCGCNN
                     KAVITRNGQARASPVVGEPLQKYQSLDFGSMLFGSCPSALPINTADRYHNSKGPVKRT
                     KSTPFELIQQRKTNDLAVGDGFSCLESQLHEHYSLRELQVQRVAHVSSEELNYSLPGA
                     CDASCVPRHSPGALRVHLYTSLAEDPYFSSSPPNSADSKMSFDLPEKQDGATSPGALL
                     PASSTTSFFYSNPHDSLVMNTLTSFSPPLNQETAVEAPSRRTDDEIPPPLPERTPESF
                     IVVEEAGEPSPRVTESLPLVVTFGASPECSGTSEMKSHDSVGFTPSKNVKLRSPKSDR
                     HQDGSPPPPLPERTLESFFLADEDCIQAQAVQTSSTSYPETTENSTSSKQTLRTPGKS
                     FTRSKSLKIFRNMKKSVCNSSSPSKPTERVQPKNSSSFLNFGFGNRFSKPKGPRNPPS
                     AWNM"
     exon            212..320
                     /gene="Ptpn22"
                     /gene_synonym="70zpep; PEP; Ptpn8"
                     /inference="alignment:Splign:2.1.0"
     exon            321..397
                     /gene="Ptpn22"
                     /gene_synonym="70zpep; PEP; Ptpn8"
                     /inference="alignment:Splign:2.1.0"
     exon            398..493
                     /gene="Ptpn22"
                     /gene_synonym="70zpep; PEP; Ptpn8"
                     /inference="alignment:Splign:2.1.0"
     exon            494..532
                     /gene="Ptpn22"
                     /gene_synonym="70zpep; PEP; Ptpn8"
                     /inference="alignment:Splign:2.1.0"
     exon            533..604
                     /gene="Ptpn22"
                     /gene_synonym="70zpep; PEP; Ptpn8"
                     /inference="alignment:Splign:2.1.0"
     exon            605..664
                     /gene="Ptpn22"
                     /gene_synonym="70zpep; PEP; Ptpn8"
                     /inference="alignment:Splign:2.1.0"
     exon            665..807
                     /gene="Ptpn22"
                     /gene_synonym="70zpep; PEP; Ptpn8"
                     /inference="alignment:Splign:2.1.0"
     exon            808..874
                     /gene="Ptpn22"
                     /gene_synonym="70zpep; PEP; Ptpn8"
                     /inference="alignment:Splign:2.1.0"
     exon            875..952
                     /gene="Ptpn22"
                     /gene_synonym="70zpep; PEP; Ptpn8"
                     /inference="alignment:Splign:2.1.0"
     exon            953..1039
                     /gene="Ptpn22"
                     /gene_synonym="70zpep; PEP; Ptpn8"
                     /inference="alignment:Splign:2.1.0"
     exon            1040..1116
                     /gene="Ptpn22"
                     /gene_synonym="70zpep; PEP; Ptpn8"
                     /inference="alignment:Splign:2.1.0"
     exon            1117..1931
                     /gene="Ptpn22"
                     /gene_synonym="70zpep; PEP; Ptpn8"
                     /inference="alignment:Splign:2.1.0"
     exon            1932..2015
                     /gene="Ptpn22"
                     /gene_synonym="70zpep; PEP; Ptpn8"
                     /inference="alignment:Splign:2.1.0"
     exon            2016..2137
                     /gene="Ptpn22"
                     /gene_synonym="70zpep; PEP; Ptpn8"
                     /inference="alignment:Splign:2.1.0"
     exon            2138..2165
                     /gene="Ptpn22"
                     /gene_synonym="70zpep; PEP; Ptpn8"
                     /inference="alignment:Splign:2.1.0"
     exon            2166..2243
                     /gene="Ptpn22"
                     /gene_synonym="70zpep; PEP; Ptpn8"
                     /inference="alignment:Splign:2.1.0"
     exon            2244..2359
                     /gene="Ptpn22"
                     /gene_synonym="70zpep; PEP; Ptpn8"
                     /inference="alignment:Splign:2.1.0"
     exon            2360..2390
                     /gene="Ptpn22"
                     /gene_synonym="70zpep; PEP; Ptpn8"
                     /inference="alignment:Splign:2.1.0"
     exon            2391..2468
                     /gene="Ptpn22"
                     /gene_synonym="70zpep; PEP; Ptpn8"
                     /inference="alignment:Splign:2.1.0"
     exon            2469..2745
                     /gene="Ptpn22"
                     /gene_synonym="70zpep; PEP; Ptpn8"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2723..2728
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ptpn22"
                     /gene_synonym="70zpep; PEP; Ptpn8"
                     /note="hexamer: AATAAA"
     polyA_site      2740
                     /gene="Ptpn22"
                     /gene_synonym="70zpep; PEP; Ptpn8"
                     /note="major polyA site"
ORIGIN      
        1 agtaaaccac agcctccagc acgctgtgct cctgcagcag cagtggcttc ttggtgctgc
       61 cttggccatg acacatattt gacatgccct cccttaacct actcacagac tcttgctctg
      121 cggcatggac caaagagaaa ttctgcagca actactgaaa gaagcccaga aaaagaaact
      181 caacagtgag gagtttgcca gtgaatttct gaagctgaaa aggcaatcca ccaagtacaa
      241 ggccgacaaa atctatccta caactgtggc tcagaggccc aagaatatca agaaaaacag
      301 atacaaggat attttgccct atgatcacag cctggtagag ctgtctctgt taacttccga
      361 tgaggattcc agttatatca atgccagctt tattaagggt gtctatggac ccaaggctta
      421 tattgctacc cagggtcctt tatctacaac tctcctggac ttctggagga tgatttggga
      481 gtaccgcatc ttggtcattg tcatggcatg tatggagttt gaaatgggaa agaaaaaatg
      541 tgagcgttat tgggccgaac caggagaaac gcagctgcaa tttggcccct tttctatatc
      601 ctgtgaagct gagaaaaaga aatctgatta taaaatcagg actctgaagg ccaagttcaa
      661 taatgaaact cgaattattt accagtttca ttataagaat tggccagacc atgatgtgcc
      721 ttcatctata gaccctattc ttcagctcat ctgggatatg cgttgttacc aagaagatga
      781 ctgtgttcct atatgcattc actgcagtgc cggctgcgga aggacaggtg tcatttgtgc
      841 tgttgattat acatggatgc tgctgaaaga tgggataatt cctaagaact tcagtgtttt
      901 taatttgatt caggagatgc gaacacagag gccttcgcta gttcaaactc aggaacagta
      961 cgaactggtc tacagtgctg tgttagagct gtttaagagg cacatggatg ttatctctga
     1021 taatcacctt ggaagagaga ttcaagcaca atgctcaatt cctgaacaaa gcctcacggt
     1081 agaagctgac tcttgtcctc tggatttacc aaaaaacgcc atgagggatg tgaaaacgac
     1141 aaaccagcat agcaaacaag gggctgaagc ggagagcact ggagggtctt cccttggcct
     1201 taggacttct acgatgaatg ccgaggaaga gttggttttg cactcggcta aatcaagccc
     1261 ttcttttaac tgtttagagc taaactgcgg gtgtaacaac aaggctgtca taaccaggaa
     1321 cgggcaggca agggcttctc cagtcgtggg agagcccctt cagaagtatc aaagtctgga
     1381 ttttggttcc atgttgtttg ggtcgtgtcc tagtgctctg cccataaaca cagcggacag
     1441 gtatcacaat tcaaaggggc cggtaaaacg gaccaaatca actccctttg aactgattca
     1501 gcagagaaaa acaaatgact tggccgtggg agacggtttt tcatgcctgg aatctcagct
     1561 gcatgagcat tacagtctca gggagctgca ggtgcaaaga gtggcccatg tttcttcaga
     1621 agagctgaat tattcactgc ctggtgcctg tgatgcgtcg tgtgtgcccc ggcacagccc
     1681 cggcgctttg agagtgcatc tgtacacatc tttagcggaa gatccttatt tttcatcatc
     1741 ccctccgaat agtgctgatt cgaagatgtc ttttgatctg cctgagaaac aggatggagc
     1801 cacttcccct ggcgctctat tgccagcctc ttctacaacc tccttctttt atagcaaccc
     1861 acacgactcc ctagtgatga acactctgac cagcttttcc ccaccgttaa accaagagac
     1921 agctgtagaa gctccttctc ggaggacaga tgatgaaatc cccccgccac tccctgaacg
     1981 gacacccgag tcttttattg tggttgagga agccggagag ccctcaccac gtgttaccga
     2041 atccttacct ctggtggtaa catttggagc atcaccagaa tgcagtggga catctgaaat
     2101 gaagagccat gactctgtag ggtttacacc aagcaagaat gtgaaactcc gaagtcccaa
     2161 atcagatcga catcaggatg gttctcctcc acctcctctc ccagaaagaa ctctagagtc
     2221 cttctttctt gctgatgagg actgtataca ggcccaagcc gtgcaaactt cttctactag
     2281 ctatcctgaa accacagaga actccacatc ttctaaacaa acattgagga cccctggaaa
     2341 aagtttcaca aggagtaaga gtttgaagat ttttcgaaat atgaaaaaaa gtgtttgtaa
     2401 ttcttcctca ccaagcaagc ctacagaacg tgttcagcca aaaaattcca gctcctttct
     2461 gaattttggt ttcggaaatc gtttttcaaa acccaaagga ccaaggaacc cgccatcagc
     2521 ttggaatatg taacgcacct ctggatttat aagaatattt gttaaaattg tacctgcaga
     2581 taaagctact tgaatactgc tataataata atatcagtaa tgaggatata ttttgtcaat
     2641 agtcttgaaa aggaaagcaa tatgtgacaa acttccagca aacttgtatt ttcatattcc
     2701 ttatatttca ctgggaactg ccaataaagt ttgtacttca gttta
//
