LOCUS       NM_175168               4255 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus PTK7 protein tyrosine kinase 7 (Ptk7), mRNA.
ACCESSION   NM_175168
VERSION     NM_175168.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4255)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 4255)
  AUTHORS   Yun,J., Hansen,S., Morris,O., Madden,D.T., Libeu,C.P., Kumar,A.J.,
            Wehrfritz,C., Nile,A.H., Zhang,Y., Zhou,L., Liang,Y., Modrusan,Z.,
            Chen,M.B., Overall,C.C., Garfield,D., Campisi,J., Schilling,B.,
            Hannoush,R.N. and Jasper,H.
  TITLE     Senescent cells perturb intestinal stem cell differentiation
            through Ptk7 induced noncanonical Wnt and YAP signaling
  JOURNAL   Nat Commun 14 (1), 156 (2023)
   PUBMED   36631445
  REMARK    GeneRIF: Senescent cells perturb intestinal stem cell
            differentiation through Ptk7 induced noncanonical Wnt and YAP
            signaling.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4255)
  AUTHORS   Wong,T.L.M., Wong,T.L., Zhou,L., Man,K., Purcell,J., Lee,T.K.,
            Yun,J.P. and Ma,S.
  TITLE     Protein Tyrosine Kinase 7 (PTK7) Promotes Metastasis in
            Hepatocellular Carcinoma via SOX9 Regulation and TGF-beta Signaling
  JOURNAL   Cell Mol Gastroenterol Hepatol 15 (1), 13-37 (2023)
   PUBMED   36202326
  REMARK    GeneRIF: Protein Tyrosine Kinase 7 (PTK7) Promotes Metastasis in
            Hepatocellular Carcinoma via SOX9 Regulation and TGF-beta
            Signaling.
REFERENCE   4  (bases 1 to 4255)
  AUTHORS   Zhao,T., McMahon,M., Reynolds,K., Saha,S.K., Stokes,A. and
            Zhou,C.J.
  TITLE     The role of Lrp6-mediated Wnt/beta-catenin signaling in the
            development and intervention of spinal neural tube defects in mice
  JOURNAL   Dis Model Mech 15 (6) (2022)
   PUBMED   35514236
REFERENCE   5  (bases 1 to 4255)
  AUTHORS   Xie,Z. and Bankaitis,V.A.
  TITLE     Phosphatidylinositol transfer protein/planar cell polarity axis
            regulates neocortical morphogenesis by supporting interkinetic
            nuclear migration
  JOURNAL   Cell Rep 39 (9), 110869 (2022)
   PUBMED   35649377
REFERENCE   6  (bases 1 to 4255)
  AUTHORS   Jung,J.W., Shin,W.S., Song,J. and Lee,S.T.
  TITLE     Cloning and characterization of the full-length mouse Ptk7 cDNA
            encoding a defective receptor protein tyrosine kinase
  JOURNAL   Gene 328, 75-84 (2004)
   PUBMED   15019986
  REMARK    GeneRIF: Ptk7 mRNA was expressed at high levels in lung and
            un-pregnant uterus among adult tissues, and in the tail, limbs,
            somites, gut, and craniofacial regions among embryonic tissues, and
            suggest that PTK7 plays multiple roles in embryonic development.
REFERENCE   7  (bases 1 to 4255)
  AUTHORS   Toyofuku,T., Zhang,H., Kumanogoh,A., Takegahara,N., Suto,F.,
            Kamei,J., Aoki,K., Yabuki,M., Hori,M., Fujisawa,H. and Kikutani,H.
  TITLE     Dual roles of Sema6D in cardiac morphogenesis through
            region-specific association of its receptor, Plexin-A1, with
            off-track and vascular endothelial growth factor receptor type 2
  JOURNAL   Genes Dev 18 (4), 435-447 (2004)
   PUBMED   14977921
REFERENCE   8  (bases 1 to 4255)
  AUTHORS   Daigo,Y., Takayama,I., Ward,S.M., Sanders,K.M. and Fujino,M.A.
  TITLE     Isolation of novel mouse genes that were differentially expressed
            in W/W(V) mouse fundus
  JOURNAL   J Gastroenterol 39 (3), 238-241 (2004)
   PUBMED   15065000
REFERENCE   9  (bases 1 to 4255)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   10 (bases 1 to 4255)
  AUTHORS   Mitchell,K.J., Pinson,K.I., Kelly,O.G., Brennan,J., Zupicich,J.,
            Scherz,P., Leighton,P.A., Goodrich,L.V., Lu,X., Avery,B.J.,
            Tate,P., Dill,K., Pangilinan,E., Wakenight,P., Tessier-Lavigne,M.
            and Skarnes,W.C.
  TITLE     Functional analysis of secreted and transmembrane proteins critical
            to mouse development
  JOURNAL   Nat Genet 28 (3), 241-249 (2001)
   PUBMED   11431694
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC076578.1 and AK053044.1.
            
            On Dec 11, 2009 this sequence version replaced NM_175168.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC076578.1, AK053044.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-4235              BC076578.1         1-4235
            4236-4255           AK053044.1         4168-4187
FEATURES             Location/Qualifiers
     source          1..4255
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 22.9 cM"
     gene            1..4255
                     /gene="Ptk7"
                     /gene_synonym="8430404F20Rik; chz; mPTK7/CCK4"
                     /note="PTK7 protein tyrosine kinase 7"
                     /db_xref="GeneID:71461"
                     /db_xref="MGI:MGI:1918711"
     exon            1..237
                     /gene="Ptk7"
                     /gene_synonym="8430404F20Rik; chz; mPTK7/CCK4"
                     /inference="alignment:Splign:2.1.0"
     CDS             183..3371
                     /gene="Ptk7"
                     /gene_synonym="8430404F20Rik; chz; mPTK7/CCK4"
                     /EC_number="2.7.10.1"
                     /note="tyrosine-protein kinase-like 7; inactive
                     tyrosine-protein kinase 7; receptor tyrosine kinase-like
                     protein; protein-tyrosine kinase 7; protein chuzhoi;
                     pseudo tyrosine kinase receptor 7"
                     /codon_start=1
                     /product="inactive tyrosine-protein kinase 7 precursor"
                     /protein_id="NP_780377.1"
                     /db_xref="CCDS:CCDS37637.1"
                     /db_xref="GeneID:71461"
                     /db_xref="MGI:MGI:1918711"
                     /translation="MGARPLTLLRALLLPLLAGAQAAIVFIKEPSSQDALQGRRALLR
                     CEVEAPDPVHVYWLLNGVPVQDTERRFAQGSSLSFAAVDRLQDSGAFQCVARDNVTGE
                     EVRSTNASFNIKWIEAGPVVLKHPASEAEIQPQTQVTLRCHIDGHPRPTYQWFRDGTP
                     LSDDQSTHTVSSRERNLTLRPASPEHSGLYSCCAHNAFGQACSSQNFTLSVADESFAR
                     VVLAPQDVVVARNEEAMFHCQFSAQPPPSLQWVFEDETPITNRSRPPHLRRAVVFANG
                     SLLLTQVRPRNAGVYRCIGQGQRGPPIVLEATLHLAEIEDMLPFEPRVFIAGDEERVT
                     CPAPQGLPTPSVWWEHAGVPLPAHGRVHQKGLELVFVTIAESDTGVYTCHASNLAGQR
                     RQDVNITVATVPTWLRKPQDSQLEEGKPGYLHCLTQATPKPTVIWYRNQMLISEDSRF
                     EVSKNGTLRINSVEVYDGTLYRCVSSTPAGSIEAQARVQVLEKLKFTPPPQPQQCMEF
                     DKEATVPCSATGREKPTVKWVRADGSSLPEWVTDNAGTLHFARVTRDDAGNYTCIASN
                     EPQGQIRAHVQLTVAVFITFKVEPERTTVYQGHTALLRCEAQGDPKPLIQWKGKDRIL
                     DPTKLGPRMHIFQNGSLVIHDVAPEDSGSYTCIAGNSCNIRHTEAPLLVVDKPVMEDS
                     EGPGSPPPYKMIQTIGLSVGAAVAYIIAVLGLMFYCKKRCKAKRLQKQPEGEEPEMEC
                     LNGGPLQNGQPSAEIQEEVALTSLGSGPPATNKRHSAGDRMHFPRASLQPITTLGKSE
                     FGEVFLAKAQGVEEGATETLVLVKSLQSRDEQQQLDFRREVEMFGKLNHANVVRLLGL
                     CREAEPHYMVLEYVDLGDLKQFLRISKNKDEKLKSQPLSTKQKVALCSQVALGMEHLS
                     NNRFVHKDLAARNCLISAQRQVKVSALGLSKDVYNSEYYHFRQAWVPLRWMSPEAVLE
                     GDFSTKSDVWAFGVLMWEVFTHGEMPHGGQADDEVLADLQAGKARLPQPEGCPSKLYR
                     LMQRCWAPNPKDRPSFSEIASTLGDSPADSKQ"
     exon            238..525
                     /gene="Ptk7"
                     /gene_synonym="8430404F20Rik; chz; mPTK7/CCK4"
                     /inference="alignment:Splign:2.1.0"
     exon            526..628
                     /gene="Ptk7"
                     /gene_synonym="8430404F20Rik; chz; mPTK7/CCK4"
                     /inference="alignment:Splign:2.1.0"
     exon            629..819
                     /gene="Ptk7"
                     /gene_synonym="8430404F20Rik; chz; mPTK7/CCK4"
                     /inference="alignment:Splign:2.1.0"
     exon            820..970
                     /gene="Ptk7"
                     /gene_synonym="8430404F20Rik; chz; mPTK7/CCK4"
                     /inference="alignment:Splign:2.1.0"
     exon            971..1119
                     /gene="Ptk7"
                     /gene_synonym="8430404F20Rik; chz; mPTK7/CCK4"
                     /inference="alignment:Splign:2.1.0"
     exon            1120..1386
                     /gene="Ptk7"
                     /gene_synonym="8430404F20Rik; chz; mPTK7/CCK4"
                     /inference="alignment:Splign:2.1.0"
     exon            1387..1520
                     /gene="Ptk7"
                     /gene_synonym="8430404F20Rik; chz; mPTK7/CCK4"
                     /inference="alignment:Splign:2.1.0"
     exon            1521..1656
                     /gene="Ptk7"
                     /gene_synonym="8430404F20Rik; chz; mPTK7/CCK4"
                     /inference="alignment:Splign:2.1.0"
     exon            1657..1776
                     /gene="Ptk7"
                     /gene_synonym="8430404F20Rik; chz; mPTK7/CCK4"
                     /inference="alignment:Splign:2.1.0"
     exon            1777..1926
                     /gene="Ptk7"
                     /gene_synonym="8430404F20Rik; chz; mPTK7/CCK4"
                     /inference="alignment:Splign:2.1.0"
     exon            1927..2077
                     /gene="Ptk7"
                     /gene_synonym="8430404F20Rik; chz; mPTK7/CCK4"
                     /inference="alignment:Splign:2.1.0"
     exon            2078..2205
                     /gene="Ptk7"
                     /gene_synonym="8430404F20Rik; chz; mPTK7/CCK4"
                     /inference="alignment:Splign:2.1.0"
     exon            2206..2409
                     /gene="Ptk7"
                     /gene_synonym="8430404F20Rik; chz; mPTK7/CCK4"
                     /inference="alignment:Splign:2.1.0"
     exon            2410..2565
                     /gene="Ptk7"
                     /gene_synonym="8430404F20Rik; chz; mPTK7/CCK4"
                     /inference="alignment:Splign:2.1.0"
     exon            2566..2798
                     /gene="Ptk7"
                     /gene_synonym="8430404F20Rik; chz; mPTK7/CCK4"
                     /inference="alignment:Splign:2.1.0"
     exon            2799..2879
                     /gene="Ptk7"
                     /gene_synonym="8430404F20Rik; chz; mPTK7/CCK4"
                     /inference="alignment:Splign:2.1.0"
     exon            2880..3031
                     /gene="Ptk7"
                     /gene_synonym="8430404F20Rik; chz; mPTK7/CCK4"
                     /inference="alignment:Splign:2.1.0"
     exon            3032..3210
                     /gene="Ptk7"
                     /gene_synonym="8430404F20Rik; chz; mPTK7/CCK4"
                     /inference="alignment:Splign:2.1.0"
     exon            3211..4255
                     /gene="Ptk7"
                     /gene_synonym="8430404F20Rik; chz; mPTK7/CCK4"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4214..4219
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ptk7"
                     /gene_synonym="8430404F20Rik; chz; mPTK7/CCK4"
                     /note="hexamer: AATAAA"
     polyA_site      4235
                     /gene="Ptk7"
                     /gene_synonym="8430404F20Rik; chz; mPTK7/CCK4"
                     /note="major polyA site"
ORIGIN      
        1 cgggggcgtg gcttggctgc ggcggcggcg cgctcgaggg cttggatgta cggggcgcgc
       61 gcggctccag ctccggacgc ctcgggctcg ggctgtagct gctgcggcgg cccccgcgct
      121 ccggtccgcg cgcccgctcg ccgtgtgcct tgaacctcgc tgctcgtctg cagcccgcca
      181 ggatgggagc ccgcccgctg actctgctca gagccctgct tctgccgctg ctggccggtg
      241 cccaagccgc tatcgtcttt atcaaggagc cgtcctccca ggatgcactt caagggcgcc
      301 gggcgctgct ccgttgtgaa gtggaggctc cggacccggt gcacgtgtac tggctgctca
      361 atggggtgcc tgtccaggac acggagcgac ggtttgccca gggcagcagc ctgagtttcg
      421 cagctgtgga ccggctccag gattctggtg ctttccagtg tgtggctcgg gataacgtca
      481 ctggagagga agtccgcagt actaatgcct ccttcaacat caaatggatc gaagcaggtc
      541 ctgtggtcct gaagcaccca gcctcagaag ctgagatcca gccccagacc caggtcacac
      601 tgcgatgtca cattgacggg caccctcggc ctacctacca gtggttccga gatgggaccc
      661 ccctctctga tgatcagagc acccacaccg tcagcagcag ggagaggaac ctgaccctac
      721 ggccagccag tcccgaacat agtggcctct actcctgctg tgcccacaat gcctttggcc
      781 aggcctgcag cagccagaac ttcaccttga gtgttgcaga tgaaagcttt gccagggtgg
      841 tgctggcacc tcaggatgtt gttgtagcaa ggaacgagga ggccatgttc cattgccagt
      901 tttcagccca gccacccccg agcctgcagt gggtctttga ggacgagact cccatcacta
      961 accgaagccg tccccctcac ctccgcagag ctgtggtgtt tgccaatggc tctctgctgc
     1021 tgacccaagt ccggccacgg aatgcaggcg tctaccgttg catcggtcag ggacagaggg
     1081 gcccacccat tgtcctggaa gccactctcc acctggcaga gattgaagac atgctgccgt
     1141 ttgaaccacg ggtgttcata gctggtgatg aggaacgagt cacctgccca gccccccagg
     1201 gcctgcctac acccagtgtc tggtgggagc atgctggagt ccctcttcct gcccatggca
     1261 gggtccacca gaagggcctt gagcttgtgt ttgtcaccat cgctgagagt gatactggtg
     1321 tctacacctg ccatgcaagc aacctggctg gtcagcggcg acaggatgtc aatatcacag
     1381 tggccactgt acccacatgg cttaggaagc cccaagacag ccagctggaa gagggcaagc
     1441 ctggctactt gcactgtctg acacaggcca cacccaagcc cactgtgatc tggtacagga
     1501 accagatgct gatctcagag gactcgaggt tcgaagtttc gaagaatggg accttgcgca
     1561 tcaatagtgt ggaggtgtat gacgggacat tgtaccgttg cgtgagcagt accccagccg
     1621 gcagcatcga ggcccaggcc cgagtccagg tgctggaaaa actcaagttc acgccaccac
     1681 cgcagccaca gcagtgcatg gagtttgata aggaggctac ggtgccctgc tcagccactg
     1741 gccgggagaa gcccacggtt aagtgggtac gggcagatgg aagtagcctc cctgaatggg
     1801 tgacagacaa tgctggaacc ctacactttg cccgagtgac ccgagatgat gctggcaact
     1861 acacttgcat tgcatccaac gagccacagg gccagatccg cgctcatgtc cagctgacgg
     1921 tggcagtttt catcaccttc aaagtggaac ctgagcgtac aactgtgtac cagggccaca
     1981 cagcgctgct gcggtgtgag gctcagggcg accccaagcc tctcattcag tggaaaggca
     2041 aagaccggat cctggaccct accaagctgg gacccaggat gcacatcttc cagaacggtt
     2101 ccctggtgat ccatgacgtg gcccctgagg actcaggctc ctacacctgc atcgctggca
     2161 acagctgtaa catcaggcac acagaggccc cgctcttagt cgtggacaag ccagtgatgg
     2221 aagactcgga gggcccaggc agccctcccc catacaagat gatccagacc atcgggctgt
     2281 cggtgggcgc agcggtagcc tacatcatcg cggtcctggg cctcatgttc tactgcaaga
     2341 agcggtgtaa agccaagcgg ctgcagaaac agcctgaggg ggaggagcca gagatggagt
     2401 gcctcaatgg tgggcctttg cagaatggtc agccatcagc cgagatccag gaagaagtgg
     2461 cgttgaccag cttgggctct ggccccccag ccaccaacaa gcgccacagc gccggtgata
     2521 ggatgcattt cccgagagcc agcctgcagc ctatcaccac tctggggaaa agcgagttcg
     2581 gggaggtgtt cctggcaaag gcgcagggcg tagaggaagg cgcgacggag accctggtcc
     2641 tcgtgaagag cctgcagagc agggacgagc aacaacagct ggacttccgg agagaggtgg
     2701 agatgttcgg gaagttgaac catgccaacg tggtgcggct tctggggctg tgccgggagg
     2761 ctgagcccca ctacatggtg ctggagtatg tggacctggg agatctcaaa cagttcctga
     2821 ggatttccaa gaacaaggat gaaaagttga agtcacagcc cctcagcacc aaacagaagg
     2881 tggccctgtg ttcccaggtg gccctgggca tggagcacct gtccaacaac cgctttgtgc
     2941 acaaggactt agcggctcgc aactgcctga tcagtgccca gaggcaggtg aaggtgtccg
     3001 cactgggcct gagcaaggat gtatacaaca gtgagtacta ccacttccgc caggcctggg
     3061 tacctctgcg ttggatgtct ccagaggctg tcctggaggg tgacttctcc actaagtctg
     3121 atgtctgggc ctttggtgtg ctcatgtggg aagtgttcac tcatggagag atgccccatg
     3181 gtggacaggc agatgatgag gtgctggcag acttgcaggc tggcaaggct cgactcccgc
     3241 agcccgaagg ctgcccgtct aagctctacc ggctgatgca gcgctgctgg gccccgaacc
     3301 ccaaggaccg gccctccttc agtgagatcg ccagcaccct gggagacagc cctgcagaca
     3361 gcaagcagtg agggagcctt gcaggctgtc ctcaggatgg cgtgggcagg ggagaacccc
     3421 tcttgagggg agcctgcagc atgatgggca ggataaccct gtccttggcc ctggggtccc
     3481 tgcccaagca cagcaggcat tgctgaagac tggcagtgcc taggcgtttc tcttcgccac
     3541 aaccactggg gaggctgatt cgaacccagg ctgggtgact aagactttgg accaggcatc
     3601 tttctttgcc accccttccc ttatcaggga cagtatgggt acctcaggta accccaattt
     3661 ctggcctgag acttcttttg gccaagttca gctctgccac taatctgcca atgttgcctg
     3721 gggagggctg gactggggct gagctaggtt tgggggactt ctttaataca cagatatact
     3781 caaagttcca agataactct gggcacacag gaccaacggg cctcttggcc cacaggtccc
     3841 acctagtggg gggtctagga ggtcacagca gtggagtcct ccccaccgtg ggcttgtgca
     3901 cactaagcca gactcctggc ctcagtctcc tctcctcacc ctaagtgcct ggcagatgaa
     3961 caagagcgtt tgggagcttt tgacacttat atgacccgcc ccttttgtac gcaccatggg
     4021 cggcctttgt attattgcag cgtggggtgg gtgggcttgg ggaggtctgg gtggaccctg
     4081 gaggaagtag ggagggaggg ccaccctggc ctcatacttt attgttgttg ttattgtttg
     4141 tttgttttat ggttttgttt ttgttttctt tgtttttttg tgtttttttt ttttttttac
     4201 actcgctgct ctcaataaaa aagccttttt ttacagcctg tttgttagac ccttc
//
