LOCUS       NM_207232               4429 bp    mRNA    linear   ROD 11-FEB-2025
DEFINITION  Mus musculus protein tyrosine phosphatase domain containing 1
            (Ptpdc1), transcript variant 2, mRNA.
ACCESSION   NM_207232 XM_147740
VERSION     NM_207232.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4429)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 4429)
  AUTHORS   Koerner,M.V., Chhatbar,K., Webb,S., Cholewa-Waclaw,J.,
            Selfridge,J., De Sousa,D., Skarnes,B., Rosen,B., Thomas,M.,
            Bottomley,J., Ramires-Solis,R., Lelliott,C., Adams,D.J. and Bird,A.
  TITLE     An Orphan CpG Island Drives Expression of a let-7 miRNA Precursor
            with an Important Role in Mouse Development
  JOURNAL   Epigenomes 3 (1), 7 (2019)
   PUBMED   31354981
REFERENCE   3  (bases 1 to 4429)
  AUTHORS   Dickinson,M.E., Flenniken,A.M., Ji,X., Teboul,L., Wong,M.D.,
            White,J.K., Meehan,T.F., Weninger,W.J., Westerberg,H., Adissu,H.,
            Baker,C.N., Bower,L., Brown,J.M., Caddle,L.B., Chiani,F., Clary,D.,
            Cleak,J., Daly,M.J., Denegre,J.M., Doe,B., Dolan,M.E., Edie,S.M.,
            Fuchs,H., Gailus-Durner,V., Galli,A., Gambadoro,A., Gallegos,J.,
            Guo,S., Horner,N.R., Hsu,C.W., Johnson,S.J., Kalaga,S., Keith,L.C.,
            Lanoue,L., Lawson,T.N., Lek,M., Mark,M., Marschall,S., Mason,J.,
            McElwee,M.L., Newbigging,S., Nutter,L.M., Peterson,K.A.,
            Ramirez-Solis,R., Rowland,D.J., Ryder,E., Samocha,K.E.,
            Seavitt,J.R., Selloum,M., Szoke-Kovacs,Z., Tamura,M., Trainor,A.G.,
            Tudose,I., Wakana,S., Warren,J., Wendling,O., West,D.B., Wong,L.,
            Yoshiki,A., MacArthur,D.G., Tocchini-Valentini,G.P., Gao,X.,
            Flicek,P., Bradley,A., Skarnes,W.C., Justice,M.J., Parkinson,H.E.,
            Moore,M., Wells,S., Braun,R.E., Svenson,K.L., de Angelis,M.H.,
            Herault,Y., Mohun,T., Mallon,A.M., Henkelman,R.M., Brown,S.D.,
            Adams,D.J., Lloyd,K.C., McKerlie,C., Beaudet,A.L., Bucan,M. and
            Murray,S.A.
  CONSRTM   International Mouse Phenotyping Consortium; Jackson Laboratory;
            Infrastructure Nationale PHENOMIN, Institut Clinique de la Souris
            (ICS); Charles River Laboratories; MRC Harwell; Toronto Centre for
            Phenogenomics; Wellcome Trust Sanger Institute; RIKEN BioResource
            Center
  TITLE     High-throughput discovery of novel developmental phenotypes
  JOURNAL   Nature 537 (7621), 508-514 (2016)
   PUBMED   27626380
  REMARK    Erratum:[Nature. 2017 Nov 16;551(7680):398. doi:
            10.1038/nature24643.. PMID: 29144450]
REFERENCE   4  (bases 1 to 4429)
  AUTHORS   Takasuga,A., Sato,K., Nakamura,R., Saito,Y., Sasaki,S., Tsuji,T.,
            Suzuki,A., Kobayashi,H., Matsuhashi,T., Setoguchi,K., Okabe,H.,
            Ootsubo,T., Tabuchi,I., Fujita,T., Watanabe,N., Hirano,T.,
            Nishimura,S., Watanabe,T., Hayakawa,M., Sugimoto,Y. and Kojima,T.
  TITLE     Non-synonymous FGD3 Variant as Positional Candidate for
            Disproportional Tall Stature Accounting for a Carcass Weight QTL
            (CW-3) and Skeletal Dysplasia in Japanese Black Cattle
  JOURNAL   PLoS Genet 11 (8), e1005433 (2015)
   PUBMED   26306008
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4429)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   6  (bases 1 to 4429)
  AUTHORS   Lai,C.K., Gupta,N., Wen,X., Rangell,L., Chih,B., Peterson,A.S.,
            Bazan,J.F., Li,L. and Scales,S.J.
  TITLE     Functional characterization of putative cilia genes by high-content
            analysis
  JOURNAL   Mol Biol Cell 22 (7), 1104-1119 (2011)
   PUBMED   21289087
REFERENCE   7  (bases 1 to 4429)
  AUTHORS   Zineldeen,D.H., Shimada,M., Niida,H., Katsuno,Y. and Nakanishi,M.
  TITLE     Ptpcd-1 is a novel cell cycle related phosphatase that regulates
            centriole duplication and cytokinesis
  JOURNAL   Biochem Biophys Res Commun 380 (3), 460-466 (2009)
   PUBMED   19284988
  REMARK    GeneRIF: These results suggested that Ptpcd1 is involved in
            centrosomal duplication and cytokinesis.
REFERENCE   8  (bases 1 to 4429)
  AUTHORS   McClintock,T.S., Glasser,C.E., Bose,S.C. and Bergman,D.A.
  TITLE     Tissue expression patterns identify mouse cilia genes
  JOURNAL   Physiol Genomics 32 (2), 198-206 (2008)
   PUBMED   17971504
  REMARK    GeneRIF: AW456874 is most abundantly expressed in tissues rich in
            highly ciliated cells, such as olfactory sensory neurons, and is
            predicted to be important to cilia.
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from CJ169499.1, AK030415.1 and
            AI843923.1.
            
            On Sep 13, 2014 this sequence version replaced NM_207232.1.
            
            Summary: The protein encoded by this gene is a centrosomal mitotic
            phosphatase. This protein has been implicated in centrosomal
            duplication and cytokinesis. In addition, knockdown of expression
            levels in non-cycling cells results in extra long cilia, suggesting
            that this protein may function in regulating cilia length
            independent of a function in cell cycle control. Alternative
            splicing results in multiple transcript variants encoding different
            isoforms. [provided by RefSeq, Sep 2014].
            
            Transcript Variant: This variant (2) lacks an alternate in-frame
            exon compared to variant 1. The encoded isoform (2) is shorter than
            isoform 1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC066081.1, AK030415.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-8                 CJ169499.1         2-9
            9-4412              AK030415.1         2-4405
            4413-4429           AI843923.1         1-17                c
FEATURES             Location/Qualifiers
     source          1..4429
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="13"
                     /map="13 24.86 cM"
     gene            1..4429
                     /gene="Ptpdc1"
                     /gene_synonym="Naa-1; Ptpcd1"
                     /note="protein tyrosine phosphatase domain containing 1"
                     /db_xref="GeneID:218232"
                     /db_xref="MGI:MGI:2145430"
     exon            1..296
                     /gene="Ptpdc1"
                     /gene_synonym="Naa-1; Ptpcd1"
                     /inference="alignment:Splign:2.1.0"
     exon            297..384
                     /gene="Ptpdc1"
                     /gene_synonym="Naa-1; Ptpcd1"
                     /inference="alignment:Splign:2.1.0"
     CDS             303..2546
                     /gene="Ptpdc1"
                     /gene_synonym="Naa-1; Ptpcd1"
                     /EC_number="3.1.3.48"
                     /note="isoform 2 is encoded by transcript variant 2;
                     protein tyrosine phosphatase domain-containing protein 1"
                     /codon_start=1
                     /product="protein tyrosine phosphatase domain-containing
                     protein 1 isoform 2"
                     /protein_id="NP_997115.1"
                     /db_xref="CCDS:CCDS26495.1"
                     /db_xref="GeneID:218232"
                     /db_xref="MGI:MGI:2145430"
                     /translation="MAAGVLPQNEDPYSTLVNSSGHAAHMDENSGRPAPKYTKVGERL
                     RHVIPGHMACSMACGGRACKYENPARWSEQEQAIKGVYSSWVTDNILAMARPSSELLE
                     KYRIIEQFLGQGIKTIINLQRPGEHASCGSALEQESGFTYLPEAFMEAGIYFYNFGWK
                     DYGVASLTAILDMVKVMTFALQEGKVAVHCHAGLGRTGVLIACYLVFATRMTADQAII
                     FVRAKRPNSIQTRGQLLCVREFTQFLAPLRNIFSCCDPKAHAVTLAQYLIRQRHLLHG
                     YEARLLKYVPKIIHLVCKLLLDLAENRPVVMKSMLEGPVLSAEIEKTVSEMVTLQLDQ
                     ELLRQNSDVPDPFNPTAEVAEFENQDVILSTEQEFDPLWKRRDIECLQPLTHLKRQLS
                     YSDSDLKRAKAILEQGETPWTVPAQELLDHSLQHQKPTSHCYMPPTPELGFNKEALVQ
                     NTFSFWTPSKCGGLEGLKDEGSLLLCRKDIPKEVQRSRTFSVGVSCSHNPGEPVPPNF
                     TSIHKDPEQVTHCRCEAPGGWVPGPVHEMVRSPCSPLNCGSSPKAQFPHGQETQDSTD
                     LSEAVPHAGLQPELSAEARRILAAKALANLNEFVEKEEVKRKVEMWQKELNSREEAWE
                     RICGERDPFILCSLMWSWVEQLKEPVITKEDVDMLVDRQADAAEALFLLEKGQYQTIL
                     CVLHCIVSLQTLPMEVEEACLLHAIKAFTKVNFDSENGPIVYDTLKKIFKHTLEEKRK
                     MAKDSLS"
     exon            385..556
                     /gene="Ptpdc1"
                     /gene_synonym="Naa-1; Ptpcd1"
                     /inference="alignment:Splign:2.1.0"
     exon            557..637
                     /gene="Ptpdc1"
                     /gene_synonym="Naa-1; Ptpcd1"
                     /inference="alignment:Splign:2.1.0"
     exon            638..756
                     /gene="Ptpdc1"
                     /gene_synonym="Naa-1; Ptpcd1"
                     /inference="alignment:Splign:2.1.0"
     exon            757..894
                     /gene="Ptpdc1"
                     /gene_synonym="Naa-1; Ptpcd1"
                     /inference="alignment:Splign:2.1.0"
     exon            895..2141
                     /gene="Ptpdc1"
                     /gene_synonym="Naa-1; Ptpcd1"
                     /inference="alignment:Splign:2.1.0"
     exon            2142..2327
                     /gene="Ptpdc1"
                     /gene_synonym="Naa-1; Ptpcd1"
                     /inference="alignment:Splign:2.1.0"
     exon            2328..2438
                     /gene="Ptpdc1"
                     /gene_synonym="Naa-1; Ptpcd1"
                     /inference="alignment:Splign:2.1.0"
     exon            2439..4413
                     /gene="Ptpdc1"
                     /gene_synonym="Naa-1; Ptpcd1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4387..4392
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ptpdc1"
                     /gene_synonym="Naa-1; Ptpcd1"
                     /note="hexamer: AATAAA"
     polyA_site      4413
                     /gene="Ptpdc1"
                     /gene_synonym="Naa-1; Ptpcd1"
                     /note="major polyA site"
ORIGIN      
        1 gttgggtcgg gcgcgcgcaa ggccgcggcg gcgacagggc gtcctcggcg gccgggctgt
       61 ggagtggccc gtgcgcgcgc ccgagggaga cgttgtgtag cgcgcctggc ggggagtctc
      121 cctgctcaga ggcgcggcgg gaggccgggc ctgcgggcag gccagcgccg cggaacccgc
      181 ccgagcagcg cccggggccg gccggtcctc tccgcccgcg cctcccggcc ctagacgtga
      241 gacaccgacc cgtcggctcc agggctccga agccggagag cgaagcgcgc caagagacga
      301 ggatggccgc aggagtcttg ccacagaatg aagatccata ttccacgttg gtgaatagca
      361 gtgggcatgc tgcacacatg gatgaaaatt caggacgccc agcaccaaaa tacacgaaag
      421 tgggagaacg tttgcggcat gtcatccctg ggcacatggc atgttccatg gcgtgtggtg
      481 ggagagcgtg taagtatgag aacccagccc gctggagtga gcaggagcaa gccattaagg
      541 gagtatactc atcctgggtc actgacaata tcctggccat ggctcgtccg tcctccgagc
      601 tgctggagaa gtatcgcatc atcgagcagt tcctcggtca aggcataaaa acaataatca
      661 acctgcagcg ccctggagag catgccagct gtgggagcgc tctggaacaa gaaagtggtt
      721 tcacctacct tcctgaggca ttcatggagg ctggcattta tttctacaac tttgggtgga
      781 aggattatgg cgtggcttcc ctcactgcca tcttggacat ggtaaaggtg atgacatttg
      841 ccttacagga agggaaagtg gctgtccact gccacgcggg gctcggccgc acaggtgtgc
      901 taatagcatg ttatttagtt tttgcaacaa gaatgactgc tgaccaagca attatatttg
      961 ttcgggcaaa acgccccaat tccatacaaa caagaggaca actgctctgt gtacgggaat
     1021 tcacgcagtt cctggctcca ctccgtaata ttttctcttg ctgtgacccc aaagcacatg
     1081 ctgttacctt agcccagtac ctgattcgcc agcgacatct gcttcatggc tacgaggcac
     1141 gacttctgaa gtacgtgccg aagatcatcc acctggtttg caaactgctg cttgacttgg
     1201 ctgagaaccg gccagtggtg atgaagagca tgctagaagg acctgtgctc tctgctgaaa
     1261 tcgaaaagac cgtgtctgag atggtcacgc tgcagctaga tcaagagtta ctcaggcaaa
     1321 acagtgatgt gcccgacccg tttaacccca ctgcagaggt ggccgagttc gagaatcagg
     1381 atgtgattct ctctactgag caggagtttg accccctctg gaagaggagg gatattgagt
     1441 gccttcagcc cctgacacat ctgaaaagac agctcagcta cagcgactca gacttaaaga
     1501 gggccaaagc catcctggaa caaggggaga caccttggac agtgcctgcc caggagttgc
     1561 tagaccacag tctccagcat cagaagccca cgagccattg ctacatgcca ccaactccag
     1621 agctgggttt taataaggag gcactggtcc aaaatacctt ttctttctgg actccgtcaa
     1681 agtgtggagg cttagaagga ctgaaggatg agggatcgct gcttttgtgc aggaaggaca
     1741 ttccaaagga agtacagcgg agcagaacct tctctgtggg tgtttcttgt tcacacaatc
     1801 ctggagagcc agtgccgccc aacttcacaa gtatccataa ggatccagag caggtcaccc
     1861 attgccggtg tgaggctcct ggtggctggg tcccgggccc tgttcacgag atggtcagga
     1921 gcccctgtag ccctctgaac tgtggctcca gtcctaaggc gcagttccca cacggacagg
     1981 aaacccaaga cagcacagac ctgtctgagg cagtgccgca tgctggtctg cagcctgaac
     2041 tgagtgctga agcaaggaga atactggcgg ccaaagccct ggcaaactta aatgagtttg
     2101 ttgaaaagga ggaagtgaaa aggaaagtgg agatgtggca gaaagaacta aattcccggg
     2161 aggaagcctg ggaacgaata tgcggcgaga gagacccttt catcttgtgc agtttgatgt
     2221 ggtcttgggt tgagcaactg aaagagcctg taatcaccaa agaggatgtg gacatgctgg
     2281 tcgacagaca agcagatgct gccgaagccc tgtttttact agagaagggg cagtaccaga
     2341 ccatcctctg tgtgctgcac tgcatagtga gcctgcagac gcttcccatg gaggtggagg
     2401 aagcttgcct tttacatgcc attaaagctt tcaccaaggt taattttgat tctgaaaacg
     2461 gaccaatagt ttacgacacc ttgaaaaaaa tatttaagca cacgttggaa gaaaagagga
     2521 aaatggcaaa agacagcctc tcctgaggct ttcttctctg gacaagcatc caacctgagc
     2581 atccacccct cctgagggtg gcgcttctgc tccccgcccc gaggaccagt gctggccgcg
     2641 cttcctgcct cagtccattg tcagtgccgc ctccctgggc tgaggatgac ggctcctctt
     2701 ttagttattt attttaaaaa tatctttgaa ctgtgtcttg aaaaatcgcc atgaagttgg
     2761 tgccacttta tttatttact cactgacttg atgttgttgt gttggcatat ttagtatgtt
     2821 gtatctgtgc ccttactctt gttgacattt gagaggaaaa aataaccctt tcaaaacagt
     2881 tatttttttg acaaaactct ttgtggagtt tttaccaaat agatcatttt agtagtaaaa
     2941 cttcactatg tatccttccc aagacatgtg tcccctccct cagaaatatg acctaagata
     3001 gtcaccaagt gtcttaaaca gttttatatt tgttactact aagaaggcta ttaatacatt
     3061 ttaaagtact ttaaaaaaaa aacttgaagc cttttgttct tcttttcttt ctttacagat
     3121 gtggtcaggt ctttgaagga atattatttt cagtgattcg gcagttcagc ttaccttagc
     3181 agactggctg gagtgggtcg gattctgtac ttatagaaag tagacttgct ctttgtcagg
     3241 cttccagaca acctctccct tggctgtcag gggagggagc agctctcaac ccagagacct
     3301 tatcctgctt cccccacctg ctgctgagcc aggtccctgc tgtacagaga aacggaccac
     3361 aagtggccag gatgggcagc tgctaaggag cagaagtgac ccttgtcctc cccggactgt
     3421 gcagaaaaga cagcagtacc agggcacagc tcctagccag ccctgctccc tgggggcagt
     3481 gtgaccatcc ttcacaggcg ctcagagcta gagtaagcca ggccagccac tttctgtcag
     3541 gagtgctggc attgctgccc ggcttgtgcc cagccccaaa gctgcccttt cataagccca
     3601 ttgcctcagc ctgccttggc ctgctctgtt gctagtggct gttttgctgt aaggattata
     3661 atttttaagt tgaatttgac cctaactggc ttcaaataag gacaggtggc tggtcaaact
     3721 tgttccttta gattaaacag gtaatcagca attgaggcct tatttaaatc gaattaatac
     3781 ataggagtag cagagcccat gccataatag ttttcttgac aaaggtggta actagaccaa
     3841 ttcaaactaa agaattaact ctttgattct cagaatttta ggaaacaagc aagactgaat
     3901 tagaacaaat gaaatttccc taactcatgc atttctgaat tacagtctag tgtatccaaa
     3961 actatttcca tcattagcct caccaactct gatgacaaaa gccaagtgca atttccttca
     4021 ccatgaatgt tcttcttggg aaaggaaata cggtgatggt taatgaaccg gcttacccag
     4081 tgctgaagta tccttttaag tgcctagcct aacaacagga aatccgtgca ctctgtctcc
     4141 tgtgtacatt ctaaaagctg atattcaaag agaatgcttg tcatcgcctt ttgtcagcct
     4201 tgaacgggca agtgacactg tggacctcgg tcacctccct ccctgaagcc agtgcgcctg
     4261 tgcatttgca acatttgttt taagttctgg caccgtcatg tgctgacacc actgcatgtc
     4321 agaaaatcca aatacagcag cctgaggaga cgctgtcagg ctctgtgtgg gcattgtgct
     4381 tatttgaata aaggtgaaaa ggaccaacca ctaaaaaaaa aaaaaaaaa
//
