LOCUS       NM_011206               1587 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus protein tyrosine phosphatase, non-receptor type 18
            (Ptpn18), transcript variant 1, mRNA.
ACCESSION   NM_011206
VERSION     NM_011206.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1587)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1587)
  AUTHORS   Cui,W., Dai,X., Marcho,C., Han,Z., Zhang,K., Tremblay,K.D. and
            Mager,J.
  TITLE     Towards Functional Annotation of the Preimplantation Transcriptome:
            An RNAi Screen in Mammalian Embryos
  JOURNAL   Sci Rep 6, 37396 (2016)
   PUBMED   27869233
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1587)
  AUTHORS   Sultana,D.A., Tomita,S., Hamada,M., Iwanaga,Y., Kitahama,Y.,
            Khang,N.V., Hirai,S., Ohigashi,I., Nitta,S., Amagai,T.,
            Takahashi,S. and Takahama,Y.
  TITLE     Gene expression profile of the third pharyngeal pouch reveals role
            of mesenchymal MafB in embryonic thymus development
  JOURNAL   Blood 113 (13), 2976-2987 (2009)
   PUBMED   19164599
REFERENCE   4  (bases 1 to 1587)
  AUTHORS   Gensler,M., Buschbeck,M. and Ullrich,A.
  TITLE     Negative regulation of HER2 signaling by the PEST-type
            protein-tyrosine phosphatase BDP1
  JOURNAL   J Biol Chem 279 (13), 12110-12116 (2004)
   PUBMED   14660651
  REMARK    GeneRIF: BDP1 has a role in negative regulation of HER2 signaling
REFERENCE   5  (bases 1 to 1587)
  AUTHORS   Wang,B., Lemay,S., Tsai,S. and Veillette,A.
  TITLE     SH2 domain-mediated interaction of inhibitory protein tyrosine
            kinase Csk with protein tyrosine phosphatase-HSCF
  JOURNAL   Mol Cell Biol 21 (4), 1077-1088 (2001)
   PUBMED   11158295
REFERENCE   6  (bases 1 to 1587)
  AUTHORS   Wu,Y., Dowbenko,D. and Lasky,L.A.
  TITLE     PSTPIP 2, a second tyrosine phosphorylated, cytoskeletal-associated
            protein that binds a PEST-type protein-tyrosine phosphatase
  JOURNAL   J Biol Chem 273 (46), 30487-30496 (1998)
   PUBMED   9804817
REFERENCE   7  (bases 1 to 1587)
  AUTHORS   Spencer,S., Dowbenko,D., Cheng,J., Li,W., Brush,J., Utzig,S.,
            Simanis,V. and Lasky,L.A.
  TITLE     PSTPIP: a tyrosine phosphorylated cleavage furrow-associated
            protein that is a substrate for a PEST tyrosine phosphatase
  JOURNAL   J Cell Biol 138 (4), 845-860 (1997)
   PUBMED   9265651
REFERENCE   8  (bases 1 to 1587)
  AUTHORS   Dosil,M., Leibman,N. and Lemischka,I.R.
  TITLE     Cloning and characterization of fetal liver phosphatase 1, a
            nuclear protein tyrosine phosphatase isolated from hematopoietic
            stem cells
  JOURNAL   Blood 88 (12), 4510-4525 (1996)
   PUBMED   8977243
REFERENCE   9  (bases 1 to 1587)
  AUTHORS   Huang,K., Sommers,C.L., Grinberg,A., Kozak,C.A. and Love,P.E.
  TITLE     Cloning and characterization of PTP-K1, a novel nonreceptor protein
            tyrosine phosphatase highly expressed in bone marrow
  JOURNAL   Oncogene 13 (7), 1567-1573 (1996)
   PUBMED   8875997
REFERENCE   10 (bases 1 to 1587)
  AUTHORS   Cheng,J., Daimaru,L., Fennie,C. and Lasky,L.A.
  TITLE     A novel protein tyrosine phosphatase expressed in
            lin(lo)CD34(hi)Sca(hi) hematopoietic progenitor cells
  JOURNAL   Blood 88 (4), 1156-1167 (1996)
   PUBMED   8695832
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CJ166432.1, AK144353.1 and CD740968.1.
            
            On Aug 25, 2006 this sequence version replaced NM_011206.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U52523.1, U35124.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-19                CJ166432.1         2-20
            20-1569             AK144353.1         2-1551
            1570-1587           CD740968.1         1-18                c
FEATURES             Location/Qualifiers
     source          1..1587
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 13.25 cM"
     gene            1..1587
                     /gene="Ptpn18"
                     /gene_synonym="FLP-1; FLP1; HSCF; PTP-HSCF; PTP-K1; Ptpk1"
                     /note="protein tyrosine phosphatase, non-receptor type 18"
                     /db_xref="GeneID:19253"
                     /db_xref="MGI:MGI:108410"
     exon            1..171
                     /gene="Ptpn18"
                     /gene_synonym="FLP-1; FLP1; HSCF; PTP-HSCF; PTP-K1; Ptpk1"
                     /inference="alignment:Splign:2.1.0"
     CDS             79..1440
                     /gene="Ptpn18"
                     /gene_synonym="FLP-1; FLP1; HSCF; PTP-HSCF; PTP-K1; Ptpk1"
                     /EC_number="3.1.3.48"
                     /note="isoform 1 is encoded by transcript variant 1;
                     tyrosine-protein phosphatase non-receptor type 18; fetal
                     liver phosphatase 1"
                     /codon_start=1
                     /product="tyrosine-protein phosphatase non-receptor type
                     18 isoform 1"
                     /protein_id="NP_035336.2"
                     /db_xref="CCDS:CCDS14867.1"
                     /db_xref="GeneID:19253"
                     /db_xref="MGI:MGI:108410"
                     /translation="MSRHTDLVRSFLEQLEARDYREGAILAREFSDIKARSVAWKSEG
                     VCSTKAGSRLGNTNKNRYKDVVAYDETRVILSLLQEEGHGDYINANFIRGIDGSQAYI
                     ATQGPLPHTLLDFWRLVWEFGVKVILMACQETENGRRKCERYWAREQEPLKAGPFCIT
                     LTKETTLNADITLRTLQVTFQKEFRSVHQLQYMSWPDHGVPSSSDHILTMVEEARCLQ
                     GLGPGPLCVHCSAGCGRTGVLCAVDYVRQLLLTQTIPPNFSLFQVVLEMRKQRPAAVQ
                     TEEQYRFLYHTVAQLFSRTLQDTSPHYQNLKENCAPICKEAFSLRTSSALPATSRPPG
                     GVLRSISVPAPPTLPMADTYAVVQKRGASAGTGPGPRAPTSTDTPIYSQVAPRAQRPV
                     AHTEDAQGTTALRRVPADQNSSGPDAYEEVTDGAQTGGLGFNLRIGRPKGPRDPPAEW
                     TRV"
     exon            172..280
                     /gene="Ptpn18"
                     /gene_synonym="FLP-1; FLP1; HSCF; PTP-HSCF; PTP-K1; Ptpk1"
                     /inference="alignment:Splign:2.1.0"
     exon            281..357
                     /gene="Ptpn18"
                     /gene_synonym="FLP-1; FLP1; HSCF; PTP-HSCF; PTP-K1; Ptpk1"
                     /inference="alignment:Splign:2.1.0"
     exon            358..453
                     /gene="Ptpn18"
                     /gene_synonym="FLP-1; FLP1; HSCF; PTP-HSCF; PTP-K1; Ptpk1"
                     /inference="alignment:Splign:2.1.0"
     exon            454..492
                     /gene="Ptpn18"
                     /gene_synonym="FLP-1; FLP1; HSCF; PTP-HSCF; PTP-K1; Ptpk1"
                     /inference="alignment:Splign:2.1.0"
     exon            493..561
                     /gene="Ptpn18"
                     /gene_synonym="FLP-1; FLP1; HSCF; PTP-HSCF; PTP-K1; Ptpk1"
                     /inference="alignment:Splign:2.1.0"
     exon            562..624
                     /gene="Ptpn18"
                     /gene_synonym="FLP-1; FLP1; HSCF; PTP-HSCF; PTP-K1; Ptpk1"
                     /inference="alignment:Splign:2.1.0"
     exon            625..767
                     /gene="Ptpn18"
                     /gene_synonym="FLP-1; FLP1; HSCF; PTP-HSCF; PTP-K1; Ptpk1"
                     /inference="alignment:Splign:2.1.0"
     exon            768..834
                     /gene="Ptpn18"
                     /gene_synonym="FLP-1; FLP1; HSCF; PTP-HSCF; PTP-K1; Ptpk1"
                     /inference="alignment:Splign:2.1.0"
     exon            835..912
                     /gene="Ptpn18"
                     /gene_synonym="FLP-1; FLP1; HSCF; PTP-HSCF; PTP-K1; Ptpk1"
                     /inference="alignment:Splign:2.1.0"
     exon            913..1002
                     /gene="Ptpn18"
                     /gene_synonym="FLP-1; FLP1; HSCF; PTP-HSCF; PTP-K1; Ptpk1"
                     /inference="alignment:Splign:2.1.0"
     exon            1003..1091
                     /gene="Ptpn18"
                     /gene_synonym="FLP-1; FLP1; HSCF; PTP-HSCF; PTP-K1; Ptpk1"
                     /inference="alignment:Splign:2.1.0"
     exon            1092..1297
                     /gene="Ptpn18"
                     /gene_synonym="FLP-1; FLP1; HSCF; PTP-HSCF; PTP-K1; Ptpk1"
                     /inference="alignment:Splign:2.1.0"
     exon            1298..1372
                     /gene="Ptpn18"
                     /gene_synonym="FLP-1; FLP1; HSCF; PTP-HSCF; PTP-K1; Ptpk1"
                     /inference="alignment:Splign:2.1.0"
     exon            1373..1578
                     /gene="Ptpn18"
                     /gene_synonym="FLP-1; FLP1; HSCF; PTP-HSCF; PTP-K1; Ptpk1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1551..1556
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ptpn18"
                     /gene_synonym="FLP-1; FLP1; HSCF; PTP-HSCF; PTP-K1; Ptpk1"
                     /note="hexamer: AATAAA"
     polyA_site      1578
                     /gene="Ptpn18"
                     /gene_synonym="FLP-1; FLP1; HSCF; PTP-HSCF; PTP-K1; Ptpk1"
                     /note="major polyA site"
ORIGIN      
        1 atggaggccc cacctcgcag tggctaaatt ctcggagtcg gatcactcct tgtgggagac
       61 ctcagagcgg gtcgcagcat gagtcgccat acggacttgg tgaggagctt cttggagcag
      121 ctggaggccc gggactaccg ggagggggca atcctcgctc gtgagttcag cgacattaag
      181 gcccgctcag tggcctggaa gtctgaaggt gtgtgttcca ctaaagccgg cagtcggctt
      241 gggaacacga acaagaaccg ctacaaagat gtggtagcat atgatgagac aagagtcatc
      301 ctttccctgc tccaagagga gggacatgga gattacatca atgccaactt catccggggc
      361 atagatggaa gccaggccta cattgcgacg caaggacccc tgcctcacac actgttggac
      421 ttctggcgcc tggtttggga gtttggggtc aaggtaatcc tgatggcctg tcaagagaca
      481 gaaaatggac ggaggaagtg tgaacgctac tgggcccggg agcaggagcc tctaaaggct
      541 gggcctttct gcatcaccct gacaaaggag acaacactga atgcagacat cactctcagg
      601 accctccagg ttacattcca gaaggaattc cgctctgtgc accagctaca gtatatgtcc
      661 tggccagacc acggggttcc cagcagttct gatcacattc tcaccatggt ggaggaggcc
      721 cgctgcctcc aagggcttgg acctggaccc ctctgtgtcc actgcagtgc tggctgcgga
      781 cgaacaggtg tcctgtgcgc tgttgactat gtgaggcagt tgctgctgac ccagacaatc
      841 cctcccaact tcagtctctt ccaagtggtc ctggagatgc ggaaacagcg gcctgcagca
      901 gtgcagacag aggagcagta caggttcctg taccacacag tggctcagct attctcccgc
      961 actctccagg acaccagccc ccactaccag aacctcaagg agaactgcgc tccaatctgc
     1021 aaggaagcct tctccctcag gacctcctca gccctgcctg ccacatcccg gccaccagga
     1081 ggggttctca ggagcatctc ggtgcctgcg cccccgaccc tccccatggc tgacacttac
     1141 gctgtggtgc agaagcgtgg cgcttcggcg ggcacagggc cggggccgcg ggcgcccacc
     1201 agcacggaca ccccgatcta cagccaggtg gctccacgtg cccagcgacc ggtggcacac
     1261 acggaggacg cacaggggac aacggcactg cgccgagttc ctgcggacca aaactcttcc
     1321 gggcctgatg cctacgaaga agtaacagat ggagcacaga ctggagggct aggcttcaac
     1381 ttgcgcatcg gaaggcccaa agggccccgg gatcctccag cagagtggac acgggtgtaa
     1441 cgagtgctgt gccagttata gcctgccact cggtggtggc tggactcctg gaaccaccat
     1501 actgctgtgc agtgtgttat gtatgagtgg gacttgtggg cctgattcaa aataaaagtt
     1561 tctcagggca gaaaaaaaaa aaaaaaa
//
