LOCUS       NM_008973               1588 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus pleiotrophin (Ptn), transcript variant 1, mRNA.
ACCESSION   NM_008973
VERSION     NM_008973.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1588)
  AUTHORS   Qiu,X., Guo,Y., Liu,M.F., Zhang,B., Li,J., Wei,J.F. and Li,M.
  TITLE     Single-cell RNA-sequencing analysis reveals enhanced non-canonical
            neurotrophic factor signaling in the subacute phase of traumatic
            brain injury
  JOURNAL   CNS Neurosci Ther 29 (11), 3446-3459 (2023)
   PUBMED   37269057
  REMARK    GeneRIF: Single-cell RNA-sequencing analysis reveals enhanced
            non-canonical neurotrophic factor signaling in the subacute phase
            of traumatic brain injury.
REFERENCE   2  (bases 1 to 1588)
  AUTHORS   Li,H., Xu,L., Jiang,W., Qiu,X., Xu,H., Zhu,F., Hu,Y., Liang,S.,
            Cai,C., Qiu,W., Lu,Z., Cui,Y. and Tang,C.
  TITLE     Pleiotrophin ameliorates age-induced adult hippocampal neurogenesis
            decline and cognitive dysfunction
  JOURNAL   Cell Rep 42 (9), 113022 (2023)
   PUBMED   37610873
  REMARK    GeneRIF: Pleiotrophin ameliorates age-induced adult hippocampal
            neurogenesis decline and cognitive dysfunction.
REFERENCE   3  (bases 1 to 1588)
  AUTHORS   Zhou,Y., Li,H., Liu,X., Chi,X., Gu,Z., Cui,B., Bergquist,J.,
            Wang,B., Tian,G., Yang,C., Xu,F. and Mi,J.
  TITLE     The Combination of Quantitative Proteomics and Systems Genetics
            Analysis Reveals that PTN Is Associated with Sleep-Loss-Induced
            Cognitive Impairment
  JOURNAL   J Proteome Res 22 (9), 2936-2949 (2023)
   PUBMED   37611228
  REMARK    GeneRIF: The Combination of Quantitative Proteomics and Systems
            Genetics Analysis Reveals that PTN Is Associated with
            Sleep-Loss-Induced Cognitive Impairment.
REFERENCE   4  (bases 1 to 1588)
  AUTHORS   Ganguly,D., Schmidt,M.O., Coleman,M., Ngo,T.C., Sorrelle,N.,
            Dominguez,A.T.A., Murimwa,G.Z., Toombs,J.E., Lewis,C., Fang,Y.V.,
            Valdes-Mora,F., Gallego-Ortega,D., Wellstein,A. and Brekken,R.A.
  TITLE     Pleiotrophin drives a prometastatic immune niche in breast cancer
  JOURNAL   J Exp Med 220 (5) (2023)
   PUBMED   36828390
  REMARK    GeneRIF: Pleiotrophin drives a prometastatic immune niche in breast
            cancer.
REFERENCE   5  (bases 1 to 1588)
  AUTHORS   Wang,X., Zhou,D., Zhou,W., Liu,J., Xue,Q., Huang,Y., Cheng,C.,
            Wang,Y., Chang,J., Wang,P. and Miao,C.
  TITLE     Clematichinenoside AR inhibits the pathology of rheumatoid
            arthritis by blocking the circPTN/miR-145-5p/FZD4 signal axis
  JOURNAL   Int Immunopharmacol 113 (Pt A), 109376 (2022)
   PUBMED   36279670
  REMARK    GeneRIF: Clematichinenoside AR inhibits the pathology of rheumatoid
            arthritis by blocking the circPTN/miR-145-5p/FZD4 signal axis.
REFERENCE   6  (bases 1 to 1588)
  AUTHORS   Li,Y.S., Hoffman,R.M., Le Beau,M.M., Espinosa,R. 3rd, Jenkins,N.A.,
            Gilbert,D.J., Copeland,N.G. and Deuel,T.F.
  TITLE     Characterization of the human pleiotrophin gene. Promoter region
            and chromosomal localization
  JOURNAL   J Biol Chem 267 (36), 26011-26016 (1992)
   PUBMED   1464612
REFERENCE   7  (bases 1 to 1588)
  AUTHORS   Katoh,K., Takeshita,S., Sato,M., Ito,T. and Amann,E.
  TITLE     Genomic organization of the mouse OSF-1 gene
  JOURNAL   DNA Cell Biol 11 (10), 735-743 (1992)
   PUBMED   1457042
REFERENCE   8  (bases 1 to 1588)
  AUTHORS   Nurcombe,V., Fraser,N., Herlaar,E. and Heath,J.K.
  TITLE     MK: a pluripotential embryonic stem-cell-derived neuroregulatory
            factor
  JOURNAL   Development 116 (4), 1175-1183 (1992)
   PUBMED   1295735
REFERENCE   9  (bases 1 to 1588)
  AUTHORS   Li,Y.S., Gurrieri,M. and Deuel,T.F.
  TITLE     Pleiotrophin gene expression is highly restricted and is regulated
            by platelet-derived growth factor
  JOURNAL   Biochem Biophys Res Commun 184 (1), 427-432 (1992)
   PUBMED   1373617
REFERENCE   10 (bases 1 to 1588)
  AUTHORS   Naito,A., Yoshikura,H. and Iwamoto,A.
  TITLE     Similarity of the genomic structure between the two members in a
            new family of heparin-binding factors
  JOURNAL   Biochem Biophys Res Commun 183 (2), 701-707 (1992)
   PUBMED   1550576
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK011346.1, AK011699.1 and AI838962.1.
            
            On Feb 24, 2018 this sequence version replaced NM_008973.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC061695.1, AK011346.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164137
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-177               AK011346.1         43-219
            178-205             AK011699.1         143-170
            206-1451            AK011346.1         245-1490
            1452-1588           AI838962.1         1-137               c
FEATURES             Location/Qualifiers
     source          1..1588
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 15.48 cM"
     gene            1..1588
                     /gene="Ptn"
                     /gene_synonym="HARP; HB-GAM; HBBM; HBBN; HBGF-8; HBNF;
                     OSF; Osf-1; Osf1"
                     /note="pleiotrophin"
                     /db_xref="GeneID:19242"
                     /db_xref="MGI:MGI:97804"
     exon            1..286
                     /gene="Ptn"
                     /gene_synonym="HARP; HB-GAM; HBBM; HBBN; HBGF-8; HBNF;
                     OSF; Osf-1; Osf1"
                     /inference="alignment:Splign:2.1.0"
     exon            287..403
                     /gene="Ptn"
                     /gene_synonym="HARP; HB-GAM; HBBM; HBBN; HBGF-8; HBNF;
                     OSF; Osf-1; Osf1"
                     /inference="alignment:Splign:2.1.0"
     CDS             289..795
                     /gene="Ptn"
                     /gene_synonym="HARP; HB-GAM; HBBM; HBBN; HBGF-8; HBNF;
                     OSF; Osf-1; Osf1"
                     /note="osteoblast-specific factor 1; heparin-binding
                     neutrophic factor; heparin-binding brain mitogen;
                     heparin-binding growth factor 8; heparin-binding
                     growth-associated molecule"
                     /codon_start=1
                     /product="pleiotrophin precursor"
                     /protein_id="NP_032999.1"
                     /db_xref="CCDS:CCDS20005.1"
                     /db_xref="GeneID:19242"
                     /db_xref="MGI:MGI:97804"
                     /translation="MSSQQYQQQRRKFAAAFLALIFILAAVDTAEAGKKEKPEKKVKK
                     SDCGEWQWSVCVPTSGDCGLGTREGTRTGAECKQTMKTQRCKIPCNWKKQFGAECKYQ
                     FQAWGECDLNTALKTRTGSLKRALHNADCQKTVTISKPCGKLTKPKPQAESKKKKKEG
                     KKQEKMLD"
     exon            404..577
                     /gene="Ptn"
                     /gene_synonym="HARP; HB-GAM; HBBM; HBBN; HBGF-8; HBNF;
                     OSF; Osf-1; Osf1"
                     /inference="alignment:Splign:2.1.0"
     exon            578..739
                     /gene="Ptn"
                     /gene_synonym="HARP; HB-GAM; HBBM; HBBN; HBGF-8; HBNF;
                     OSF; Osf-1; Osf1"
                     /inference="alignment:Splign:2.1.0"
     exon            740..1574
                     /gene="Ptn"
                     /gene_synonym="HARP; HB-GAM; HBBM; HBBN; HBGF-8; HBNF;
                     OSF; Osf-1; Osf1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1549..1554
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ptn"
                     /gene_synonym="HARP; HB-GAM; HBBM; HBBN; HBGF-8; HBNF;
                     OSF; Osf-1; Osf1"
                     /note="hexamer: AATAAA"
     regulatory      1569..1574
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ptn"
                     /gene_synonym="HARP; HB-GAM; HBBM; HBBN; HBGF-8; HBNF;
                     OSF; Osf-1; Osf1"
                     /note="hexamer: ATTAAA"
     polyA_site      1569
                     /gene="Ptn"
                     /gene_synonym="HARP; HB-GAM; HBBM; HBBN; HBGF-8; HBNF;
                     OSF; Osf-1; Osf1"
     polyA_site      1574
                     /gene="Ptn"
                     /gene_synonym="HARP; HB-GAM; HBBM; HBBN; HBGF-8; HBNF;
                     OSF; Osf-1; Osf1"
                     /note="major polyA site"
ORIGIN      
        1 attctctatt tccctccccg gcagggtgta gttgagtgaa ggcaggatca ggttccccgc
       61 ctacccgtcc aaatatcccg ccaaggaagc cccagagcac aagaaaaccc aaagtggaga
      121 gaggggaaga aagaaagcac tgagtcatcc atccagaagg ggggagagca gagcgcagcc
      181 gcccaggcag gagcatcagc cagcgatacc tggagtctgc agaaacctcg cccgcacttt
      241 gcaacaaagg cagccagcta gtcagcgagg acctctgcaa gccaaaaaat gtcgtcccag
      301 caatatcagc agcaacgtag aaaatttgca gctgccttcc tggcattgat tttcatcttg
      361 gcagctgtgg acactgctga ggccgggaag aaagagaaac ctgaaaaaaa ggtgaaaaag
      421 tctgactgtg gagaatggca gtggagtgtg tgcgtgccta ccagcgggga ctgtggattg
      481 ggcacccggg agggcactcg cactggcgcc gagtgcaaac agaccatgaa gactcagaga
      541 tgtaagatcc cttgcaactg gaagaagcag tttggagctg agtgcaagta ccagttccag
      601 gcttggggag aatgtgacct caataccgcc ttgaagacca gaactggcag cctgaagcga
      661 gctctgcaca atgctgactg tcagaaaact gtcaccatct ccaagccctg tggcaagctc
      721 accaagccca agcctcaagc ggagtcaaag aagaagaaaa aggaaggcaa gaaacaggag
      781 aagatgctgg attaaaagac gccaccgtct gtggaccagg aaaagggcat cagcaaacag
      841 gatcagttaa ttattccatt tatacctact gtaggctttt tattcaacag ttatctgtag
      901 cttaagtaca tgataggcaa aaacaaagag aaaagaaatg tttttgtagt agtggttttt
      961 ttgtttttgt ttttgttttt gtttttttta atgtatacca tagtaccagt aggggcttat
     1021 aataaaggat tgtaatacta tttaggaagt tgaactctgt agtacataat aggaggtagg
     1081 attgaggtaa gttttttggt gttgttattt tgttttgttt cattttggtt tggtttggtt
     1141 tttgaagtta tgtgatattt cacatttaaa tcttttttct tttttacatg ttttctcttg
     1201 tgcatcaatt taaatgttac aaccatgtaa actacttctc ttgttagata gattttcacc
     1261 tagacttttt ttcccaaatc agaaaaaaaa tacacactaa ataaagcagc aataaaatat
     1321 aaatcattct attggagaga aatgcattgt tttctgccag tggatatttt ctttgaaagt
     1381 ttgcagactg agaggagaga ggcagagcaa cgatgtagtg aaatgttgat ctttgttttt
     1441 tttttttttt taagataaga ttgaaacatg aaatcctttc actttggcag aaaaacattt
     1501 gttttcttga tgaaattatt tttacatctg aggaaaaaaa tctaggaaaa taaaacaagt
     1561 gatgctgaat taaaaaaaaa aaaaaaaa
//
