LOCUS       NM_008978               3090 bp    mRNA    linear   ROD 29-OCT-2024
DEFINITION  Mus musculus protein tyrosine phosphatase, non-receptor type 20
            (Ptpn20), mRNA.
ACCESSION   NM_008978
VERSION     NM_008978.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3090)
  AUTHORS   Wada,S., Ideno,H., Nakashima,K., Komatsu,K., Demura,N.,
            Tomonari,H., Kimura,H., Tachibana,M. and Nifuji,A.
  TITLE     The histone H3K9 methyltransferase G9a regulates tendon formation
            during development
  JOURNAL   Sci Rep 14 (1), 20771 (2024)
   PUBMED   39237663
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3090)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 3090)
  AUTHORS   Xu,H., Miyajima,M., Nakajima,M., Ogino,I., Kawamura,K., Akiba,C.,
            Kamohara,C., Sakamoto,K., Karagiozov,K., Nakamura,E., Tada,N.,
            Arai,H. and Kondo,A.
  TITLE     Ptpn20 deletion in H-Tx rats enhances phosphorylation of the NKCC1
            cotransporter in the choroid plexus: an evidence of genetic risk
            for hydrocephalus in an experimental study
  JOURNAL   Fluids Barriers CNS 19 (1), 39 (2022)
   PUBMED   35658898
  REMARK    GeneRIF: Ptpn20 deletion in H-Tx rats enhances phosphorylation of
            the NKCC1 cotransporter in the choroid plexus: an evidence of
            genetic risk for hydrocephalus in an experimental study.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3090)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   5  (bases 1 to 3090)
  AUTHORS   Ohsugi,M., Kuramochi,S., Matsuda,S. and Yamamoto,T.
  TITLE     Molecular cloning and characterization of a novel cytoplasmic
            protein-tyrosine phosphatase that is specifically expressed in
            spermatocytes
  JOURNAL   J Biol Chem 272 (52), 33092-33099 (1997)
   PUBMED   9407093
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AC154465.2.
            
            On Nov 17, 2006 this sequence version replaced NM_008978.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: D64141.1, AK029493.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849384 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-20                AC154465.2         116979-116998
            21-101              AC154465.2         130817-130897
            102-252             AC154465.2         132643-132793
            253-347             AC154465.2         135242-135336
            348-445             AC154465.2         140005-140102
            446-579             AC154465.2         142142-142275
            580-728             AC154465.2         150191-150339
            729-819             AC154465.2         152608-152698
            820-1154            AC154465.2         158616-158950
            1155-1370           AC154465.2         160615-160830
            1371-1433           AC154465.2         166029-166091
            1434-3090           AC154465.2         166807-168463
FEATURES             Location/Qualifiers
     source          1..3090
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="14"
                     /map="14 20.51 cM"
     gene            1..3090
                     /gene="Ptpn20"
                     /gene_synonym="typ"
                     /note="protein tyrosine phosphatase, non-receptor type 20"
                     /db_xref="GeneID:19256"
                     /db_xref="MGI:MGI:1196295"
     exon            1..20
                     /gene="Ptpn20"
                     /gene_synonym="typ"
                     /inference="alignment:Splign:2.1.0"
     exon            21..101
                     /gene="Ptpn20"
                     /gene_synonym="typ"
                     /inference="alignment:Splign:2.1.0"
     exon            102..252
                     /gene="Ptpn20"
                     /gene_synonym="typ"
                     /inference="alignment:Splign:2.1.0"
     CDS             219..1499
                     /gene="Ptpn20"
                     /gene_synonym="typ"
                     /EC_number="3.1.3.48"
                     /note="testis-specific tyrosine phosphatase"
                     /codon_start=1
                     /product="tyrosine-protein phosphatase non-receptor type
                     20"
                     /protein_id="NP_033004.1"
                     /db_xref="CCDS:CCDS36870.1"
                     /db_xref="GeneID:19256"
                     /db_xref="MGI:MGI:1196295"
                     /translation="MSSPRKVRGKTGRDNDEEEGNSGNLNLRNSLPSSSQKMTPTKPI
                     FGNKMNSENVKPSHHLSFSDKYELVYPEPLESDTDETVWDVSDRSLRNRWNSMDSETA
                     GPSKTVSPVLSGSSRLSKDTETSVSEKELTQLAQIRPLIFNSSARSAMRDCLNTLQKK
                     EELDIIREFLELEQMTLPDDFNSGNTLQNRDKNRYRDILPYDSTRVPLGKNKDYINAS
                     YIRIVNHEEEYFYIATQGPLPETIEDFWQMVLENNCNVIAMITREIECGVIKCYSYWP
                     ISLKEPLEFEHFSVFLETFHVTQYFTVRVFQIVKKSTGKSQCVKHLQFTKWPDHGTPA
                     SADFFIKYVRYVRKSHITGPLLVHCSAGVGRTGVFICVDVVFSAIEKNYSFDIMNIVT
                     QMRKQRCGMIQTKEQYQFCYEIVLEVLQNLLALY"
     exon            253..347
                     /gene="Ptpn20"
                     /gene_synonym="typ"
                     /inference="alignment:Splign:2.1.0"
     exon            348..445
                     /gene="Ptpn20"
                     /gene_synonym="typ"
                     /inference="alignment:Splign:2.1.0"
     exon            446..579
                     /gene="Ptpn20"
                     /gene_synonym="typ"
                     /inference="alignment:Splign:2.1.0"
     exon            580..728
                     /gene="Ptpn20"
                     /gene_synonym="typ"
                     /inference="alignment:Splign:2.1.0"
     exon            729..819
                     /gene="Ptpn20"
                     /gene_synonym="typ"
                     /inference="alignment:Splign:2.1.0"
     exon            820..1154
                     /gene="Ptpn20"
                     /gene_synonym="typ"
                     /inference="alignment:Splign:2.1.0"
     exon            1155..1370
                     /gene="Ptpn20"
                     /gene_synonym="typ"
                     /inference="alignment:Splign:2.1.0"
     exon            1371..1433
                     /gene="Ptpn20"
                     /gene_synonym="typ"
                     /inference="alignment:Splign:2.1.0"
     exon            1434..3090
                     /gene="Ptpn20"
                     /gene_synonym="typ"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3067..3072
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ptpn20"
                     /gene_synonym="typ"
                     /note="hexamer: ATTAAA"
     polyA_site      3087
                     /gene="Ptpn20"
                     /gene_synonym="typ"
                     /note="major polyA site"
ORIGIN      
        1 cccgaggcct acaggcccag ggttatgtct gactcactgc actggagttt ggcaaaagca
       61 tctcagaagt ggttgtgctt ttttgaatga aatgatcaat ggagtgctcc agttgtatgc
      121 tggcctctgg atactaacta gacctgcctg actccaggaa ctaaggctca gtatctgcag
      181 aagctttttg cccatctcat tccggctatg gggacaacat gtcttcaccc aggaaggtta
      241 gaggaaaaac tggaagagat aatgatgaag aggagggtaa ttcaggtaac ctgaatctcc
      301 gcaactcttt gccttcatcg agtcagaaaa tgacgcctac gaagccgatt tttgggaata
      361 aaatgaattc agagaatgta aaaccctccc atcacctgtc attctcagat aagtatgagc
      421 ttgtttaccc agagcctttg gaaagtgaca ctgatgagac tgtgtgggat gtcagtgacc
      481 ggtctctcag aaacaggtgg aacagtatgg attcagagac tgcagggccg tcaaagactg
      541 tctccccagt gctttctggt agtagtaggc tctcaaagga cactgaaaca tctgtctctg
      601 aaaaggagct aactcagttg gctcagattc gaccattaat attcaacagt tctgcacggt
      661 ctgctatgcg ggattgtttg aacacgcttc agaaaaaaga agaacttgat atcatccgtg
      721 agtttttgga gttagaacaa atgactctgc ctgatgactt caattctggg aatacactac
      781 agaacagaga taagaacaga taccgagata ttcttccata tgattcaaca cgtgttcctc
      841 ttggaaaaaa caaggactac atcaacgcta gttatattag aatagtaaat catgaagaag
      901 agtattttta tattgccact caaggaccat tgccagaaac tatagaagac ttttggcaaa
      961 tggttctgga aaataattgt aatgttattg ctatgataac cagagagata gaatgtggag
     1021 ttatcaagtg ttacagttac tggcccattt ctctgaagga gcctttggaa ttcgaacact
     1081 ttagtgtctt tctggagacc tttcatgtaa ctcaatattt caccgttcga gtatttcaga
     1141 ttgtgaagaa gtccacagga aagagccaat gtgtaaaaca cttgcagttc accaagtggc
     1201 cagaccatgg cactcctgcc tcagcagatt ttttcataaa atatgtccgt tatgtgagga
     1261 agagccacat tacaggaccc ctccttgttc actgcagtgc tggtgtaggc cgaacagggg
     1321 tgttcatatg tgtggatgtt gtgttctctg ccatcgagaa gaactactct tttgacatta
     1381 tgaacatagt gacccagatg agaaagcagc gctgtggcat gattcaaacc aaggagcagt
     1441 accagttttg ttatgaaatt gtgcttgaag ttcttcagaa ccttctggct ttgtattaag
     1501 agagacttct gcgcctgtcc ctcgaggtta ccgagcagct tggagcctga gccgtgctga
     1561 agcgtctgcg ggccgtgcag tctgccttct gatttttctc tctgaaagtc cctgaaggta
     1621 gcactactgg gcacagagtg aactgtttcc acttgatctt tctgaacaag agcaaaatac
     1681 cctccatgcc ttctacggaa acggaagttg catgaaacaa cctccgcttg gctgtctggt
     1741 ttgtggtatt acagagctta ataaaagact tagatgtgtt tgataagatt ttatttggaa
     1801 aggtggtcaa aagcctcaga caatttctaa cactttacaa gccctactct gggagaacat
     1861 gggggcagta aactgcaggc tcacagactg ccctcttgtg gtcattttgg agacacgtga
     1921 aatgtgtgtt agaatctata cttccagctg gtaaccgaat aactcaaaag gactctaatt
     1981 agggtggact gacttttgat ataaaatggg ttttgtgtct tatacttcca tggtcccaga
     2041 gtgccctagg gattttgaag gaagagctac cttcctggag gagcagtcag acccttgtcg
     2101 gctgccctgg caagcacctt gtaggtgact agtgcccctc cttactatcc cctgaacaca
     2161 ctggtcagca gtgccaaact aaaatagaca tccatctgta aattcagtgg aaatgtttgc
     2221 cgggcccagg cagacttctc tcctgccctg ccccacagtt aacatacttt tccatgtgct
     2281 ttatcagaag caagggctac acgacacgtg cctctggatc tttagctagc ccataaatgt
     2341 taatatgtga tattgttatt taagtttgag tcattcttgg tacctgttgt atcaaggttt
     2401 ttttcttttt aactaagatc taaaaaagat ttttttttcc tctagaggac cattaagtca
     2461 tttctttcct ctacaggaat atttagatgc tggacattgg actagatttt ggaaagccaa
     2521 attcatagtt gtaaaagtaa aaatttccac atgcttgtta agaaaactct ggtccgctgt
     2581 tccattcatt atatcaggac tcagacaaat gtggtggttc cttggttaaa ggctttcaat
     2641 gattagacac tcctaattat cagccacaaa gaaattgata agcgtatttg tacagtgaat
     2701 tcagaactgt gaatcatatt gaaaattcct aaaattataa atgctaaact tttaagaggc
     2761 tcatttcttt ggttaaatga atacacttga attggttgaa ttaaaattga taattctcac
     2821 tttagaaata attatatata attatactat agaaatatta tatattatat atatatttga
     2881 ccttaactca agttgatgat tatagctatt tatactgttt atatacataa tgatctgtgc
     2941 tgaacaataa tatcattctg attattggtt attaacattt gtaactgtaa ctgtattttc
     3001 attctgttac tataaaataa taagtataat atagaagaat attctcacca tggcctgtat
     3061 gttgttatta aatgaaaata tttactatgc
//
