LOCUS       NM_001166388            2430 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus protein tyrosine phosphatase 4a3 (Ptp4a3), transcript
            variant 1, mRNA.
ACCESSION   NM_001166388
VERSION     NM_001166388.2
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2430)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2430)
  AUTHORS   Hou,S., Li,Z., Dong,J., Gao,Y., Chang,Z., Ding,X., Li,S., Li,Y.,
            Zeng,Y., Xin,Q., Wang,B., Ni,Y., Ning,X., Hu,Y., Fan,X., Hou,Y.,
            Li,X., Wen,L., Zhou,B., Liu,B., Tang,F. and Lan,Y.
  TITLE     Heterogeneity in endothelial cells and widespread venous
            arterialization during early vascular development in mammals
  JOURNAL   Cell Res 32 (4), 333-348 (2022)
   PUBMED   35079138
REFERENCE   3  (bases 1 to 2430)
  AUTHORS   Rubio,T., Weyershaeuser,J., Montero,M.G., Hoffmann,A., Lujan,P.,
            Jechlinger,M., Sotillo,R. and Kohn,M.
  TITLE     The phosphatase PRL-3 affects intestinal homeostasis by altering
            the crypt cell composition
  JOURNAL   J Mol Med (Berl) 99 (10), 1413-1426 (2021)
   PUBMED   34129057
  REMARK    GeneRIF: The phosphatase PRL-3 affects intestinal homeostasis by
            altering the crypt cell composition.
REFERENCE   4  (bases 1 to 2430)
  AUTHORS   Funato,Y., Yoshida,A., Hirata,Y., Hashizume,O., Yamazaki,D. and
            Miki,H.
  TITLE     The Oncogenic PRL Protein Causes Acid Addiction of Cells by
            Stimulating Lysosomal Exocytosis
  JOURNAL   Dev Cell 55 (4), 387-397 (2020)
   PUBMED   32918875
  REMARK    GeneRIF: The Oncogenic PRL Protein Causes Acid Addiction of Cells
            by Stimulating Lysosomal Exocytosis.
REFERENCE   5  (bases 1 to 2430)
  AUTHORS   Kozlov,G., Funato,Y., Chen,Y.S., Zhang,Z., Illes,K., Miki,H. and
            Gehring,K.
  TITLE     PRL3 pseudophosphatase activity is necessary and sufficient to
            promote metastatic growth
  JOURNAL   J Biol Chem 295 (33), 11682-11692 (2020)
   PUBMED   32571875
  REMARK    GeneRIF: PRL3 pseudophosphatase activity is necessary and
            sufficient to promote metastatic growth.
REFERENCE   6  (bases 1 to 2430)
  AUTHORS   Blackshaw,S., Harpavat,S., Trimarchi,J., Cai,L., Huang,H.,
            Kuo,W.P., Weber,G., Lee,K., Fraioli,R.E., Cho,S.H., Yung,R.,
            Asch,E., Ohno-Machado,L., Wong,W.H. and Cepko,C.L.
  TITLE     Genomic analysis of mouse retinal development
  JOURNAL   PLoS Biol 2 (9), E247 (2004)
   PUBMED   15226823
REFERENCE   7  (bases 1 to 2430)
  AUTHORS   Wu,X., Zeng,H., Zhang,X., Zhao,Y., Sha,H., Ge,X., Zhang,M., Gao,X.
            and Xu,Q.
  TITLE     Phosphatase of regenerating liver-3 promotes motility and
            metastasis of mouse melanoma cells
  JOURNAL   Am J Pathol 164 (6), 2039-2054 (2004)
   PUBMED   15161639
  REMARK    GeneRIF: PRL-3 was highly expressed in metastatic melanoma B16-BL6
            cells but not in its lowly metastatic parental cell line, B16 cells
REFERENCE   8  (bases 1 to 2430)
  AUTHORS   Zeng,Q., Dong,J.M., Guo,K., Li,J., Tan,H.X., Koh,V., Pallen,C.J.,
            Manser,E. and Hong,W.
  TITLE     PRL-3 and PRL-1 promote cell migration, invasion, and metastasis
  JOURNAL   Cancer Res 63 (11), 2716-2722 (2003)
   PUBMED   12782572
REFERENCE   9  (bases 1 to 2430)
  AUTHORS   Zeng,Q., Si,X., Horstmann,H., Xu,Y., Hong,W. and Pallen,C.J.
  TITLE     Prenylation-dependent association of protein-tyrosine phosphatases
            PRL-1, -2, and -3 with the plasma membrane and the early endosome
  JOURNAL   J Biol Chem 275 (28), 21444-21452 (2000)
   PUBMED   10747914
REFERENCE   10 (bases 1 to 2430)
  AUTHORS   Zeng,Q., Hong,W. and Tan,Y.H.
  TITLE     Mouse PRL-2 and PRL-3, two potentially prenylated protein tyrosine
            phosphatases homologous to PRL-1
  JOURNAL   Biochem Biophys Res Commun 244 (2), 421-427 (1998)
   PUBMED   9514946
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC119884.13.
            
            On Aug 31, 2022 this sequence version replaced NM_001166388.1.
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC066043.1, SRR7345562.378618.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-802               AC119884.13        65189-65990
            803-1701            AC119884.13        91550-92448
            1702-1794           AC119884.13        94177-94269
            1795-1925           AC119884.13        95715-95845
            1926-2000           AC119884.13        96449-96523
            2001-2430           AC119884.13        97218-97647
FEATURES             Location/Qualifiers
     source          1..2430
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="15"
                     /map="15 34.05 cM"
     gene            1..2430
                     /gene="Ptp4a3"
                     /gene_synonym="pPtp4a3; Prl-3"
                     /note="protein tyrosine phosphatase 4a3"
                     /db_xref="GeneID:19245"
                     /db_xref="MGI:MGI:1277098"
     exon            1..802
                     /gene="Ptp4a3"
                     /gene_synonym="pPtp4a3; Prl-3"
                     /inference="alignment:Splign:2.1.0"
     exon            803..1701
                     /gene="Ptp4a3"
                     /gene_synonym="pPtp4a3; Prl-3"
                     /inference="alignment:Splign:2.1.0"
     CDS             1597..2118
                     /gene="Ptp4a3"
                     /gene_synonym="pPtp4a3; Prl-3"
                     /EC_number="3.1.3.48"
                     /note="isoform 1 is encoded by transcript variant 1;
                     protein tyrosine phosphatase type IVA 3; protein-tyrosine
                     phosphatase of regenerating liver 3"
                     /codon_start=1
                     /product="protein tyrosine phosphatase type IVA 3 isoform
                     1"
                     /protein_id="NP_001159860.1"
                     /db_xref="CCDS:CCDS27519.1"
                     /db_xref="GeneID:19245"
                     /db_xref="MGI:MGI:1277098"
                     /translation="MARMNRPAPVEVSYRHMRFLITHNPSNATLSTFIEDLKKYGATT
                     VVRVCEVTYDKTPLEKDGITVVDWPFDDGAPPPGKVVEDWLSLLKAKFYNDPGSCVAV
                     HCVAGLGRAPVLVALALIESGMKYEDAIQFIRQKRRGAINSKQLTYLEKYRPKQRLRF
                     KDPHTHKTRCCVM"
     exon            1702..1794
                     /gene="Ptp4a3"
                     /gene_synonym="pPtp4a3; Prl-3"
                     /inference="alignment:Splign:2.1.0"
     exon            1795..1925
                     /gene="Ptp4a3"
                     /gene_synonym="pPtp4a3; Prl-3"
                     /inference="alignment:Splign:2.1.0"
     exon            1926..2000
                     /gene="Ptp4a3"
                     /gene_synonym="pPtp4a3; Prl-3"
                     /inference="alignment:Splign:2.1.0"
     exon            2001..2430
                     /gene="Ptp4a3"
                     /gene_synonym="pPtp4a3; Prl-3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2413..2418
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ptp4a3"
                     /gene_synonym="pPtp4a3; Prl-3"
                     /note="hexamer: AATAAA"
     polyA_site      2430
                     /gene="Ptp4a3"
                     /gene_synonym="pPtp4a3; Prl-3"
                     /note="major polyA site"
ORIGIN      
        1 ctgacggcgc cgaggccgcg ccctgtgcgc gcgcgtgccg agccctccgc gtcgtgccgg
       61 cgccggcgcc cggaccgcca ggtcagtctc caccgcgccg ctcgggcggg ggcgcgcagg
      121 gggccgtcgg cgggggcgcc gcctcgggga cgcgcaggcg gggacgcgcg ccggtctgag
      181 tgtttgctcc cggcgggggc cgcgccccgc ggcagcccct gtgtgaaccc ggccggtggt
      241 tgccacgtgc agggccggag ccgcagggag gccaggagtg gggactcagc cagctgtttt
      301 ttcggtgtgg cgaccagacc tgatgggtga aaagggtgac tctgctccca tttctagggg
      361 tgcggaagat tccctcaaca tctgcccggt tttcatcttc cctaagagat ccctatctag
      421 gatttggttc gcctcaattt ccttctctgc atagcttggg ggcataggac cccatatcct
      481 ttcttgcctc ccgcatgaat gtcagtgggt cacctttgaa ggctgggcat taagtcttgg
      541 gtcccttaga gacccgagtc ctggcttagg cactctgggt caggccagat gggacagcac
      601 ctcactgtcc atggggtcct gccgtagcct gtccacatgc agccggctta agcaggcgac
      661 tcctggtagg gagctgcagg catggctgga ctggatgcca tgcttagccc ccaaggcagg
      721 cagagtgacc atccctctga ccctatcagt gaggggcaga gtggattcca ggccggttgt
      781 cacagtgtgc tgtgtccatt ggattgtgcc ttctgaagac cagggtggga ttgatggaga
      841 agccccagga gggcagctct gactactgcc gttcccaaca ccgtgggtgc tgccgctgag
      901 gagacctgta cacctctggc cctcaccatt gtccttgcct cccaatggcc tctgctgcca
      961 ggccggaggc cagcactgct gcctgagccc gctgcccctc ttcaggactt gccgttccct
     1021 gatggggtaa cgtgacagac cggatcagag gctgcctgcc caccacggcc cagggccgct
     1081 agagtttggt tgagttcaag ttcattttcc ctttggtcct gacttctggg gcccaactct
     1141 gaccaaaggg gacactcctc cgtccaccca tgcagagagg gtgtctccag cgacggcccc
     1201 atagaggaca ctgctctgcg gccggagtca ccaacccgaa gttctctctg ctcagttttt
     1261 tttggttgtt gttattttta ttttgactcc ttgtaacttc tccactctga gggacaggac
     1321 tttggcgctg cccgtcttgc tgcggggtgg ggggagaagt gtgcttgttt cttttctttt
     1381 ttagaattgg tttttttgga attatccgcc acgaggcagc ttcctctccc tctcccaggt
     1441 atttgcacaa tatttgtgcg gggcgtaggg gcgaggtttt aagaagtctt ttctttgtgg
     1501 acaagcacgg ggatctcact ggacttggtg tggggggctg ggggaccccc cgtgcagccc
     1561 ttgctggcta gtcccctctg ggtccccgga ggaggcatgg cccgcatgaa ccggcctgcg
     1621 cctgtggagg tgagctaccg gcacatgcgc ttcctcatca cccacaaccc cagcaatgcc
     1681 accctcagca cgttcatcga ggacctgaag aagtacgggg ctaccactgt ggtgcgcgtg
     1741 tgtgaagtga cctatgacaa gacccccctg gagaaggacg gcatcactgt tgtggactgg
     1801 ccctttgatg atggagcgcc ccctcctggc aaagtggtag aggactggct gagcctgctg
     1861 aaggccaagt tctacaatga cccgggaagc tgcgtagctg tgcactgtgt ggcgggcctg
     1921 ggaagggccc cagtgctcgt ggctctcgcc ctcatcgaga gcgggatgaa gtacgaggac
     1981 gccatccagt tcatccgaca gaagcgccgt ggggccatca acagcaagca gctcacctac
     2041 ctggagaagt accggcctaa gcagagactg aggttcaaag acccacacac gcacaagacc
     2101 agatgctgcg tcatgtagct caggccctgg ccctgtacct cattacatct gtgtctaagg
     2161 agtccaacgg ctatgtgcgt ccctgctctg tccccatctg tacccacggc tgtctttctg
     2221 aagctgtccc tggaccctct gccagtcctg tccaacccct gtccctcacc ccccactgcc
     2281 caggccttcc ccctggcctg tgtattgcag gtgggagttt ttaaaccact gggcccaatg
     2341 cctcagcggc gtggccctca ccctaacctt tttccagcac ctttgttacc aggtgctctg
     2401 gactctcaag gcaataaatc aggagctgtg
//
