LOCUS       NM_008970               1455 bp    mRNA    linear   ROD 10-DEC-2024
DEFINITION  Mus musculus parathyroid hormone-like peptide (Pthlh), mRNA.
ACCESSION   NM_008970
VERSION     NM_008970.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1455)
  AUTHORS   Almubarak,A., Zhang,Q., Zhang,C.H., Abdelwahab,N., Kume,T.,
            Lassar,A.B. and Berry,F.B.
  TITLE     FOXC1 and FOXC2 regulate growth plate chondrocyte maturation
            towards hypertrophy in the embryonic mouse limb skeleton
  JOURNAL   Development 151 (16) (2024)
   PUBMED   39012257
REFERENCE   2  (bases 1 to 1455)
  AUTHORS   McGarry,S., Kover,K., Heruth,D.P., Dallas,M., Jin,X., Wu,S. and De
            Luca,F.
  TITLE     Intermittent mechanical loading on mouse tibia accelerates
            longitudinal bone growth by inducing PTHrP expression in the female
            tibial growth plate
  JOURNAL   Physiol Rep 12 (15), e16168 (2024)
   PUBMED   39090666
  REMARK    GeneRIF: Intermittent mechanical loading on mouse tibia accelerates
            longitudinal bone growth by inducing PTHrP expression in the female
            tibial growth plate.
REFERENCE   3  (bases 1 to 1455)
  AUTHORS   Raudales,R., Kim,G., Kelly,S.M., Hatfield,J., Guan,W., Zhao,S.,
            Paul,A., Qian,Y., Li,B. and Huang,Z.J.
  TITLE     Specific and comprehensive genetic targeting reveals brain-wide
            distribution and synaptic input patterns of GABAergic axo-axonic
            interneurons
  JOURNAL   Elife 13, 93481 (2024)
   PUBMED   39012795
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1455)
  AUTHORS   Carabana,C., Sun,W., Veludo Ramos,C., Huyghe,M., Perkins,M.,
            Maillot,A., Journot,R., Hartani,F., Faraldo,M.M., Lloyd-Lewis,B.
            and Fre,S.
  TITLE     Spatially distinct epithelial and mesenchymal cell subsets along
            progressive lineage restriction in the branching embryonic mammary
            gland
  JOURNAL   EMBO J 43 (12), 2308-2336 (2024)
   PUBMED   38760574
REFERENCE   5  (bases 1 to 1455)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   6  (bases 1 to 1455)
  AUTHORS   Seldin,M.F., Mattei,M.G. and Hendy,G.N.
  TITLE     Localization of mouse parathyroid hormone-like peptide gene (Pthlh)
            to distal chromosome 6 using interspecific backcross mice and in
            situ hybridization
  JOURNAL   Cytogenet Cell Genet 60 (3-4), 252-254 (1992)
   PUBMED   1354597
REFERENCE   7  (bases 1 to 1455)
  AUTHORS   Szpirer,C., Riviere,M., Szpirer,J., Hanson,C., Levan,G. and
            Hendy,G.N.
  TITLE     Assignment of the rat parathyroid hormone-like peptide gene (PTHLH)
            to chromosome 4: evidence for conserved synteny between human
            chromosome 12, mouse chromosome 6, and rat chromosome 4
  JOURNAL   Cytogenet Cell Genet 56 (3-4), 193-195 (1991)
   PUBMED   2055117
REFERENCE   8  (bases 1 to 1455)
  AUTHORS   Mangin,M., Ikeda,K. and Broadus,A.E.
  TITLE     Structure of the mouse gene encoding parathyroid hormone-related
            peptide
  JOURNAL   Gene 95 (2), 195-202 (1990)
   PUBMED   2249778
REFERENCE   9  (bases 1 to 1455)
  AUTHORS   Hendy,G.N., Sakaguchi,A.Y., Lalley,P.A., Martinez,L., Yasuda,T.,
            Banville,D. and Goltzman,D.
  TITLE     Gene for parathyroid hormone-like peptide is on mouse chromosome 6
  JOURNAL   Cytogenet Cell Genet 53 (2-3), 80-82 (1990)
   PUBMED   1973379
REFERENCE   10 (bases 1 to 1455)
  AUTHORS   Yasuda,T., Banville,D., Rabbani,S.A., Hendy,G.N. and Goltzman,D.
  TITLE     Rat parathyroid hormone-like peptide: comparison with the human
            homologue and expression in malignant and normal tissue
  JOURNAL   Mol Endocrinol 3 (3), 518-525 (1989)
   PUBMED   2747658
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from CJ063300.1, CJ063309.1,
            AY220497.1, AC156278.8 and AW488290.1.
            
            On Jul 11, 2015 this sequence version replaced NM_008970.3.
            
            Summary: This gene encodes a member of the parathyroid family of
            hormones that possesses distinct paracrine and intracrine signaling
            roles such as regulation of circulating calcium, transplacental
            calcium transport, osteoclast inhibition, renal bicarbonate
            excretion and regulation of apoptosis. The encoded protein
            undergoes proteolytic processing to generate multiple active
            peptides with distinct signaling functions. The homozygous deletion
            of this gene leads to death shortly after birth with a
            chondrodystrophic phenotype characterized by premature chondrocyte
            differentiation and accelerated bone formation. [provided by
            RefSeq, Jul 2015].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC058187.1, AY220497.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164133 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-92                CJ063300.1         2-93
            93-167              CJ063309.1         49-123
            168-949             AY220497.1         1-782
            950-950             AC156278.8         69363-69363
            951-1396            AY220497.1         784-1229
            1397-1455           AW488290.1         1-59                c
FEATURES             Location/Qualifiers
     source          1..1455
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 78.19 cM"
     gene            1..1455
                     /gene="Pthlh"
                     /gene_synonym="PLP; PTH-like; Pthrp"
                     /note="parathyroid hormone-like peptide"
                     /db_xref="GeneID:19227"
                     /db_xref="MGI:MGI:97800"
     exon            1..429
                     /gene="Pthlh"
                     /gene_synonym="PLP; PTH-like; Pthrp"
                     /inference="alignment:Splign:2.1.0"
     exon            430..555
                     /gene="Pthlh"
                     /gene_synonym="PLP; PTH-like; Pthrp"
                     /inference="alignment:Splign:2.1.0"
     CDS             455..982
                     /gene="Pthlh"
                     /gene_synonym="PLP; PTH-like; Pthrp"
                     /note="parathyroid hormone-like protein; parathyroid
                     hormone-related peptide; parathyroid hormone-related
                     protein; PTH-related peptide; parathyroid hormone-like
                     hormone"
                     /codon_start=1
                     /product="parathyroid hormone-related protein
                     preproprotein"
                     /protein_id="NP_032996.2"
                     /db_xref="CCDS:CCDS39717.1"
                     /db_xref="GeneID:19227"
                     /db_xref="MGI:MGI:97800"
                     /translation="MLRRLVQQWSVLVFLLSYSVPSRGRSVEGLGRRLKRAVSEHQLL
                     HDKGKSIQDLRRRFFLHHLIAEIHTAEIRATSEVSPNSKPAPNTKNHPVRFGSDDEGR
                     YLTQETNKVETYKEQPLKTPGKKKKGKPGKRREQEKKKRRTRSAWPSTAASGLLEDPL
                     PHTSRPSLEPSLRTH"
     exon            556..972
                     /gene="Pthlh"
                     /gene_synonym="PLP; PTH-like; Pthrp"
                     /inference="alignment:Splign:2.1.0"
     exon            973..1441
                     /gene="Pthlh"
                     /gene_synonym="PLP; PTH-like; Pthrp"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcggccacct ggccctcgca tccacgacac gcgcgcctgc aacttgttca agggcgttgt
       61 ggaatcaact ttccggaagc aaccagccca ccgaaggagg tagaccgaca gctatgtata
      121 tatacgcgct ctgccgcaag tggctgtgca cccagaggcc cggtgcgcag gacagctgac
      181 tcctgaggaa cacccgcgtt tgaagagggg tttgacctgc cccacgaccc agagtgctgc
      241 cgccaagact aattagacat tgctatggga gccacagcaa cgcgccacgc atccccgacg
      301 cctatgtaaa acgcccggtt ttcgctcttc tttcagagga agctctctga ttgctttttc
      361 ccctctcggg tccctttttg cctgtgcggt ttgagagagg cgcagttaga ggcgctgatt
      421 cctacacaag tccccagagc cagcgagcgg cacgatgctg cggaggctgg ttcagcagtg
      481 gagtgtcctg gtattcctgc tcagctactc cgtgccctcc cgcgggcgtt cggtggaggg
      541 gcttggccgc aggctcaaac gcgctgtgtc tgaacatcag ctactgcatg acaagggcaa
      601 gtccatccaa gacttgcgcc gccgtttctt cctccaccat ctgatcgcgg agatccacac
      661 agccgaaatc agagctacct cggaggtgtc ccccaactcc aaacctgctc ccaacaccaa
      721 aaaccacccc gtgcggtttg ggtcagacga tgagggcaga tacctaactc aggaaaccaa
      781 caaggtggag acgtacaaag aacagccact caagacaccc gggaagaaga agaaaggcaa
      841 gcctgggaaa cgcagagaac aggagaaaaa gaagcgaagg actcggtctg cctggccaag
      901 cacagctgcg agtggcctgc ttgaggaccc cctgccccac acctccaggc cctcgctgga
      961 gcccagctta aggacgcatt gaaattttca tcgaagatct tccaaggaca cgttacagga
     1021 ttttgtaata gtaaacatat ggaaagtatt agacatattt attgcctgta catactgtaa
     1081 atgcattggg atcaaactgt ctccccagga aactgcacat gggtcatgtg aatatttttc
     1141 ccttttgcca aggctaatcc aattattcct gtcactgtta ccataattta ttttgtcaac
     1201 tgatgtattt atttgtaaat gtatcttggt gctgctgact ctgttttttt gtaacataat
     1261 gcactttagg tatacatatc gagtatgtgg atgaatttaa cacataaaag gatctctatt
     1321 ttgtggttca ttttaatgag ttctgaaata taattatcta gactgatttc cttctgtgca
     1381 tgtaaaaatg gcagtatttt aaatttgtaa agaatgtcta ataaaatata atctaattat
     1441 aaaaaaaaaa aaaaa
//
