LOCUS       NM_139270               2414 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus parathyroid hormone 2 receptor (Pth2r), mRNA.
ACCESSION   NM_139270
VERSION     NM_139270.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2414)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2414)
  AUTHORS   Ingham,N.J., Pearson,S.A., Vancollie,V.E., Rook,V., Lewis,M.A.,
            Chen,J., Buniello,A., Martelletti,E., Preite,L., Lam,C.C.,
            Weiss,F.D., Powis,Z., Suwannarat,P., Lelliott,C.J., Dawson,S.J.,
            White,J.K. and Steel,K.P.
  TITLE     Mouse screen reveals multiple new genes underlying mouse and human
            hearing loss
  JOURNAL   PLoS Biol 17 (4), e3000194 (2019)
   PUBMED   30973865
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2414)
  AUTHORS   Li,J., Deng,S.P., Wei,G. and Yu,P.
  TITLE     CITGeneDB: a comprehensive database of human and mouse genes
            enhancing or suppressing cold-induced thermogenesis validated by
            perturbation experiments in mice
  JOURNAL   Database (Oxford) 2018 (2018)
   PUBMED   29688375
REFERENCE   4  (bases 1 to 2414)
  AUTHORS   Gellen,B., Zelena,D., Usdin,T.B. and Dobolyi,A.
  TITLE     The parathyroid hormone 2 receptor participates in physiological
            and behavioral alterations of mother mice
  JOURNAL   Physiol Behav 181, 51-58 (2017)
   PUBMED   28890271
  REMARK    GeneRIF: This study demonstrated that The parathyroid hormone 2
            receptor participates in physiological and behavioral alterations
            of mother mice.
REFERENCE   5  (bases 1 to 2414)
  AUTHORS   Sato,E., Zhang,L.J., Dorschner,R.A., Adase,C.A., Choudhury,B.P. and
            Gallo,R.L.
  TITLE     Activation of Parathyroid Hormone 2 Receptor Induces Decorin
            Expression and Promotes Wound Repair
  JOURNAL   J Invest Dermatol 137 (8), 1774-1783 (2017)
   PUBMED   28454729
REFERENCE   6  (bases 1 to 2414)
  AUTHORS   Faber,C.A., Dobolyi,A., Sleeman,M. and Usdin,T.B.
  TITLE     Distribution of tuberoinfundibular peptide of 39 residues and its
            receptor, parathyroid hormone 2 receptor, in the mouse brain
  JOURNAL   J Comp Neurol 502 (4), 563-583 (2007)
   PUBMED   17394159
  REMARK    GeneRIF: We propose that TIP39 is an endogenous ligand of the PTH2R
            and that they form a neuromodulator system, which is optimally
            positioned to regulate limbic, endocrine, and auditory brain
            functions.
REFERENCE   7  (bases 1 to 2414)
  AUTHORS   Proctor,W.R., Wu,P.H., Bennett,B. and Johnson,T.E.
  TITLE     Differential effects of ethanol on gamma-aminobutyric acid-A
            receptor-mediated synaptic currents in congenic strains of inbred
            long and short-sleep mice
  JOURNAL   Alcohol Clin Exp Res 28 (9), 1277-1283 (2004)
   PUBMED   15365296
REFERENCE   8  (bases 1 to 2414)
  AUTHORS   John,M.R., Arai,M., Rubin,D.A., Jonsson,K.B. and Juppner,H.
  TITLE     Identification and characterization of the murine and human gene
            encoding the tuberoinfundibular peptide of 39 residues
  JOURNAL   Endocrinology 143 (3), 1047-1057 (2002)
   PUBMED   11861531
REFERENCE   9  (bases 1 to 2414)
  AUTHORS   Ehringer,M.A., Thompson,J., Conroy,O., Xu,Y., Yang,F., Canniff,J.,
            Beeson,M., Gordon,L., Bennett,B., Johnson,T.E. and Sikela,J.M.
  TITLE     High-throughput sequence identification of gene coding variants
            within alcohol-related QTLs
  JOURNAL   Mamm Genome 12 (8), 657-663 (2001)
   PUBMED   11471062
REFERENCE   10 (bases 1 to 2414)
  AUTHORS   Rubin,D.A., Hellman,P., Zon,L.I., Lobb,C.J., Bergwitz,C. and
            Juppner,H.
  TITLE     A G protein-coupled receptor from zebrafish is activated by human
            parathyroid hormone and not by human or teleost parathyroid
            hormone-related peptide. Implications for the evolutionary
            conservation of calcium-regulating peptide hormones
  JOURNAL   J Biol Chem 274 (33), 23035-23042 (1999)
   PUBMED   10438471
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AK045576.1.
            
            On Jul 23, 2006 this sequence version replaced NM_139270.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK045576.1, AF332077.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164132
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2414
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 33.05 cM"
     gene            1..2414
                     /gene="Pth2r"
                     /gene_synonym="Pthr2"
                     /note="parathyroid hormone 2 receptor"
                     /db_xref="GeneID:213527"
                     /db_xref="MGI:MGI:2180917"
     exon            1..414
                     /gene="Pth2r"
                     /gene_synonym="Pthr2"
                     /inference="alignment:Splign:2.1.0"
     CDS             340..1980
                     /gene="Pth2r"
                     /gene_synonym="Pthr2"
                     /note="PTH2 receptor; parathyroid hormone receptor 2"
                     /codon_start=1
                     /product="parathyroid hormone 2 receptor precursor"
                     /protein_id="NP_644676.1"
                     /db_xref="CCDS:CCDS15017.1"
                     /db_xref="GeneID:213527"
                     /db_xref="MGI:MGI:2180917"
                     /translation="MAWLETFTYICGWLILSSCLLVRAQLDSDGTITIEEQIVLVMKA
                     KMQCELNITAQLQEGEGNCFPEWDGIICWPRGTVGKMSAVPCPPYVYDFNHKGVAFRH
                     CTPNGTWDSIHGSNKTWANYSDCFLQPDINIGKQEFFESLYILYTVGYSISFGSLAVA
                     ILIIGYFRRLHCTRNYIHLHLFVSFMLRAMSIFVKDRVAQAHLGVEALQSLVMQGDLQ
                     NFIGGPSVDKSQYVGCKIAVVMFIYFLATNYYWILVEGLYLHNLIFVSFFSDTKYLWG
                     FISIGWGFPAVFVVAWAVARATLADTRCWELSAGDRWIYQAPILAAIGLNFILFLNTV
                     RVLATKIWETNAVGHDMRKQYRKLAKSTLVLVLVFGVHYIVFVCQPHSFSGLWWEIRM
                     HCELFFNSFQGFFVSIVYCYCNGEVQAEVKKMWTRWNLSIDWKRAPPCGGQRYGSVLT
                     TVTHSTSSQSQMGASTRLVLISGKPTKNACRQIDSHVTLPGYVWSSSEQDCQTHSPPE
                     ETKEGHRRQGDDSPVMESSRPVAFTLDTEGCKGETHPI"
     exon            415..517
                     /gene="Pth2r"
                     /gene_synonym="Pthr2"
                     /inference="alignment:Splign:2.1.0"
     exon            518..628
                     /gene="Pth2r"
                     /gene_synonym="Pthr2"
                     /inference="alignment:Splign:2.1.0"
     exon            629..744
                     /gene="Pth2r"
                     /gene_synonym="Pthr2"
                     /inference="alignment:Splign:2.1.0"
     exon            745..842
                     /gene="Pth2r"
                     /gene_synonym="Pthr2"
                     /inference="alignment:Splign:2.1.0"
     exon            843..1032
                     /gene="Pth2r"
                     /gene_synonym="Pthr2"
                     /inference="alignment:Splign:2.1.0"
     exon            1033..1186
                     /gene="Pth2r"
                     /gene_synonym="Pthr2"
                     /inference="alignment:Splign:2.1.0"
     exon            1187..1247
                     /gene="Pth2r"
                     /gene_synonym="Pthr2"
                     /inference="alignment:Splign:2.1.0"
     exon            1248..1311
                     /gene="Pth2r"
                     /gene_synonym="Pthr2"
                     /inference="alignment:Splign:2.1.0"
     exon            1312..1406
                     /gene="Pth2r"
                     /gene_synonym="Pthr2"
                     /inference="alignment:Splign:2.1.0"
     exon            1407..1545
                     /gene="Pth2r"
                     /gene_synonym="Pthr2"
                     /inference="alignment:Splign:2.1.0"
     exon            1546..1587
                     /gene="Pth2r"
                     /gene_synonym="Pthr2"
                     /inference="alignment:Splign:2.1.0"
     exon            1588..2414
                     /gene="Pth2r"
                     /gene_synonym="Pthr2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2114..2119
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Pth2r"
                     /gene_synonym="Pthr2"
                     /note="hexamer: ATTAAA"
     polyA_site      2133
                     /gene="Pth2r"
                     /gene_synonym="Pthr2"
                     /note="major polyA site"
ORIGIN      
        1 agcagacaca ccgagagtca agcctggctg cagccctgct tcgggatcgc atggcatctg
       61 agctcctggg ttgcggactg agtgactggc aaaggacgca ctggcgtcct ccgccccctc
      121 cctgcagctg tcctcggtag aaggcgggac cacccagagc cctcaggacg gggttccaga
      181 ctctggggcg caggcagcca gacccccgag agtcctggct agtgactccc gcgcctcagc
      241 tgcccagcgg tgcctcgctc cccatcacaa gtttggtcca tactggacaa gtaagcgagc
      301 ctgggataca gactgctttt gccttgggca gttttggaca tggcctggct ggagactttc
      361 acctacattt gtggatggct gattctcagt agctgtctcc tggttagagc gcagctggat
      421 tctgacggca ccatcactat agaagagcag attgttcttg ttatgaaggc taaaatgcag
      481 tgtgaactta acatcacagc ccagctccaa gaaggagaag gcaattgctt cccagaatgg
      541 gatgggatca tttgttggcc cagaggaaca gtggggaaaa tgtcagctgt gccttgccct
      601 ccgtatgttt acgacttcaa tcataaagga gttgctttcc ggcactgcac ccccaatggg
      661 acgtgggatt ctattcatgg ctcaaataaa acctgggcta actattcaga ctgctttctg
      721 cagcctgata tcaacatagg aaagcaagag ttctttgaaa gcctctacat cctgtacact
      781 gttggctact ccatctcttt tggctccttg gctgtagcca ttctcattat tggctacttc
      841 aggcgattgc attgcacgag gaactatatc catttgcatt tgttcgtgtc cttcatgctg
      901 agagccatga gcatctttgt caaggacaga gtagcccagg ctcacctggg agtagaggca
      961 ctgcagtctc tggtgatgca gggtgacctt cagaacttca ttggaggacc atctgtggac
     1021 aaatctcagt atgtggggtg caagatcgct gtcgtgatgt ttatttattt cttggctaca
     1081 aactattact ggatcctggt ggaagggctc tacctgcaca acttaatctt tgtgtctttc
     1141 ttttccgaca ccaaatacct gtggggcttc atctcgatag gctggggatt tccagcagta
     1201 tttgttgtgg cctgggcagt ggcacgagcc actctggcgg ataccaggtg ttgggaactt
     1261 agtgctggag acaggtggat ttaccaggct ccgatcttag ctgctattgg gctgaatttt
     1321 attctgttcc tgaatacagt tagagttctt gctaccaaaa tttgggaaac caatgcggtt
     1381 gggcatgaca tgagaaagca gtacaggaaa ctggctaagt caacactggt cctggtgctg
     1441 gtatttggcg tgcattacat cgtgtttgtc tgccagccgc actccttctc tgggctctgg
     1501 tgggagatcc gcatgcactg tgaactcttc ttcaactcct tccagggttt cttcgtgtct
     1561 attgtctatt gctactgcaa tggagaggtg caggctgagg tgaagaagat gtggactcga
     1621 tggaatctgt ccatcgactg gaaaagggcg ccgccttgtg gcggccaaag gtacggctcg
     1681 gtgctcacca ctgtcactca cagcaccagc agccagtcac agatgggggc aagcacgcgc
     1741 ctggtgctca tctctggcaa acccaccaag aatgcctgca gacagatcga cagccatgtg
     1801 actctacctg gctatgtctg gagtagttct gagcaggact gccaaacaca ctcgcccccc
     1861 gaggagacta aggaaggtca caggcgacag ggagatgata gtccagtgat ggagtcttcc
     1921 aggccagtgg cgttcaccct agacactgaa ggatgcaagg gagaaaccca tcctatctga
     1981 atcaccattt ccatttccgt tcctgtggat tggcagatct ggctgtgtgg gaggatctaa
     2041 gatggaagac tggaatcctg gaataaggca ttgcttaaac attttcagtt tctaccagtt
     2101 ggcttctaaa aatattaaac acacaaaagg gtattattgg ggtaatttat taatttatgt
     2161 gggcactacc ccccaaatta atactttctc tatagttatt actattttgc ttcttttgga
     2221 taagaaaagt ttcaaatgcc tgactctacc tttctctcat aaatatcacc ctgaataaga
     2281 taaagatcgt ttagtttgca tcattttcct tttaagaaat cactaatctt tatattctca
     2341 ttttaatgaa cttctgttat cacattaatt ttgtctatgt accgcaacaa tctaagaatg
     2401 tacattggaa aact
//
