LOCUS       NM_011200               4153 bp    mRNA    linear   ROD 19-DEC-2022
DEFINITION  Mus musculus protein tyrosine phosphatase 4a1 (Ptp4a1), mRNA.
ACCESSION   NM_011200
VERSION     NM_011200.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4153)
  AUTHORS   Miyamoto Y, Torii T, Homma K, Oizumi H, Ohbuchi K, Mizoguchi K,
            Takashima S and Yamauchi J.
  TITLE     The adaptor SH2B1 and the phosphatase PTP4A1 regulate the
            phosphorylation of cytohesin-2 in myelinating Schwann cells in mice
  JOURNAL   Sci Signal 15 (718), eabi5276 (2022)
   PUBMED   35077201
  REMARK    GeneRIF: The adaptor SH2B1 and the phosphatase PTP4A1 regulate the
            phosphorylation of cytohesin-2 in myelinating Schwann cells in
            mice.
REFERENCE   2  (bases 1 to 4153)
  AUTHORS   Sacchetti C, Bai Y, Stanford SM, Di Benedetto P, Cipriani P,
            Santelli E, Piera-Velazquez S, Chernitskiy V, Kiosses WB, Ceponis
            A, Kaestner KH, Boin F, Jimenez SA, Giacomelli R, Zhang ZY and
            Bottini N.
  TITLE     PTP4A1 promotes TGFbeta signaling and fibrosis in systemic
            sclerosis
  JOURNAL   Nat Commun 8 (1), 1060 (2017)
   PUBMED   29057934
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4153)
  AUTHORS   Gimenez-Mascarell P, Oyenarte I, Hardy S, Breiderhoff T, Stuiver M,
            Kostantin E, Diercks T, Pey AL, Ereno-Orbea J, Martinez-Chantar ML,
            Khalaf-Nazzal R, Claverie-Martin F, Muller D, Tremblay ML and
            Martinez-Cruz LA.
  TITLE     Structural Basis of the Oncogenic Interaction of Phosphatase PRL-1
            with the Magnesium Transporter CNNM2
  JOURNAL   J Biol Chem 292 (3), 786-801 (2017)
   PUBMED   27899452
  REMARK    GeneRIF: data shed new light on the structural basis underlying the
            interaction between PRL phosphatases and CNNM transporters and
            provides a hypothesis about the molecular mechanism by which PRL-1,
            upon binding to CNNM2, might increase the intracellular
            concentration of Mg(2+) thereby contributing to tumor progression
            and metastasis.
REFERENCE   4  (bases 1 to 4153)
  AUTHORS   Bai Y, Zhou HM, Zhang L, Dong Y, Zeng Q, Shou W and Zhang ZY.
  TITLE     Role of phosphatase of regenerating liver 1 (PRL1) in
            spermatogenesis
  JOURNAL   Sci Rep 6, 34211 (2016)
   PUBMED   27666520
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4153)
  AUTHORS   Jiao Y, Ye DZ, Li Z, Teta-Bissett M, Peng Y, Taub R, Greenbaum LE
            and Kaestner KH.
  TITLE     Protein tyrosine phosphatase of liver regeneration-1 is required
            for normal timing of cell cycle progression during liver
            regeneration
  JOURNAL   Am J Physiol Gastrointest Liver Physiol 308 (2), G85-G91 (2015)
   PUBMED   25377314
  REMARK    GeneRIF: Prl-1 is required for proper timing of liver regeneration
            after partial hepatectomy
REFERENCE   6  (bases 1 to 4153)
  AUTHORS   Oh B, Hwang S, McLaughlin J, Solter D and Knowles BB.
  TITLE     Timely translation during the mouse oocyte-to-embryo transition
  JOURNAL   Development 127 (17), 3795-3803 (2000)
   PUBMED   10934024
REFERENCE   7  (bases 1 to 4153)
  AUTHORS   Zeng Q, Si X, Horstmann H, Xu Y, Hong W and Pallen CJ.
  TITLE     Prenylation-dependent association of protein-tyrosine phosphatases
            PRL-1, -2, and -3 with the plasma membrane and the early endosome
  JOURNAL   J Biol Chem 275 (28), 21444-21452 (2000)
   PUBMED   10747914
REFERENCE   8  (bases 1 to 4153)
  AUTHORS   Rundle CH and Kappen C.
  TITLE     Developmental expression of the murine Prl-1 protein tyrosine
            phosphatase gene
  JOURNAL   J Exp Zool 283 (6), 612-617 (1999)
   PUBMED   10194868
REFERENCE   9  (bases 1 to 4153)
  AUTHORS   Zeng Q, Hong W and Tan YH.
  TITLE     Mouse PRL-2 and PRL-3, two potentially prenylated protein tyrosine
            phosphatases homologous to PRL-1
  JOURNAL   Biochem Biophys Res Commun 244 (2), 421-427 (1998)
   PUBMED   9514946
REFERENCE   10 (bases 1 to 4153)
  AUTHORS   Diamond RH, Cressman DE, Laz TM, Abrams CS and Taub R.
  TITLE     PRL-1, a unique nuclear protein tyrosine phosphatase, affects cell
            growth
  JOURNAL   Mol Cell Biol 14 (6), 3752-3762 (1994)
   PUBMED   8196618
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK148288.1, CA315780.1, AK151533.1, AK078120.1 and AI451864.1.
            
            [WARNING] On May 6, 2023 this sequence was replaced by NM_011200.3.
            
            On Nov 8, 2006 this sequence version replaced NM_011200.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC031734.1, SRR7652917.874003.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-616               AK148288.1         2-617
            617-621             CA315780.1         607-611
            622-1633            AK148288.1         618-1629
            1634-1720           AK151533.1         1264-1350
            1721-2791           AK148288.1         1717-2787
            2792-3965           AK078120.1         1099-2272
            3966-4153           AI451864.1         190-377
FEATURES             Location/Qualifiers
     source          1..4153
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1"
     gene            1..4153
                     /gene="Ptp4a1"
                     /gene_synonym="C130021B01; Prl-1"
                     /note="protein tyrosine phosphatase 4a1"
                     /db_xref="GeneID:19243"
                     /db_xref="MGI:MGI:1277096"
     exon            1..207
                     /gene="Ptp4a1"
                     /gene_synonym="C130021B01; Prl-1"
                     /inference="alignment:Splign:2.1.0"
     exon            208..809
                     /gene="Ptp4a1"
                     /gene_synonym="C130021B01; Prl-1"
                     /inference="alignment:Splign:2.1.0"
     CDS             705..1226
                     /gene="Ptp4a1"
                     /gene_synonym="C130021B01; Prl-1"
                     /EC_number="3.1.3.48"
                     /note="protein-tyrosine phosphatase of regenerating liver
                     1"
                     /codon_start=1
                     /product="protein tyrosine phosphatase type IVA 1"
                     /protein_id="NP_035330.1"
                     /db_xref="CCDS:CCDS14858.1"
                     /db_xref="GeneID:19243"
                     /db_xref="MGI:MGI:1277096"
                     /translation="MARMNRPAPVEVTYKNMRFLITHNPTNATLNKFIEELKKYGVTT
                     IVRVCEATYDTTLVEKEGIHVLDWPFDDGAPPSNQIVDDWLSLVKIKFREEPGCCIAV
                     HCVAGLGRAPVLVALALIEGGMKYEDAVQFIRQKRRGAFNSKQLLYLEKYRPKMRLRF
                     KDSNGHRNNCCIQ"
     exon            810..902
                     /gene="Ptp4a1"
                     /gene_synonym="C130021B01; Prl-1"
                     /inference="alignment:Splign:2.1.0"
     exon            903..1033
                     /gene="Ptp4a1"
                     /gene_synonym="C130021B01; Prl-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1034..1108
                     /gene="Ptp4a1"
                     /gene_synonym="C130021B01; Prl-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1109..4129
                     /gene="Ptp4a1"
                     /gene_synonym="C130021B01; Prl-1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctgggcgcgc gcattggctc tgggctgcgg ccggctcggc gacgctcctc gggcagctca
       61 ctgcatggtc gtctggtgcc cccgccgcct gcatccccgc cgccgccccg cgacgcccac
      121 cgccgcctgc cctgccgccg ccgcctgcgc cgcctcggga ccggctgtat gattaggcca
      181 caatcttcaa tgagtagaca tattcctcag ttctgtggtg ttctcggtca cacatttatg
      241 gagtttctga agggcagtgg agattactgc caggcacagc acgacctcta tgcagacaag
      301 tgaactgtag aaattcatta ctactccacc aagaaacccc cataagagtg gataacctgg
      361 acacaggcgt gttgaattga aatctgcaga gcatttgaca agagctcaga cctggatggg
      421 gtaaacctca gtgcacttcc tttgtattgc ctcagtatta ctggattgaa gactcactgc
      481 ttcttgttag gaggttcatt tcattgcccg tttctcccaa ttcatactca agcactgaga
      541 atttcaagtg gagtatattg aatattgaag tagacttcag gttgtttttt ggttttgttt
      601 tggttttttt tttttttttt tctgttttgg ttttaaatca tttctgtatt caatttttta
      661 attctttcat aaccctattg ggtgtttttt taaactaaat taacatggct cgaatgaacc
      721 gccctgctcc tgtggaagtc acatacaaga acatgcgatt tcttattaca cacaatccaa
      781 ccaatgcgac cttaaacaaa tttatagagg aacttaagaa gtatggagtt accacaatag
      841 taagagtatg tgaagcaact tacgacacta ctcttgtgga gaaagaaggc attcatgttc
      901 ttgactggcc ttttgatgat ggtgcaccac catccaacca gattgtcgat gactggctaa
      961 gtcttgtgaa gattaagttt cgtgaagaac ctggttgctg tattgctgtc cattgtgtcg
     1021 caggccttgg cagagctccg gtgcttgttg ccctagcatt aattgaaggt ggaatgaaat
     1081 atgaagatgc agtacaattc ataagacaaa agcggcgtgg agcttttaac agcaagcaac
     1141 ttttgtatct ggagaagtac cgtccgaaaa tgcggctccg cttcaaggat tccaatggtc
     1201 atagaaacaa ctgttgtatt caataaaact ggggtgcctg atgccattgc cttggaagtg
     1261 gaacttcaga tgggacctga tttgtcatgc atattaccca atgtgtcggc ttactgaata
     1321 agtctactgc agctccacag gaatactgaa aaaccagtct taccaggcca caagtttgac
     1381 agaattgcaa cctctatatt tgggctatga tcaacatgtt tggacactta gcaaaagatt
     1441 tttgctggtc agcatttaaa atgtgcttat tatttgtacc aattgacctt tcctaaaata
     1501 aggtattgag ttatgtcatt aaatgtactc ctgtgccaga atattattag tctataagga
     1561 atttagaagg attaggtgcc aaaataccca gcacaatact tgtatatttt tagcatcata
     1621 cagaaccaaa attgcaggaa ctgagaactc tagaccatcc atggtgtatt ccttcagtca
     1681 tttcaaacac tgcagggctt ctctcgttat ctgcctgctc actctgttta catctcccac
     1741 acttatgcca gaatacgtca ggtttgctta gccatccttt atttttttta tttttttttt
     1801 taactaagtc ttgcgctgat tatttaatat gtctgtctca ttttgttttg ttttgggaaa
     1861 cctctgtttg aaaatcaact ttgttacaga agcacatatc ttcaacaatg tctccagaca
     1921 aaaagcctta tagttaattt aatgtttgca ctcagaagtg caacctaaca gggagggcct
     1981 gaaaaagaaa cgagaggagg ctattaaata tttttagtaa tatgttgcct ttgtcatgtg
     2041 cagaacatgt agagtatgct ctttaattta gtaaatattt ttaagacata gagatacatt
     2101 gttgtagcta accaattctt aatcaaaatt tctgaaattt ttgtgttttc catacctatc
     2161 agaagttttc cagcttgttt gaattatggc tttcctcttc ccaatctctt gcaaaaaaga
     2221 caaagtggga tggatctgct agtgaactga gcagaaatgt tttatacgcc ttttgagcta
     2281 tgtaacttaa taattggata cttgatcatt tgttttatta tgtaatcgat aaaatggtga
     2341 tgtgtattaa agttagttca accatatatt tatactgtct gggaatgtgt ggttatagtt
     2401 ctgtgggaga aatagtttgt cagtgttcac cagcttgtaa aaacttagta tgagagcttc
     2461 aacatttaaa taaatgatga accgcattcg tcactgagga cacttttgcc taaaattaac
     2521 ttaatttgta gaaaacaatg gattcagtta atatcatttc aatttatgga aaaaattgtt
     2581 agggttgcca agtgcttttt attaaaagtt tctctttaaa ggtctagata attgtgaatc
     2641 agttgaatgt tgggcaccga ggggaaacag tttgtaatag atgatctaga tttttcagtt
     2701 cagttccatc agtcacttgt agctctgcaa tttccagacc agttttctca tttttaagtt
     2761 cattacatgc ctgtatatat tttgaaatta atttgaacct gagtatttgg cacatgatgg
     2821 cttaataaat tttaactttc aataatctga aatgtttcct tttcctagtt catgctcgtg
     2881 ttagataaat aggatttttt gaaattttga aaaaaggata tttcatctta cacatttaag
     2941 gctttacatg cgaatctagc acttaaaacg tgctggtcta taggcctttg cttctttact
     3001 aaatgataca ctattgccac acagcccata agtaaacatg ctttttggga gaagaaaggt
     3061 gctgtcatga ctactgaaag ttttgacttt attaggttgt atatatggtg ctagaagtca
     3121 cttgcattat aaacttacct gtatgttaca aactgagatt tgctttatat tttctatctg
     3181 tgagtacact atcattctgc aataacatcc aagaaatacc ttgggtctaa taagaattta
     3241 aagacttata agctgcattc ttaaatgcaa gttggctgtt ataaatttaa cttcctagga
     3301 ggttggggta tatatatata tatatatata gctcagtgaa tgaatgcttg cctagcacac
     3361 aggaagccct gagtttaatt cccagtgtca gataaatcat gcatagtggt atgcagagat
     3421 tagaaatcca aggtcatcct tagctacata atttagctag cctggtctac atgaaatgct
     3481 gtgtctaaat gtactatgcc tgcttaagct ggggcacttt tactagataa catagtgact
     3541 acttgctctg gcttctgaat tgggatcaca atgatactga ggcaagtgat gtgattactc
     3601 attcaggaga agaggccgtc tccactaaga ggtaccataa aatagatgcc agcagtcatt
     3661 gtgcccactg agatcaaggt cagagctttc tacacccaga caactaactg cctgcctagt
     3721 gatcacattg catgtgctca agttccagag tgttgtaaat gataaccggc cccatagcct
     3781 agctgtaatc gcaatcctgg gatctgttgt gttacagtca tctggcaaat atctgctcct
     3841 gatatttagg aatactgcaa agggtttaga attgggtgcc agattctgtt aattatcgca
     3901 ctccttacca gtaacaattt ttttgtattg aagtttcagg aaatgttaat ttggtgagaa
     3961 tgcttcaaat ggaagtgact tggtttctta atttataagt gaaaggttaa aatacacaaa
     4021 ttagtatctg ctgtacacat ttatacccca cattcttgag tccttgaatt aatggtgtgt
     4081 ctgcattttt aactcatgaa ttggaaatta aagacttgct ttaaaagtga aaaaaaaaaa
     4141 aaaaaaaaaa aaa
//
