LOCUS       NM_008976              10766 bp    mRNA    linear   ROD 09-OCT-2024
DEFINITION  Mus musculus protein tyrosine phosphatase, non-receptor type 14
            (Ptpn14), mRNA.
ACCESSION   NM_008976
VERSION     NM_008976.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 10766)
  AUTHORS   Ma,Q., He,X., Wang,X., Zhao,G., Zhang,Y., Su,C., Wei,M., Zhang,K.,
            Liu,M., Zhu,Y. and He,J.
  TITLE     PTPN14 aggravates neointimal hyperplasia via boosting PDGFRbeta
            signaling in smooth muscle cells
  JOURNAL   Nat Commun 15 (1), 7398 (2024)
   PUBMED   39191789
  REMARK    GeneRIF: PTPN14 aggravates neointimal hyperplasia via boosting
            PDGFRbeta signaling in smooth muscle cells.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 10766)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 10766)
  AUTHORS   Romero-Masters,J.C., Grace,M., Lee,D., Lei,J., DePamphilis,M.,
            Buehler,D., Hu,R., Ward-Shaw,E., Blaine-Sauer,S., Lavoie,N.,
            White,E.A., Munger,K. and Lambert,P.F.
  TITLE     MmuPV1 E7's interaction with PTPN14 delays Epithelial
            differentiation and contributes to virus-induced skin disease
  JOURNAL   PLoS Pathog 19 (4), e1011215 (2023)
   PUBMED   37036883
  REMARK    GeneRIF: MmuPV1 E7's interaction with PTPN14 delays Epithelial
            differentiation and contributes to virus-induced skin disease.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 10766)
  AUTHORS   Lin,Y., Shao,Z., Zhao,M., Li,J. and Xu,X.
  TITLE     PTPN14 deficiency alleviates podocyte injury through suppressing
            inflammation and fibrosis by targeting TRIP6 in diabetic
            nephropathy
  JOURNAL   Biochem Biophys Res Commun 550, 62-69 (2021)
   PUBMED   33684622
  REMARK    GeneRIF: PTPN14 deficiency alleviates podocyte injury through
            suppressing inflammation and fibrosis by targeting TRIP6 in
            diabetic nephropathy.
REFERENCE   5  (bases 1 to 10766)
  AUTHORS   Fu,B., Yin,S., Lin,X., Shi,L., Wang,Y., Zhang,S., Zhao,Q., Li,Z.,
            Yang,Y. and Wu,H.
  TITLE     PTPN14 aggravates inflammation through promoting proteasomal
            degradation of SOCS7 in acute liver failure
  JOURNAL   Cell Death Dis 11 (9), 803 (2020)
   PUBMED   32978373
  REMARK    GeneRIF: PTPN14 aggravates inflammation through promoting
            proteasomal degradation of SOCS7 in acute liver failure.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 10766)
  AUTHORS   Norman,B., Davis,J. and Piatigorsky,J.
  TITLE     Postnatal gene expression in the normal mouse cornea by SAGE
  JOURNAL   Invest Ophthalmol Vis Sci 45 (2), 429-440 (2004)
   PUBMED   14744882
REFERENCE   7  (bases 1 to 10766)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   8  (bases 1 to 10766)
  AUTHORS   Aoyama,K., Matsuda,T. and Aoki,N.
  TITLE     Characterization of newly identified four isoforms for a putative
            cytosolic protein tyrosine phosphatase PTP36
  JOURNAL   Biochem Biophys Res Commun 266 (2), 523-531 (1999)
   PUBMED   10600535
REFERENCE   9  (bases 1 to 10766)
  AUTHORS   Araki,K., Imaizumi,T., Sekimoto,T., Yoshinobu,K., Yoshimuta,J.,
            Akizuki,M., Miura,K., Araki,M. and Yamamura,K.
  TITLE     Exchangeable gene trap using the Cre/mutated lox system
  JOURNAL   Cell Mol Biol (Noisy-le-grand) 45 (5), 737-750 (1999)
   PUBMED   10512203
REFERENCE   10 (bases 1 to 10766)
  AUTHORS   Sawada,M., Ogata,M., Fujino,Y. and Hamaoka,T.
  TITLE     cDNA cloning of a novel protein tyrosine phosphatase with homology
            to cytoskeletal protein 4.1 and its expression in T-lineage cells
  JOURNAL   Biochem Biophys Res Commun 203 (1), 479-484 (1994)
   PUBMED   8074693
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK037646.1, BB663191.1, AC140461.4, CK780322.1, AC140250.3,
            AK136544.1 and DV552967.1.
            
            On Jul 28, 2006 this sequence version replaced NM_008976.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            CDS exon combination :: AK156480.1, D31842.1 [ECO:0000331]
            RNAseq introns       :: single sample supports all introns
                                    SAMN00849374, SAMN00849379 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-60                AK037646.1         2-61
            61-179              BB663191.1         53-171
            180-3109            AK037646.1         181-3110
            3110-3110           AC140461.4         7414-7414           c
            3111-3407           AK037646.1         3112-3408
            3408-3438           AC140461.4         5521-5551           c
            3439-4163           CK780322.1         1-725
            4164-8436           AC140250.3         103886-108158       c
            8437-10740          AK136544.1         249-2552
            10741-10766         DV552967.1         205-230
FEATURES             Location/Qualifiers
     source          1..10766
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 95.03 cM"
     gene            1..10766
                     /gene="Ptpn14"
                     /gene_synonym="C130080N23Rik; PTP36"
                     /note="protein tyrosine phosphatase, non-receptor type 14"
                     /db_xref="GeneID:19250"
                     /db_xref="MGI:MGI:102467"
     exon            1..397
                     /gene="Ptpn14"
                     /gene_synonym="C130080N23Rik; PTP36"
                     /inference="alignment:Splign:2.1.0"
     exon            398..710
                     /gene="Ptpn14"
                     /gene_synonym="C130080N23Rik; PTP36"
                     /inference="alignment:Splign:2.1.0"
     CDS             537..4106
                     /gene="Ptpn14"
                     /gene_synonym="C130080N23Rik; PTP36"
                     /EC_number="3.1.3.48"
                     /note="protein-tyrosine phosphatase PTP36"
                     /codon_start=1
                     /product="tyrosine-protein phosphatase non-receptor type
                     14"
                     /protein_id="NP_033002.2"
                     /db_xref="CCDS:CCDS15609.1"
                     /db_xref="GeneID:19250"
                     /db_xref="MGI:MGI:102467"
                     /translation="MPFGLKLRRTRRYNVLSKNCFVTRIRLLDSNVIECTLSVESTGQ
                     ECLEAVAQRLELRETHYFGLWFLSKSQQARWVELEKPLKKHLDKFANEPLLFFGVMFY
                     VPNVSRLQQEATRYQYYLQVKKDVLEGRLRCSLEQVIRLAGLAVQADFGDYNQFDSQE
                     FLREYVLFPMDLAMEEAALEELTQKVAQEHKAHSGILPAEAELMYINEVERLDGFGQE
                     IFPVKDSHGNSVHLGIFFMGIFVRNRVGRQAVIYRWNDIGSVTHSKAAILLELIDKEE
                     TALFHTDDIENAKYISRLFTTRHKFYKQNKICTEQSNSPPPIRRQPTWSRSSLPRQQP
                     YILPPMHVQCSEHYSETHTSQDSIFPGNEEALYCRSHNSLDLNYLNGTVTNGSVCSVH
                     SVNSLSCSQSFIQASPVSSNLSIPGSDIMRADYIPSHRHSTIIVPSYRPTPDYETVMR
                     QMKRGLMHADSQSRSLRNLNIINTHAYNQPEELVYSQPEMRERHPYTVPYAHQGCYGH
                     KLVSPSDQMNPQNCAMPIKPGASSISHTVSTPELANMQLQGAQHYSTAHMLKNYLFRP
                     PPPYPRPRPATSTPDLASHRHKYVSGSSPDLVTRKVQLSVKTFQEDSSPVVHQSLQEV
                     SEPLTATKHHGGGGGTVNKRHSLEVMNSMVRGMEAMTLKSLNIPMARRNTLREQGPSE
                     ETGGHEVHGLPQYHHKKTFSDATMLIHSSESEEEEETLEAAPQVPVLREKVEYSAQLQ
                     AALARIPNRPPPEYPGPRKSVSNGALRQDQGTPLPAMARCRVLRHGPSKALSVSRAEQ
                     LAVNGASLGPSISEPDLTSVKERVKKEPVKERPVSEMFSLEDSIIEREMMIRNLEKQK
                     MTGPQAQKRPLMLAALNGLSVARVSGREDGHHDATRVPIDERLRALKKKLEDGMVFTE
                     YEQIPNKKANGVFSTATLPENAERSRIREVVPYEENRVELIPTKENNTGYINASHIKV
                     VVGGSEWHYIATQGPLPHTCHDFWQMVWEQGVNVIAMVTAEEEGGRTKSHRYWPKLGS
                     KHSSATYGKFKVTTKFRTDSGCYATTGLKVKHLLSGQERTVWHLQYTDWPHHGCPEDV
                     QGFLSYLEEIQSVRRHTNSVLEGIRTRHPPIVVHCSAGVGRTGVVILSELMIYCLEHN
                     EKVEVPTMLRFLREQRMFMIQTIAQYKFVYQVLVQFLQNSRLI"
     exon            711..880
                     /gene="Ptpn14"
                     /gene_synonym="C130080N23Rik; PTP36"
                     /inference="alignment:Splign:2.1.0"
     exon            881..978
                     /gene="Ptpn14"
                     /gene_synonym="C130080N23Rik; PTP36"
                     /inference="alignment:Splign:2.1.0"
     exon            979..1046
                     /gene="Ptpn14"
                     /gene_synonym="C130080N23Rik; PTP36"
                     /inference="alignment:Splign:2.1.0"
     exon            1047..1117
                     /gene="Ptpn14"
                     /gene_synonym="C130080N23Rik; PTP36"
                     /inference="alignment:Splign:2.1.0"
     exon            1118..1205
                     /gene="Ptpn14"
                     /gene_synonym="C130080N23Rik; PTP36"
                     /inference="alignment:Splign:2.1.0"
     exon            1206..1294
                     /gene="Ptpn14"
                     /gene_synonym="C130080N23Rik; PTP36"
                     /inference="alignment:Splign:2.1.0"
     exon            1295..1382
                     /gene="Ptpn14"
                     /gene_synonym="C130080N23Rik; PTP36"
                     /inference="alignment:Splign:2.1.0"
     exon            1383..1465
                     /gene="Ptpn14"
                     /gene_synonym="C130080N23Rik; PTP36"
                     /inference="alignment:Splign:2.1.0"
     exon            1466..1523
                     /gene="Ptpn14"
                     /gene_synonym="C130080N23Rik; PTP36"
                     /inference="alignment:Splign:2.1.0"
     exon            1524..1602
                     /gene="Ptpn14"
                     /gene_synonym="C130080N23Rik; PTP36"
                     /inference="alignment:Splign:2.1.0"
     exon            1603..3086
                     /gene="Ptpn14"
                     /gene_synonym="C130080N23Rik; PTP36"
                     /inference="alignment:Splign:2.1.0"
     exon            3087..3230
                     /gene="Ptpn14"
                     /gene_synonym="C130080N23Rik; PTP36"
                     /inference="alignment:Splign:2.1.0"
     exon            3231..3449
                     /gene="Ptpn14"
                     /gene_synonym="C130080N23Rik; PTP36"
                     /inference="alignment:Splign:2.1.0"
     exon            3450..3578
                     /gene="Ptpn14"
                     /gene_synonym="C130080N23Rik; PTP36"
                     /inference="alignment:Splign:2.1.0"
     exon            3579..3813
                     /gene="Ptpn14"
                     /gene_synonym="C130080N23Rik; PTP36"
                     /inference="alignment:Splign:2.1.0"
     exon            3814..3977
                     /gene="Ptpn14"
                     /gene_synonym="C130080N23Rik; PTP36"
                     /inference="alignment:Splign:2.1.0"
     exon            3978..10746
                     /gene="Ptpn14"
                     /gene_synonym="C130080N23Rik; PTP36"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      4287
                     /gene="Ptpn14"
                     /gene_synonym="C130080N23Rik; PTP36"
     regulatory      10723..10728
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ptpn14"
                     /gene_synonym="C130080N23Rik; PTP36"
                     /note="hexamer: AATAAA"
     polyA_site      10746
                     /gene="Ptpn14"
                     /gene_synonym="C130080N23Rik; PTP36"
                     /note="major polyA site"
ORIGIN      
        1 gctcgcgctt cctggcgctc gggctctccg gaggctcaag ttctgcacaa cttctcccgg
       61 ctgcccagcg cctcggccgc gggcccggcc agctagctgc gctcctcggc tcagccgtct
      121 cgtccacagg gcaggtcctc gtggagcatc tggtaccaag tggccgctgg cggtccctct
      181 ctgcgcccca cctctctgat cgcccgggtc ccctcgcgtg ggacggcggt gcttaggttc
      241 ttggcccttt ctcctccccg gtgcgcccgg cgcgccggcc gctgcgtaac cctccctgcg
      301 cccctcctct gccagctcct ggaagccagt ggtggggacc cagactccct gatggtcaac
      361 gtgcggcacc cggggcactc ccgggccatg taagcagctg tccggcagag agcctggtgg
      421 gcatggacat ctttatccac ataccttagt gtgaccacgc cgacagaaaa ctactaaggc
      481 catctcaggg gtgcctgtgc caggagaggg gggcggtgtc cccgggccgc agagccatgc
      541 ctttcggcct gaagctccgc aggactcggc gctacaacgt cctgagcaag aactgctttg
      601 ttacccggat ccgcctgctg gacagcaatg tcatcgagtg cacgctgtcg gtggaaagca
      661 cggggcaaga gtgcctggag gccgtggccc agaggctgga gctgagggag acgcactact
      721 tcggcctttg gtttctcagc aagagccagc aggcgagatg ggtagagctg gagaagccac
      781 tgaagaaaca tctggacaag tttgctaacg agcctctgct tttcttcgga gtcatgttct
      841 atgtgccaaa tgtgtcacgg cttcagcagg aggccacaag atatcagtat tacctgcaag
      901 tcaaaaaaga cgtgcttgaa ggacggttgc ggtgctccct ggaacaagtg atccggctgg
      961 ctggcttagc tgtgcaagct gacttcggag attataacca gtttgattcc caagagttcc
     1021 tccgagagta tgtgctcttt cctatggatt tggccatgga ggaggcggct ctggaggagc
     1081 taacccagaa ggtggcccag gaacacaaag ctcatagcgg gatcctgccg gctgaagctg
     1141 aactgatgta catcaacgag gtagagcgtt tggatggatt tggacaggag atcttccccg
     1201 tgaaggacag tcatggcaac agcgtgcacc tcggcatctt cttcatgggg atttttgtga
     1261 ggaacagggt cgggagacag gcagtgatat acaggtggaa tgacattggg agtgttactc
     1321 acagcaaagc agccatcctg ttggagctga ttgacaagga ggagaccgcg ctcttccata
     1381 cagatgatat tgaaaatgcc aagtacattt ctcggttgtt taccactcgg cacaaatttt
     1441 acaaacagaa caagatctgc actgaacagt caaattctcc acccccaatt agacgccagc
     1501 ccacctggag ccggtcctca ctgccaaggc agcagccgta tatcttgcct cccatgcatg
     1561 tccagtgcag tgagcactac tcggagaccc atacttccca agacagcatt ttccccggga
     1621 acgaagaagc cttgtactgc cgttctcaca acagcctgga ccttaattac ttgaacggca
     1681 ccgtcaccaa tggcagcgtg tgcagcgttc acagcgtcaa ctccctcagc tgctctcaga
     1741 gcttcatcca ggcgtctcca gtgtcctcca accttagcat ccctgggagt gacatcatga
     1801 gggccgatta catccccagc caccgccaca gcaccatcat cgtgccgtct tacaggccga
     1861 ccccagatta cgagacggtc atgaggcaga tgaagagggg tctgatgcac gcagacagcc
     1921 agagccggtc tctgcgtaac ctcaatatca tcaacaccca tgcctataac cagcccgagg
     1981 aactggtgta cagccagccg gagatgcggg agaggcatcc ctacacggtc ccctatgcac
     2041 accaggggtg ctacggtcac aaacttgtaa gtccgtctga ccagatgaac ccccaaaatt
     2101 gtgcgatgcc tatcaagcca ggggccagtt ccatctcaca cacagtgagc actccagaac
     2161 tagccaacat gcagctccaa ggagcacaac actatagcac agcccacatg ctcaagaact
     2221 atctattcag gccgccaccc ccttaccctc ggccccgtcc tgccaccagc accccagacc
     2281 tcgccagcca ccgccacaag tacgtcagcg gcagcagccc tgatctggta actcggaagg
     2341 tgcagctctc cgtaaagacc ttccaggagg acagctcacc tgtggtccat cagtctctgc
     2401 aggaggtgag cgaacccctt acagccacca agcaccatgg cggcggcggt ggcacggtga
     2461 ataaacgcca cagcctggag gtgatgaaca gcatggtgag aggcatggag gccatgacac
     2521 tgaagtcact caatatcccc atggctcgcc gcaacaccct tcgggagcag ggcccttccg
     2581 aggagacggg cggccacgaa gtgcacggtc tcccccagta tcaccacaag aagacattct
     2641 cggatgccac catgctgatc cacagcagtg agagcgagga agaggaggag accctggagg
     2701 ctgcacctca ggttcctgtg cttcgagaga aagtagaata cagtgcccag ctgcaggctg
     2761 ccctggcccg catccccaac aggcccccac ctgagtaccc agggccaaga aaaagtgtca
     2821 gtaatggggc actgagacag gaccagggaa cccctcttcc tgccatggcc aggtgcaggg
     2881 tgctgagaca cggaccatcc aaggccctca gtgtctcccg ggcagagcag ctggctgtca
     2941 acggtgcctc tctgggtccc tccatctctg agcctgacct aaccagcgtg aaggagcggg
     3001 tcaagaaaga gcctgtgaag gaaaggccgg tgtcagagat gttctccctg gaggacagca
     3061 ttatagagag agagatgatg atcaggaatc tagagaagca gaagatgacg ggcccgcagg
     3121 cacagaagag accgctgatg ttggcagcgc tgaatgggct ctcggtggcc cgagtgtcgg
     3181 ggcgggaaga cggtcaccat gatgccaccc gagtccccat agacgagagg ctcagagccc
     3241 tgaagaagaa gctggaagat ggaatggtgt tcacagaata tgagcagatt ccaaacaaaa
     3301 aggccaacgg cgtcttcagc accgccactc tgcctgagaa tgccgagcgc agccggatcc
     3361 gagaagttgt cccatacgag gagaatcgag tggagctcat cccgaccaaa gaaaacaaca
     3421 caggctatat caacgcctcc cacatcaagg tggtggtcgg cggatcagaa tggcactaca
     3481 tcgccaccca ggggcccttg ccacatacgt gccatgactt ctggcagatg gtgtgggagc
     3541 agggggtgaa tgtgatcgcc atggtcactg cagaggagga gggtggacgg accaaaagcc
     3601 atcgatactg gcccaaactg gggtccaagc atagttctgc cacctacggc aagttcaagg
     3661 tcaccacaaa gttccggaca gattctggtt gctatgcaac gacgggccta aaggtgaagc
     3721 acctgctgtc cgggcaggag aggaccgtgt ggcacttgca gtacacggac tggccccacc
     3781 acggctgtcc agaagacgtc caaggatttt tgtcctactt ggaggaaatc cagtcagtcc
     3841 gacgccacac caacagcgtg ctggaaggca tcaggaccag gcaccccccc atcgtggttc
     3901 actgcagcgc gggtgtggga aggactggtg tggttatcct ctctgagctc atgatctact
     3961 gcctggaaca caacgaaaag gtggaggtgc ccacgatgct gcgattcctc agggagcaga
     4021 ggatgttcat gatccagacc attgcgcagt acaagttcgt ctaccaagtc ctcgtccagt
     4081 tcctgcagaa ttccaggctc atttgatctc ctccgggatg cagcttctgg aggagggacg
     4141 cagctctgtc ctgcaggggg cgccacttcg acaacatctg cctcccccag ccagaggtgg
     4201 atggctggca gcaggcagaa gccagagtta ctcacaaaca tcatgtatta ttttatataa
     4261 gataatttat tttttccctc tttggaataa gttctgtgag ttattatata atgcttcccc
     4321 cccatacaca cacacaataa tatagtgctt ctcatttgaa ccacacgttg actgatctgc
     4381 agtgttagcc tccgggaggg aaggtggtgg cccccatggg acattttaga cacagaggca
     4441 taaagggaaa gcatctctag tgaagttgca ggcaaactgg taatgctcca gtcaaaagtg
     4501 gcaagagaga gaaaccatcc tcagctggaa gggagagagc caaggtcctg gaaagtgatc
     4561 caaacacact gggttcctgc accttgctgg gtgcttgctt ttctctcctg catttctgtc
     4621 ctctgtcctc gccctcagca atctttctcc ggaagcctag gtgaagggtg ggattggctg
     4681 gagagcatgg tgcctccaag ggtggtgatg ccgtctttgg tcaatggggg cgctgctgtc
     4741 ctttctctca ccccttgttc tggctcagaa gtctgataca gtgatgggtg gcaggctggg
     4801 tatctgctgc tttgtcttgt atactcacaa cactgtagtc tggtggccct gggccaggcg
     4861 gtctgcacag ctcagccctc tgcctgattc tgactgtgag aagataaccc accagggtgg
     4921 gaatggagtt gggtgtggcc tcggtgtggc ctcttagcta cacaatgttg cgtgtggtgg
     4981 atggtgacgt agaagatgaa gttcaggtac attccatctt cctatctgtt cctaagttgt
     5041 tagaagggtc ttaaggaaac tcacattggg gagctgtcag gcacttagta gggccctgcc
     5101 cgggaggtac acacctgtgt ccaactcact gtgtgctgct tggttttagg ctgtagctga
     5161 tgagggctga gttggttcct cttagagctt ccttgttgtc ctgaggcaga gttcctgggt
     5221 gatcttgagt ttgctgtgta gaggatggct cctaattttt cacatcttcc cctcccacgt
     5281 gctggggttt caggtgtgtc ccaccacact atgaatgctg agactgtcta ctaaaaaacc
     5341 ttccaccgcc tccctctcct gtgcagccca gcctgggtca gtgatgatat cgaccgtgtt
     5401 cgatttgaag tccagtttcc tgcttatgtc caattttgct cagagtataa ttttctaaac
     5461 tgtgagtttg tggaactgaa tgtgtcaggt cttcctccac agttacattt ttccctattt
     5521 cctgagctga aaagaccaaa cagaaagtgt gtgtctttgt ggcttctttc tccaccccct
     5581 agtgagtgct tatgacagca gaatccccat gaactcctct ggaaggtgag ccaagctgtc
     5641 ttcacactgg gcaggggtgg tgctggtgct gatgttgata cagcatttgt gggttcagaa
     5701 tctgtagaag aggtgcttcc atcctccctt ccgccatgca gattgaacca aggagtctaa
     5761 gtgtgcaagc cttgtggatc tggtgcactg tgtaaactct gacataggta ttttggggaa
     5821 atgttacagt gttaagggtg ggaagtcttg tttcacttcc tttgatgatg tttctccttt
     5881 acattcggtc ccacttacgg tttcattatg caatgaagaa cgctgctgat cctctcctgt
     5941 tgtctctgag ctgtagtcgg tcagaatgta tctccctcgg gcagcaagga gatatgatgc
     6001 cactttgcac gggtcactcg ggggctgttt ttaccctgtg ttagcagaac aaggtgcagg
     6061 gaagtagcag aacaaggtgc agggaagatg tcggttggct acccaacttc ctagtgtgca
     6121 tggtgagccc taaaggagaa cattaagtgt cccgagtacg tatgtgttcc attctcagac
     6181 accattgctt ctggttcttc agtaacattc caaattcctt tcccatccct aggaagtccc
     6241 cgtggatctc tggttaaatt atcatcaggc atataaagtg gcatctgcat aatgattgcc
     6301 cagagatgct ttctatctgg gaagtgagcc aaggaataaa ccttgaagta aagtgtatta
     6361 aattagttat ctggttaggc cttttggaaa gatttcctgt gatgcatggg ggccagagct
     6421 ggagttgtca gggcccattg ccgcagtttg gatttgaagg aggggaaaat taaaacagga
     6481 gccagtaagt catcccatct cacagcagag cagtggactg cttgctcgat ggccctggtt
     6541 tggagttttt tccagtggta ccacactctt ttacttacac tcatcggcct acgtccacct
     6601 ttgtcctggt tcaggggtct ctgtatcctg gctgcttaac gtggtgtctt catccctgag
     6661 atcctgagtt gtgttaaaga tgaagctgcg gagtttctgg ctgggctgtg gctggtctta
     6721 ggtggctctg cagtaacttc aggtggaatc ccaggggtca gggggctgca catccatata
     6781 ttctcctttt tcagtaagaa gtagaggaga aaacaggatt gggcatgtaa gtcgctttat
     6841 ggaggtgaag actagtgggt tcctctgatc acttggagat gagccgcaga tacgatacta
     6901 gggaggctgg gggcatctca cgtggaccgt atcgtgtaat aagccttgat ttaatgcgct
     6961 tactttggga gacttgtact gttatgagaa agggattact cacgattaga agcaagccgt
     7021 catcccgttc cccccaacac ccactccagt cttgggctct ctcagccacc tctgcttcag
     7081 gacatggtcc tcatgggaca cagccaccag cttctatgca agccataccc tgccctctct
     7141 cagcttccac ttttcagcag ctacctcctg aactggttct ttgtgaccct gctacctcgc
     7201 tgtgctggcc ttgcatctgg tcaagctggg aggtgcccct ggatgctgac aggctgggat
     7261 gacagatgtg ttgccgtgta gtcttctgtc acccccttga agctcaggcc ggcctgctta
     7321 tcgatgagcc atttaggctc tccccttttt agtggcatgt ctgatggaga gagcgaattt
     7381 agttaattga ttaatgtttg gagatgtgcc agttacttga ggtggagagg ggaagagtac
     7441 caggtcattc tagaataaac tcaacgaaca tgattagcct tgacccctgt ttgtaataac
     7501 ttattcattt tgtctcagta ttaggaatga gctgtccacg gagtgcgcgg tcactgccgt
     7561 gtggccctca acttctgcat ttaccaaaga ttctgccgct gctgcatctt gtctgcgctc
     7621 tagccaggca gctggcaacc aggttctcat tcagtgttct tctcctcgag tagcagctcc
     7681 ggctcactct agcagggagc tttgggcctt ccatggggac ggcacgttcc ctggtgacct
     7741 acaacttgat gtattggccc tggagggtgg actcagtcac agttagcccc agagggttac
     7801 tacagtctga gcatactggc cttcacctcg cttctgtgtc cttcggtggc aaatcacctt
     7861 tccggggaca tctgctgaat gtagtaccca catgtctggg gaaatatgag ggtgtgctca
     7921 gcacatgctg ccaacccggc ttatccagat gtcagttatt ctaggggagc tgggacagtg
     7981 tccagcagct tgtccacatt catcctcctg ttctcagctt ttgcatttcc attataacct
     8041 tcggggaagt gagtgttttc accgggtgtg tccagtcctt cgtaaccttt gccgtttagt
     8101 atggaacatc acctttctca ggctctcgct gacgtgttcc tgttagcctg ttcatgactg
     8161 ggcactgggg gtctggcacc cttcaatctc atggatggat agtgtgctgc tgtttggaga
     8221 tcggttcttg ccgtttggag ctgggttcag cctcctcatt ttagagataa attaaagggc
     8281 atttggttgt ctggcagggg ttggagcaaa tgccagccta aatatggtta actgttgcat
     8341 agaaagtgac tcttgggcta cactcttgcc agcaggacca tcattcacta aaagtgctca
     8401 gagcttgtcc aaggacagta gggagtggtt agatcacccc tggatttctt accccaaatt
     8461 ttttgggcat ataatttttt ttgaaccctg ccacaatgtc agaattggaa actgtgacgc
     8521 aacgccccag gaagactgtg ctccagcctt gagggctact tctcctgggc tccttgcctg
     8581 ccccctgtat cgggttgtga cgtgtgatct ttgctctggg gactcctcgc ctgatactgc
     8641 atgcttgtga gcagagagtt ctgcccattc gtgctactcc catgctcagc actcgcagac
     8701 tctcttgcct gtgagtgcct gtgcaagtca tgtttataca aacgccgggc tgtgcagcgg
     8761 ccatgagcat ccttgtgcgg ggatgaggtg gtgccccgtg tgtcgtcact gtctgcattc
     8821 gaggtcactt tgtccaccca gagtgcctcc agctttcctt ccttgctcac ttgctttcca
     8881 gaccagctct ctgaagttca tttttaattt taccctacct gtccacaaag ctcctataaa
     8941 agtcaaatct ggcaaaggac catggcctta aacctctcta aaatgtccac agaggaattc
     9001 ttaagaaaga atggttccgt agcttctggg gatgggggat gggatctggg aaatgagtgt
     9061 ccaagatgaa tcgtgtagaa ggcttctcac aaccaggcct ccctcctgtc ctaagggaca
     9121 acactgtccc tcagtaccag aagaaatgaa aaaaaaaatg acggctatta gtgcaaatag
     9181 aaatgagggc agcaggcttc ctgtttgttt ccgggtgtcc ctagcaggat ttggggtgag
     9241 gagagcgctg tggtgacctg cagtctacct acttctggct tgctggactg ttcgcttcag
     9301 tctccctggt cagctgtggg acaggtgcac ctcagggctt cccagggagc cccacactgc
     9361 tctgacggat agctaatgca tgataagcta tctatccaac cccctgcctt ctttattttt
     9421 tcttctccaa cctctacctt tagggacaca aactctttgg ggtagaaagc tgagagggga
     9481 gaggctaagt gttttagatg gggtttttcc gtgccttggg gtgggacctc cgctaaaccc
     9541 tcaggaatgc cgagtgtagc caggtggctc gtgcttggcg ttctcagcat ttctttgggg
     9601 ctccagcctc cttcagtgca gtgttggcta ataaatacct tcagcattga actgaaaact
     9661 gtcctttgga gccatttttt tagactcaaa ggttgtaaag ttttattgca atctcctttg
     9721 aagttccttg ccactattgg tagtcctaaa attctgtaac cagattcttt tagatacaag
     9781 ctcacacttc cttagagatg atctcccttg gtggtcagct gacctggctg agggctccct
     9841 gggggaggtt acatatgcag atgactattg aaagtgtaac cttttgtgac gtgttacata
     9901 ataactggct agtttgcttc actagtcagt cacttcagtc agtattttga tgcttgcttt
     9961 tggttgcttc tgtctgatgt cagtagtttt ggtttccttc aaaataattg acatttaata
    10021 gttttatttt gaaatgatgc atagacaccc ccacccccag cttagaaacc agcttttatt
    10081 tagggttctt gggtcagccc acagaagccc tcagacctca gccatcatgg ctggaatgca
    10141 gtgctatgcc agatgtggtt ggcttttgtg ggctggcctg gacatgggct agcacccact
    10201 acgttgtaaa tggtaaaata aataaataag aaaatataaa gcattccagg ttgggactcg
    10261 gcacccagcc tgtggcagct gctctgtcct cggcagagat ggctgtcaaa tctctctctc
    10321 ctagcaaact gcacctaagg gcaggggaag gacagaggag acagaggaca ttccttccta
    10381 agttaccgat gatcatgttg actgctttgg cagagactct ctgtcacgtg aataacatta
    10441 aatgccctaa ataaagctat gcacactgct ccatgggctg ttgtctctcg gtaacaagct
    10501 tcgctcgcca gcctctcaca cagctctgag gtgtagggtg ccgacttttg acagtattcc
    10561 tttgcactgt tccctctttc tacaaagtct tatttagata ttggttgtct ctgtcctggt
    10621 cattgctgtg taagatgtcg cctatgtgcc tttacaaatg tgagatcttt attctaaccc
    10681 ccttttgttt ttggtaaaag atatctattg atttctacat gcaataaacc ttgttttgag
    10741 agaaaaaaaa aaaaaaaaaa aaaaaa
//
