LOCUS       NM_001127177            8423 bp    mRNA    linear   ROD 29-JUL-2024
DEFINITION  Mus musculus protein tyrosine phosphatase, non-receptor type 2
            (Ptpn2), transcript variant 2, mRNA.
ACCESSION   NM_001127177
VERSION     NM_001127177.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 8423)
  AUTHORS   Zhang,B., Sun,C., Zhu,Y., Qin,H., Kong,D., Zhang,J., Shao,B.,
            Li,X., Ren,S., Wang,H., Hao,J. and Wang,H.
  TITLE     Upregulation of TCPTP in Macrophages Is Involved in IL-35 Mediated
            Attenuation of Experimental Colitis
  JOURNAL   Mediators Inflamm 2024, 3282679 (2024)
   PUBMED   38962170
  REMARK    GeneRIF: Upregulation of TCPTP in Macrophages Is Involved in IL-35
            Mediated Attenuation of Experimental Colitis.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 8423)
  AUTHORS   Kim,Y.K., Kim,Y.R., Wells,K.L., Sarbaugh,D., Guney,M., Tsai,C.F.,
            Zee,T., Karsenty,G., Nakayasu,E.S. and Sussel,L.
  TITLE     PTPN2 Regulates Metabolic Flux to Affect beta-Cell Susceptibility
            to Inflammatory Stress
  JOURNAL   Diabetes 73 (3), 434-447 (2024)
   PUBMED   38015772
  REMARK    GeneRIF: PTPN2 Regulates Metabolic Flux to Affect beta-Cell
            Susceptibility to Inflammatory Stress.
REFERENCE   3  (bases 1 to 8423)
  AUTHORS   Liu,S., Liu,F., Zhang,Z., Zhuang,Z. and Chen,Y.
  TITLE     PTPN2 inhibits the proliferation of psoriatic keratinocytes by
            dephosphorylation of STAT3
  JOURNAL   Cell Biochem Funct 42 (2), e3947 (2024)
   PUBMED   38379221
  REMARK    GeneRIF: PTPN2 inhibits the proliferation of psoriatic
            keratinocytes by dephosphorylation of STAT3.
REFERENCE   4  (bases 1 to 8423)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   5  (bases 1 to 8423)
  AUTHORS   Zhang,Z., Guo,Q., Zhao,Z., Nie,M., Shi,Q., Li,E., Liu,K., Yu,H.,
            Rao,L. and Li,M.
  TITLE     DNMT3B activates FGFR3-mediated endoplasmic reticulum stress by
            regulating PTPN2 promoter methylation to promote the development of
            atherosclerosis
  JOURNAL   FASEB J 37 (8), e23085 (2023)
   PUBMED   37462502
  REMARK    GeneRIF: DNMT3B activates FGFR3-mediated endoplasmic reticulum
            stress by regulating PTPN2 promoter methylation to promote the
            development of atherosclerosis.
REFERENCE   6  (bases 1 to 8423)
  AUTHORS   Reddy,R.S. and Swarup,G.
  TITLE     Alternative splicing generates four different forms of a
            non-transmembrane protein tyrosine phosphatase mRNA
  JOURNAL   DNA Cell Biol 14 (12), 1007-1015 (1995)
   PUBMED   8534367
REFERENCE   7  (bases 1 to 8423)
  AUTHORS   Kaneko,Y., Takano,S., Okumura,K., Takenawa,J., Higashituji,H.,
            Fukumoto,M., Nakayama,H. and Fujita,J.
  TITLE     Identification of protein tyrosine phosphatases expressed in murine
            male germ cells
  JOURNAL   Biochem Biophys Res Commun 197 (2), 625-631 (1993)
   PUBMED   8267598
REFERENCE   8  (bases 1 to 8423)
  AUTHORS   Miyasaka,H. and Li,S.S.
  TITLE     Molecular cloning, nucleotide sequence and expression of a cDNA
            encoding an intracellular protein tyrosine phosphatase, PTPase-2,
            from mouse testis and T-cells
  JOURNAL   Mol Cell Biochem 118 (1), 91-98 (1992)
   PUBMED   1283199
REFERENCE   9  (bases 1 to 8423)
  AUTHORS   Mosinger,B. Jr., Tillmann,U., Westphal,H. and Tremblay,M.L.
  TITLE     Cloning and characterization of a mouse cDNA encoding a cytoplasmic
            protein-tyrosine-phosphatase
  JOURNAL   Proc Natl Acad Sci U S A 89 (2), 499-503 (1992)
   PUBMED   1731319
REFERENCE   10 (bases 1 to 8423)
  AUTHORS   Sakaguchi,A.Y., Sylvia,V.L., Martinez,L., Smith,E.A., Han,E.S.,
            Lalley,P.A., Shows,T.B. and Choudhury,G.G.
  TITLE     Assignment of tyrosine-specific T-cell phosphatase to conserved
            syntenic groups on human chromosome 18 and mouse chromosome 18
  JOURNAL   Genomics 12 (1), 151-154 (1992)
   PUBMED   1733852
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CA560046.1, AK014528.1, AK076072.1, AK132013.1, AC108434.12 and
            DV552728.1.
            
            Transcript Variant: This variant (2) represents the longer
            transcript.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660821.162739.1,
                                           SRR1660819.177819.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164134, SAMN01164142
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-33                CA560046.1         1-33
            34-617              AK014528.1         2-585
            618-1238            AK076072.1         571-1191
            1239-2693           AK132013.1         1202-2656
            2694-8030           AC108434.12        35363-40699         c
            8031-8386           AK014528.1         1206-1561
            8387-8423           DV552728.1         185-221
FEATURES             Location/Qualifiers
     source          1..8423
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="18"
                     /map="18 40.06 cM"
     gene            1..8423
                     /gene="Ptpn2"
                     /gene_synonym="Ptpt; TC-PTP"
                     /note="protein tyrosine phosphatase, non-receptor type 2"
                     /db_xref="GeneID:19255"
                     /db_xref="MGI:MGI:97806"
     exon            1..180
                     /gene="Ptpn2"
                     /gene_synonym="Ptpt; TC-PTP"
                     /inference="alignment:Splign:2.1.0"
     CDS             112..1332
                     /gene="Ptpn2"
                     /gene_synonym="Ptpt; TC-PTP"
                     /EC_number="3.1.3.48"
                     /note="isoform b is encoded by transcript variant 2; T
                     cell protein-tyrosine phosphatase; tyrosine-protein
                     phosphatase non-receptor type 2; MPTP; protein-tyrosine
                     phosphatase PTP-2"
                     /codon_start=1
                     /product="tyrosine-protein phosphatase non-receptor type 2
                     isoform b"
                     /protein_id="NP_001120649.1"
                     /db_xref="CCDS:CCDS50311.1"
                     /db_xref="GeneID:19255"
                     /db_xref="MGI:MGI:97806"
                     /translation="MSATIEREFEELDAQCRWQPLYLEIRNESHDYPHRVAKFPENRN
                     RNRYRDVSPYDHSRVKLQSTENDYINASLVDIEEAQRSYILTQGPLPNTCCHFWLMVW
                     QQKTKAVVMLNRTVEKESVKCAQYWPTDDREMVFKETGFSVKLLSEDVKSYYTVHLLQ
                     LENINTGETRTISHFHYTTWPDFGVPESPASFLNFLFKVRESGCLTPDHGPAVIHCSA
                     GIGRSGTFSLVDTCLVLMEKGEDVNVKQLLLNMRKYRMGLIQTPDQLRFSYMAIIEGA
                     KYTKGDSNIQKRWKELSKEDLSPICDHSQNRVMVEKYNGKRIGSEDEKLTGLPSKVQD
                     TVEESSESILRKRIREDRKATTAQKVQQMKQRLNETERKRKRWLYWQPILTKMGFVSV
                     ILVGALVGWTLLFH"
     exon            181..271
                     /gene="Ptpn2"
                     /gene_synonym="Ptpt; TC-PTP"
                     /inference="alignment:Splign:2.1.0"
     exon            272..372
                     /gene="Ptpn2"
                     /gene_synonym="Ptpt; TC-PTP"
                     /inference="alignment:Splign:2.1.0"
     exon            373..471
                     /gene="Ptpn2"
                     /gene_synonym="Ptpt; TC-PTP"
                     /inference="alignment:Splign:2.1.0"
     exon            472..606
                     /gene="Ptpn2"
                     /gene_synonym="Ptpt; TC-PTP"
                     /inference="alignment:Splign:2.1.0"
     exon            607..816
                     /gene="Ptpn2"
                     /gene_synonym="Ptpt; TC-PTP"
                     /inference="alignment:Splign:2.1.0"
     exon            817..969
                     /gene="Ptpn2"
                     /gene_synonym="Ptpt; TC-PTP"
                     /inference="alignment:Splign:2.1.0"
     exon            970..1136
                     /gene="Ptpn2"
                     /gene_synonym="Ptpt; TC-PTP"
                     /inference="alignment:Splign:2.1.0"
     exon            1137..8404
                     /gene="Ptpn2"
                     /gene_synonym="Ptpt; TC-PTP"
                     /inference="alignment:Splign:2.1.0"
     regulatory      8371..8376
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ptpn2"
                     /gene_synonym="Ptpt; TC-PTP"
                     /note="hexamer: ATTAAA"
     polyA_site      8393
                     /gene="Ptpn2"
                     /gene_synonym="Ptpt; TC-PTP"
                     /note="major polyA site"
ORIGIN      
        1 ggcggggcgg ggcgcggagc gcgcatgcgc cacagtgcca gcgctctccc cggatagagc
       61 ggggcccgag cctgtccgct gtggtagttc cgctcgcgct gccccgccgc catgtcggca
      121 accatcgagc gggagttcga ggaactggat gctcagtgtc gctggcagcc gttatacttg
      181 gaaattcgaa atgaatccca tgactatcct catagagtgg ccaagtttcc agaaaacaga
      241 aaccgaaaca gatacagaga tgtaagccca tatgatcaca gtcgtgttaa actgcaaagt
      301 actgaaaatg attatattaa tgccagctta gttgacatag aagaggcaca aagaagttac
      361 atcttaacac agggcccact tccgaacaca tgctgccatt tctggctcat ggtgtggcag
      421 caaaagacca aagcagttgt catgctaaac cgaactgtag aaaaagaatc ggttaaatgt
      481 gcacagtact ggccaacgga tgacagagaa atggtgttta aggaaacggg attcagtgtg
      541 aagctcttat ctgaagatgt aaaatcatat tatacagtac atctactaca gttagaaaat
      601 atcaatactg gtgaaaccag aaccatatct cacttccatt ataccacctg gccagatttt
      661 ggggttccag agtcaccagc ttcatttcta aacttcttgt ttaaagttag agaatctggt
      721 tgtttgaccc ctgaccatgg acctgcagtg atccattgca gtgcgggcat cgggcgctct
      781 ggcaccttct ctcttgtaga tacctgtctt gttctgatgg aaaaaggaga ggatgttaat
      841 gtgaaacaat tattactgaa tatgagaaag tatcgaatgg gacttattca gacaccggac
      901 caactcagat tctcctacat ggccataata gaaggagcaa agtacacaaa aggagattca
      961 aatatacaga aacggtggaa agaactttct aaagaagatt tatctcctat ttgtgatcat
     1021 tcacagaaca gagtgatggt tgagaagtac aatgggaaga gaataggttc agaagatgaa
     1081 aagttaacag ggcttccttc taaggtgcag gatactgtgg aggagagcag tgagagcatt
     1141 ctacggaaac gtattcgaga ggatagaaag gctacgacgg ctcagaaggt gcagcagatg
     1201 aaacagaggc taaatgaaac tgaacgaaaa agaaaaaggt ggttatattg gcaacctatt
     1261 ctcactaaga tggggtttgt gtcagtcatt ttggttggcg ctttggttgg ctggacactg
     1321 ctttttcact aaatgttcta taaattaata gttttaccca gcacctttct gcactagtag
     1381 ctgaccgtgg tgcattaatc tcaagggttt gttagcaatg cctcataccc agaaacactg
     1441 cgctagagta gacatcagcc agataaggga tattacagtc acaagcccag catctcagga
     1501 ctcatcactg caggttcctc tgagacccag actgtcaatg gctcacaata aagacaagca
     1561 tgcttgttgg atactgttac ttcttacagc tgcgttcaca ccagtgtatt gagaaatcct
     1621 ttatcccaag gattggcttt tggaggcctt ctggatttta acctgcactt gatataagca
     1681 ataaacattg tggttttttt ctacattatt aatggaaaga aaatatcctt taaacaatgt
     1741 atgtaatatg taatgtactg ttgaaatggg cattacaact ttatataacc attttagggt
     1801 aaatatattt tataagtacc tatttaatct tacttttgta gttaaatgta ctttttaaag
     1861 gttcaatctg aaagtctgtt atcatagaaa aataaattgt atgttgactc agttgtatac
     1921 tgaatacatt ttccctttcc taagcagacg tttgatagag gcagttgaaa ctataagcaa
     1981 gctaagacta ctacacattc ttatttcctt tctatttatg ctttatctta ttttaaaaag
     2041 aaaaacaaaa attttctaaa catgtcattg aaggaaattg tttttttctg cgatagttaa
     2101 gaagtgacag ttggtcaaaa tatagttgaa aacaaacaaa aacttggttt ctgcaggatg
     2161 tggtagcaca cacagtgctc aggaagctaa aacaagaggc tcaatggttt gaagccagcc
     2221 aaaactacat agcaaggtcc tatctttaaa gataagagaa aaatagaggt ggtggaggag
     2281 agatcagaca acaccaagaa taagaaatcg attcttagcc atatttaatg gacaaacctg
     2341 tcatctcagc ttttgggaga tagaggcaga aggctcacaa gttcaaggcc agcttcaact
     2401 acatagctag ccccagagtt tggggccagt caggactgca agaaacactg tctcagaaac
     2461 tgaagtggtt taaaaacatt ttgatttctg taaagtaaag cccatgcatg actacactgt
     2521 taattttttg tgaaaatgta aatgtaatta cccagacggg ataaattatg gttagtaagt
     2581 taaaggaacc agtgttttat acttttgatt tcagttcact agactgaaat tttgaagtaa
     2641 aaaaaaattt aatttcttta caagttcaat aaatagtaca atggtgtaca aacttacatt
     2701 gtcccttacc tttgtaatga gtatttttaa agcataacca ctaattgggt tttggtggtt
     2761 tcaaaccctg cttggtggaa aggttccaaa ccattaggac agcattgctg cttcatctct
     2821 tttatatatc acgtaaaagt gcgtggtaaa tcttaattag tttaaatgag acagttaatt
     2881 tcttaatgca gtttgaaccc cataggtgta gttagaaatt gtgaatggcc ttgaaaagca
     2941 tctcacaaag cgtatgatgt atgtgtgtgt cctgactcag catagctgtc ctaaggcttt
     3001 gaaatggaga gcaggtaaga aggatgtttc ctcttgtctg tttaatctct gtttaagcgg
     3061 aggccttaga attagatggc tatgggtttt gagctttcta acacttactg gtttgttttt
     3121 ccaaaatgta gtatgttatc ctactagacc ttattaaaac ttacagtcca agccaataag
     3181 gtggcgtaca cctttaatct caacactaag aacaccaaga cagacagatc cctgtgagtt
     3241 caaggctagt ctggtccaca taataagttc ccaggcagcc agaaatagac attgagatcc
     3301 tgtcttgaaa gaaagcaaac caactgaaga tagcctgagc ttaaacaact tcccacaaga
     3361 aaaactgata aggctgagac cagtccttcc ttggacgata tgctttctag agatagcatt
     3421 gagcaccact ctttctgcct cttggtgtgt attttatgtt tgtgaggatt cctttggcat
     3481 acggaaccct cagtgctcct ccccggagcc cgtctttctc ccctgaacac atctttaagg
     3541 atgagtttta acaggagaac ctttaagtca cactgtcatg ttgcttacta aaggtacatg
     3601 gcctgtggtg acagtgtcac tggcatcatc ctgagcctgt atgagatgtg ctgtgctgat
     3661 gagagaaggg tgctgggcag agaagggata ctagcagttt ctgatgggtt cacggcttta
     3721 aacacagtgt gcgtcagtct cggtagcagc ttattttaac taatttagga ataatagttt
     3781 gtcttggatc aaattctgtt ttttgtttgt ttgtttgttt tttgtttttg gtgtttggtt
     3841 tttttttaat ttggggaaaa aataggcttt ttaaagggga ttattgttta ctggaaagaa
     3901 tcctcacttc ctgtttcctc ccaccttgct gtaatgtcag tggtcacaag attcaccagg
     3961 tactgtgtta tctcagcctc ctgatttcta tccatgctca aacctaaagt gtaaaagtac
     4021 acattccttt ttaaaaatac gcatatgcat catttctacg ttcagcagaa tctacacatt
     4081 tgtcaagttt tccacagttc tcagttcttt ttatccattc cgttatgtgt cacctcatgt
     4141 atcaaacagt gaacataaaa agatatgaag acctgtatta attagttttt gtccaaacag
     4201 ctgtgctctg aagctgcgtc agaggaaagg tcctaatttc tgagctcagc ttccatgcac
     4261 tcggctcggc cctttgtctt aaagtaaagc tagtgctgtg agtttagaac tgtggcccac
     4321 gtttcaagtt atgacacaga acagccctct ctggttgtca tttcatttcc ttgtttgctt
     4381 ttagcaccag tcccagggtg ctggctccca ttttctgcca ggcacagaaa ggctacagct
     4441 gactgcttta aaaatagctc tgcgtagatt ctgcagagaa gctggaacct aatggtagta
     4501 aaagtacttt tttttggcca ttgtatacaa tctacttaac aagtttacat ttctgtcaag
     4561 acattgcaga ctgaagatct acattgcctt aatttgttac ttactgatac aaatctttat
     4621 ttgtagttgt tgttttggat aggtttgtat attctttttt tttttttttt ttttttttgt
     4681 atgtgtgttg agatagtacc ttgccattgc ccaagcctgg ccttaaactc agctcaaacg
     4741 actttcctac ctcagcctgt tgagtaacta acaccacagg tacacactgt gcacacagct
     4801 ttcaagtata aatcttaaag agattatttt aaaactgtag ataagatttc aggcccttag
     4861 tcaagcgtgg tgcatacctt ctctgagtag ggccatctct gggtcctggt gagtagtgtc
     4921 tatgtctgtg ggaaggaagg gctgctcggg gccttcatct ggctgagctc gattcatctg
     4981 ttcatagcat gggacaaaat accaacagaa atgtccattc tatttacatg ccaacaccta
     5041 acaaagtctc ttatttttaa aactccttta tatggctttg ccatagaatc ttgtatatac
     5101 tttttttttt ttttcaaaat agaaatgatt ttttttctca ttaaatttgt catcttatta
     5161 cttgaaacgt gggcctttgt tattggcagt ggcttgctcc cgaggaggcc tgttctgtcc
     5221 accctgtccc agaacgcact catttgagtc agatgccaca gttcttcctc acactggtct
     5281 ttggtttata ccatgcagca ccatacctag agtcacagct gtctctaatt gtcccctgaa
     5341 tatggaatga gagactcagg ctgtgccctc attcactgct gctctgcact ggagcctgtc
     5401 cccaatcaga gaacttgcct cgtggccagc agtcttcctt cctgggtcct gagcagcttc
     5461 aagccttctg cattagtgct ttctcttagc cgtggctgtt gggaagaaga cccactgttc
     5521 tccacaggtt gggttgtttt tttttttttt cctggctgtc cttgtcccag cacagtgcca
     5581 tcagccattg tgagcagtgc ttaaagtgga aagctacacc agcctaagag gctttgtgta
     5641 agctgacgtt taggatttaa agagcctgga ccatctgagt tctgactctg aagctctgct
     5701 tggttgtaaa gttccagttg attctgagca gtgaggtgtg aggccactgt caccggtagg
     5761 gtctgcttgg atgccgcctg ctttacttgg atctgttttg ttggggactg ctgcaaggag
     5821 aattgcatgg gaattttctt ctttttcttt acagagactt ataagcatcg agttattctt
     5881 tgtagtcact cattaggcat agtttttttt ttttaagacc catgatgctg ttgctattcc
     5941 cccccccctt ttttttttgg ttttttgaga cagggtttct ctgtataact ctggctgtcc
     6001 tggaactcac tttgtagacc tcaaactcag aaatccccct gcctttgcct cctgagtgct
     6061 gggattaaag gcatgcgcca ccacggcccg gctgctgttg atattttaaa tgactatttt
     6121 aaaaagtcgt tcagtgtgga aagttgagga gaggaagcct aggtaagttc ctttaaagca
     6181 tgcttggctc acctcggtta gtcctgatca atctcagtcg gatgctaatg taaatgtcgt
     6241 gtggcaaaac aacttttaat gcagtctgac tttccctcta acacgggcaa ggaagaagac
     6301 accagcattt gcctctgcag cacagaggca gcccccagga tacccacgta gctcattgct
     6361 tggtttgctc gcccatttta cttttgcctt attaaaaata aaatggtgaa gatccattca
     6421 agtgaatata atagaattat ctcaaaagcc atttatctta atagtcttac aaataaagtc
     6481 atttcttaga agctattcca ttgatttcct cttattttgc tacccctaaa cactatttga
     6541 aaagaagtaa tgagtttcaa aaaccacagc gtgtctgtta aatggcaaat ttattattct
     6601 tggtaaatgt gtatttaaca aacactagga aaggatatct cgtgtgtatg tgagagagaa
     6661 agagagagtg cttcacaaca ctttaaataa tgccagccat attttcagat aagaaaccca
     6721 gtggaggtgt gactcacgcc ttattttcca gcctgtgcag atagagctga gatgcagact
     6781 ccaggctgtg gtttcagtcc ctccaaggct caggctcatt gtgctactcc actgtgtatt
     6841 tacttaaacc agatgtttaa gcggggaaat agtagacacc ccactagtgg aggggtggaa
     6901 tcccttttac aatgcttcac tgactatggc ggaccagaac gtttctgtgc caaagcccca
     6961 cttcattcct ttctgttctg ttccacattc tgccagagtc agaaccagcc gtttggtccc
     7021 aggtcctgcg acccattgct atctaaagag tatggttccc taatgagaac actgcagaga
     7081 atcactgttg ggaaatcaaa caagactttg tagaccacca caggggcttg gtagatctgc
     7141 ctgcctatgg agaaagaagc cagtagacag gaagaagctt cattctcatg gttggggagg
     7201 agcctaagtg gtggagatct agtgtattgc ctgtttatac agtgataaag tcaagtattt
     7261 tcatgggtag agagcgaggg tggaggaagg gaggggctgc gatcggtgca aaaatggaaa
     7321 tacctttaat ctcccaaaag ctttgaccac tggcaaacaa ttgaaatatc agcaaagact
     7381 actgctctta atggtcacac cctcttgttt aaatggcgtc cccctcccaa gcattaaatt
     7441 gcgctgaact atcacagttt tacttagttc tagtagttat aatcattagc attctccttc
     7501 aggagaaaat ctaaatgctg gaaatctaat tcagagataa caagccaact ttatgtgcaa
     7561 actttatatt taaactgttt ctagcagtgt tacagtgatt gtccaaactg gattagactt
     7621 ttgcgttgaa atcaaagtat gggtaagtct agcacatgta ataaaacctt gctgtttctt
     7681 gtggctacat tttttttttt aacttgtctg tctcttagcc taccatgtag aggtcatttc
     7741 ttgagttaag atgggatggc ctaaaagatt cagtgtgtag ttactgaaga agtaagtccc
     7801 ggcgcctcag agcagtctgt ctcacagccc cgcttccatt tggaaacctg ccattctgga
     7861 aggaagcact tggtgttctt ggaatgttca tgttggaatg atttttgttg ttgttgttgt
     7921 tgttgacttt ttagttcagt cttagttctt ttgtgtttgt atctatctat gtacatctgt
     7981 gtgtgtggtg gccatggatt gaatagatga cttcttattt tatgttttag gccaagattg
     8041 acagacacct aaatgttcat gacttgagac tattctgcag ctataaaatt tgaacctttg
     8101 atgtgcaaag caagacctga agcccactcc ggaaactaaa gtgaggcttg ctaaccctgt
     8161 agattgcctc acaagttgtc tgtttacaaa gtaagctttc catccagggg atgaagaacg
     8221 ccaccagcag aagacttgca aaccctttaa tttgatgtat tgttttttaa catgtgtatg
     8281 aaatgtagaa agatgtaaag gaaataaatt aggagcgact actttgtatt gtactgccat
     8341 tcctaatgta tttttatact ttttggcagc attaaatatt tttattaaat agactatgtt
     8401 ggttaaaaaa aaaaaaaaaa aaa
//
