LOCUS       NM_053256                569 bp    mRNA    linear   ROD 03-JUN-2024
DEFINITION  Mus musculus parathyroid hormone 2 (Pth2), mRNA.
ACCESSION   NM_053256
VERSION     NM_053256.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 569)
  AUTHORS   Sato,E., Zhang,L.J., Dorschner,R.A., Adase,C.A., Choudhury,B.P. and
            Gallo,R.L.
  TITLE     Activation of Parathyroid Hormone 2 Receptor Induces Decorin
            Expression and Promotes Wound Repair
  JOURNAL   J Invest Dermatol 137 (8), 1774-1783 (2017)
   PUBMED   28454729
  REMARK    GeneRIF: TIP39-PTH2R system appears to be a previously unrecognized
            mechanism for regulation of extracellular matrix formation and
            wound repair.
REFERENCE   2  (bases 1 to 569)
  AUTHORS   Sato,E., Muto,J., Zhang,L.J., Adase,C.A., Sanford,J.A.,
            Takahashi,T., Nakatsuji,T., Usdin,T.B. and Gallo,R.L.
  TITLE     The Parathyroid Hormone Second Receptor PTH2R and its Ligand
            Tuberoinfundibular Peptide of 39 Residues TIP39 Regulate
            Intracellular Calcium and Influence Keratinocyte Differentiation
  JOURNAL   J Invest Dermatol 136 (7), 1449-1459 (2016)
   PUBMED   27000502
REFERENCE   3  (bases 1 to 569)
  AUTHORS   Tsuda,M.C., Yeung,H.M., Kuo,J. and Usdin,T.B.
  TITLE     Incubation of Fear Is Regulated by TIP39 Peptide Signaling in the
            Medial Nucleus of the Amygdala
  JOURNAL   J Neurosci 35 (35), 12152-12161 (2015)
   PUBMED   26338326
  REMARK    GeneRIF: This study demonstrated that TIP39 signaling plays a role
            in fear incubation and suggest that may serve to ameliorate the
            long-term negative outcome of traumatic experience via
            PTH2R-expressing neurons in the Medial Nucleus of the Amygdala.
REFERENCE   4  (bases 1 to 569)
  AUTHORS   Dimitrov,E.L., Kuo,J., Kohno,K. and Usdin,T.B.
  TITLE     Neuropathic and inflammatory pain are modulated by
            tuberoinfundibular peptide of 39 residues
  JOURNAL   Proc Natl Acad Sci U S A 110 (32), 13156-13161 (2013)
   PUBMED   23878240
  REMARK    GeneRIF: Data indicate that the nociceptive phenotype of
            TIP39-knockout {KO) mice was similar to the PTH2R-KO.
REFERENCE   5  (bases 1 to 569)
  AUTHORS   Della Penna,K., Kinose,F., Sun,H., Koblan,K.S. and Wang,H.
  TITLE     Tuberoinfundibular peptide of 39 residues (TIP39): molecular
            structure and activity for parathyroid hormone 2 receptor
  JOURNAL   Neuropharmacology 44 (1), 141-153 (2003)
   PUBMED   12559132
REFERENCE   6  (bases 1 to 569)
  AUTHORS   Hansen,I.A., Jakob,O., Wortmann,S., Arzberger,T., Allolio,B. and
            Blind,E.
  TITLE     Characterization of the human and mouse genes encoding the
            tuberoinfundibular peptide of 39 residues, a ligand of the
            parathyroid hormone receptor family
  JOURNAL   J Endocrinol 174 (1), 95-102 (2002)
   PUBMED   12098667
REFERENCE   7  (bases 1 to 569)
  AUTHORS   Hoare,S.R. and Usdin,T.B.
  TITLE     Specificity and stability of a new PTH1 receptor antagonist, mouse
            TIP(7-39)
  JOURNAL   Peptides 23 (5), 989-998 (2002)
   PUBMED   12084532
  REMARK    GeneRIF: PTH1 receptor antagonism
REFERENCE   8  (bases 1 to 569)
  AUTHORS   John,M.R., Arai,M., Rubin,D.A., Jonsson,K.B. and Juppner,H.
  TITLE     Identification and characterization of the murine and human gene
            encoding the tuberoinfundibular peptide of 39 residues
  JOURNAL   Endocrinology 143 (3), 1047-1057 (2002)
   PUBMED   11861531
REFERENCE   9  (bases 1 to 569)
  AUTHORS   Suzuki,T., Li,W., Zhang,Q., Karim,A., Novak,E.K., Sviderskaya,E.V.,
            Hill,S.P., Bennett,D.C., Levin,A.V., Nieuwenhuis,H.K., Fong,C.T.,
            Castellan,C., Miterski,B., Swank,R.T. and Spritz,R.A.
  TITLE     Hermansky-Pudlak syndrome is caused by mutations in HPS4, the human
            homolog of the mouse light-ear gene
  JOURNAL   Nat Genet 30 (3), 321-324 (2002)
   PUBMED   11836498
REFERENCE   10 (bases 1 to 569)
  AUTHORS   Dobolyi,A., Ueda,H., Uchida,H., Palkovits,M. and Usdin,T.B.
  TITLE     Anatomical and physiological evidence for involvement of
            tuberoinfundibular peptide of 39 residues in nociception
  JOURNAL   Proc Natl Acad Sci U S A 99 (3), 1651-1656 (2002)
   PUBMED   11818570
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC149868.2 and AF399674.1.
            
            On Apr 29, 2010 this sequence version replaced NM_053256.1.
            
            Summary: This gene encodes the precursor of a peptide hormone that
            shares sequence similarity with the parathyroid hormone. This gene
            is expressed in various regions of the brain where it plays a role
            in the release of pituitary hormones, anxiety and nociception. The
            encoded precursor protein is proteolytically processed to generate
            the biologically active neuropeptide. Mice lacking the encoded
            protein display increased fear and anxiety after exposure to
            stressful events, and decreased sensitivity to pain. [provided by
            RefSeq, Aug 2015].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY048587.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-197               AC149868.2         166582-166778
            198-328             AC149868.2         166878-167008
            329-569             AF399674.1         241-481
FEATURES             Location/Qualifiers
     source          1..569
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 29.17 cM"
     gene            1..569
                     /gene="Pth2"
                     /gene_synonym="Tifp39; Tip39"
                     /note="parathyroid hormone 2"
                     /db_xref="GeneID:114640"
                     /db_xref="MGI:MGI:2152297"
     exon            1..197
                     /gene="Pth2"
                     /gene_synonym="Tifp39; Tip39"
                     /inference="alignment:Splign:2.1.0"
     exon            198..328
                     /gene="Pth2"
                     /gene_synonym="Tifp39; Tip39"
                     /inference="alignment:Splign:2.1.0"
     CDS             201..503
                     /gene="Pth2"
                     /gene_synonym="Tifp39; Tip39"
                     /note="tuberoinfundibular peptide of 39 residues (TIP39)
                     preprohormone; tuberoinfundibular 39 residue protein"
                     /codon_start=1
                     /product="tuberoinfundibular peptide of 39 residues
                     preproprotein"
                     /protein_id="NP_444486.1"
                     /db_xref="CCDS:CCDS21233.1"
                     /db_xref="GeneID:114640"
                     /db_xref="MGI:MGI:2152297"
                     /translation="METCQMSRSPRERLLLLLLLLLLVPWGTGPASGVALPLAGVFSL
                     RAPGRAWAGLGSPLSRRSLALADDAAFRERARLLAALERRRWLDSYMQKLLLLDAP"
     exon            329..569
                     /gene="Pth2"
                     /gene_synonym="Tifp39; Tip39"
                     /inference="alignment:Splign:2.1.0"
     regulatory      508..513
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Pth2"
                     /gene_synonym="Tifp39; Tip39"
                     /note="hexamer: AATAAA"
     polyA_site      531
                     /gene="Pth2"
                     /gene_synonym="Tifp39; Tip39"
                     /note="major polyA site"
ORIGIN      
        1 agctctgggt cccaattagt tggtgttggc cacggcagcg cagggcccca ccaggcttct
       61 cattaccgct ggcggctcct aatgagcgtg gggtggagtg accccgcgcc cccagcccgg
      121 cctgcgtcac tgccgccgcg ggggctgtga gggtatataa aaggggcgtg agcatagctg
      181 cctgagccca ctgcacggtg atggagacct gccagatgtc caggagcccc cgagagcggc
      241 tgttgctgct tttgctgctg ctactgcttg tgccctgggg cactggccct gcctcaggtg
      301 ttgccctgcc cctcgctggt gtgttcagcc tccgcgcccc gggtcgtgcc tgggcgggct
      361 tgggtagccc cctgtctcgg cgcagcctgg cgctagctga cgacgcggcc tttcgggagc
      421 gcgcgcgcct gctggccgcc ctggagcgcc gccgctggct ggactcttac atgcagaagc
      481 tgttgctact ggacgcgccc tgagcctaat aaagagcctg tcgcactgcg actgcgcctc
      541 tttgctgcgc cactctcttg tgggtgtgt
//
