LOCUS       NM_008974               3413 bp    mRNA    linear   ROD 04-AUG-2023
DEFINITION  Mus musculus protein tyrosine phosphatase 4a2 (Ptp4a2), transcript
            variant 1, mRNA.
ACCESSION   NM_008974
VERSION     NM_008974.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3413)
  AUTHORS   Bai Y, Yu G, Zhou HM, Amarasinghe O, Zhou Y, Zhu P, Li Q, Zhang L,
            Nguele Meke F, Miao Y, Chapman E, Tao WA and Zhang ZY.
  TITLE     PTP4A2 promotes lysophagy by dephosphorylation of VCP/p97 at Tyr805
  JOURNAL   Autophagy 19 (5), 1562-1581 (2023)
   PUBMED   36300783
  REMARK    GeneRIF: PTP4A2 promotes lysophagy by dephosphorylation of VCP/p97
            at Tyr805.
REFERENCE   2  (bases 1 to 3413)
  AUTHORS   Chen H, Bai Y, Kobayashi M, Xiao S, Cai W, Barajas S, Chen S, Miao
            J, Meke FN, Vemula S, Ropa JP, Croop JM, Boswell HS, Wan J, Jia Y,
            Liu H, Li LS, Altman JK, Eklund EA, Ji P, Tong W, Band H, Huang DT,
            Platanias LC, Zhang ZY and Liu Y.
  TITLE     PRL2 phosphatase enhances oncogenic FLT3 signaling via
            dephosphorylation of the E3 ubiquitin ligase CBL at tyrosine 371
  JOURNAL   Blood 141 (3), 244-259 (2023)
   PUBMED   36206490
REFERENCE   3  (bases 1 to 3413)
  AUTHORS   Poulet M, Sirois J, Boye K, Uetani N, Hardy S, Daubon T, Dubrac A,
            Tremblay ML and Bikfalvi A.
  TITLE     PRL-2 phosphatase is required for vascular morphogenesis and
            angiogenic signaling
  JOURNAL   Commun Biol 3 (1), 603 (2020)
   PUBMED   33097786
  REMARK    GeneRIF: PRL-2 phosphatase is required for vascular morphogenesis
            and angiogenic signaling.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3413)
  AUTHORS   Li Q, Bai Y, Lyle LT, Yu G, Amarasinghe O, Nguele Meke F, Carlock C
            and Zhang ZY.
  TITLE     Mechanism of PRL2 phosphatase-mediated PTEN degradation and
            tumorigenesis
  JOURNAL   Proc Natl Acad Sci U S A 117 (34), 20538-20548 (2020)
   PUBMED   32788364
  REMARK    GeneRIF: Mechanism of PRL2 phosphatase-mediated PTEN degradation
            and tumorigenesis.
REFERENCE   5  (bases 1 to 3413)
  AUTHORS   Yin C, Wu C, Du X, Fang Y, Pu J, Wu J, Tang L, Zhao W, Weng Y, Guo
            X, Chen G and Wang Z.
  TITLE     PRL2 Controls Phagocyte Bactericidal Activity by Sensing and
            Regulating ROS
  JOURNAL   Front Immunol 9, 2609 (2018)
   PUBMED   30483267
  REMARK    GeneRIF: PRL2 binds to GTPase Rac.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3413)
  AUTHORS   Zimmerman MW, Homanics GE and Lazo JS.
  TITLE     Targeted deletion of the metastasis-associated phosphatase Ptp4a3
            (PRL-3) suppresses murine colon cancer
  JOURNAL   PLoS One 8 (3), e58300 (2013)
   PUBMED   23555575
REFERENCE   7  (bases 1 to 3413)
  AUTHORS   Dong Y, Zhang L, Zhang S, Bai Y, Chen H, Sun X, Yong W, Li W,
            Colvin SC, Rhodes SJ, Shou W and Zhang ZY.
  TITLE     Phosphatase of regenerating liver 2 (PRL2) is essential for
            placental development by down-regulating PTEN (Phosphatase and
            Tensin Homologue Deleted on Chromosome 10) and activating Akt
            protein
  JOURNAL   J Biol Chem 287 (38), 32172-32179 (2012)
   PUBMED   22791713
  REMARK    GeneRIF: Phosphatase of regenerating liver 2 (PRL2) is essential
            for placental development by down-regulating PTEN (Phosphatase and
            Tensin Homologue Deleted on Chromosome 10) and activating Akt
            protein
REFERENCE   8  (bases 1 to 3413)
  AUTHORS   Carninci P, Waki K, Shiraki T, Konno H, Shibata K, Itoh M, Aizawa
            K, Arakawa T, Ishii Y, Sasaki D, Bono H, Kondo S, Sugahara Y, Saito
            R, Osato N, Fukuda S, Sato K, Watahiki A, Hirozane-Kishikawa T,
            Nakamura M, Shibata Y, Yasunishi A, Kikuchi N, Yoshiki A, Kusakabe
            M, Gustincich S, Beisel K, Pavan W, Aidinis V, Nakagawara A, Held
            WA, Iwata H, Kono T, Nakauchi H, Lyons P, Wells C, Hume DA,
            Fagiolini M, Hensch TK, Brinkmeier M, Camper S, Hirota J, Mombaerts
            P, Muramatsu M, Okazaki Y, Kawai J and Hayashizaki Y.
  TITLE     Targeting a complex transcriptome: the construction of the mouse
            full-length cDNA encyclopedia
  JOURNAL   Genome Res 13 (6B), 1273-1289 (2003)
   PUBMED   12819125
REFERENCE   9  (bases 1 to 3413)
  AUTHORS   Zeng Q, Si X, Horstmann H, Xu Y, Hong W and Pallen CJ.
  TITLE     Prenylation-dependent association of protein-tyrosine phosphatases
            PRL-1, -2, and -3 with the plasma membrane and the early endosome
  JOURNAL   J Biol Chem 275 (28), 21444-21452 (2000)
   PUBMED   10747914
REFERENCE   10 (bases 1 to 3413)
  AUTHORS   Zeng Q, Hong W and Tan YH.
  TITLE     Mouse PRL-2 and PRL-3, two potentially prenylated protein tyrosine
            phosphatases homologous to PRL-1
  JOURNAL   Biochem Biophys Res Commun 244 (2), 421-427 (1998)
   PUBMED   9514946
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY110331.1, BC087551.1, BC086794.1 and BB675559.1.
            
            [WARNING] On Oct 12, 2023 this sequence was replaced by
            NM_008974.5.
            
            On Sep 17, 2009 this sequence version replaced NM_008974.3.
            
            Transcript Variant: This variant (1) represents the longer
            transcript. Variants 1 and 2 encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR7974084.30815.1,
                                           SRR7652917.237341.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-309               BY110331.1         1-309
            310-1797            BC087551.1         338-1825
            1798-3385           BC086794.1         1179-2766
            3386-3413           BB675559.1         394-421
FEATURES             Location/Qualifiers
     source          1..3413
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 63.38 cM"
     gene            1..3413
                     /gene="Ptp4a2"
                     /gene_synonym="Prl-2"
                     /note="protein tyrosine phosphatase 4a2"
                     /db_xref="GeneID:19244"
                     /db_xref="MGI:MGI:1277117"
     exon            1..123
                     /gene="Ptp4a2"
                     /gene_synonym="Prl-2"
                     /inference="alignment:Splign:2.1.0"
     exon            124..824
                     /gene="Ptp4a2"
                     /gene_synonym="Prl-2"
                     /inference="alignment:Splign:2.1.0"
     CDS             729..1232
                     /gene="Ptp4a2"
                     /gene_synonym="Prl-2"
                     /EC_number="3.1.3.48"
                     /note="protein-tyrosine phosphatase of regenerating liver
                     2"
                     /codon_start=1
                     /product="protein tyrosine phosphatase type IVA 2"
                     /protein_id="NP_033000.1"
                     /db_xref="CCDS:CCDS18704.1"
                     /db_xref="GeneID:19244"
                     /db_xref="MGI:MGI:1277117"
                     /translation="MNRPAPVEISYENMRFLITHNPTNATLNKFTEELKKYGVTTLVR
                     VCDATYDKAPVEKEGIHVLDWPFDDGAPPPNQIVDDWLNLLKTKFREEPGCCVAVHCV
                     AGLGRAPVLVALALIECGMKYEDAVQFIRQKRRGAFNSKQLLYLEKYRPKMRLRFRDT
                     NGHCCVQ"
     exon            825..917
                     /gene="Ptp4a2"
                     /gene_synonym="Prl-2"
                     /inference="alignment:Splign:2.1.0"
     exon            918..1048
                     /gene="Ptp4a2"
                     /gene_synonym="Prl-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1049..1123
                     /gene="Ptp4a2"
                     /gene_synonym="Prl-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1124..3413
                     /gene="Ptp4a2"
                     /gene_synonym="Prl-2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gagtcgtcgc cgccgccgcc gccgctcccg ccgccgccgc cgccgccgag gtgactgagg
       61 agagaggcgc ctcctcgctc ccgcctccgc cggccttcaa tgcccagtcc ccagcttgcc
      121 agcgtttttc gttggaatat acgttgcaca tttatggcga ttctgagcgt gagggcagac
      181 ttctgccagg ctcagcacag cctttccgct gacaagtgag cttggggtta tacgtgccat
      241 aattaacatt gccttgacga ctctggacac cgagactggc ctcagaagta gtaggctttt
      301 ttttttttta aattgcaagc gtattctttt aatgactcca gtaaaattaa gcatcaagta
      361 aacaaaagtg gagaagaacc tacactttta acttgtctca ctagtgccta aatgtagtaa
      421 aaaggctgct taaattttgt atgtagttgg atttattttg gaagctgaag gtatccatct
      481 gcagacattg aggctcaagt tgaatttgga ttcaagtgga ttcttaatac ttctgcctgt
      541 gctgaagaga gaagcttcct aaggaacaag caagttgaat agagaaaata gtgatcaata
      601 ataggcattt tagtggtctt tttaatgttt tctgctgcgg aacatttcaa gatttattga
      661 tttcctcctc cccccatttt tttcccacca cactcacaca cgcacgctca cactttttat
      721 ttgccataat gaaccgtcca gcccctgtgg agatctctta tgagaacatg cgttttctga
      781 taactcacaa ccccaccaat gcgactctca acaagttcac agaggaactt aagaagtacg
      841 gagtgacaac tttggttcga gtttgtgatg ctacatatga taaagctcca gttgaaaaag
      901 aaggaatcca cgttctagat tggccgtttg atgatggagc tccaccccct aatcagatag
      961 tagatgattg gctaaacctg ttaaaaacca aatttcgtga agagccaggc tgttgtgttg
     1021 cagtgcattg tgttgcagga ttgggaaggg ctcctgtgct agttgcgctt gcattgattg
     1081 aatgcggaat gaagtatgaa gatgctgttc aatttataag acaaaaaaga agaggagcat
     1141 tcaattccaa acagctgctt tacttggaga agtaccgacc taagatgcgg ttacgcttca
     1201 gagataccaa tgggcactgc tgtgttcagt agaagtagaa gcaggctggc tggatcgtgg
     1261 cattagaggg aactcttggt acctggaaat gtgaatctgg attcttacct gtgtcatcag
     1321 agtagtaatg gattcagtac tcctcaactc ctaatgattg agaagaaggc aaacgataaa
     1381 gaaatccctc tattacacga ataaaatgtt taagaaaaga aaaaagaaag gaaaggggat
     1441 taatttagtg aaagatgatt ttgctcctag ttttgatttc tgccaggatt gaattatttc
     1501 aaaatctcct gtgtttttta agctttttca aaatagatgt ctgaggaaaa ccagcagaat
     1561 attaaccagt gtggagccag ttgttgggag cacacacttc cattatgctt ggcacatagg
     1621 tctccttgtg gtgggtggga tctgggggag gtagattttc ctcatctctc ttcctgcctc
     1681 cctcccatct cctgatccac atagatggaa tagaaagcag cctttgttgc tgtagatgtg
     1741 cgtgtgtctg gcagccttaa gcccacctgg gcacttttag ggaaaaaaaa aaaaaaacaa
     1801 aaaaaaccaa caaaaaaata aataaaaata aaagcaaaga aaaggcagtg gcgcatatat
     1861 tctgtggtcc aggctgtttc tagtctattg atgatggatg cttatattag tttttttttt
     1921 taaccccctt gtgcccctga tctaccatta gggtgtgaga ggtagccagg aacctttggt
     1981 tttataaatg gtgacgaaat gacatcctaa acagagtctt tctcctgtaa tttagctgag
     2041 agaattcttt ttcccaacag tgaaacaagt gggcctccta gaaactttat tgcagagatg
     2101 actggaggcc attggtgttt ccaggagagc tagcatgttt ctacaagtgt aggactggat
     2161 tgtggatctg ctatctaaca atgtcatgga aaagtggtat cttaaaattt taggaccgat
     2221 ttcagaaata gtcaaaggag caacagaaca ttcattgtat tttggtcttg agaaatgcct
     2281 atagttttcc aaattattct tgtacagttt tatttgtaca gttcagtgta accacctatc
     2341 atcttgttaa cactagattc ttctgagatt caaaaagaaa aatcactgtc agagctagcc
     2401 ttgcctagtg agtctgtgtc cacaggctgt aacagggtgg aagagcaaca gtaggcagcc
     2461 cagggagcag catgtgctca cggcatcatg tggcagtggt gtggggtctc tgctcagtgt
     2521 gttgatacag aaaagctgtt tttccttgtt tgcagaagtt gaccagacaa agcaaatgga
     2581 ggggcacctc tgtgtaccct cttcacctaa gtgtttataa ccagcagtac cctgctacaa
     2641 gccttgggtg cagccatcac tggattttga tcgtcaggcc agcaggatgg atgacatctc
     2701 attgatagta cccagatgtt ggtggctttc tgagttgcct gtttactgtt gatgcaattg
     2761 ttttgatttt taactaaatg caaatacctt cctgcctcat cccagaaaat gaaaaataat
     2821 gcttttgaca ctgtttctag aattttaaag ttgaaaaatg atgatataat ccagaaattg
     2881 ttacttcgga gcatgacaat agatttcttt aacaaagact caagatcaaa tttcttacct
     2941 aaaagtttag gttaactgtt gactcctcaa gggttttgat caatatcacc caaacctttt
     3001 ccacttgaca tgctagaatt ttggtgtgtg tgtgtgtgtg tgtgtatttg ttcacgagca
     3061 caatagctcc catgggggtc tgcacatgca ggtgtccacc agcatagcct gcctgagata
     3121 gtgtcattcc tggttctggg gagaagggtg tgtgaaggag aataaagcag ccctttgtct
     3181 taaagaagac taatgttaat tgttctcaga actggacgtt ttttttcccc ccatcaaaat
     3241 taaaactctt tcttttggat ttaatgaagt attgctaact gaagccagtt tgacttgtga
     3301 gagaggttag actgacagaa ggtgtgcagc ctgatttaca accaaaccct gaaccctttt
     3361 gaagaacaat aaaacatatt ttacatgctt tttgtgaatt tcttccccac tcc
//
