LOCUS       NM_009184               2286 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus PTK6 protein tyrosine kinase 6 (Ptk6), transcript
            variant 1, mRNA.
ACCESSION   NM_009184
VERSION     NM_009184.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2286)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2286)
  AUTHORS   Alwanian,W.M., Vlajic,K., Bie,W., Kajdacsy-Balla,A. and Tyner,A.L.
  TITLE     Protein tyrosine kinase 6 regulates activation of SRC kinase
  JOURNAL   J Biol Chem 298 (11), 102584 (2022)
   PUBMED   36228719
  REMARK    GeneRIF: Protein tyrosine kinase 6 regulates activation of SRC
            kinase.
REFERENCE   3  (bases 1 to 2286)
  AUTHORS   Wozniak,D.J., Kajdacsy-Balla,A., Macias,V., Ball-Kell,S.,
            Zenner,M.L., Bie,W. and Tyner,A.L.
  TITLE     PTEN is a protein phosphatase that targets active PTK6 and inhibits
            PTK6 oncogenic signaling in prostate cancer
  JOURNAL   Nat Commun 8 (1), 1508 (2017)
   PUBMED   29142193
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2286)
  AUTHORS   Haines,R.J., Beard,R.S. Jr., Eitner,R.A., Chen,L. and Wu,M.H.
  TITLE     TNFalpha/IFNgamma Mediated Intestinal Epithelial Barrier
            Dysfunction Is Attenuated by MicroRNA-93 Downregulation of PTK6 in
            Mouse Colonic Epithelial Cells
  JOURNAL   PLoS One 11 (4), e0154351 (2016)
   PUBMED   27119373
  REMARK    GeneRIF: PTK6 may act as a novel mediator of TNFalpha/IFNgamma
            intestinal epithelial permeability during inflammatory injury, and
            miR-93 may protect intestinal epithelial barrier function, at least
            in part, by targeting PTK6
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2286)
  AUTHORS   Peng,M., Ball-Kell,S.M. and Tyner,A.L.
  TITLE     Protein tyrosine kinase 6 promotes ERBB2-induced mammary gland
            tumorigenesis in the mouse
  JOURNAL   Cell Death Dis 6 (8), e1848 (2015)
   PUBMED   26247733
  REMARK    GeneRIF: Ptk6 promotes ERBB2-induced mammary gland tumorigenesis in
            the mouse.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2286)
  AUTHORS   Llor,X., Serfas,M.S., Bie,W., Vasioukhin,V., Polonskaia,M.,
            Derry,J., Abbott,C.M. and Tyner,A.L.
  TITLE     BRK/Sik expression in the gastrointestinal tract and in colon
            tumors
  JOURNAL   Clin Cancer Res 5 (7), 1767-1777 (1999)
   PUBMED   10430081
REFERENCE   7  (bases 1 to 2286)
  AUTHORS   Vasioukhin,V. and Tyner,A.L.
  TITLE     A role for the epithelial-cell-specific tyrosine kinase Sik during
            keratinocyte differentiation
  JOURNAL   Proc Natl Acad Sci U S A 94 (26), 14477-14482 (1997)
   PUBMED   9405638
REFERENCE   8  (bases 1 to 2286)
  AUTHORS   Vasioukhin,V., Serfas,M.S., Siyanova,E.Y., Polonskaia,M.,
            Costigan,V.J., Liu,B., Thomason,A. and Tyner,A.L.
  TITLE     A novel intracellular epithelial cell tyrosine kinase is expressed
            in the skin and gastrointestinal tract
  JOURNAL   Oncogene 10 (2), 349-357 (1995)
   PUBMED   7838533
REFERENCE   9  (bases 1 to 2286)
  AUTHORS   Kawachi,Y., Nakauchi,H. and Otsuka,F.
  TITLE     Identification of a novel cDNA clone encoding protein tyrosine
            kinase in murine skin
  JOURNAL   J Dermatol 21 (8), 533-538 (1994)
   PUBMED   7962951
REFERENCE   10 (bases 1 to 2286)
  AUTHORS   Siyanova,E.Y., Serfas,M.S., Mazo,I.A. and Tyner,A.L.
  TITLE     Tyrosine kinase gene expression in the mouse small intestine
  JOURNAL   Oncogene 9 (7), 2053-2057 (1994)
   PUBMED   8208550
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL450341.10.
            
            On Mar 21, 2007 this sequence version replaced NM_009184.1.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U16805.1, BC125342.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849380 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-515               AL450341.10        201412-201926       c
            516-637             AL450341.10        199268-199389       c
            638-801             AL450341.10        198736-198899       c
            802-955             AL450341.10        198214-198367       c
            956-1117            AL450341.10        197517-197678       c
            1118-1299           AL450341.10        196082-196263       c
            1300-1453           AL450341.10        195438-195591       c
            1454-2286           AL450341.10        194261-195093       c
FEATURES             Location/Qualifiers
     source          1..2286
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 103.62 cM"
     gene            1..2286
                     /gene="Ptk6"
                     /gene_synonym="BRK; Sik; tks; Tksk"
                     /note="PTK6 protein tyrosine kinase 6"
                     /db_xref="GeneID:20459"
                     /db_xref="MGI:MGI:99683"
     exon            1..515
                     /gene="Ptk6"
                     /gene_synonym="BRK; Sik; tks; Tksk"
                     /inference="alignment:Splign:2.1.0"
     CDS             286..1641
                     /gene="Ptk6"
                     /gene_synonym="BRK; Sik; tks; Tksk"
                     /EC_number="2.7.10.2"
                     /note="isoform 1 is encoded by transcript variant 1;
                     protein-tyrosine kinase 6; src-related intestinal kinase;
                     tyrosine kinase identified from skin"
                     /codon_start=1
                     /product="protein-tyrosine kinase 6 isoform 1"
                     /protein_id="NP_033210.1"
                     /db_xref="CCDS:CCDS17203.1"
                     /db_xref="GeneID:20459"
                     /db_xref="MGI:MGI:99683"
                     /translation="MVSWDKAHLGPKYVGLWDFKARTDEELSFQAGDLLHVTKKEELW
                     WWATLLDAEGKALAEGYVPHNYLAEKETVESEPWFFGCISRSEAMHRLQAEDNSKGAF
                     LIRVSQKPGADYVLSVRDAQAVRHYRIWKNNEGRLHLNEAVSFSNLSELVDYHKTQSL
                     SHGLQLSMPCWKHKTEPLPHWDDWERPREEFTLCKKLGAGYFGEVFEALWKGQVHVAV
                     KVISRDNLLHQHTFQAEIQAMKKLRHKHILSLYAVATAGDPVYIITELMPKGNLLQLL
                     RDSDEKALPILELVDFASQVAEGMCYLESQNYIHRDLAARNVLVTENNLCKVGDFGLA
                     RLVKEDIYLSHEHNVPYKWTAPEALSRGHYSIKSDVWSFGVLLHEIFSRGQMPYPGMS
                     NHETFLRVDAGYRMPCPLECPPNIHKLMLSCWSRDPKQRPCFKDLCEKLTGITRYENL
                     V"
     exon            516..637
                     /gene="Ptk6"
                     /gene_synonym="BRK; Sik; tks; Tksk"
                     /inference="alignment:Splign:2.1.0"
     exon            638..801
                     /gene="Ptk6"
                     /gene_synonym="BRK; Sik; tks; Tksk"
                     /inference="alignment:Splign:2.1.0"
     exon            802..955
                     /gene="Ptk6"
                     /gene_synonym="BRK; Sik; tks; Tksk"
                     /inference="alignment:Splign:2.1.0"
     exon            956..1117
                     /gene="Ptk6"
                     /gene_synonym="BRK; Sik; tks; Tksk"
                     /inference="alignment:Splign:2.1.0"
     exon            1118..1299
                     /gene="Ptk6"
                     /gene_synonym="BRK; Sik; tks; Tksk"
                     /inference="alignment:Splign:2.1.0"
     exon            1300..1453
                     /gene="Ptk6"
                     /gene_synonym="BRK; Sik; tks; Tksk"
                     /inference="alignment:Splign:2.1.0"
     exon            1454..2286
                     /gene="Ptk6"
                     /gene_synonym="BRK; Sik; tks; Tksk"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tccatgtaac tgtggctagg tcttgtcaag gggttgttta gctggctggc tttcactgag
       61 cacacagcat ggctttatcc tgtggacaaa agaagataca gggtctagaa gggccttcgg
      121 ggtggggctg ggatagtcca tctctaatca gtgctgggtg tggctgctct cctgcccatc
      181 ataaggaagt aggtgtgact agctttctgg gaaaagtccc tcctacccct accagtacta
      241 agtgtccaca agcaggccac agctgactct gccactaagc ttgccatggt gtcttgggac
      301 aaggctcacc tgggtcctaa gtatgtgggc ctctgggact tcaaggcacg gacagatgag
      361 gagctgagct ttcaggcagg agacctcctc catgttacca agaaggagga actgtggtgg
      421 tgggccaccc tgctggatgc agaaggcaag gccttggctg agggctatgt gcctcacaac
      481 tacctggctg agaaggaaac tgtggagtct gaaccgtggt tctttggttg catctcccgc
      541 tcagaggcca tgcacaggct gcaggctgag gacaactcga agggtgcctt cctgatcaga
      601 gtcagccaga agccaggagc agactatgtc ctctctgtcc gggatgctca ggccgtgcga
      661 cattacagga tctggaagaa caacgagggc cggctgcacc tgaatgaggc ggtatccttc
      721 tccaatctgt ctgagcttgt ggactaccat aagacccaga gcctgtctca tggcctacag
      781 ctgtccatgc cctgctggaa gcacaaaact gagcccttgc cccactggga tgactgggag
      841 aggccgaggg aggagttcac actctgtaag aagctggggg ccggctactt tggggaggtc
      901 tttgaagcgc tctggaaagg ccaggtccat gtggctgtga aggtgatctc tagagacaat
      961 ctcctgcacc agcacacctt ccaggctgag attcaggcca tgaagaagct gcggcacaag
     1021 cacatcctgt cactgtacgc tgtggcgact gcaggggacc cggtctacat catcacggag
     1081 ctcatgccca aggggaacct gctgcagcta ctgcgtgact ctgatgagaa agccctgcct
     1141 attttggagc tggtggactt tgcatcacag gttgctgagg gcatgtgcta cctggaatct
     1201 cagaattaca tccaccgtga cctggctgca aggaacgttc ttgttacaga gaacaatctc
     1261 tgcaaagtgg gggactttgg gcttgccagg cttgtcaagg aggacatcta cctttcccat
     1321 gagcacaatg tcccctacaa atggacagca cctgaggcac tttcccgagg gcattactcc
     1381 atcaagtctg atgtctggtc ttttggagtt cttcttcatg aaattttcag cagggggcag
     1441 atgccctacc caggcatgtc caatcatgaa accttcctga gggtggatgc cggctaccgc
     1501 atgccctgcc ctctggagtg cccacccaac atacacaagc tgatgctcag ctgctggagc
     1561 agagacccca agcagagacc ttgcttcaaa gacctgtgtg agaaactcac aggtatcacc
     1621 aggtatgaga acctggtctg agctccttgg acgtggccag gacccacaga agagggcctc
     1681 gtgattatcc tggacttcta ttgaaggcat gaaccatcct tcagtttact gagatgaagg
     1741 gataggaaac ataccaaaca tacctcaaat actgcgtttt gtcaaggaaa gagtaaagag
     1801 gctcctttcc cttttttggg gggggggggt ttcgagacag ggtttctctg tatagccctg
     1861 gctctcctgg aactcacttt gtagaggagg ctggcctcaa actcagaaat ctgcctgcct
     1921 ctgcctccca agtgctggga tcaaaggcgt gcgcaacccg gcttcctttc cctcctccag
     1981 gaggcaatac acaaaatcca gaaagtcact ctctggcttc ttcctccctt ctcctgtgaa
     2041 gacttcatgt gacagagaag ccaagaagag tctaggcaac aggccttgtg gagttctttt
     2101 cataccactt ttggagcttg actgtccaca aacacatacc ctacccttta gcaccttaat
     2161 tctgcaggat cttatgccac atacaaccca gaacaagttt acatgatttt ctctttataa
     2221 ccttggtttt gttggaggat cctcacctag aaagttgaag acagagataa atggatatga
     2281 aatttc
//
