LOCUS       NM_001409794            3219 bp    mRNA    linear   ROD 15-OCT-2024
DEFINITION  Mus musculus protein tyrosine phosphatase, non-receptor type 22
            (lymphoid) (Ptpn22), transcript variant 3, mRNA.
ACCESSION   NM_001409794 XM_036162958
VERSION     NM_001409794.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3219)
  AUTHORS   Cai,H., Chen,S., Jiang,Z., Chen,L. and Yang,X.
  TITLE     PTPN22 through the regulation of Th17/Treg balance acts as a
            potential target for the treatment of Graves' disease
  JOURNAL   Tissue Cell 90, 102502 (2024)
   PUBMED   39083881
  REMARK    GeneRIF: PTPN22 through the regulation of Th17/Treg balance acts as
            a potential target for the treatment of Graves' disease.
REFERENCE   2  (bases 1 to 3219)
  AUTHORS   Lee,J., Yurkovetskiy,L.A., Reiman,D., Frommer,L., Strong,Z.,
            Chang,A., Kahaly,G.J., Khan,A.A. and Chervonsky,A.V.
  TITLE     Androgens contribute to sex bias of autoimmunity in mice by T
            cell-intrinsic regulation of Ptpn22 phosphatase expression
  JOURNAL   Nat Commun 15 (1), 7688 (2024)
   PUBMED   39227386
  REMARK    GeneRIF: Androgens contribute to sex bias of autoimmunity in mice
            by T cell-intrinsic regulation of Ptpn22 phosphatase expression.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3219)
  AUTHORS   Orozco,R.C., Marquardt,K., Pratumchai,I., Shaikh,A.F., Mowen,K.,
            Domissy,A., Teijaro,J.R. and Sherman,L.A.
  TITLE     Autoimmunity-associated allele of tyrosine phosphatase gene PTPN22
            enhances anti-viral immunity
  JOURNAL   PLoS Pathog 20 (3), e1012095 (2024)
   PUBMED   38512979
  REMARK    GeneRIF: Autoimmunity-associated allele of tyrosine phosphatase
            gene PTPN22 enhances anti-viral immunity.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3219)
  AUTHORS   Li,S., Luo,Z., Su,S., Wen,L., Xian,G., Zhao,J., Xu,X., Xu,D. and
            Zeng,Q.
  TITLE     Targeted inhibition of PTPN22 is a novel approach to alleviate
            osteogenic responses in aortic valve interstitial cells and aortic
            valve lesions in mice
  JOURNAL   BMC Med 21 (1), 252 (2023)
   PUBMED   37443055
  REMARK    GeneRIF: Targeted inhibition of PTPN22 is a novel approach to
            alleviate osteogenic responses in aortic valve interstitial cells
            and aortic valve lesions in mice.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3219)
  AUTHORS   Wang,X., Wei,G., Ding,Y., Gui,X., Tong,H., Xu,X., Zhang,S., Sun,Z.,
            Ju,W., Li,Y., Yao,R., Wu,Q., Lu,Z., Fu,C., Li,Z., Zhang,S.,
            Gardiner,E.E., Andrews,R.K., Hu,H., Zeng,L., Xu,K. and Qiao,J.
  TITLE     Protein tyrosine phosphatase PTPN22 negatively modulates platelet
            function and thrombus formation
  JOURNAL   Blood 140 (9), 1038-1051 (2022)
   PUBMED   35767715
  REMARK    GeneRIF: Protein tyrosine phosphatase PTPN22 negatively modulates
            platelet function and thrombus formation.
REFERENCE   6  (bases 1 to 3219)
  AUTHORS   Kannan,K., Kaminski,N., Rechavi,G., Jakob-Hirsch,J., Amariglio,N.
            and Givol,D.
  TITLE     DNA microarray analysis of genes involved in p53 mediated
            apoptosis: activation of Apaf-1
  JOURNAL   Oncogene 20 (26), 3449-3455 (2001)
   PUBMED   11423996
REFERENCE   7  (bases 1 to 3219)
  AUTHORS   Gjorloff-Wingren,A., Saxena,M., Han,S., Wang,X., Alonso,A.,
            Renedo,M., Oh,P., Williams,S., Schnitzer,J. and Mustelin,T.
  TITLE     Subcellular localization of intracellular protein tyrosine
            phosphatases in T cells
  JOURNAL   Eur J Immunol 30 (8), 2412-2421 (2000)
   PUBMED   10940933
REFERENCE   8  (bases 1 to 3219)
  AUTHORS   Gregorieff,A., Cloutier,J.F. and Veillette,A.
  TITLE     Sequence requirements for association of protein-tyrosine
            phosphatase PEP with the Src homology 3 domain of inhibitory
            tyrosine protein kinase p50(csk)
  JOURNAL   J Biol Chem 273 (21), 13217-13222 (1998)
   PUBMED   9582365
REFERENCE   9  (bases 1 to 3219)
  AUTHORS   Cloutier,J.F. and Veillette,A.
  TITLE     Association of inhibitory tyrosine protein kinase p50csk with
            protein tyrosine phosphatase PEP in T cells and other hemopoietic
            cells
  JOURNAL   EMBO J 15 (18), 4909-4918 (1996)
   PUBMED   8890164
REFERENCE   10 (bases 1 to 3219)
  AUTHORS   Matthews,R.J., Bowne,D.B., Flores,E. and Thomas,M.L.
  TITLE     Characterization of hematopoietic intracellular protein tyrosine
            phosphatases: description of a phosphatase containing an SH2 domain
            and another enriched in proline-, glutamic acid-, serine-, and
            threonine-rich sequences
  JOURNAL   Mol Cell Biol 12 (5), 2396-2405 (1992)
   PUBMED   1373816
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC124698.4.
            
            On Jul 22, 2022 this sequence version replaced XM_036162958.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660825.124863.1,
                                           SRR1660821.141970.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849380, SAMN00849381
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-582               AC124698.4         76118-76699
            583-685             AC124698.4         77068-77170
            686-794             AC124698.4         90325-90433
            795-871             AC124698.4         90661-90737
            872-967             AC124698.4         90860-90955
            968-1006            AC124698.4         91345-91383
            1007-1078           AC124698.4         92413-92484
            1079-1138           AC124698.4         92586-92645
            1139-1281           AC124698.4         93275-93417
            1282-1348           AC124698.4         93985-94051
            1349-1426           AC124698.4         96258-96335
            1427-1513           AC124698.4         98730-98816
            1514-1590           AC124698.4         102002-102078
            1591-2405           AC124698.4         102207-103021
            2406-2489           AC124698.4         105192-105275
            2490-2611           AC124698.4         105415-105536
            2612-2639           AC124698.4         106936-106963
            2640-2717           AC124698.4         118794-118871
            2718-2833           AC124698.4         120050-120165
            2834-2864           AC124698.4         121836-121866
            2865-2942           AC124698.4         126061-126138
            2943-3219           AC124698.4         128656-128932
FEATURES             Location/Qualifiers
     source          1..3219
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 45.52 cM"
     gene            1..3219
                     /gene="Ptpn22"
                     /gene_synonym="70zpep; PEP; Ptpn8"
                     /note="protein tyrosine phosphatase, non-receptor type 22
                     (lymphoid)"
                     /db_xref="GeneID:19260"
                     /db_xref="MGI:MGI:107170"
     exon            1..582
                     /gene="Ptpn22"
                     /gene_synonym="70zpep; PEP; Ptpn8"
                     /inference="alignment:Splign:2.1.0"
     exon            583..685
                     /gene="Ptpn22"
                     /gene_synonym="70zpep; PEP; Ptpn8"
                     /inference="alignment:Splign:2.1.0"
     CDS             599..3007
                     /gene="Ptpn22"
                     /gene_synonym="70zpep; PEP; Ptpn8"
                     /EC_number="3.1.3.48"
                     /note="isoform 1 is encoded by transcript variant 3;
                     protein tyrosine phosphatase, non-receptor type 8; PEST
                     domain-enriched tyrosine phosphatase; tyrosine-protein
                     phosphatase non-receptor type 22; hematopoietic cell
                     protein-tyrosine phosphatase 70Z-PEP"
                     /codon_start=1
                     /product="tyrosine-protein phosphatase non-receptor type
                     22 isoform 1"
                     /protein_id="NP_001396723.1"
                     /db_xref="GeneID:19260"
                     /db_xref="MGI:MGI:107170"
                     /translation="MDQREILQQLLKEAQKKKLNSEEFASEFLKLKRQSTKYKADKIY
                     PTTVAQRPKNIKKNRYKDILPYDHSLVELSLLTSDEDSSYINASFIKGVYGPKAYIAT
                     QGPLSTTLLDFWRMIWEYRILVIVMACMEFEMGKKKCERYWAEPGETQLQFGPFSISC
                     EAEKKKSDYKIRTLKAKFNNETRIIYQFHYKNWPDHDVPSSIDPILQLIWDMRCYQED
                     DCVPICIHCSAGCGRTGVICAVDYTWMLLKDGIIPKNFSVFNLIQEMRTQRPSLVQTQ
                     EQYELVYSAVLELFKRHMDVISDNHLGREIQAQCSIPEQSLTVEADSCPLDLPKNAMR
                     DVKTTNQHSKQGAEAESTGGSSLGLRTSTMNAEEELVLHSAKSSPSFNCLELNCGCNN
                     KAVITRNGQARASPVVGEPLQKYQSLDFGSMLFGSCPSALPINTADRYHNSKGPVKRT
                     KSTPFELIQQRKTNDLAVGDGFSCLESQLHEHYSLRELQVQRVAHVSSEELNYSLPGA
                     CDASCVPRHSPGALRVHLYTSLAEDPYFSSSPPNSADSKMSFDLPEKQDGATSPGALL
                     PASSTTSFFYSNPHDSLVMNTLTSFSPPLNQETAVEAPSRRTDDEIPPPLPERTPESF
                     IVVEEAGEPSPRVTESLPLVVTFGASPECSGTSEMKSHDSVGFTPSKNVKLRSPKSDR
                     HQDGSPPPPLPERTLESFFLADEDCIQAQAVQTSSTSYPETTENSTSSKQTLRTPGKS
                     FTRSKSLKIFRNMKKSVCNSSSPSKPTERVQPKNSSSFLNFGFGNRFSKPKGPRNPPS
                     AWNM"
     exon            686..794
                     /gene="Ptpn22"
                     /gene_synonym="70zpep; PEP; Ptpn8"
                     /inference="alignment:Splign:2.1.0"
     exon            795..871
                     /gene="Ptpn22"
                     /gene_synonym="70zpep; PEP; Ptpn8"
                     /inference="alignment:Splign:2.1.0"
     exon            872..967
                     /gene="Ptpn22"
                     /gene_synonym="70zpep; PEP; Ptpn8"
                     /inference="alignment:Splign:2.1.0"
     exon            968..1006
                     /gene="Ptpn22"
                     /gene_synonym="70zpep; PEP; Ptpn8"
                     /inference="alignment:Splign:2.1.0"
     exon            1007..1078
                     /gene="Ptpn22"
                     /gene_synonym="70zpep; PEP; Ptpn8"
                     /inference="alignment:Splign:2.1.0"
     exon            1079..1138
                     /gene="Ptpn22"
                     /gene_synonym="70zpep; PEP; Ptpn8"
                     /inference="alignment:Splign:2.1.0"
     exon            1139..1281
                     /gene="Ptpn22"
                     /gene_synonym="70zpep; PEP; Ptpn8"
                     /inference="alignment:Splign:2.1.0"
     exon            1282..1348
                     /gene="Ptpn22"
                     /gene_synonym="70zpep; PEP; Ptpn8"
                     /inference="alignment:Splign:2.1.0"
     exon            1349..1426
                     /gene="Ptpn22"
                     /gene_synonym="70zpep; PEP; Ptpn8"
                     /inference="alignment:Splign:2.1.0"
     exon            1427..1513
                     /gene="Ptpn22"
                     /gene_synonym="70zpep; PEP; Ptpn8"
                     /inference="alignment:Splign:2.1.0"
     exon            1514..1590
                     /gene="Ptpn22"
                     /gene_synonym="70zpep; PEP; Ptpn8"
                     /inference="alignment:Splign:2.1.0"
     exon            1591..2405
                     /gene="Ptpn22"
                     /gene_synonym="70zpep; PEP; Ptpn8"
                     /inference="alignment:Splign:2.1.0"
     exon            2406..2489
                     /gene="Ptpn22"
                     /gene_synonym="70zpep; PEP; Ptpn8"
                     /inference="alignment:Splign:2.1.0"
     exon            2490..2611
                     /gene="Ptpn22"
                     /gene_synonym="70zpep; PEP; Ptpn8"
                     /inference="alignment:Splign:2.1.0"
     exon            2612..2639
                     /gene="Ptpn22"
                     /gene_synonym="70zpep; PEP; Ptpn8"
                     /inference="alignment:Splign:2.1.0"
     exon            2640..2717
                     /gene="Ptpn22"
                     /gene_synonym="70zpep; PEP; Ptpn8"
                     /inference="alignment:Splign:2.1.0"
     exon            2718..2833
                     /gene="Ptpn22"
                     /gene_synonym="70zpep; PEP; Ptpn8"
                     /inference="alignment:Splign:2.1.0"
     exon            2834..2864
                     /gene="Ptpn22"
                     /gene_synonym="70zpep; PEP; Ptpn8"
                     /inference="alignment:Splign:2.1.0"
     exon            2865..2942
                     /gene="Ptpn22"
                     /gene_synonym="70zpep; PEP; Ptpn8"
                     /inference="alignment:Splign:2.1.0"
     exon            2943..3219
                     /gene="Ptpn22"
                     /gene_synonym="70zpep; PEP; Ptpn8"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3197..3202
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ptpn22"
                     /gene_synonym="70zpep; PEP; Ptpn8"
                     /note="hexamer: AATAAA"
     polyA_site      3214
                     /gene="Ptpn22"
                     /gene_synonym="70zpep; PEP; Ptpn8"
                     /note="major polyA site"
ORIGIN      
        1 gagactcaag tgatcttgca gctggggaca gtcctgagga gctgggactg caccacctct
       61 cctcaattct ctccagacag gctgacctag atagaatctg tatggttctc agcaagcaat
      121 attttagctt tagttccgtt ttgtcctttc gctgtttgct agcagtgcgt tctggggata
      181 ttgtgctaac tgcctccccg gtgcttccca tcctgtgtag agctgtactc tcagtgtttg
      241 caaagctact ggaggtctga agaagtacag agaccaacac ttcccttaat gagggccagt
      301 acttccccag tcacgggtga gatggaccat cagaagcagt ggactttgct tcctctaaaa
      361 gaaaaacgtg aggtttataa tggaagcttg acaaattctg aaacaaaatg cccgcttgat
      421 gagcagaggt ctgccatgat catatctata ggagactttg gggataatgg tccgggtcgg
      481 agataggtaa ctccagtgtt tgtctcctct cctgcagcag ggcataggtg ggcgtcaccc
      541 aggcctttct gctcactggg atgtgaaaag ctgaactcac agactcttgc tctgcggcat
      601 ggaccaaaga gaaattctgc agcaactact gaaagaagcc cagaaaaaga aactcaacag
      661 tgaggagttt gccagtgaat ttctgaagct gaaaaggcaa tccaccaagt acaaggccga
      721 caaaatctat cctacaactg tggctcagag gcccaagaat atcaagaaaa acagatacaa
      781 ggatattttg ccctatgatc acagcctggt agagctgtct ctgttaactt ccgatgagga
      841 ttccagttat atcaatgcca gctttattaa gggtgtctat ggacccaagg cttatattgc
      901 tacccagggt cctttatcta caactctcct ggacttctgg aggatgattt gggagtaccg
      961 catcttggtc attgtcatgg catgtatgga gtttgaaatg ggaaagaaaa aatgtgagcg
     1021 ttattgggcc gaaccaggag aaacgcagct gcaatttggc cccttttcta tatcctgtga
     1081 agctgagaaa aagaaatctg attataaaat caggactctg aaggccaagt tcaataatga
     1141 aactcgaatt atttaccagt ttcattataa gaattggcca gaccatgatg tgccttcatc
     1201 tatagaccct attcttcagc tcatctggga tatgcgttgt taccaagaag atgactgtgt
     1261 tcctatatgc attcactgca gtgccggctg cggaaggaca ggtgtcattt gtgctgttga
     1321 ttatacatgg atgctgctga aagatgggat aattcctaag aacttcagtg tttttaattt
     1381 gattcaggag atgcgaacac agaggccttc gctagttcaa actcaggaac agtacgaact
     1441 ggtctacagt gctgtgttag agctgtttaa gaggcacatg gatgttatct ctgataatca
     1501 ccttggaaga gagattcaag cacaatgctc aattcctgaa caaagcctca cggtagaagc
     1561 tgactcttgt cctctggatt taccaaaaaa cgccatgagg gatgtgaaaa cgacaaacca
     1621 gcatagcaaa caaggggctg aagcggagag cactggaggg tcttcccttg gccttaggac
     1681 ttctacgatg aatgccgagg aagagttggt tttgcactcg gctaaatcaa gcccttcttt
     1741 taactgttta gagctaaact gcgggtgtaa caacaaggct gtcataacca ggaacgggca
     1801 ggcaagggct tctccagtcg tgggagagcc ccttcagaag tatcaaagtc tggattttgg
     1861 ttccatgttg tttgggtcgt gtcctagtgc tctgcccata aacacagcgg acaggtatca
     1921 caattcaaag gggccggtaa aacggaccaa atcaactccc tttgaactga ttcagcagag
     1981 aaaaacaaat gacttggccg tgggagacgg tttttcatgc ctggaatctc agctgcatga
     2041 gcattacagt ctcagggagc tgcaggtgca aagagtggcc catgtttctt cagaagagct
     2101 gaattattca ctgcctggtg cctgtgatgc gtcgtgtgtg ccccggcaca gccccggcgc
     2161 tttgagagtg catctgtaca catctttagc ggaagatcct tatttttcat catcccctcc
     2221 gaatagtgct gattcgaaga tgtcttttga tctgcctgag aaacaggatg gagccacttc
     2281 ccctggcgct ctattgccag cctcttctac aacctccttc ttttatagca acccacacga
     2341 ctccctagtg atgaacactc tgaccagctt ttccccaccg ttaaaccaag agacagctgt
     2401 agaagctcct tctcggagga cagatgatga aatccccccg ccactccctg aacggacacc
     2461 cgagtctttt attgtggttg aggaagccgg agagccctca ccacgtgtta ccgaatcctt
     2521 acctctggtg gtaacatttg gagcatcacc agaatgcagt gggacatctg aaatgaagag
     2581 ccatgactct gtagggttta caccaagcaa gaatgtgaaa ctccgaagtc ccaaatcaga
     2641 tcgacatcag gatggttctc ctccacctcc tctcccagaa agaactctag agtccttctt
     2701 tcttgctgat gaggactgta tacaggccca agccgtgcaa acttcttcta ctagctatcc
     2761 tgaaaccaca gagaactcca catcttctaa acaaacattg aggacccctg gaaaaagttt
     2821 cacaaggagt aagagtttga agatttttcg aaatatgaaa aaaagtgttt gtaattcttc
     2881 ctcaccaagc aagcctacag aacgtgttca gccaaaaaat tccagctcct ttctgaattt
     2941 tggtttcgga aatcgttttt caaaacccaa aggaccaagg aacccgccat cagcttggaa
     3001 tatgtaacgc acctctggat ttataagaat atttgttaaa attgtacctg cagataaagc
     3061 tacttgaata ctgctataat aataatatca gtaatgagga tatattttgt caatagtctt
     3121 gaaaaggaaa gcaatatgtg acaaacttcc agcaaacttg tattttcata ttccttatat
     3181 ttcactggga actgccaata aagtttgtac ttcagttta
//
