LOCUS       NM_001109992            5616 bp    mRNA    linear   ROD 28-JAN-2025
DEFINITION  Mus musculus protein tyrosine phosphatase, non-receptor type 11
            (Ptpn11), transcript variant 2, mRNA.
ACCESSION   NM_001109992
VERSION     NM_001109992.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5616)
  AUTHORS   Guhathakurta,D., Selzam,F., Petruskova,A., Weiss,E.M., Akdas,E.Y.,
            Montenegro-Venegas,C., Zenker,M. and Fejtova,A.
  TITLE     Rasopathy-Associated Mutation Ptpn11D61Y has Age-Dependent Effect
            on Synaptic Vesicle Recycling
  JOURNAL   Cell Mol Neurobiol 44 (1), 77 (2024)
   PUBMED   39570442
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5616)
  AUTHORS   Chouhan,S., Sridaran,D., Weimholt,C., Luo,J., Li,T., Hodgson,M.C.,
            Santos,L.N., Le Sommer,S., Fang,B., Koomen,J.M., Seeliger,M.,
            Qu,C.K., Yart,A., Kontaridis,M.I., Mahajan,K. and Mahajan,N.P.
  TITLE     SHP2 as a primordial epigenetic enzyme expunges histone H3 pTyr-54
            to amend androgen receptor homeostasis
  JOURNAL   Nat Commun 15 (1), 5629 (2024)
   PUBMED   38965223
  REMARK    GeneRIF: SHP2 as a primordial epigenetic enzyme expunges histone H3
            pTyr-54 to amend androgen receptor homeostasis.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5616)
  AUTHORS   Perrin,S., Protic,S., Bretegnier,V., Laurendeau,I., de
            Lageneste,O.D., Panara,N., Ruckebusch,O., Luka,M., Masson,C.,
            Maillard,T., Coulpier,F., Pannier,S., Wicart,P., Hadj-Rabia,S.,
            Radomska,K.J., Zarhrate,M., Menager,M., Vidaud,D., Topilko,P.,
            Parfait,B. and Colnot,C.
  TITLE     MEK-SHP2 inhibition prevents tibial pseudarthrosis caused by NF1
            loss in Schwann cells and skeletal stem/progenitor cells
  JOURNAL   Sci Transl Med 16 (753), eadj1597 (2024)
   PUBMED   38924432
  REMARK    GeneRIF: MEK-SHP2 inhibition prevents tibial pseudarthrosis caused
            by NF1 loss in Schwann cells and skeletal stem/progenitor cells.
            Erratum:[Sci Transl Med. 2024 Aug 28;16(762):eads3171. doi:
            10.1126/scitranslmed.ads3171. PMID: 39196963]
REFERENCE   4  (bases 1 to 5616)
  AUTHORS   Weiss,E.M., Guhathakurta,D., Petruskova,A., Hundrup,V., Zenker,M.
            and Fejtova,A.
  TITLE     Developmental effect of RASopathy mutations on neuronal network
            activity on a chip
  JOURNAL   Front Cell Neurosci 18, 1388409 (2024)
   PUBMED   38910965
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 5616)
  AUTHORS   Kan,C., Tan,Z., Liu,L., Liu,B., Zhan,L., Zhu,J., Li,X., Lin,K.,
            Liu,J., Liu,Y., Yang,F., Wong,M., Wang,S. and Zheng,H.
  TITLE     Phase separation of SHP2E76K promotes malignant transformation of
            mesenchymal stem cells by activating mitochondrial complexes
  JOURNAL   JCI Insight 9 (8), e170340 (2024)
   PUBMED   38451719
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 5616)
  AUTHORS   Tauchi,T., Feng,G.S., Marshall,M.S., Shen,R., Mantel,C., Pawson,T.
            and Broxmeyer,H.E.
  TITLE     The ubiquitously expressed Syp phosphatase interacts with c-kit and
            Grb2 in hematopoietic cells
  JOURNAL   J Biol Chem 269 (40), 25206-25211 (1994)
   PUBMED   7523381
REFERENCE   7  (bases 1 to 5616)
  AUTHORS   Welham,M.J., Dechert,U., Leslie,K.B., Jirik,F. and Schrader,J.W.
  TITLE     Interleukin (IL)-3 and granulocyte/macrophage colony-stimulating
            factor, but not IL-4, induce tyrosine phosphorylation, activation,
            and association of SHPTP2 with Grb2 and phosphatidylinositol
            3'-kinase
  JOURNAL   J Biol Chem 269 (38), 23764-23768 (1994)
   PUBMED   7522233
REFERENCE   8  (bases 1 to 5616)
  AUTHORS   Lee,C.H., Kominos,D., Jacques,S., Margolis,B., Schlessinger,J.,
            Shoelson,S.E. and Kuriyan,J.
  TITLE     Crystal structures of peptide complexes of the amino-terminal SH2
            domain of the Syp tyrosine phosphatase
  JOURNAL   Structure 2 (5), 423-438 (1994)
   PUBMED   7521735
REFERENCE   9  (bases 1 to 5616)
  AUTHORS   Feng,G.S., Hui,C.C. and Pawson,T.
  TITLE     SH2-containing phosphotyrosine phosphatase as a target of
            protein-tyrosine kinases
  JOURNAL   Science 259 (5101), 1607-1611 (1993)
   PUBMED   8096088
REFERENCE   10 (bases 1 to 5616)
  AUTHORS   Vogel,W., Lammers,R., Huang,J. and Ullrich,A.
  TITLE     Activation of a phosphotyrosine phosphatase by tyrosine
            phosphorylation
  JOURNAL   Science 259 (5101), 1611-1614 (1993)
   PUBMED   7681217
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK159501.1, BC057398.1, CF751511.1 and BM899214.1.
            
            Transcript Variant: This variant (2) uses an alternate in-frame
            splice site in the 3' coding region, compared to variant 1. It
            encodes isoform b, which is shorter than isoform a.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK159587.1, AK159501.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-68                AK159501.1         1-68
            69-1406             BC057398.1         1-1338
            1407-5068           BC057398.1         1351-5012
            5069-5566           CF751511.1         225-722
            5567-5616           BM899214.1         1-50                c
FEATURES             Location/Qualifiers
     source          1..5616
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 61.72 cM"
     gene            1..5616
                     /gene="Ptpn11"
                     /gene_synonym="2700084A17Rik; PTP1D; PTP2C; SAP-2;
                     SH-PTP2; SH-PTP3; SHP-2; Shp2; Syp"
                     /note="protein tyrosine phosphatase, non-receptor type 11"
                     /db_xref="GeneID:19247"
                     /db_xref="MGI:MGI:99511"
     exon            1..196
                     /gene="Ptpn11"
                     /gene_synonym="2700084A17Rik; PTP1D; PTP2C; SAP-2;
                     SH-PTP2; SH-PTP3; SHP-2; Shp2; Syp"
                     /inference="alignment:Splign:2.1.0"
     exon            197..319
                     /gene="Ptpn11"
                     /gene_synonym="2700084A17Rik; PTP1D; PTP2C; SAP-2;
                     SH-PTP2; SH-PTP3; SHP-2; Shp2; Syp"
                     /inference="alignment:Splign:2.1.0"
     exon            320..514
                     /gene="Ptpn11"
                     /gene_synonym="2700084A17Rik; PTP1D; PTP2C; SAP-2;
                     SH-PTP2; SH-PTP3; SHP-2; Shp2; Syp"
                     /inference="alignment:Splign:2.1.0"
     exon            515..707
                     /gene="Ptpn11"
                     /gene_synonym="2700084A17Rik; PTP1D; PTP2C; SAP-2;
                     SH-PTP2; SH-PTP3; SHP-2; Shp2; Syp"
                     /inference="alignment:Splign:2.1.0"
     exon            708..824
                     /gene="Ptpn11"
                     /gene_synonym="2700084A17Rik; PTP1D; PTP2C; SAP-2;
                     SH-PTP2; SH-PTP3; SHP-2; Shp2; Syp"
                     /inference="alignment:Splign:2.1.0"
     exon            825..938
                     /gene="Ptpn11"
                     /gene_synonym="2700084A17Rik; PTP1D; PTP2C; SAP-2;
                     SH-PTP2; SH-PTP3; SHP-2; Shp2; Syp"
                     /inference="alignment:Splign:2.1.0"
     exon            939..1035
                     /gene="Ptpn11"
                     /gene_synonym="2700084A17Rik; PTP1D; PTP2C; SAP-2;
                     SH-PTP2; SH-PTP3; SHP-2; Shp2; Syp"
                     /inference="alignment:Splign:2.1.0"
     exon            1036..1115
                     /gene="Ptpn11"
                     /gene_synonym="2700084A17Rik; PTP1D; PTP2C; SAP-2;
                     SH-PTP2; SH-PTP3; SHP-2; Shp2; Syp"
                     /inference="alignment:Splign:2.1.0"
     exon            1116..1274
                     /gene="Ptpn11"
                     /gene_synonym="2700084A17Rik; PTP1D; PTP2C; SAP-2;
                     SH-PTP2; SH-PTP3; SHP-2; Shp2; Syp"
                     /inference="alignment:Splign:2.1.0"
     exon            1275..1406
                     /gene="Ptpn11"
                     /gene_synonym="2700084A17Rik; PTP1D; PTP2C; SAP-2;
                     SH-PTP2; SH-PTP3; SHP-2; Shp2; Syp"
                     /inference="alignment:Splign:2.1.0"
     exon            1407..1561
                     /gene="Ptpn11"
                     /gene_synonym="2700084A17Rik; PTP1D; PTP2C; SAP-2;
                     SH-PTP2; SH-PTP3; SHP-2; Shp2; Syp"
                     /inference="alignment:Splign:2.1.0"
     exon            1562..1629
                     /gene="Ptpn11"
                     /gene_synonym="2700084A17Rik; PTP1D; PTP2C; SAP-2;
                     SH-PTP2; SH-PTP3; SHP-2; Shp2; Syp"
                     /inference="alignment:Splign:2.1.0"
     exon            1630..1781
                     /gene="Ptpn11"
                     /gene_synonym="2700084A17Rik; PTP1D; PTP2C; SAP-2;
                     SH-PTP2; SH-PTP3; SHP-2; Shp2; Syp"
                     /inference="alignment:Splign:2.1.0"
     exon            1782..1894
                     /gene="Ptpn11"
                     /gene_synonym="2700084A17Rik; PTP1D; PTP2C; SAP-2;
                     SH-PTP2; SH-PTP3; SHP-2; Shp2; Syp"
                     /inference="alignment:Splign:2.1.0"
     exon            1895..1985
                     /gene="Ptpn11"
                     /gene_synonym="2700084A17Rik; PTP1D; PTP2C; SAP-2;
                     SH-PTP2; SH-PTP3; SHP-2; Shp2; Syp"
                     /inference="alignment:Splign:2.1.0"
     exon            1986..5599
                     /gene="Ptpn11"
                     /gene_synonym="2700084A17Rik; PTP1D; PTP2C; SAP-2;
                     SH-PTP2; SH-PTP3; SHP-2; Shp2; Syp"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5572..5577
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ptpn11"
                     /gene_synonym="2700084A17Rik; PTP1D; PTP2C; SAP-2;
                     SH-PTP2; SH-PTP3; SHP-2; Shp2; Syp"
                     /note="hexamer: AATAAA"
     polyA_site      5599
                     /gene="Ptpn11"
                     /gene_synonym="2700084A17Rik; PTP1D; PTP2C; SAP-2;
                     SH-PTP2; SH-PTP3; SHP-2; Shp2; Syp"
                     /note="major polyA site"
ORIGIN      
        1 gggcggccgc gcagtgtccg ggatccaggc ctggcagggg gttgtgcgcg cgcggccggc
       61 cggctctgcc cgcacccgtg tcggctccgg agcggggcct cgctcgggcc ccctccatgt
      121 gacggtaccc cgcggagcct gagcgagcag cgggtccgtg cggagccgga gacgggagga
      181 acatgacatc gcggagatgg tttcacccca acatcactgg tgtggaggca gagaatctcc
      241 tgctgaccag aggagtcgat ggcagttttt tagcaaggcc cagtaagagt aaccctggag
      301 acttcactct gtctgttaga agaaatggag ctgttaccca catcaagatt cagaacactg
      361 gggactacta tgacctctat ggtggggaga agtttgccac tttggctgaa ctggttcagt
      421 attacatgga acaccatggg cagctgaaag agaagaatgg agatgttatc gagctcaagt
      481 acccgctgaa ctgtgcagac cctacctctg aaaggtggtt ccatggtcac ttgtctggaa
      541 aagaagcaga gaagctgctg acggagaagg gcaagcatgg cagcttcctc gttcgagaga
      601 gccagagcca ccccggagac ttcgttctct ccgtgcgcac tggtgacgac aaaggggaga
      661 gcaacgacgg caagtccaaa gtgacccacg tcatgatccg ctgtcaggag ctgaaatacg
      721 acgttggtgg gggagagcgc tttgactctc tgacagacct ggtggagcat tacaagaaga
      781 accccatggt ggagacgctg ggcacagtcc tgcagctcaa gcagcccctc aacacaactc
      841 gtatcaatgc tgctgaaatt gaaagccggg ttcgagagtt aagcaagctg gctgagacca
      901 cagataaagt caagcagggc ttttgggaag agtttgagac gctccagcaa caggaatgca
      961 aacttctcta tagccgaaaa gaaggacaga gacaagaaaa taaaaacaaa aacagataca
     1021 aaaacatcct gccctttgat cataccaggg tcgttctgca tgatggggat cccaatgagc
     1081 ctgtttctga ttacattaat gcaaacatca tcatgcctga gtttgagacc aagtgcaaca
     1141 attccaaacc caaaaagagt tacattgcca ctcaaggctg cctgcagaac acggtgaatg
     1201 acttctggcg gatggtgttc caggagaact ctcgagtcat tgtcatgacc acaaaggaag
     1261 tggagagagg gaagagcaaa tgtgtcaagt actggcctga tgagtatgcg ctcaaagaat
     1321 acggggtcat gcgtgttagg aacgtcaaag aaagtgccgc ccatgactac actttacgag
     1381 agctcaaact ctctaaggtc ggacaaggaa acacagagag aaccgtctgg cagtaccact
     1441 ttcggacctg gccagaccat ggcgtgccta gtgaccctgg aggtgtgctg gacttcctgg
     1501 aggaggtcca ccacaagcag gagagcatcg tggatgcagg ccctgtcgtg gttcactgca
     1561 gcgctgggat tggccggaca ggaaccttca ttgtgattga catccttatt gacatcattc
     1621 gagagaaagg tgtggactgt gacatcgacg ttcctaaaac cattcagatg gtgcggtccc
     1681 agaggtcggg gatggtccag acagaagcac agtaccggtt tatctacatg gctgtccagc
     1741 actacataga gacgctgcag cgccggatcg aggaggagca gaaaagcaaa agaaaaggac
     1801 atgaatatac caatattaag tattccttgg tggaccagac aagtggtgat cagagtcccc
     1861 tgccaccctg caccccaacg ccaccctgtg cagaaatgag ggaggacagc gcccgagtct
     1921 atgagaacgt gggcctcatg cagcagcaga ggagtttcag atgagcccac ggcgacagaa
     1981 cgcagatgtg aactttcacc cctttcctaa aatgtcaaga ctagacgagc gttcccagga
     2041 cccgtgcgtg cgttcagaag ccggcactgg ctggactgcc tcttgagaag cgaagtttgg
     2101 aaccatttga acagcacgtg cctaattggc acctcctttc ctcagctaag gagagactgc
     2161 tctgcgttct tgacaatgct attttcatag aattggtttt gaattgtgga agcagctaaa
     2221 ttgtgctctg tattttctac attatgggac tcaaattcta gttatgggca ggattttgtt
     2281 tttttttatg accttaacag atctgatttt ttttttcttt ctctctcttt ggggaatcat
     2341 gggccccttg taagaagaaa ggatttaggg agattccggc acagcctccc caaaagccag
     2401 ccgtctgtaa cccactgttc atcttgctgc tctgcacagg gctcccaggg ccctggctgg
     2461 agactgctta gggtcatcat catcacagag gctcactgtt tagttccagg gaccagtagg
     2521 ccaggctgca ggcttgcacc tggtgagggc cttctggctg tgctacactg gacgggagag
     2581 caccaagtgg ggaatcactt ttatggcaca agttcactgc accctcaaga cccaggtatc
     2641 ccttatcatc tcactgtcca cacagtgaca ttgggaggtc tttgtgctcc ctgcagacac
     2701 atgtcagggc acttttaaaa cagattgacc cagccaagga cagttcactt ttggtggctt
     2761 cttttgttta gtgaaacggt cattcagcca ctgaatgaga gggtcaggag gtagacagtc
     2821 atggctgaaa gaaaggccct gggaactggt gtgtgaagtc tttcttctga agatgactcc
     2881 ttggctgcag gtgtggacag agaagctgtt ctgggcaaag tgaccatgtt gtctctgtac
     2941 tggagtatta gtaagatccc ggggtgagcg gtatttggtc ctcacttgtt cctgaccacc
     3001 ccattcccgt tcttcagtgc agcacatctg atctgggttg catgagcccc cactgtcctg
     3061 taagggtcac ttgggaggtt ggcaacatgg tcagaaccct gggtgtctgc ttcagggagg
     3121 tgtttccctg tctcttctcc tgggtgtctg agtagcctta cgagcagggt ggctggaccc
     3181 ttatgtgtcc cccagggtga aagccagaag tggccaggtc ttcttcaggc gcaggcctgg
     3241 agtgaccatg atgacttctt ccgtggctgc tgtgagagaa tcaggctcag cccaaggtgt
     3301 gaagtcctat gctctggggc caccagtcag acagccccag cccgtggcat agaagcaagt
     3361 ggctgtagtt agcaagagcc caggctgctt atagtatctg gtgtaaactg tgtgtcggat
     3421 gggaaatgta cagcaggtct tctagaagct tccgagcccc gcacgtgtgc tgcagcgccc
     3481 acctgaggac ctggtgtggt cgggttggtg gtgtgtacgt gggagcccat ccctgaagca
     3541 ccgctggggt gggaaggcga tgcttcccgg gccttggctg agtatgaaga gcggcagtcc
     3601 tggctaggcc tcctatcagt tccagtcagc cgtgtctgcc ctaaccaaac agcaggattt
     3661 gctaatgttc tgccgtaagt gccttctcca gagatgtccc tctgcccagt gttgatcctt
     3721 gagagcacgt ttcagcgaga gcttccagat gtgatgctcg tgaccaagca accgcacagt
     3781 ctccacttga ttcttcttgc ttccattcct gaaaggaaga attggacctg ccctgcagct
     3841 gccctgtctg gggcctcctg ctccctggca gcctgaggta gttggggagc acaggggcca
     3901 ccattttctt agagcatgtg catcgatcct ggccccttct ccaactgaat tcgattgctt
     3961 cagagcacag catggcctgg tgggaatgtg gagactgctg tcttctccga gagtttgtaa
     4021 tgagatcagt tcagcattca cagccaggat cccagatcct actctctata gcacattgtc
     4081 acaatgaact gtgttgggtt ggtggtaatg tctagactct ggacttggag ggcaaagttt
     4141 ctcaccagca cacagaggtt agctgagctg ctgatctctc aagctaacat ttctacttgc
     4201 agcttgagat cctggaacag agacctgccc ttggccccct gtgttcggta cagcaagtgt
     4261 tttcctttgg attcccccca gaagccagcc agctgtcatt ccaatagggc aacaggaatc
     4321 cctaggtgtc ccagatctgt cagtgttatg gaaggtggtt gcagggtctc agctgtgtgc
     4381 tgtgcggtgc ggtgtctggg aagatgaggt atgggaggtg tggatttgag acagcgagag
     4441 tggaagttgc acaggtggct catgagcagg tcagaggcac agggccagca tcgagcaggc
     4501 tgcatgtgac ccgagtctcc cctcactgct gagcctttaa atcagaagta taggattttt
     4561 ctatttgggg agggggtggg gtggggcatt gtctagcaca tggtattggt ttctagaaag
     4621 ctatacttga gagtcgtaat gcttgtcaca tgggtgtgca gccttcctga ggccccaggt
     4681 tgcctctgcc attgcagctg gtgcctttct aatggaagac tggggttagg aagtggtgct
     4741 gtcagcagct cagaggtgct cagtgttgtt tctaggggtt ttggtgggag tccaagaata
     4801 taagccttgt ttctgggaca ggactggggc agatgcgctc gggaaggaag cacaggcaga
     4861 agtgtgggct cgttctacat tgtcctagtt tcagacgcct gtctcagggt ctgtgctagc
     4921 ccactgcttt gttgaaccct ttccctttct tggaaggaag ctcccgagta gagctcactg
     4981 catccccagt cactagcagc tgttgctctt gtggggtgtt gagggcacag gaagcagaga
     5041 gcagttcctg ttggtgctgt agaacctggc tgtgcatcca agtagttttc acaactcctc
     5101 ttcctaaacc tcaatcatgg gattaataat atacctgttt atttatgacc taattgtgac
     5161 tctgattaat aaaagctggt gggaaaggcc catccaagaa gccgatggcc agactcacac
     5221 ttagctttcc cacagcgtat gaagcatcca tcaggcagag tattaaagaa atataatatt
     5281 ttactgatag acctgtcctt taaaaggaac gtgtttttgg gtgtcatcat tttggtgtga
     5341 atcatgtaag ggttggctgt ttgctgttta atacacttta gtgtcaagag acgcactcag
     5401 ctgacttttt gcccacgcat atcatgtagt ctggattttt aagcgacatt aacagaatag
     5461 tttgtgtaga gaaacctcaa gtttccccag ctgtgccatg agtgtatctg catatactct
     5521 gggtattgtc agaggcagtg gatttgtgag ctgtctggaa ctaaaaatta gaataaaatc
     5581 attttcttgt attacagtaa aaaaaaaaaa aaaaaa
//
