LOCUS       NM_011204               8298 bp    mRNA    linear   ROD 10-FEB-2025
DEFINITION  Mus musculus protein tyrosine phosphatase, non-receptor type 13
            (Ptpn13), mRNA.
ACCESSION   NM_011204
VERSION     NM_011204.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 8298)
  AUTHORS   Hou,J., Ji,Q., Ji,J., Ju,S., Xu,C., Yong,X., Xu,X., Muddassir,M.,
            Chen,X., Xie,J. and Han,X.
  TITLE     Co-delivery of siPTPN13 and siNOX4 via (myo)fibroblast-targeting
            polymeric micelles for idiopathic pulmonary fibrosis therapy
  JOURNAL   Theranostics 11 (7), 3244-3261 (2021)
   PUBMED   33537085
  REMARK    GeneRIF: Co-delivery of siPTPN13 and siNOX4 via
            (myo)fibroblast-targeting polymeric micelles for idiopathic
            pulmonary fibrosis therapy.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 8298)
  AUTHORS   Kock,G., Dicks,M., Yip,K.T., Kohl,B., Putz,S., Heumann,R.,
            Erdmann,K.S. and Stoll,R.
  TITLE     Molecular Basis of Class III Ligand Recognition by PDZ3 in Murine
            Protein Tyrosine Phosphatase PTPN13
  JOURNAL   J Mol Biol 430 (21), 4275-4292 (2018)
   PUBMED   30189200
  REMARK    GeneRIF: Both in its ligand-free state and when bind to PRK2, PDZ3
            of PTPN13 adopts the classical compact, globular D/E fold. PDZ3 of
            PTPN13 binds five carboxy-terminal amino acids of PRK2 via a groove
            located between the EB-strand and the DB-helix.
REFERENCE   3  (bases 1 to 8298)
  AUTHORS   Zhang,Z., Li,Q., Diao,M., Liu,N., Cheng,W., Xiao,P., Zou,J., Su,L.,
            Yu,K., Wu,J., Li,L. and Jiang,Q.
  TITLE     Sporadic Hirschsprung Disease: Mutational Spectrum and Novel
            Candidate Genes Revealed by Next-generation Sequencing
  JOURNAL   Sci Rep 7 (1), 14796 (2017)
   PUBMED   29093530
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 8298)
  AUTHORS   Wang,Y., Hall,R.A., Lee,M., Kamgar-Parsi,A., Bi,X. and Baudry,M.
  TITLE     The tyrosine phosphatase PTPN13/FAP-1 links calpain-2, TBI and tau
            tyrosine phosphorylation
  JOURNAL   Sci Rep 7 (1), 11771 (2017)
   PUBMED   28924170
  REMARK    GeneRIF: Following TBI, calpain-2 activation cleaved PTPN13,
            activated c-Abl and triggered tau tyrosine phosphorylation.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 8298)
  AUTHORS   Kalyani,R., Lee,J.Y., Min,H., Yoon,H. and Kim,M.H.
  TITLE     Genes Frequently Coexpressed with Hoxc8 Provide Insight into the
            Discovery of Target Genes
  JOURNAL   Mol Cells 39 (5), 395-402 (2016)
   PUBMED   27025388
  REMARK    Erratum:[Mol Cells. 2017 Apr;40(4):314. doi:
            10.14348/molcells.2017.1311.. PMID: 28486794]
REFERENCE   6  (bases 1 to 8298)
  AUTHORS   Hendriks,W., Schepens,J., Bachner,D., Rijss,J., Zeeuwen,P.,
            Zechner,U., Hameister,H. and Wieringa,B.
  TITLE     Molecular cloning of a mouse epithelial protein-tyrosine
            phosphatase with similarities to submembranous proteins
  JOURNAL   J Cell Biochem 59 (4), 418-430 (1995)
   PUBMED   8749712
REFERENCE   7  (bases 1 to 8298)
  AUTHORS   Sato,T., Irie,S., Kitada,S. and Reed,J.C.
  TITLE     FAP-1: a protein tyrosine phosphatase that associates with Fas
  JOURNAL   Science 268 (5209), 411-415 (1995)
   PUBMED   7536343
REFERENCE   8  (bases 1 to 8298)
  AUTHORS   Chida,D., Kume,T., Mukouyama,Y., Tabata,S., Nomura,N., Thomas,M.L.,
            Watanabe,T. and Oishi,M.
  TITLE     Characterization of a protein tyrosine phosphatase (RIP) expressed
            at a very early stage of differentiation in both mouse
            erythroleukemia and embryonal carcinoma cells
  JOURNAL   FEBS Lett 358 (3), 233-239 (1995)
   PUBMED   7843407
REFERENCE   9  (bases 1 to 8298)
  AUTHORS   Hendriks,W., Schepens,J., Brugman,C., Zeeuwen,P. and Wieringa,B.
  TITLE     A novel receptor-type protein tyrosine phosphatase with a single
            catalytic domain is specifically expressed in mouse brain
  JOURNAL   Biochem J 305 (Pt 2) (Pt 2), 499-504 (1995)
   PUBMED   7832766
REFERENCE   10 (bases 1 to 8298)
  AUTHORS   Sawada,M., Ogata,M., Fujino,Y. and Hamaoka,T.
  TITLE     cDNA cloning of a novel protein tyrosine phosphatase with homology
            to cytoskeletal protein 4.1 and its expression in T-lineage cells
  JOURNAL   Biochem Biophys Res Commun 203 (1), 479-484 (1994)
   PUBMED   8074693
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK014577.1, AK080313.1, Z32740.1, CK391553.1, CX202144.1,
            AK161200.1, AK164471.1 and CF553324.1.
            
            On Mar 31, 2007 this sequence version replaced NM_011204.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: D83966.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849381, SAMN00849384
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-442               AK014577.1         14-455
            443-1708            AK080313.1         446-1711
            1709-4769           Z32740.1           1366-4426
            4770-5283           CK391553.1         75-588
            5284-5855           CX202144.1         155-726
            5856-7163           AK161200.1         489-1796
            7164-8214           AK164471.1         309-1359
            8215-8298           CF553324.1         516-599
FEATURES             Location/Qualifiers
     source          1..8298
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 50.43 cM"
     gene            1..8298
                     /gene="Ptpn13"
                     /gene_synonym="PTP-BL; PTPL1; Ptpri; RIP"
                     /note="protein tyrosine phosphatase, non-receptor type 13"
                     /db_xref="GeneID:19249"
                     /db_xref="MGI:MGI:103293"
     exon            1..345
                     /gene="Ptpn13"
                     /gene_synonym="PTP-BL; PTPL1; Ptpri; RIP"
                     /inference="alignment:Splign:2.1.0"
     exon            346..465
                     /gene="Ptpn13"
                     /gene_synonym="PTP-BL; PTPL1; Ptpri; RIP"
                     /inference="alignment:Splign:2.1.0"
     CDS             351..7706
                     /gene="Ptpn13"
                     /gene_synonym="PTP-BL; PTPL1; Ptpri; RIP"
                     /EC_number="3.1.3.48"
                     /note="tyrosine phosphatase; PTP36; protein-tyrosine
                     phosphatase RIP; protein tyrosine phosphatase DPZPTP;
                     protein tyrosine phosphatase PTP-BL"
                     /codon_start=1
                     /product="tyrosine-protein phosphatase non-receptor type
                     13"
                     /protein_id="NP_035334.2"
                     /db_xref="CCDS:CCDS39186.1"
                     /db_xref="GeneID:19249"
                     /db_xref="MGI:MGI:103293"
                     /translation="MHVSLAEALEVRGGPLQEEEIWAVLNQSAESLQEVFRRVSIADP
                     AALGFIISPWSLLLLPSGSVSFTDENVSNQDLRAFTAPEVLQSHSLTSLADVEKIHIY
                     SLGMTLYWGADHEVPQSQPIKLGDHLNSILLGMCEDVIYARVSVRTVLDACSAHIRNS
                     NCAPSFSYVKQLVKLVLGNISGTDPLSRSSEQKPDRSQAIRDRLRGKGLPTGRSSTSD
                     ALDTHEAPLSQQTFLNKGLSKSMGFLSIRDTRDEEDYLKDTPSDNNSRHEDSETFSSP
                     YQFKTSTPQMDALSKKKTWASSMDLLCAANRDISGETGRYQRCDPETVTGRTSITPRK
                     KEGRYSDGSIALDIFGPQKVEPVIHTRELPTSTAVSSALDRIRERQKKLQVLREAMNV
                     EEPVRRYKTYHSDIFSISSESPSVISSESDFRQVRKSEASKRFESSSGLPGVDETGQT
                     RPSRQYETSLEGNLINQDIMLRRQEEEMMQLQARMALRQSRLSLYPGDTVKASMLDIS
                     RDPLREMALETAMTQRKLRNFFGPEFVKMTVEPFVSLDLPRSILSQTKKGKSEDQRRK
                     VNIRLLSGQRLELTCDTKTICKDVFDMVVAHIGLVEHHLFALATRKENEYFFVDPDLK
                     LTKVAPEGWKEEPKRKGKAAVDFTLFFRIKFFMDDVSLIQHDLTCHQYYLQLRKDLLD
                     ERVHCDDEAALLLASLALQAEYGDYQPEVHGVSYFRLEHYLPARVMEKLDVSYIKEEL
                     PKLHNTYAGASEKETELEFLKVCQRLTEYGVHFHRVHPEKKSQTGILLGVCSKGVLVF
                     EVHNGVRALVLRFPWRETKKISFSKKKITLQNTSDGIKHAFQTDSSKACQYLLHLCSS
                     QHKFQLQMRARQSNQDAQDIERASFRSLNLQAESVRGFNMGRAISTGSLASSTINKLA
                     VRPLSVQAEILKRLSSSEWSLYQPLQNSSKEKTDKASWEEKPRGMSKSYHDLSQASLC
                     PHRKQVINMEALPQAFAELVGKPLYPMARSDTESLAGLPKLDNSKSVASLNRSPERRN
                     HESDSSTEDPGQAYVVGMSLPSSGKSSSQVPFKDNDTLHKRWSIVSSPEREITLVNLK
                     KDPKHGLGFQIIGGEKMGRLDLGVFISAVTPGGPADLDGCLKPGDRLISVNSVSLEGV
                     SHHAAVDILQNAPEDVTLVISQPKEKPSKVPSTPVHFANGMKSYTKKPAYMQDSAMDP
                     SEDQPWPRGTLRHIPESPFGLSGGLREGSLSSQDSRTESASLSQSQVNGFFASHLGDR
                     GWQEPQHSSPSPSVTTKVNEKTFSDSNRSKAKRRGISDLIEHLDCADSDKDDSTYTSS
                     QDHQTSKQEPSSSLSTSNKTSFPTSSASPPKPGDTFEVELAKTDGSLGISVTGGVNTS
                     VRHGGIYVKAIIPKGAAESDGRIHKGDRVLAVNGVSLEGATHKQAVETLRNTGQVVHL
                     LLEKGQVPTSRERDPAGPQSPPPDQDAQRQAPEKVAKQTPHVKDYSFVTEDNTFEVKL
                     FKNSSGLGFSFSREDNLIPEQINGSIVRVKKLFPGQPAAESGKIDVGDVILKVNGAPL
                     KGLSQQDVISALRGTAPEVSLLLCRPAPGVLPEIDTTFLNPLYSPANSFLNSSKETSQ
                     PSSSVEQGASSDDNGVSGKTKNHCRAPSRRESYSDHSESGEDDSVRAPAKMPNVTRVA
                     AFPHEAPRSQEESICAMFYLPRKIPGKLESESSHPPPLDVSPGQTCQPPAECAPSDAT
                     GKHFTHLASQLSKEENITTLKNDLGNHLEDSELEVELLITLVKSEKGSLGFTVTKGSQ
                     SIGCYVHDVIQDPAKGDGRLKAGDRLIKVNDTDVTNMTHTDAVNLLRAAPKTVRLVLG
                     RILELPRMPVFPHLLPDITVTCHGEELGFSLSGGQGSPHGVVYISDINPRSAAAVDGS
                     LQLLDIIHYVNGVSTQGMTLEDANRALDLSLPSVVLKVTRDGCPVVPTTRAAISAPRF
                     TKANGLTSMEPSGQPALMPKNSFSKVNGEGVHEAVCPAGEGSSSQMKESAGLTETKES
                     NSRDDDIYDDPQEAEVIQSLLDVVDEEAQNLLNQRHATRRACSPDPLRTNGEAPEEGD
                     TDYDGSPLPEDVPESVSSGEGKVDLASLTAASQEEKPIEEDATQESRNSTTETTDGED
                     SSKDPPFLTNEELAALPVVRVPPSGKYTGTQLQATIRTLQGLLDQGIPSKELENLQEL
                     KPLDQCLIGQTKENRRKNRYKNILPYDTTRVPLGDEGGYINASFIRIPVGTQEFVYIA
                     CQGPLPTTVGDFWQMVWEQNSTVIAMMTQEVEGEKIKCQRYWPSILGTTTMANERLRL
                     ALLRMQQLKGFIVRVMALEDIQTGEVRHISHLNFTAWPDHDTPSQPDDLLTFISYMRH
                     IRRSGPVITHCSAGIGRSGTLICIDVVLGLISQDLEFDISDLVRCMRLQRHGMVQTEG
                     QYVFCYQVILYVLTHLQAEEQKAQPGLPQ"
     exon            466..644
                     /gene="Ptpn13"
                     /gene_synonym="PTP-BL; PTPL1; Ptpri; RIP"
                     /inference="alignment:Splign:2.1.0"
     exon            645..710
                     /gene="Ptpn13"
                     /gene_synonym="PTP-BL; PTPL1; Ptpri; RIP"
                     /inference="alignment:Splign:2.1.0"
     exon            711..896
                     /gene="Ptpn13"
                     /gene_synonym="PTP-BL; PTPL1; Ptpri; RIP"
                     /inference="alignment:Splign:2.1.0"
     exon            897..984
                     /gene="Ptpn13"
                     /gene_synonym="PTP-BL; PTPL1; Ptpri; RIP"
                     /inference="alignment:Splign:2.1.0"
     exon            985..1530
                     /gene="Ptpn13"
                     /gene_synonym="PTP-BL; PTPL1; Ptpri; RIP"
                     /inference="alignment:Splign:2.1.0"
     exon            1531..1626
                     /gene="Ptpn13"
                     /gene_synonym="PTP-BL; PTPL1; Ptpri; RIP"
                     /inference="alignment:Splign:2.1.0"
     exon            1627..1708
                     /gene="Ptpn13"
                     /gene_synonym="PTP-BL; PTPL1; Ptpri; RIP"
                     /inference="alignment:Splign:2.1.0"
     exon            1709..1931
                     /gene="Ptpn13"
                     /gene_synonym="PTP-BL; PTPL1; Ptpri; RIP"
                     /inference="alignment:Splign:2.1.0"
     exon            1932..2006
                     /gene="Ptpn13"
                     /gene_synonym="PTP-BL; PTPL1; Ptpri; RIP"
                     /inference="alignment:Splign:2.1.0"
     exon            2007..2187
                     /gene="Ptpn13"
                     /gene_synonym="PTP-BL; PTPL1; Ptpri; RIP"
                     /inference="alignment:Splign:2.1.0"
     exon            2188..2341
                     /gene="Ptpn13"
                     /gene_synonym="PTP-BL; PTPL1; Ptpri; RIP"
                     /inference="alignment:Splign:2.1.0"
     exon            2342..2480
                     /gene="Ptpn13"
                     /gene_synonym="PTP-BL; PTPL1; Ptpri; RIP"
                     /inference="alignment:Splign:2.1.0"
     exon            2481..2633
                     /gene="Ptpn13"
                     /gene_synonym="PTP-BL; PTPL1; Ptpri; RIP"
                     /inference="alignment:Splign:2.1.0"
     exon            2634..2816
                     /gene="Ptpn13"
                     /gene_synonym="PTP-BL; PTPL1; Ptpri; RIP"
                     /inference="alignment:Splign:2.1.0"
     exon            2817..2979
                     /gene="Ptpn13"
                     /gene_synonym="PTP-BL; PTPL1; Ptpri; RIP"
                     /inference="alignment:Splign:2.1.0"
     exon            2980..3394
                     /gene="Ptpn13"
                     /gene_synonym="PTP-BL; PTPL1; Ptpri; RIP"
                     /inference="alignment:Splign:2.1.0"
     exon            3395..3489
                     /gene="Ptpn13"
                     /gene_synonym="PTP-BL; PTPL1; Ptpri; RIP"
                     /inference="alignment:Splign:2.1.0"
     exon            3490..3546
                     /gene="Ptpn13"
                     /gene_synonym="PTP-BL; PTPL1; Ptpri; RIP"
                     /inference="alignment:Splign:2.1.0"
     exon            3547..3636
                     /gene="Ptpn13"
                     /gene_synonym="PTP-BL; PTPL1; Ptpri; RIP"
                     /inference="alignment:Splign:2.1.0"
     exon            3637..3744
                     /gene="Ptpn13"
                     /gene_synonym="PTP-BL; PTPL1; Ptpri; RIP"
                     /inference="alignment:Splign:2.1.0"
     exon            3745..3876
                     /gene="Ptpn13"
                     /gene_synonym="PTP-BL; PTPL1; Ptpri; RIP"
                     /inference="alignment:Splign:2.1.0"
     exon            3877..4334
                     /gene="Ptpn13"
                     /gene_synonym="PTP-BL; PTPL1; Ptpri; RIP"
                     /inference="alignment:Splign:2.1.0"
     exon            4335..4466
                     /gene="Ptpn13"
                     /gene_synonym="PTP-BL; PTPL1; Ptpri; RIP"
                     /inference="alignment:Splign:2.1.0"
     exon            4467..4560
                     /gene="Ptpn13"
                     /gene_synonym="PTP-BL; PTPL1; Ptpri; RIP"
                     /inference="alignment:Splign:2.1.0"
     exon            4561..4646
                     /gene="Ptpn13"
                     /gene_synonym="PTP-BL; PTPL1; Ptpri; RIP"
                     /inference="alignment:Splign:2.1.0"
     exon            4647..4809
                     /gene="Ptpn13"
                     /gene_synonym="PTP-BL; PTPL1; Ptpri; RIP"
                     /inference="alignment:Splign:2.1.0"
     exon            4810..5024
                     /gene="Ptpn13"
                     /gene_synonym="PTP-BL; PTPL1; Ptpri; RIP"
                     /inference="alignment:Splign:2.1.0"
     exon            5025..5123
                     /gene="Ptpn13"
                     /gene_synonym="PTP-BL; PTPL1; Ptpri; RIP"
                     /inference="alignment:Splign:2.1.0"
     exon            5124..5452
                     /gene="Ptpn13"
                     /gene_synonym="PTP-BL; PTPL1; Ptpri; RIP"
                     /inference="alignment:Splign:2.1.0"
     exon            5453..5627
                     /gene="Ptpn13"
                     /gene_synonym="PTP-BL; PTPL1; Ptpri; RIP"
                     /inference="alignment:Splign:2.1.0"
     exon            5628..5786
                     /gene="Ptpn13"
                     /gene_synonym="PTP-BL; PTPL1; Ptpri; RIP"
                     /inference="alignment:Splign:2.1.0"
     exon            5787..5958
                     /gene="Ptpn13"
                     /gene_synonym="PTP-BL; PTPL1; Ptpri; RIP"
                     /inference="alignment:Splign:2.1.0"
     exon            5959..6169
                     /gene="Ptpn13"
                     /gene_synonym="PTP-BL; PTPL1; Ptpri; RIP"
                     /inference="alignment:Splign:2.1.0"
     exon            6170..6237
                     /gene="Ptpn13"
                     /gene_synonym="PTP-BL; PTPL1; Ptpri; RIP"
                     /inference="alignment:Splign:2.1.0"
     exon            6238..6299
                     /gene="Ptpn13"
                     /gene_synonym="PTP-BL; PTPL1; Ptpri; RIP"
                     /inference="alignment:Splign:2.1.0"
     exon            6300..6393
                     /gene="Ptpn13"
                     /gene_synonym="PTP-BL; PTPL1; Ptpri; RIP"
                     /inference="alignment:Splign:2.1.0"
     exon            6394..6531
                     /gene="Ptpn13"
                     /gene_synonym="PTP-BL; PTPL1; Ptpri; RIP"
                     /inference="alignment:Splign:2.1.0"
     exon            6532..6614
                     /gene="Ptpn13"
                     /gene_synonym="PTP-BL; PTPL1; Ptpri; RIP"
                     /inference="alignment:Splign:2.1.0"
     exon            6615..6652
                     /gene="Ptpn13"
                     /gene_synonym="PTP-BL; PTPL1; Ptpri; RIP"
                     /inference="alignment:Splign:2.1.0"
     exon            6653..6756
                     /gene="Ptpn13"
                     /gene_synonym="PTP-BL; PTPL1; Ptpri; RIP"
                     /inference="alignment:Splign:2.1.0"
     exon            6757..6905
                     /gene="Ptpn13"
                     /gene_synonym="PTP-BL; PTPL1; Ptpri; RIP"
                     /inference="alignment:Splign:2.1.0"
     exon            6906..6996
                     /gene="Ptpn13"
                     /gene_synonym="PTP-BL; PTPL1; Ptpri; RIP"
                     /inference="alignment:Splign:2.1.0"
     exon            6997..7334
                     /gene="Ptpn13"
                     /gene_synonym="PTP-BL; PTPL1; Ptpri; RIP"
                     /inference="alignment:Splign:2.1.0"
     exon            7335..7550
                     /gene="Ptpn13"
                     /gene_synonym="PTP-BL; PTPL1; Ptpri; RIP"
                     /inference="alignment:Splign:2.1.0"
     exon            7551..7613
                     /gene="Ptpn13"
                     /gene_synonym="PTP-BL; PTPL1; Ptpri; RIP"
                     /inference="alignment:Splign:2.1.0"
     exon            7614..8282
                     /gene="Ptpn13"
                     /gene_synonym="PTP-BL; PTPL1; Ptpri; RIP"
                     /inference="alignment:Splign:2.1.0"
     regulatory      8178..8183
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ptpn13"
                     /gene_synonym="PTP-BL; PTPL1; Ptpri; RIP"
                     /note="hexamer: AATATA"
     polyA_site      8224
                     /gene="Ptpn13"
                     /gene_synonym="PTP-BL; PTPL1; Ptpri; RIP"
     regulatory      8250..8255
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ptpn13"
                     /gene_synonym="PTP-BL; PTPL1; Ptpri; RIP"
                     /note="hexamer: AATAAA"
     polyA_site      8273
                     /gene="Ptpn13"
                     /gene_synonym="PTP-BL; PTPL1; Ptpri; RIP"
                     /note="major polyA site"
ORIGIN      
        1 ggagctgcgc gccgtgagga gctgggccgg gcgcgccgcg gcgagggtga cacaccatgg
       61 tcacagttct ccgaggtctc cgcgccgctg ccgagcagcg ctccccggct ctcccgtccg
      121 cctcagcctc ctggacagcg ccgcgcgcgg gcggccgtcg ttgaggcgct gcgaagtcgc
      181 ggcgggcggg cgggagctcg gcgggggtcg ccgcccggcg atgctgcttc tgtcgccgcc
      241 gaccctctct gcgcacgccc gaagcagctc ggggaagaag aggcggcggc tctcggtgcc
      301 cgcgcgctgc gctccggtcg ccgcaccggg gctccccacg cgccgataat atgcatgtgt
      361 cactggcaga agccctggag gttcggggtg gacctctgca ggaggaggaa atatgggctg
      421 tattaaatca gagtgctgaa agcctgcaag aagtatttag aagagtgagc attgctgacc
      481 ctgctgcgct gggcttcatc atctctccat ggtcgctgct gttgctgcca tcgggcagtg
      541 tgtcctttac ggatgaaaat gtctccaatc aggaccttag agcattcacc gcaccggagg
      601 ttcttcagag ccattctctg acttctctcg cagatgtaga gaagatccat atttattctc
      661 ttggaatgac attgtattgg ggggctgacc atgaagtacc tcaaagccag cccatcaagc
      721 tgggagacca tcttaatagc atcctgctgg gcatgtgtga ggatgtcatc tatgctcggg
      781 tgtcggttcg gaccgtcctg gatgcttgca gtgcccacat caggaacagc aactgcgcgc
      841 cttcgttttc ctatgtgaaa cagttggtaa agctggttct gggcaatatt tctgggacgg
      901 atccactttc ccgtagcagt gaacaaaaac ctgaccggag ccaggccatt cgagaccgac
      961 tgagaggaaa aggattgccc acaggaagaa gctccacttc agacgcacta gacacacacg
     1021 aggctccact ctctcagcag acctttctta acaaagggct tagtaagtct atgggatttc
     1081 tgtccatcag agacacacga gatgaggaag actatctcaa ggatactcca tctgataata
     1141 attccaggca tgaagattct gagactttct cttcccctta ccagttcaaa actagtactc
     1201 cacagatgga tgcactctcc aagaagaaga catgggcttc ctccatggac ttgctctgtg
     1261 cagctaacag agacatttct ggagagacgg gcaggtacca acgctgtgac cctgagacag
     1321 tgacaggacg gacgtccatc actcctagaa aaaaagaagg aaggtactct gatggaagca
     1381 ttgccttgga tatctttggc cctcagaagg tggagccggt gatccacacc cgagaactgc
     1441 cgacctccac cgcggtatca agcgctttgg accgaattcg agagagacaa aagaaacttc
     1501 aggttctgag agaagccatg aatgtagaag agccagttcg aagatacaaa acttaccaca
     1561 gcgatatctt tagtatttcc agtgaaagcc catctgttat ttcctcggaa tcagacttca
     1621 gacaagtaag aaaaagtgaa gcttccaaga ggtttgaatc cagcagtggt cttcccggag
     1681 tagatgaaac tggccagaca cgaccaagta gacaatatga aacatccctc gaaggcaact
     1741 tgatcaatca ggacataatg ctaaggcgtc aagaggaaga aatgatgcag ctgcaagcca
     1801 ggatggctct ccgacagtcg cggctcagcc tgtatccagg ggacaccgtc aaagcttcca
     1861 tgctcgacat ctctagagac cccctaaggg aaatggccct ggagacagcc atgacccaga
     1921 ggaagctcag gaatttcttt ggacctgagt ttgtgaagat gacggttgag ccatttgtat
     1981 ctttggattt gccacggtct atcctctcgc agaccaagaa ggggaagagt gaggaccagc
     2041 ggcggaaagt gaacataagg ctcctgagcg ggcagcggct ggagctcacc tgcgacacca
     2101 agaccatctg caaggatgtg ttcgacatgg tggtggcgca catcggcttg gtggagcacc
     2161 atttgtttgc tctcgccacc cgcaaagaga atgaatattt ctttgttgat cctgacttaa
     2221 aattaaccaa agtggccccg gaggggtgga aggaagaacc gaagagaaag ggcaaggccg
     2281 ccgttgactt tacgttgttt ttccgaatta aatttttcat ggatgatgtt agtctgatac
     2341 aacatgacct cacgtgccat cagtattacc ttcagctgag gaaagacctt ctggatgaga
     2401 gggtgcactg tgacgacgag gccgccctgc ttcttgcatc cttggctctc caggcagagt
     2461 atggagatta tcagccagag gttcatggcg tgtcctactt tcgcctggaa cattacctgc
     2521 ccgccagggt gatggagaag ctggacgtgt cctacattaa agaagagtta cccaaactgc
     2581 ataacaccta tgcaggcgct tccgagaagg agacagagct agagttctta aaggtctgcc
     2641 aaaggctgac agagtatgga gttcactttc accgggtaca ccctgagaag aagtcacaga
     2701 cagggatact gctgggggtc tgttccaaag gtgtgctggt ctttgaggtt cacaatggag
     2761 tccgtgcctt ggtccttcgc ttcccgtgga gggaaacaaa aaagatttcc ttttcaaaga
     2821 agaaaatcac attacagaac acgtcagatg gaatcaagca tgcgttccag acggacagca
     2881 gcaaggcatg ccagtacctg ctgcacctgt gctcctccca gcacaagttc caattgcaga
     2941 tgagggcgcg gcagagcaac caggatgccc aagacataga gagagcttcg tttaggagcc
     3001 tgaacctgca agcagagtct gttagaggat ttaatatggg ccgcgcaatc agcacgggca
     3061 gtctggccag cagcaccatc aacaaacttg ccgtccgacc cctgtcagtt caagctgaga
     3121 ttctgaagag gctgtccagc tcagagtggt cgctttacca gcccctgcag aacagttcaa
     3181 aagagaagac tgacaaagct tcctgggagg aaaagcctag agggatgagc aaatcgtatc
     3241 acgatctcag tcaggcctct ctctgtcctc accggaaaca ggtcattaac atggaggccc
     3301 tcccacaagc ctttgcggag ctggtgggaa aacccttgta cccgatggca agatctgaca
     3361 cagagtcact ggcaggactc ccaaagcttg ataattcaaa gtctgttgcc agtttaaata
     3421 gaagccccga aaggaggaac catgaatcag actcatccac tgaagaccct ggccaagcat
     3481 atgttgtagg aatgagtttg cctagctctg gaaaatcttc atcccaagtc ccctttaaag
     3541 acaatgatac actgcacaaa agatggagca ttgtttcgtc accagaaagg gagatcacac
     3601 tggtgaacct gaagaaagat ccaaaacacg gcttaggatt tcaaattatc ggtggggaaa
     3661 aaatgggaag actggatcta ggagtgttta tcagtgcagt tacccctgga ggacctgctg
     3721 acctggatgg atgcttaaag cctggagacc gtttgatatc tgtgaacagt gtgagtctgg
     3781 aaggggtcag tcaccacgct gcagtggaca ttctgcagaa tgcacctgaa gatgtgacac
     3841 ttgtcatctc ccagccaaaa gaaaaaccgt ccaaagtgcc ttctactcct gttcattttg
     3901 ccaatgggat gaaaagctac acaaagaaac cggcatacat gcaggacagt gctatggacc
     3961 catcagagga ccagccctgg ccacggggta ctctgaggca catcccagag agtcccttcg
     4021 ggctgtctgg gggcctgcgg gagggaagcc tcagttccca agattccagg actgaaagtg
     4081 ccagcctatc ccagagccaa gtcaacggct tctttgccag ccacttaggc gacagaggct
     4141 ggcaggaacc acagcatagc agcccatcgc catctgtgac aaccaaggtc aacgagaaga
     4201 ccttctccga cagtaaccga agcaaggcca agcggcgagg catctccgat ttgattgaac
     4261 acctcgactg tgctgattcc gacaaagacg attccactta caccagcagt caagaccatc
     4321 aaacgtcaaa acaggaacct tcctcctcac tgagtacatc gaacaaaacg agctttccaa
     4381 cctcgtctgc gtcacctcct aagcccggag acacgtttga ggttgagctg gctaaaactg
     4441 atggcagcct ggggataagt gtcacgggag gtgtgaatac cagcgtccga catggtggta
     4501 tttatgtgaa agccattatt cccaaaggag cggcagagtc agatggcaga attcacaaag
     4561 gtgatcgtgt gctggctgtt aatggagtca gtctggaagg agctacccac aagcaagctg
     4621 tggaaacgtt aagaaacaca gggcaggtgg tccatctgtt gttagaaaag gggcaggtgc
     4681 caacatctag ggaacgggat cctgcaggcc cacagagccc ccctccagac caagacgccc
     4741 aaagacaagc cccggaaaag gtggcgaagc aaacacccca tgtcaaagac tacagctttg
     4801 ttactgaaga taatacattt gaggtcaagc tgtttaaaaa tagctcaggc cttggattca
     4861 gtttttctcg ggaagataat cttataccag aacaaataaa tggcagcata gtaagggtta
     4921 aaaagctctt ccctggacag ccggcagcag aaagtgggaa aatcgatgtt ggagatgtta
     4981 tattgaaagt taacggagcc cccttgaagg gactgtctca gcaggacgtc atctctgctc
     5041 tcaggggaac agctccagaa gtgtccttgc ttctctgcag accggcacct ggtgtgctac
     5101 cagaaatcga tactacattt ttgaacccac tctactctcc agcaaactca tttctaaaca
     5161 gcagtaaaga gacttcgcag ccatcatcct cagtagagca gggtgccagc tcggacgaca
     5221 atggggtgtc tggcaaaacc aagaaccatt gcagggctcc atccaggaga gagagttaca
     5281 gcgaccacag cgagagtgga gaggatgact ccgtgagagc accagccaag atgccaaatg
     5341 tgacccgagt ggcagccttt ccacacgaag caccgagaag ccaggaagag tccatatgtg
     5401 ccatgtttta cctccctcgg aaaatacccg gaaagctgga gtccgagagc agccatcctc
     5461 ctccactgga cgtgagccct ggacagacgt gccagccccc ggcagagtgt gctccgtctg
     5521 acgccactgg caaacacttt acacatcttg cctctcagct gagcaaagag gaaaacataa
     5581 caaccttgaa aaatgacttg ggaaaccacc ttgaggattc tgagctggaa gtagagcttc
     5641 tcattaccct ggttaaatca gaaaaaggaa gtctgggctt tacagtaacc aaaggcagtc
     5701 agagtattgg ttgttatgtc catgatgtca tacaggatcc agccaaaggt gacggaaggc
     5761 taaaggctgg agaccggctt ataaaggtta atgatacaga cgttacaaac atgacccaca
     5821 cagatgcagt gaatctgctg cgagccgcac ccaaaacagt cagattagtt cttgggcgga
     5881 ttctggagtt acccaggatg ccagtatttc cccatctgct gcccgacatt acagtcacat
     5941 gccacggaga ggagttagga ttttccctgt ctggaggtca aggcagtcca catggagtgg
     6001 tgtatattag tgatatcaac ccaaggtcag ctgcagctgt tgacggtagt ctccagctat
     6061 tagacatcat ccattatgtg aacggagtca gcacacaagg aatgaccttg gaagatgcaa
     6121 acagggcatt ggacctgtca cttccttcag tggtgctgaa agtaacaaga gacggttgtc
     6181 cagtggtgcc tacaacaaga gctgccattt ctgcgcccag gttcaccaaa gccaacggcc
     6241 taaccagcat ggagccttct ggacagcctg cactcatgcc caagaactcc ttctccaagg
     6301 ttaacgggga aggagtacat gaagctgtgt gccctgcagg agaaggctcg tcttctcaga
     6361 tgaaggagtc agcaggcctg actgaaacca aagaatctaa ctcccgggat gatgacatct
     6421 atgatgatcc tcaagaagct gaagttatcc agtccttgct ggatgttgtg gacgaggaag
     6481 cacagaacct cttaaaccag aggcatgcca ccagaagagc ctgttctcca gatccactga
     6541 ggacgaatgg ggaggcacca gaagaaggag ataccgacta tgatgggtct ccgctacctg
     6601 aggacgtccc tgagtcagtg agcagcggag aaggaaaagt agaccttgca agcttaactg
     6661 cagcatcaca agaagagaag cccatcgaag aggacgccac gcaggaaagc agaaactcga
     6721 caacggagac aacagacggt gaagattcca gcaaagatcc cccctttctg acgaatgagg
     6781 agctggcagc cctgccggtg gtcagagtcc ctccctctgg caagtacacg ggcacacagc
     6841 tgcaggccac catccgcacg ctgcagggct tgctcgacca agggatccct tctaaggagc
     6901 tggagaacct tcaagaatta aaacctttgg atcagtgtct gattggacag acaaaggaaa
     6961 accgcaggaa gaacagatac aaaaatatcc ttccctatga caccacaaga gtgcctcttg
     7021 gagatgaagg tggatacatc aatgccagtt tcatcaggat cccggtgggg acccaggaat
     7081 tcgtgtacat tgcctgccag gggccgttgc ccaccactgt gggggatttt tggcagatgg
     7141 tttgggagca gaactccacg gtgatagcaa tgatgacgca ggaggtggaa ggagaaaaga
     7201 tcaaatgcca gcggtactgg ccaagcatcc tgggcacaac caccatggcc aacgagaggc
     7261 tgcgcctggc cctcctgagg atgcagcagc tgaagggctt catcgtgcgg gtgatggccc
     7321 tggaggatat tcagacaggg gaggtgcgac atatttctca tctgaatttc actgcctggc
     7381 cagaccacga tacaccgtcg cagccagacg acctgctcac attcatctcc tacatgagac
     7441 acatccgtag gtcgggccca gtcatcacac actgcagcgc tggcattgga cgctcaggaa
     7501 ccctcatttg catagacgtg gtcctaggct taatcagcca ggatctggaa ttcgacatct
     7561 ctgacctagt gcgctgcatg aggcttcaga ggcacggcat ggtgcagacc gagggtcagt
     7621 atgtcttctg ctatcaagtc atcctctatg tcctgactca tcttcaggct gaagagcaga
     7681 aggcacagcc agggctccca cagtgatgca gagcagcctc caaaggctcc ctcccttcct
     7741 gcatccagcc gactcctgct ctccactctt gagagcagca aggccaagca agcagcaccg
     7801 tgaagcttag tccctcctgc ttgaaggaca ggcgttcccg tcagatacgg acgtcaagat
     7861 gctgtgtttt tacagccact tcaaccactg atggtcatta aaactccttt ttcactaact
     7921 gaaccagcag gtcttagggc tggagacagc atttgatcat agtggacgtt gttacaaaga
     7981 cacactgagt ctatttttaa tgtaccaaat cctgtttata gcaaaaattt tccagtattt
     8041 taataaagta gatttatttt ataggggata cttgaagcca gtatttaagc ttttaatgac
     8101 agtaatattg gcatagaaga cgaactagca atgtttactg tatccatttc taatgtttac
     8161 tatatataat ttcctgtaat atatttatat acttttcatg aacatggagt taccagatac
     8221 cgtttgtacc tgtgtcatct cactttgtaa ataaaactac accttaaaac atagacaacc
     8281 aaaaaaaaaa aaaaaaaa
//
