LOCUS       NM_001162366            4051 bp    mRNA    linear   ROD 10-DEC-2024
DEFINITION  Mus musculus PTK2 protein tyrosine kinase 2 beta (Ptk2b),
            transcript variant 1, mRNA.
ACCESSION   NM_001162366 XM_006518726
VERSION     NM_001162366.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4051)
  AUTHORS   Toshima,T., Yagi,M., Do,Y., Hirai,H., Kunisaki,Y., Kang,D. and
            Uchiumi,T.
  TITLE     Mitochondrial translation failure represses cholesterol gene
            expression via Pyk2-Gsk3beta-Srebp2 axis
  JOURNAL   Life Sci Alliance 7 (7), e202302423 (2024)
   PUBMED   38719751
  REMARK    GeneRIF: Mitochondrial translation failure represses cholesterol
            gene expression via Pyk2-Gsk3beta-Srebp2 axis.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4051)
  AUTHORS   Lopez-Molina,L., Sancho-Balsells,A., Al-Massadi,O., Montalban,E.,
            Alberch,J., Arranz,B., Girault,J.A. and Giralt,A.
  TITLE     Hippocampal Pyk2 regulates specific social skills: Implications for
            schizophrenia
  JOURNAL   Neurobiol Dis 194, 106487 (2024)
   PUBMED   38552722
  REMARK    GeneRIF: Hippocampal Pyk2 regulates specific social skills:
            Implications for schizophrenia.
REFERENCE   3  (bases 1 to 4051)
  AUTHORS   Lin,Y., Yang,J., Yang,Q., Zeng,S., Zhang,J., Zhu,Y., Tong,Y.,
            Li,L., Tan,W., Chen,D. and Sun,Q.
  TITLE     PTK2B promotes TBK1 and STING oligomerization and enhances the
            STING-TBK1 signaling
  JOURNAL   Nat Commun 14 (1), 7567 (2023)
   PUBMED   37989995
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4051)
  AUTHORS   Zhou,G., Zhu,F., Zhang,H., Wang,Y., Yang,Y., Jin,G., Wang,Y.,
            Dong,G. and Xiong,H.
  TITLE     PTK2B regulates immune responses of neutrophils and protects
            mucosal inflammation in ulcerative colitis
  JOURNAL   FASEB J 37 (7), e22967 (2023)
   PUBMED   37269155
REFERENCE   5  (bases 1 to 4051)
  AUTHORS   Hao,K.M., Liu,Z., Wang,H.Y. and Qi,W.X.
  TITLE     [Time dependent expression profiling of PTK2B and its relationship
            with Abeta, Tau and LRP-1 in hippocampus and blood of APPswe/PS1dE9
            double-transgenic mouse]
  JOURNAL   Zhongguo Ying Yong Sheng Li Xue Za Zhi 38 (1), 17-24 (2022)
   PUBMED   35634664
  REMARK    GeneRIF: [Time dependent expression profiling of PTK2B and its
            relationship with Abeta, Tau and LRP-1 in hippocampus and blood of
            APPswe/PS1dE9 double-transgenic mouse].
REFERENCE   6  (bases 1 to 4051)
  AUTHORS   Guinamard,R., Okigaki,M., Schlessinger,J. and Ravetch,J.V.
  TITLE     Absence of marginal zone B cells in Pyk-2-deficient mice defines
            their role in the humoral response
  JOURNAL   Nat Immunol 1 (1), 31-36 (2000)
   PUBMED   10881171
REFERENCE   7  (bases 1 to 4051)
  AUTHORS   Masuhara,M., Nagao,K., Nishikawa,M., Sasaki,M., Yoshimura,A. and
            Osawa,M.
  TITLE     Molecular cloning of murine STAP-1, the stem-cell-specific adaptor
            protein containing PH and SH2 domains
  JOURNAL   Biochem Biophys Res Commun 268 (3), 697-703 (2000)
   PUBMED   10679268
REFERENCE   8  (bases 1 to 4051)
  AUTHORS   Timms,J.F., Swanson,K.D., Marie-Cardine,A., Raab,M., Rudd,C.E.,
            Schraven,B. and Neel,B.G.
  TITLE     SHPS-1 is a scaffold for assembling distinct adhesion-regulated
            multi-protein complexes in macrophages
  JOURNAL   Curr Biol 9 (16), 927-930 (1999)
   PUBMED   10469599
REFERENCE   9  (bases 1 to 4051)
  AUTHORS   Lakkakorpi,P.T., Nakamura,I., Nagy,R.M., Parsons,J.T., Rodan,G.A.
            and Duong,L.T.
  TITLE     Stable association of PYK2 and p130(Cas) in osteoclasts and their
            co-localization in the sealing zone
  JOURNAL   J Biol Chem 274 (8), 4900-4907 (1999)
   PUBMED   9988732
REFERENCE   10 (bases 1 to 4051)
  AUTHORS   Avraham,S., London,R., Fu,Y., Ota,S., Hiregowdara,D., Li,J.,
            Jiang,S., Pasztor,L.M., White,R.A., Groopman,J.E. et al.
  TITLE     Identification and characterization of a novel related adhesion
            focal tyrosine kinase (RAFTK) from megakaryocytes and brain
  JOURNAL   J Biol Chem 270 (46), 27742-27751 (1995)
   PUBMED   7499242
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC140329.3, BY206153.1, BY203814.1, AK150105.1, AI181574.1 and
            CD775714.1.
            
            On or before Jan 30, 2018 this sequence version replaced
            XM_006518726.3, NM_001162366.1.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1). Variants 1 and 4
            encode the same isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR7974084.24225.1,
                                           SRR6116558.14266.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-23                AC140329.3         152933-152955       c
            24-60               BY206153.1         1-37
            61-459              BY203814.1         2-400
            460-2496            AK150105.1         391-2427
            2497-2913           AI181574.1         111-527
            2914-3447           AK150105.1         2833-3366
            3448-4051           CD775714.1         1-604               c
FEATURES             Location/Qualifiers
     source          1..4051
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="14"
                     /map="14 34.36 cM"
     gene            1..4051
                     /gene="Ptk2b"
                     /gene_synonym="CADTK; CAKB; CAKbeta; E430023O05Rik; FADK2;
                     FAK2; PYK2; Raftk"
                     /note="PTK2 protein tyrosine kinase 2 beta"
                     /db_xref="GeneID:19229"
                     /db_xref="MGI:MGI:104908"
     exon            1..170
                     /gene="Ptk2b"
                     /gene_synonym="CADTK; CAKB; CAKbeta; E430023O05Rik; FADK2;
                     FAK2; PYK2; Raftk"
                     /inference="alignment:Splign:2.1.0"
     exon            171..411
                     /gene="Ptk2b"
                     /gene_synonym="CADTK; CAKB; CAKbeta; E430023O05Rik; FADK2;
                     FAK2; PYK2; Raftk"
                     /inference="alignment:Splign:2.1.0"
     exon            412..590
                     /gene="Ptk2b"
                     /gene_synonym="CADTK; CAKB; CAKbeta; E430023O05Rik; FADK2;
                     FAK2; PYK2; Raftk"
                     /inference="alignment:Splign:2.1.0"
     exon            591..678
                     /gene="Ptk2b"
                     /gene_synonym="CADTK; CAKB; CAKbeta; E430023O05Rik; FADK2;
                     FAK2; PYK2; Raftk"
                     /inference="alignment:Splign:2.1.0"
     exon            679..758
                     /gene="Ptk2b"
                     /gene_synonym="CADTK; CAKB; CAKbeta; E430023O05Rik; FADK2;
                     FAK2; PYK2; Raftk"
                     /inference="alignment:Splign:2.1.0"
     exon            759..821
                     /gene="Ptk2b"
                     /gene_synonym="CADTK; CAKB; CAKbeta; E430023O05Rik; FADK2;
                     FAK2; PYK2; Raftk"
                     /inference="alignment:Splign:2.1.0"
     exon            822..876
                     /gene="Ptk2b"
                     /gene_synonym="CADTK; CAKB; CAKbeta; E430023O05Rik; FADK2;
                     FAK2; PYK2; Raftk"
                     /inference="alignment:Splign:2.1.0"
     exon            877..1017
                     /gene="Ptk2b"
                     /gene_synonym="CADTK; CAKB; CAKbeta; E430023O05Rik; FADK2;
                     FAK2; PYK2; Raftk"
                     /inference="alignment:Splign:2.1.0"
     exon            1018..1092
                     /gene="Ptk2b"
                     /gene_synonym="CADTK; CAKB; CAKbeta; E430023O05Rik; FADK2;
                     FAK2; PYK2; Raftk"
                     /inference="alignment:Splign:2.1.0"
     exon            1093..1194
                     /gene="Ptk2b"
                     /gene_synonym="CADTK; CAKB; CAKbeta; E430023O05Rik; FADK2;
                     FAK2; PYK2; Raftk"
                     /inference="alignment:Splign:2.1.0"
     exon            1195..1312
                     /gene="Ptk2b"
                     /gene_synonym="CADTK; CAKB; CAKbeta; E430023O05Rik; FADK2;
                     FAK2; PYK2; Raftk"
                     /inference="alignment:Splign:2.1.0"
     exon            1313..1352
                     /gene="Ptk2b"
                     /gene_synonym="CADTK; CAKB; CAKbeta; E430023O05Rik; FADK2;
                     FAK2; PYK2; Raftk"
                     /inference="alignment:Splign:2.1.0"
     exon            1353..1399
                     /gene="Ptk2b"
                     /gene_synonym="CADTK; CAKB; CAKbeta; E430023O05Rik; FADK2;
                     FAK2; PYK2; Raftk"
                     /inference="alignment:Splign:2.1.0"
     exon            1400..1450
                     /gene="Ptk2b"
                     /gene_synonym="CADTK; CAKB; CAKbeta; E430023O05Rik; FADK2;
                     FAK2; PYK2; Raftk"
                     /inference="alignment:Splign:2.1.0"
     exon            1451..1548
                     /gene="Ptk2b"
                     /gene_synonym="CADTK; CAKB; CAKbeta; E430023O05Rik; FADK2;
                     FAK2; PYK2; Raftk"
                     /inference="alignment:Splign:2.1.0"
     exon            1549..1633
                     /gene="Ptk2b"
                     /gene_synonym="CADTK; CAKB; CAKbeta; E430023O05Rik; FADK2;
                     FAK2; PYK2; Raftk"
                     /inference="alignment:Splign:2.1.0"
     exon            1634..1734
                     /gene="Ptk2b"
                     /gene_synonym="CADTK; CAKB; CAKbeta; E430023O05Rik; FADK2;
                     FAK2; PYK2; Raftk"
                     /inference="alignment:Splign:2.1.0"
     exon            1735..1850
                     /gene="Ptk2b"
                     /gene_synonym="CADTK; CAKB; CAKbeta; E430023O05Rik; FADK2;
                     FAK2; PYK2; Raftk"
                     /inference="alignment:Splign:2.1.0"
     exon            1851..1951
                     /gene="Ptk2b"
                     /gene_synonym="CADTK; CAKB; CAKbeta; E430023O05Rik; FADK2;
                     FAK2; PYK2; Raftk"
                     /inference="alignment:Splign:2.1.0"
     exon            1952..2041
                     /gene="Ptk2b"
                     /gene_synonym="CADTK; CAKB; CAKbeta; E430023O05Rik; FADK2;
                     FAK2; PYK2; Raftk"
                     /inference="alignment:Splign:2.1.0"
     exon            2042..2246
                     /gene="Ptk2b"
                     /gene_synonym="CADTK; CAKB; CAKbeta; E430023O05Rik; FADK2;
                     FAK2; PYK2; Raftk"
                     /inference="alignment:Splign:2.1.0"
     exon            2247..2355
                     /gene="Ptk2b"
                     /gene_synonym="CADTK; CAKB; CAKbeta; E430023O05Rik; FADK2;
                     FAK2; PYK2; Raftk"
                     /inference="alignment:Splign:2.1.0"
     exon            2356..2421
                     /gene="Ptk2b"
                     /gene_synonym="CADTK; CAKB; CAKbeta; E430023O05Rik; FADK2;
                     FAK2; PYK2; Raftk"
                     /inference="alignment:Splign:2.1.0"
     exon            2422..2547
                     /gene="Ptk2b"
                     /gene_synonym="CADTK; CAKB; CAKbeta; E430023O05Rik; FADK2;
                     FAK2; PYK2; Raftk"
                     /inference="alignment:Splign:2.1.0"
     exon            2548..2694
                     /gene="Ptk2b"
                     /gene_synonym="CADTK; CAKB; CAKbeta; E430023O05Rik; FADK2;
                     FAK2; PYK2; Raftk"
                     /inference="alignment:Splign:2.1.0"
     exon            2695..2730
                     /gene="Ptk2b"
                     /gene_synonym="CADTK; CAKB; CAKbeta; E430023O05Rik; FADK2;
                     FAK2; PYK2; Raftk"
                     /inference="alignment:Splign:2.1.0"
     exon            2731..2755
                     /gene="Ptk2b"
                     /gene_synonym="CADTK; CAKB; CAKbeta; E430023O05Rik; FADK2;
                     FAK2; PYK2; Raftk"
                     /inference="alignment:Splign:2.1.0"
     exon            2756..2802
                     /gene="Ptk2b"
                     /gene_synonym="CADTK; CAKB; CAKbeta; E430023O05Rik; FADK2;
                     FAK2; PYK2; Raftk"
                     /inference="alignment:Splign:2.1.0"
     exon            2803..2940
                     /gene="Ptk2b"
                     /gene_synonym="CADTK; CAKB; CAKbeta; E430023O05Rik; FADK2;
                     FAK2; PYK2; Raftk"
                     /inference="alignment:Splign:2.1.0"
     exon            2941..3021
                     /gene="Ptk2b"
                     /gene_synonym="CADTK; CAKB; CAKbeta; E430023O05Rik; FADK2;
                     FAK2; PYK2; Raftk"
                     /inference="alignment:Splign:2.1.0"
     exon            3022..4034
                     /gene="Ptk2b"
                     /gene_synonym="CADTK; CAKB; CAKbeta; E430023O05Rik; FADK2;
                     FAK2; PYK2; Raftk"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4004..4009
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ptk2b"
                     /gene_synonym="CADTK; CAKB; CAKbeta; E430023O05Rik; FADK2;
                     FAK2; PYK2; Raftk"
                     /note="hexamer: ATTAAA"
     polyA_site      4034
                     /gene="Ptk2b"
                     /gene_synonym="CADTK; CAKB; CAKbeta; E430023O05Rik; FADK2;
                     FAK2; PYK2; Raftk"
                     /note="major polyA site"
ORIGIN      
        1 ggagaggaga gcagcagggg tgtggttaac gaccgagagg aggaggggga aaaacaacct
       61 gtcagcctct tactcagcct ctgcaggcag agccgcgcgt cctacctgcg gcggctgcgc
      121 tcacctggcc cagcccggag ccctggcccg agtccgcgcc tcgcccgagg gactgcaatg
      181 tgccggtcct agctgcagtc tgagaggatg tccggggtgt ctgagccctt gagccgtgta
      241 aaagtgggca ctttacgccg gcctgagggc cccccagagc ccatggtggt ggtaccagtg
      301 gatgtggaga aggaagacgt gcgcatcctc aaggtctgct tctacagcaa cagcttcaac
      361 ccagggaaga acttcaagct tgtcaaatgc acagtgcaga cagagatcca ggagatcatc
      421 acctccatcc tcctgagtgg gcgaataggg cccaacatcc agctggctga atgctatggg
      481 ctgaggctga agcacatgaa gtcagacgag atccactggc tgcacccaca gatgaccgtg
      541 ggcgaagtgc aggacaagta tgaatgtcta cacgtggaag ctgagtggag gtatgacctt
      601 caaatccgct acttgccgga agacttcatg gagagcctga aagaagacag gaccacattg
      661 ctgtactttt atcaacagct ccggaatgac tacatgcaac gctacgccag caaggtcagt
      721 gaaggcatgg ctctgcagct gggctgtctg gagctcagga gattcttcaa ggacatgccc
      781 cacaatgcac tggacaaaaa gtccaacttt gaactcctgg aaaaagaagt cggtctggac
      841 ctgtttttcc caaagcagat gcaggaaaac ttaaagccca agcagttccg gaagatgatc
      901 cagcagacct tccagcagta tgcatcactc cgggaggaag agtgtgtcat gaaattcttc
      961 aataccctag cgggctttgc caacattgac caggagacct accgctgcga actcattcaa
     1021 ggatggaaca ttactgtgga cctggtcatc ggccctaaag gcatccgtca gctgacaagt
     1081 caagatacaa agcccacctg cctggccgag tttaagcaga tcaaatccat caggtgcctc
     1141 ccattggaag agacccaggc agtcctgcag ctgggcatcg agggtgcccc ccagtccttg
     1201 tctatcaaaa cgtcgtccct ggcagaggct gagaacatgg ctgacctcat agatggctac
     1261 tgcaggctgc aaggagaaca taagggctct ctcatcatgc atgccaagaa agatggtgag
     1321 aagaggaaca gcctgcctca gatccccaca ctaaacctgg aggctcggcg gtcgcacctc
     1381 tcagaaagct gcagcataga gtcagacatc tatgcggaga ttcccgatga gaccctgcga
     1441 agaccaggag gtccacagta cggtgttgcc cgtgaagaag tagttcttaa ccgcattctg
     1501 ggtgaaggct tctttgggga ggtctatgaa ggtgtctaca cgaaccacaa aggggaaaaa
     1561 attaatgtgg ccgtcaagac ctgtaagaaa gactgtaccc aggacaacaa ggagaagttc
     1621 atgagtgagg cagtgatcat gaagaatctt gaccaccctc acatcgtgaa gctgattggc
     1681 atcattgaag aggaacccac ctggattatc atggaactgt atccttatgg ggagctggga
     1741 cactacctgg aacgaaataa aaactccctg aaggtaccca ctctggtcct gtacacccta
     1801 cagatatgca aagccatggc ctatctggag agcatcaact gtgtgcacag ggatattgct
     1861 gtccggaaca tcctggtggc ctctcctgag tgtgtgaagc tgggggactt tgggctctcc
     1921 cggtacattg aggacgaaga ctattacaaa gcctctgtga cccgtctacc catcaaatgg
     1981 atgtcccccg agtccatcaa cttccgccgc ttcacaaccg ccagtgatgt ctggatgttt
     2041 gctgtatgca tgtgggagat cctcagcttt gggaagcagc ctttcttctg gctcgaaaat
     2101 aaggatgtca tcggagtgct ggagaaaggg gacaggctgc ccaagcccga actctgtccg
     2161 cctgtccttt acacactcat gactcgctgc tgggactacg accccagtga ccggccccgc
     2221 ttcacggagc ttgtgtgcag cctcagtgac atttatcaga tggagaagga cattgccata
     2281 gagcaagaaa ggaatgctcg ctaccgaccc cccaaaatat tggagcctac tacctttcag
     2341 gaacccccac ccaagcccag ccggcccaag tacagacctc ctccacagac caacctgctg
     2401 gctcctaagc tgcagttcca ggtccctgag ggtctgtgtg ccagctctcc tacgcttacc
     2461 agccctatgg agtatccatc tccagttaac tcgctacaca ccccacctct ccaccggcac
     2521 aatgtcttca agcgccacag catgcgggag gaggacttca tccggcccag tagccgagaa
     2581 gaggcccagc agctctggga ggcagagaag atcaagatga agcaggtcct agaaagacag
     2641 cagaagcaga tggtggaaga ttcccagtgg ctgaggcgag aggaaagatg cttggaccct
     2701 atggtttata tgaatgacaa gtccccactg actccagaga aggaggccgg ctacacggag
     2761 ttcacagggc ccccacagaa accacctcgg ctcggtgcac agtccattca gcccacagcc
     2821 aacctggaca ggaccgatga cctcgtgtac cacaatgtca tgaccctggt ggaggctgtg
     2881 ctggaactca agaacaagct tggccagttg ccccctgagg actatgtggt ggtggtgaag
     2941 aacgtggggc tgaacctgcg gaagctcatc ggcagtgtgg acgatctctt gccctccttg
     3001 ccggcatctt cgaggacaga gattgaaggg acccagaaac tgctcaacaa agacctggca
     3061 gagctcatca acaagatgaa gttggctcag cagaacgccg tgacgtccct gagtgaggac
     3121 tgcaagcggc agatgctcac agcgtcccat accctggctg tggatgccaa gaacctgctg
     3181 gatgctgtgg accaagccaa ggttgtggct aatctggccc acccgcctgc agagtgatca
     3241 agagaggggc cacctgcctg catcttctgc ccccacctgt cttggcatac ctttcctgcc
     3301 ttgcctttgg ttattggtct tccagggaaa gctgagaaga gtccatcccc cttgccactt
     3361 tgcacgacac cccctcttcc cccaacccac cccagactgt gctactcagg ctgcatctgg
     3421 acagaaagga ctctgggcac agacacgggg tggggtgaca tagttcatag gggtactact
     3481 gccagccact ccctcttacc ccagcctggg ttgctggagc atcattgggg tcatgagtgt
     3541 acccctaacg gccaagatgg ctttctgcat ggacatttga gagccagtat tcctccttcc
     3601 tcttcagccc tcagggaccc ctgatacaga ggggacagag aggggtttta tttgtagaga
     3661 agctggtgag atgagggctg gacctggctc tcttgtacag tgtacattgg aatttattta
     3721 atgtgagttt gacctggatg gacagccaag ggccatagtc caggagcaaa ccaatccagt
     3781 cacaggactc tgtgttttta tggaactgag tgccacaggg aagaagcaga gagtcggagg
     3841 tcagaatggg actttgtgcc cttcctgcgt ttctcttctc cctctttcct tctcccctct
     3901 tttcttacgt ctcctttttc tcctccccct tttcacatct gctcccctcc tctctcatgt
     3961 ctgtggagaa catttacctt ccttcttttt gatcggtggt tgaattaaaa ttattaccat
     4021 ttgctttgtg gttaaaaaaa aaaaaaaaaa a
//
