LOCUS       NM_011201               4213 bp    mRNA    linear   ROD 11-JUN-2024
DEFINITION  Mus musculus protein tyrosine phosphatase, non-receptor type 1
            (Ptpn1), mRNA.
ACCESSION   NM_011201
VERSION     NM_011201.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4213)
  AUTHORS   Zifkos,K., Bochenek,M.L., Gogiraju,R., Robert,S., Pedrosa,D.,
            Kiouptsi,K., Moiko,K., Wagner,M., Mahfoud,F., Poncelet,P.,
            Munzel,T., Ruf,W., Reinhardt,C., Panicot-Dubois,L., Dubois,C. and
            Schafer,K.
  TITLE     Endothelial PTP1B Deletion Promotes VWF Exocytosis and Venous
            Thromboinflammation
  JOURNAL   Circ Res 134 (10), e93-e111 (2024)
   PUBMED   38563147
  REMARK    GeneRIF: Endothelial PTP1B Deletion Promotes VWF Exocytosis and
            Venous Thromboinflammation.
REFERENCE   2  (bases 1 to 4213)
  AUTHORS   Schwartz,L., Salamon,K., Simoni,A., Eichler,T., Jackson,A.R.,
            Murtha,M., Becknell,B., Kauffman,A., Linn-Peirano,S.,
            Holdsworth,N., Tyagi,V., Tang,H., Rust,S., Cortado,H.,
            Zabbarova,I., Kanai,A. and Spencer,J.D.
  TITLE     Insulin receptor signaling engages bladder urothelial defenses that
            limit urinary tract infection
  JOURNAL   Cell Rep 43 (4), 114007 (2024)
   PUBMED   38517889
REFERENCE   3  (bases 1 to 4213)
  AUTHORS   Ge,X., Hu,M., Zhou,M., Fang,X., Chen,X., Geng,D., Wang,L., Yang,X.,
            An,H., Zhang,M., Lin,D., Zheng,M., Cui,X., Wang,Q., Wu,Y.,
            Zheng,K., Huang,X.F. and Yu,Y.
  TITLE     Overexpression of forebrain PTP1B leads to synaptic and cognitive
            impairments in obesity
  JOURNAL   Brain Behav Immun 117, 456-470 (2024)
   PUBMED   38336024
  REMARK    GeneRIF: Overexpression of forebrain PTP1B leads to synaptic and
            cognitive impairments in obesity.
REFERENCE   4  (bases 1 to 4213)
  AUTHORS   Datta,R., Mukherjee,D., Podolsky,M.J., Yang,C.D., Alba,D.L.,
            Singh,S., Arnold,T.D., Koliwad,S., Lizama,C.O. and Atabai,K.
  TITLE     PTP1B mediates the inhibitory effect of MFGE8 on insulin signaling
            through the beta5 integrin
  JOURNAL   J Biol Chem 300 (2), 105631 (2024)
   PUBMED   38199575
  REMARK    GeneRIF: PTP1B mediates the inhibitory effect of MFGE8 on insulin
            signaling through the beta5 integrin.
REFERENCE   5  (bases 1 to 4213)
  AUTHORS   Song,Q., Ma,H., Zhu,L., Qi,Z., Lan,Z., Liu,K., Zhang,H., Wang,K.
            and Wang,N.
  TITLE     Upregulation of PTPN1 aggravates endotoxemia-induced cardiac
            dysfunction through inhibiting mitophagy
  JOURNAL   Int Immunopharmacol 126, 111315 (2024)
   PUBMED   38043267
  REMARK    GeneRIF: Upregulation of PTPN1 aggravates endotoxemia-induced
            cardiac dysfunction through inhibiting mitophagy.
REFERENCE   6  (bases 1 to 4213)
  AUTHORS   Hendriks,W., Schepens,J., Brugman,C., Zeeuwen,P. and Wieringa,B.
  TITLE     A novel receptor-type protein tyrosine phosphatase with a single
            catalytic domain is specifically expressed in mouse brain
  JOURNAL   Biochem J 305 (Pt 2) (Pt 2), 499-504 (1995)
   PUBMED   7832766
REFERENCE   7  (bases 1 to 4213)
  AUTHORS   Tagawa,M., Shirasawa,T., Fujimura,S. and Sakiyama,S.
  TITLE     Expression of protein tyrosine phosphatase genes in the developing
            brain of mouse and rat
  JOURNAL   Biochem Mol Biol Int 33 (6), 1221-1227 (1994)
   PUBMED   7804149
REFERENCE   8  (bases 1 to 4213)
  AUTHORS   Kaneko,Y., Takano,S., Okumura,K., Takenawa,J., Higashituji,H.,
            Fukumoto,M., Nakayama,H. and Fujita,J.
  TITLE     Identification of protein tyrosine phosphatases expressed in murine
            male germ cells
  JOURNAL   Biochem Biophys Res Commun 197 (2), 625-631 (1993)
   PUBMED   8267598
REFERENCE   9  (bases 1 to 4213)
  AUTHORS   Miyasaka,H. and Li,S.S.
  TITLE     The cDNA cloning, nucleotide sequence and expression of an
            intracellular protein tyrosine phosphatase from mouse testis
  JOURNAL   Biochem Biophys Res Commun 185 (3), 818-825 (1992)
   PUBMED   1378268
REFERENCE   10 (bases 1 to 4213)
  AUTHORS   Yi,T., Cleveland,J.L. and Ihle,J.N.
  TITLE     Identification of novel protein tyrosine phosphatases of
            hematopoietic cells by polymerase chain reaction amplification
  JOURNAL   Blood 78 (9), 2222-2228 (1991)
   PUBMED   1932742
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL928998.9.
            
            On Mar 16, 2007 this sequence version replaced NM_011201.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK157431.1, AK166020.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-230               AL928998.9         54161-54390
            231-321             AL928998.9         85462-85552
            322-422             AL928998.9         86844-86944
            423-521             AL928998.9         89563-89661
            522-659             AL928998.9         93527-93664
            660-869             AL928998.9         95894-96103
            870-1031            AL928998.9         96563-96724
            1032-1252           AL928998.9         97143-97363
            1253-4213           AL928998.9         98259-101219
FEATURES             Location/Qualifiers
     source          1..4213
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 87.99 cM"
     gene            1..4213
                     /gene="Ptpn1"
                     /gene_synonym="PTP-1B; PTP-HA2; PTP1B"
                     /note="protein tyrosine phosphatase, non-receptor type 1"
                     /db_xref="GeneID:19246"
                     /db_xref="MGI:MGI:97805"
     exon            1..230
                     /gene="Ptpn1"
                     /gene_synonym="PTP-1B; PTP-HA2; PTP1B"
                     /inference="alignment:Splign:2.1.0"
     exon            231..321
                     /gene="Ptpn1"
                     /gene_synonym="PTP-1B; PTP-HA2; PTP1B"
                     /inference="alignment:Splign:2.1.0"
     exon            322..422
                     /gene="Ptpn1"
                     /gene_synonym="PTP-1B; PTP-HA2; PTP1B"
                     /inference="alignment:Splign:2.1.0"
     exon            423..521
                     /gene="Ptpn1"
                     /gene_synonym="PTP-1B; PTP-HA2; PTP1B"
                     /inference="alignment:Splign:2.1.0"
     exon            522..659
                     /gene="Ptpn1"
                     /gene_synonym="PTP-1B; PTP-HA2; PTP1B"
                     /inference="alignment:Splign:2.1.0"
     exon            660..869
                     /gene="Ptpn1"
                     /gene_synonym="PTP-1B; PTP-HA2; PTP1B"
                     /inference="alignment:Splign:2.1.0"
     exon            870..1031
                     /gene="Ptpn1"
                     /gene_synonym="PTP-1B; PTP-HA2; PTP1B"
                     /inference="alignment:Splign:2.1.0"
     exon            1032..1252
                     /gene="Ptpn1"
                     /gene_synonym="PTP-1B; PTP-HA2; PTP1B"
                     /inference="alignment:Splign:2.1.0"
     exon            1253..4213
                     /gene="Ptpn1"
                     /gene_synonym="PTP-1B; PTP-HA2; PTP1B"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4193..4198
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ptpn1"
                     /gene_synonym="PTP-1B; PTP-HA2; PTP1B"
                     /note="hexamer: AATAAA"
     polyA_site      4213
                     /gene="Ptpn1"
                     /gene_synonym="PTP-1B; PTP-HA2; PTP1B"
                     /note="major polyA site"
ORIGIN      
        1 gcggtgaggc gggggtgcgt acttccggct gccggcttga catgcagaag ccgctgctgg
       61 ggagcttggg gctgcggtgg tggcgggtga cgggcttcgg gacgcggagc gacgcggcct
      121 agcgcggcgg acggccgtgg gaactcgggc agccgacccg tcccgccatg gagatggaga
      181 aggagttcga ggagatcgac aaggctggga actgggcggc tatttaccag gacattcgac
      241 atgaagccag cgacttccca tgcaaagtcg cgaagcttcc taagaacaaa aaccggaaca
      301 ggtaccgaga tgtcagccct tttgaccaca gtcggattaa attgcaccag gaagataatg
      361 actatatcaa tgccagcttg ataaaaatgg aagaagccca gaggagctat attctcaccc
      421 agggcccttt accaaacaca tgtgggcact tctgggagat ggtgtgggag cagaagagca
      481 ggggcgtggt catgctcaac cgcatcatgg agaaaggctc gttaaaatgt gcccagtatt
      541 ggccacagca agaagaaaag gagatggtct ttgatgacac aggtttgaag ttgacactaa
      601 tctctgaaga tgtcaagtca tattacacag tacgacagtt ggagttggaa aacctgacta
      661 ccaaggagac tcgagagatc ctgcatttcc actacaccac atggcctgac tttggagtcc
      721 ccgagtcacc ggcttctttc ctcaatttcc ttttcaaagt ccgagagtca ggctcactca
      781 gcctggagca tggccccatt gtggtccact gcagcgccgg catcgggagg tcagggacct
      841 tctgtctggc tgacacctgc ctcttactga tggacaagag gaaagaccca tcttccgtgg
      901 acatcaagaa agtactgctg gagatgcgca ggttccgcat ggggctcatc cagactgccg
      961 accagctgcg cttctcctac ctggctgtca tcgagggcgc caagttcatc atgggcgact
     1021 cgtcagtgca ggatcagtgg aaggagctct cccgggagga tctagacctt ccacccgagc
     1081 acgtgccccc acctccccgg ccacccaaac gcacactgga gcctcacaac gggaagtgca
     1141 aggagctctt ctccagccac cagtgggtga gcgaggagac ctgtggggat gaagacagcc
     1201 tggccagaga ggaaggcaga gcccagtcaa gtgccatgca cagcgtgagc agcatgagtc
     1261 cagacactga agttaggaga cggatggtgg gtggaggtct tcaaagtgct caggcgtctg
     1321 tccccaccga ggaagagctg tcctccactg aggaggaaca caaggcacat tggccaagtc
     1381 actggaagcc cttcctggtc aatgtgtgca tggccacgct cctggccacc ggcgcgtact
     1441 tgtgctaccg ggtgtgtttt cactgacaga ctgggaggca ctgccactgc ccagcttagg
     1501 atgcggtctg cggcgtctga cctggtgtag agggaacaac aactcgcaag cctgctctgg
     1561 aactggaagg gccagcccca ggagggtatt agtgcactgg gctttgaagg agcccctggt
     1621 cccacgaaca gagtctaatc tcagggcctt aacctgttca ggagaagtag aggaaatgcc
     1681 aaatactctt cttgctctca cctcactcct cccctttctc tgattcattt gtttttggaa
     1741 aaaaaaaaaa aaagaattac aacacattgt tgtttttaac atttataaag gcaggttttt
     1801 gttatttctg gagaaaaaaa aaagatgcta ggcactggtg agcttctctc gtgccctttg
     1861 gcatgtgatc agattcatga tttctattga tttccagtgg aaggatcccg ctgggcagga
     1921 ctgtaaagtt cctgctggcg tgggcagccc ccactgtgca cccggagctt gcaggtgccc
     1981 tggagcccca tcctgttgtg aggagggcag ccacatgggc tgcctctgaa cagcaagccc
     2041 ggctctgctt cgctcaggtg tcccccccgc ggttccatcc ttctcggtct cctccctctt
     2101 tgtgagtgcc atcttgcaaa tggcccagcc cttgccaccc tatccctgta aatccctgag
     2161 ggccttgcct cggggtcaga ggtggctgcc agcctaagtg ctggggtttc catttcattt
     2221 ggaaagtcat tactactctg tgtggaagcc actctactga ggtgcaagca agactggtga
     2281 aggagaaagg agccctggtg tcatggaagc ccctcggcag gacctgtacc cccctctgaa
     2341 acactgttcc agtgaacgct ctcgaaggca tcagatagag gatttttgca gactgcaaag
     2401 acttcctgag tggtgatttt cagagtctgg actcaaaaaa caccatggag cgcttaccgc
     2461 gctgccttcc atgctggtat ggctgaggcc gtggggaggc cggcgctgtg gctccatcca
     2521 gtgcggatgc ctttgtgcaa tcgctgccca gcagcagagc ctgcatgcca gcctctgcgc
     2581 tgcaggccac aatggccatg gcggcccaaa gagtgagctg cgatggaggc ttatcacatg
     2641 gagctgcctt ttcaggctat gcatctccct tcctgcttta ccctctgctt ccttcccgag
     2701 tagcaagccc accatcatga ggagtgcaag ggaggggcag gcattagagc ggggtgcggc
     2761 tttcgaggtg aggccacctc cgaggctgcc ctcctcttat ttattcactt tgcccggagg
     2821 tggcccccgc gtgagcatgc cctgaaactg accgtgtctg cctgcaccca tgaccgtcag
     2881 gtcagtcctg gggttgaggc atgagtgcag gactgacagg agccacagta tggccagtgc
     2941 tggggccagg agcaggagca ggagggtgtg aagagcagcc ttcaggagca taggacagtg
     3001 gtaatgcgca gagcccctgt ggctgctcct gcgacgtgca gggtggaggc tgggctttct
     3061 gcccacgacc ttctagatcc cattcccggc ctctgctttc cctgtgagtt agaagataca
     3121 cagttctgtg ctggtggcac cttgtgcttg acatgggaaa cttagaagcc tgctcactga
     3181 caggcacctc ccgtgctctg accggaagtg gccgtcgctg agtaaccacc gccactcagt
     3241 gagagcagtg ctgtccagtc aggtgccacc tgactcctgg caggacactt caggcttccg
     3301 tcctgccact ccacgccacg ccacgccatg ccccgctgga tctcagacat tccacactca
     3361 cacctcattc cctggacact taggcaagca gggttcttcc acctcttgga tcagcccctc
     3421 cattccaagt tcatgctgtc ctggagcagg ccaggactgg aagcaaggca gcttgtgaga
     3481 agcaacctcc tgggaacagt atggatgaca gccttagagt cggcctgctg tcattgctgg
     3541 ccccagggcc ccttacccag aagtgtgcag ctctccggcc tgggagagac ggatgacggt
     3601 gctcatgact cttctgggag gggaagaacc gagccttcac attgggtggc tttttaaaat
     3661 aagcgaaggc agctggaact ccgctgcctc gtgccagcat ttcacatttt gccttttacc
     3721 cagagaagcc agcacagagc cactggggaa cagtgatagc cttgcctgca gagcctgagg
     3781 aggtggcaca gccagggtcc aggctgggag cagttagcag tgggctgtgt ctggagtagt
     3841 gtggtgtgta cagtagcctt agaggtggct ctcccggaga acaggcgctc tctgccctgt
     3901 cgcccctgtt ggaggtagca agctgctgta tgccttaagt caacatttac tcagcagggc
     3961 tctgtctctc tctctctttg tctttctctc tctctctctg tctctctctc tctctaaatg
     4021 gccatagaat aaaccatttt tacaaaaata aaaaccaaca aaaaactgtg ccctggaaga
     4081 gtacctttgc aggagtgtgg ggtgtctcag ggtcttctgt gacctcacag agctgtctga
     4141 ctgcaccatt tccaacttgc tgtctcacta atgggtctgc attagttgca acaataaatg
     4201 tttttaaaga aca
//
