LOCUS       NM_025576               1322 bp    mRNA    linear   ROD 31-DEC-2024
DEFINITION  Mus musculus protein tyrosine phosphatase, mitochondrial 1
            (Ptpmt1), mRNA.
ACCESSION   NM_025576
VERSION     NM_025576.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1322)
  AUTHORS   Chen,H.X., Ma,Y.Z., Xie,P.P., Huang,J.Y., Li,L.Q., Zhang,W.,
            Zhu,Y., Zhuang,S.M. and Lin,Y.F.
  TITLE     Micropeptide MPM regulates cardiomyocyte proliferation and heart
            growth via the AKT pathway
  JOURNAL   Biochim Biophys Acta Mol Cell Res 1871 (8), 119820 (2024)
   PUBMED   39163918
REFERENCE   2  (bases 1 to 1322)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 1322)
  AUTHORS   Chen,C., Zheng,H., Horwitz,E.M., Ando,S., Araki,K., Zhao,P., Li,Z.,
            Ford,M.L., Ahmed,R. and Qu,C.K.
  TITLE     Mitochondrial metabolic flexibility is critical for CD8+ T cell
            antitumor immunity
  JOURNAL   Sci Adv 9 (49), eadf9522 (2023)
   PUBMED   38055827
REFERENCE   4  (bases 1 to 1322)
  AUTHORS   Zheng,H., Li,Q., Li,S., Li,Z., Brotto,M., Weiss,D., Prosdocimo,D.,
            Xu,C., Reddy,A., Puchowicz,M., Zhao,X., Weitzmann,M.N., Jain,M.K.
            and Qu,C.K.
  TITLE     Loss of Ptpmt1 limits mitochondrial utilization of carbohydrates
            and leads to muscle atrophy and heart failure in tissue-specific
            knockout mice
  JOURNAL   Elife 12, 86944 (2023)
   PUBMED   37672386
  REMARK    GeneRIF: Loss of Ptpmt1 limits mitochondrial utilization of
            carbohydrates and leads to muscle atrophy and heart failure in
            tissue-specific knockout mice.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1322)
  AUTHORS   Huynh,H., Zhu,S., Lee,S., Bao,Y., Pang,J., Nguyen,A., Gu,Y.,
            Chen,C., Ouyang,K., Evans,S.M. and Fang,X.
  TITLE     DELE1 is protective for mitochondrial cardiomyopathy
  JOURNAL   J Mol Cell Cardiol 175, 44-48 (2023)
   PUBMED   36539111
REFERENCE   6  (bases 1 to 1322)
  AUTHORS   Zhang,J., Guan,Z., Murphy,A.N., Wiley,S.E., Perkins,G.A.,
            Worby,C.A., Engel,J.L., Heacock,P., Nguyen,O.K., Wang,J.H.,
            Raetz,C.R., Dowhan,W. and Dixon,J.E.
  TITLE     Mitochondrial phosphatase PTPMT1 is essential for cardiolipin
            biosynthesis
  JOURNAL   Cell Metab 13 (6), 690-700 (2011)
   PUBMED   21641550
  REMARK    GeneRIF: mitochondrial phosphatase PTPMT1 is essential for
            cardiolipin biosynthesis
REFERENCE   7  (bases 1 to 1322)
  AUTHORS   Rardin,M.J., Wiley,S.E., Murphy,A.N., Pagliarini,D.J. and
            Dixon,J.E.
  TITLE     Dual specificity phosphatases 18 and 21 target to opposing sides of
            the mitochondrial inner membrane
  JOURNAL   J Biol Chem 283 (22), 15440-15450 (2008)
   PUBMED   18385140
REFERENCE   8  (bases 1 to 1322)
  AUTHORS   Wiley,S.E., Murphy,A.N., Ross,S.A., van der Geer,P. and Dixon,J.E.
  TITLE     MitoNEET is an iron-containing outer mitochondrial membrane protein
            that regulates oxidative capacity
  JOURNAL   Proc Natl Acad Sci U S A 104 (13), 5318-5323 (2007)
   PUBMED   17376863
REFERENCE   9  (bases 1 to 1322)
  AUTHORS   Pagliarini,D.J., Wiley,S.E., Kimple,M.E., Dixon,J.R., Kelly,P.,
            Worby,C.A., Casey,P.J. and Dixon,J.E.
  TITLE     Involvement of a mitochondrial phosphatase in the regulation of ATP
            production and insulin secretion in pancreatic beta cells
  JOURNAL   Mol Cell 19 (2), 197-207 (2005)
   PUBMED   16039589
  REMARK    GeneRIF: PTPMT1 is targeted to the mitochondrion by an N-terminal
            signal sequence and is found anchored to the matrix face of the
            inner membrane. Knockdown of PTPMT1 in INS-1 832/13 cells enhances
            ATP production and insulin secretion.
REFERENCE   10 (bases 1 to 1322)
  AUTHORS   Pagliarini,D.J., Worby,C.A. and Dixon,J.E.
  TITLE     A PTEN-like phosphatase with a novel substrate specificity
  JOURNAL   J Biol Chem 279 (37), 38590-38596 (2004)
   PUBMED   15247229
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK151972.1, AK014691.1 and AL672241.6.
            
            On Jan 5, 2007 this sequence version replaced NM_025576.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK012674.1, BC026750.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849380, SAMN01164131
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: reported by MitoCarta
            RefSeq Select criteria             :: based on single
                                                  protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-206               AK151972.1         2-207
            207-1162            AK014691.1         201-1156
            1163-1322           AL672241.6         58766-58925         c
FEATURES             Location/Qualifiers
     source          1..1322
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 50.44 cM"
     gene            1..1322
                     /gene="Ptpmt1"
                     /gene_synonym="1110001D10Rik; 2810004N20Rik; PLIP"
                     /note="protein tyrosine phosphatase, mitochondrial 1"
                     /db_xref="GeneID:66461"
                     /db_xref="MGI:MGI:1913711"
     exon            1..442
                     /gene="Ptpmt1"
                     /gene_synonym="1110001D10Rik; 2810004N20Rik; PLIP"
                     /inference="alignment:Splign:2.1.0"
     CDS             65..850
                     /gene="Ptpmt1"
                     /gene_synonym="1110001D10Rik; 2810004N20Rik; PLIP"
                     /EC_number="3.1.3.16"
                     /EC_number="3.1.3.48"
                     /EC_number="3.1.3.27"
                     /note="PTEN-like phosphatase; phosphoinositide lipid
                     phosphatase"
                     /codon_start=1
                     /product="phosphatidylglycerophosphatase and
                     protein-tyrosine phosphatase 1"
                     /protein_id="NP_079852.1"
                     /db_xref="GeneID:66461"
                     /db_xref="MGI:MGI:1913711"
                     /translation="MAPVPGSLGQGRDSGDSASKSREASGGPQLSSSASFSRWLVASP
                     GAGGWPLRLAGWGASPLRLAGWGGMAASAWLEAGLARVLFYPTLLYTVFRGRVRGPAH
                     RDWYHRIDHTVLLGALPLKNMTRRLVLDENVRGVITMNEEYETRFLCNTSKEWKKAGV
                     EQLRLSTVDMTGVPTLANLHKGVQFALKYQALGQCVYVHCKAGRSRSATMVAAYLIQV
                     HNWSPEEAIEAIAKIRSHISIRPSQLEVLKEFHKEITARAAKN"
     exon            443..523
                     /gene="Ptpmt1"
                     /gene_synonym="1110001D10Rik; 2810004N20Rik; PLIP"
                     /inference="alignment:Splign:2.1.0"
     exon            524..715
                     /gene="Ptpmt1"
                     /gene_synonym="1110001D10Rik; 2810004N20Rik; PLIP"
                     /inference="alignment:Splign:2.1.0"
     exon            716..1322
                     /gene="Ptpmt1"
                     /gene_synonym="1110001D10Rik; 2810004N20Rik; PLIP"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      1045
                     /gene="Ptpmt1"
                     /gene_synonym="1110001D10Rik; 2810004N20Rik; PLIP"
                     /note="major polyA site"
     polyA_site      1110
                     /gene="Ptpmt1"
                     /gene_synonym="1110001D10Rik; 2810004N20Rik; PLIP"
     regulatory      1292..1297
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ptpmt1"
                     /gene_synonym="1110001D10Rik; 2810004N20Rik; PLIP"
                     /note="hexamer: AATAAA"
     polyA_site      1322
                     /gene="Ptpmt1"
                     /gene_synonym="1110001D10Rik; 2810004N20Rik; PLIP"
ORIGIN      
        1 cttgccattc cactccctcc acccgacccc tcgccgcgcc tcgcggcgcc tctcctttgg
       61 agccatggct cctgttccgg gatccctcgg gcagggccgg gactccgggg actcagcttc
      121 gaagagtcgg gaggcatcag gtggccctca gctctcgtcc tccgcgtcct tctcgcggtg
      181 gctggtcgcg agccccgggg ccggtggctg gccgctgcgc ctggcggggt ggggcgcctc
      241 gccactgcgc ctggcggggt ggggcgggat ggcggcctcc gcgtggctgg aggccggcct
      301 ggcccgggtg ctcttctacc cgacgctgct ctacacagtg ttccggggga gggtgcgcgg
      361 cccggcgcac cgcgactggt accaccgcat cgaccacacg gttctgctgg gcgcgctgcc
      421 gctgaagaac atgacgcgcc ggctggtact ggacgagaac gtgcgcgggg tgatcactat
      481 gaacgaggag tacgagaccc gattcctgtg caacacctcg aaggaatgga agaaagcagg
      541 agttgagcag ctacggctca gcacagtcga catgactggg gtcccaacct tggccaatct
      601 ccacaaagga gtccagtttg ctctcaagta ccaggcactg ggccagtgtg tctatgtgca
      661 ttgtaaggct ggtcgatcca gaagtgccac aatggtggca gcctatctga ttcaggtaca
      721 caactggagc ccagaggagg ctatagaagc gatcgccaaa atccggtcac acatctccat
      781 caggcccagc cagctggaag ttctcaaaga gttccacaag gagatcactg caagggcagc
      841 aaagaattaa ctactgatta tctctcatgc tgacttaaga gtctgaagac tgtggataac
      901 aaagaacttg gatctccctg agatatagta acaagtttac aggacaaagc agcttaaccc
      961 gaccacactg caaatgtgct gactggtaga taatgtgtct cctttgcctt ccttcctgaa
     1021 ataacacttg gatggctaca gagaacaaga ttgtctggct aaatcttatt ttctttgaca
     1081 gggataagga aatattaatt ttaacagaga tctgttgttt ctaatgtgtg taatggcact
     1141 gtaaatcaaa gacatttaat cctagagagg gaaagaagta tctagagctg ttcttattac
     1201 tgtcagaatc caaatcttaa ttgtatgact tggcaaagtg cttgcccagc atgtataata
     1261 aggccccaat ttggtcccta gcaggtccaa aaataaaaat aaaaatacag ttttcccctg
     1321 gc
//
