LOCUS       NM_008972               1222 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus prothymosin alpha (Ptma), transcript variant 1, mRNA.
ACCESSION   NM_008972
VERSION     NM_008972.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1222)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1222)
  AUTHORS   Ueda,H.
  TITLE     Prothymosin alpha Plays Role as a Brain Guardian through Ecto-F1
            ATPase-P2Y12 Complex and TLR4/MD2
  JOURNAL   Cells 12 (3), 496 (2023)
   PUBMED   36766838
  REMARK    GeneRIF: Prothymosin alpha Plays Role as a Brain Guardian through
            Ecto-F1 ATPase-P2Y12 Complex and TLR4/MD2.
            Review article
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1222)
  AUTHORS   Wu,H.T., Kang,L., Su,Y.C., Ou,H.Y., Chan,F.Y., Chen,Y.C., Su,B.H.,
            Wang,Y.S., Wu,C.L., Shiau,A.L. and Wu,P.
  TITLE     Prothymosin alpha activates type I collagen to develop a fibrotic
            placenta in gestational diabetes
  JOURNAL   Clin Sci (Lond) 134 (18), 2435-2445 (2020)
   PUBMED   32909608
  REMARK    GeneRIF: Prothymosin alpha activates type I collagen to develop a
            fibrotic placenta in gestational diabetes.
REFERENCE   4  (bases 1 to 1222)
  AUTHORS   Renga,G., Bellet,M.M., Pariano,M., Gargaro,M., Stincardini,C.,
            D'Onofrio,F., Mosci,P., Brancorsini,S., Bartoli,A., Goldstein,A.L.,
            Garaci,E., Romani,L. and Costantini,C.
  TITLE     Thymosin alpha1 protects from CTLA-4 intestinal immunopathology
  JOURNAL   Life Sci Alliance 3 (10), e202000662 (2020)
   PUBMED   32817121
  REMARK    GeneRIF: Thymosin alpha1 protects from CTLA-4 intestinal
            immunopathology.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1222)
  AUTHORS   Halder,S.K., Sasaki,K. and Ueda,H.
  TITLE     Ggamma7-specific prothymosin alpha deletion causes stress- and
            age-dependent motor dysfunction and anxiety
  JOURNAL   Biochem Biophys Res Commun 522 (1), 264-269 (2020)
   PUBMED   31759625
  REMARK    GeneRIF: Ggamma7-specific prothymosin alpha deletion causes stress-
            and age-dependent motor dysfunction and anxiety.
REFERENCE   6  (bases 1 to 1222)
  AUTHORS   Szabo,P., Ehleiter,D., Whittington,E. and Weksler,M.E.
  TITLE     Prothymosin alpha expression occurs during G1 in proliferating B or
            T lymphocytes
  JOURNAL   Biochem Biophys Res Commun 185 (3), 953-959 (1992)
   PUBMED   1378271
REFERENCE   7  (bases 1 to 1222)
  AUTHORS   Schmidt,G. and Werner,D.
  TITLE     Nucleotide sequence of the murine prothymosin alpha cDNA and its
            deduced primary and secondary protein structure
  JOURNAL   Biochim Biophys Acta 1088 (3), 442-444 (1991)
   PUBMED   2015308
REFERENCE   8  (bases 1 to 1222)
  AUTHORS   Eilers,M., Schirm,S. and Bishop,J.M.
  TITLE     The MYC protein activates transcription of the alpha-prothymosin
            gene
  JOURNAL   EMBO J 10 (1), 133-141 (1991)
   PUBMED   1989881
REFERENCE   9  (bases 1 to 1222)
  AUTHORS   Low,T.L., Pan,T.L. and Lin,Y.S.
  TITLE     Depression of prothymosin alpha production in murine thymus
            correlates with staphylococcal enterotoxin-B-induced
            immunosuppression [corrected]
  JOURNAL   FEBS Lett 273 (1-2), 1-5 (1990)
   PUBMED   2226839
  REMARK    Erratum:[FEBS Lett 1990 Dec 17;277(1-2):285]
REFERENCE   10 (bases 1 to 1222)
  AUTHORS   Makarova,T., Grebenshikov,N., Egorov,C., Vartapetian,A. and
            Bogdanov,A.
  TITLE     Prothymosin alpha is an evolutionary conserved protein covalently
            linked to a small RNA
  JOURNAL   FEBS Lett 257 (2), 247-250 (1989)
   PUBMED   2479575
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC158132.6.
            
            On Jul 7, 2022 this sequence version replaced NM_008972.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK159128.1, AK153496.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-231               AC158132.6         73739-73969
            232-303             AC158132.6         76192-76263
            304-400             AC158132.6         76475-76571
            401-474             AC158132.6         76750-76823
            475-1222            AC158132.6         76984-77731
FEATURES             Location/Qualifiers
     source          1..1222
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 43.96 cM"
     gene            1..1222
                     /gene="Ptma"
                     /gene_synonym="Thym"
                     /note="prothymosin alpha"
                     /db_xref="GeneID:19231"
                     /db_xref="MGI:MGI:97803"
     exon            1..231
                     /gene="Ptma"
                     /gene_synonym="Thym"
                     /inference="alignment:Splign:2.1.0"
     CDS             187..522
                     /gene="Ptma"
                     /gene_synonym="Thym"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /codon_start=1
                     /product="prothymosin alpha isoform 1"
                     /protein_id="NP_032998.1"
                     /db_xref="CCDS:CCDS35649.1"
                     /db_xref="GeneID:19231"
                     /db_xref="MGI:MGI:97803"
                     /translation="MSDAAVDTSSEITTKDLKEKKEVVEEAENGRDAPANGNAQNEEN
                     GEQEADNEVDEEEEEGGEEEEEEEEGDGEEEDGDEDEEAEAPTGKRVAEDDEDDDVDT
                     KKQKTEEDD"
     exon            232..303
                     /gene="Ptma"
                     /gene_synonym="Thym"
                     /inference="alignment:Splign:2.1.0"
     exon            304..400
                     /gene="Ptma"
                     /gene_synonym="Thym"
                     /inference="alignment:Splign:2.1.0"
     exon            401..474
                     /gene="Ptma"
                     /gene_synonym="Thym"
                     /inference="alignment:Splign:2.1.0"
     exon            475..1222
                     /gene="Ptma"
                     /gene_synonym="Thym"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1172..1177
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ptma"
                     /gene_synonym="Thym"
                     /note="hexamer: AATAAA"
     polyA_site      1207
                     /gene="Ptma"
                     /gene_synonym="Thym"
                     /note="major polyA site"
     polyA_site      1222
                     /gene="Ptma"
                     /gene_synonym="Thym"
ORIGIN      
        1 tcccccactg gctgctccga aaagccatct ttgcattgtt cctgggtcgt gctccgcgct
       61 cgctgcagcc accttcgccg cccaccgcct cctccagcgc ggactccggc agctctctcg
      121 ccagagtcct cgaactcgac ttttaattcc ctcactcgcg gcatcggacc accggcgtgc
      181 cccaccatgt cagacgcggc agtggatacc agctccgaga tcaccaccaa ggacttgaag
      241 gagaagaagg aagttgtgga ggaggcagag aatggaagag atgcacctgc caatgggaac
      301 gctcaaaatg aggaaaatgg ggagcaggag gctgacaatg aggtagatga agaagaggaa
      361 gaaggtgggg aggaagagga ggaggaggaa gaaggtgacg gtgaggagga ggatggagat
      421 gaagatgagg aagctgaggc tcctacgggc aagcgggtag ctgaggatga tgaggatgac
      481 gatgtggaca ccaagaagca gaagaccgag gaggatgact agacagcaaa aggaaaaata
      541 accttacgca ccgtgaccta ttcaccctcc acttcccgtc tcagaattta aacgtggtca
      601 ccttcgagta gagaagcagg ccccgcccgc ccacagcggg caatgccacc cacagatatg
      661 acatgcgctc tccaccaccc ctccaaaact acaacatgaa ttggcaacat gggaggaaaa
      721 aagaaccaga acttcccagg ccctactttt tttcttaaaa atactttaaa aggaaaattt
      781 gtttgtattt tttatttaca ttttatattt ttgtacatat tgttaggggt cagccatttt
      841 taatgataac gggtgaccaa accagccttc agagcgtttt ctgtcctact tcagacttta
      901 cttgtggtgt gaccatgttc attataatct caaaggagaa aaaaaaaacc ttgtaaaaaa
      961 aagcaaaaac aacaacaaaa aaacaatctt attccgagca ttccagtaac ttttgtgtat
     1021 gtacctagct gtactataag tagttggttt gtatgagatg gttaaaaagg ccaaagataa
     1081 aaagattttt tttttccttt tctttctgtc tatgaagttg ctgtttattt ttttttggcc
     1141 tgtttgatgt atgtgtgaaa caatgtccaa caataaaccg gaattttatt ttgctgagtt
     1201 gttctaacaa tggtgtctca aa
//
