LOCUS       NM_020623                717 bp    mRNA    linear   ROD 28-JAN-2025
DEFINITION  Mus musculus parathyroid hormone (Pth), mRNA.
ACCESSION   NM_020623
VERSION     NM_020623.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 717)
  AUTHORS   Daryadel,A., Kung,C.J., Haykir,B., Sabrautzki,S., de Angelis,M.H.,
            Hernando,N., Rubio-Aliaga,I. and Wagner,C.A.
  TITLE     The calcium-sensing receptor has only a parathyroid
            hormone-dependent role in the acute response of renal phosphate
            transporters to phosphate intake
  JOURNAL   Am J Physiol Renal Physiol 326 (5), F792-F801 (2024)
   PUBMED   38545651
REFERENCE   2  (bases 1 to 717)
  AUTHORS   Kung,C.J., Daryadel,A., Fuente,R., Haykir,B., de Angelis,M.H.,
            Hernando,N., Rubio-Aliaga,I. and Wagner,C.A.
  TITLE     A novel mouse model for familial hypocalciuric hypercalcemia (FHH1)
            reveals PTH-dependent and independent CaSR defects
  JOURNAL   Pflugers Arch 476 (5), 833-845 (2024)
   PUBMED   38386045
  REMARK    GeneRIF: A novel mouse model for familial hypocalciuric
            hypercalcemia (FHH1) reveals PTH-dependent and independent CaSR
            defects.
REFERENCE   3  (bases 1 to 717)
  AUTHORS   Che,J., Chen,X., Ren,W. and Shang,P.
  TITLE     PTH 1-34 reduced apoptosis of MLO-Y4 osteocyte-like cells by
            activating autophagy and inhibiting ER stress under RPM conditions
  JOURNAL   Eur J Pharmacol 967, 176364 (2024)
   PUBMED   38316249
  REMARK    GeneRIF: PTH 1-34 reduced apoptosis of MLO-Y4 osteocyte-like cells
            by activating autophagy and inhibiting ER stress under RPM
            conditions.
REFERENCE   4  (bases 1 to 717)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   5  (bases 1 to 717)
  AUTHORS   Liu,H., Wada,A., Le,I., Le,P.T., Lee,A.W.F., Zhou,J., Gori,F.,
            Baron,R. and Rosen,C.J.
  TITLE     PTH regulates osteogenesis and suppresses adipogenesis through
            Zfp467 in a feed-forward, PTH1R-cyclic AMP-dependent manner
  JOURNAL   Elife 12, e83345 (2023)
   PUBMED   37159501
  REMARK    GeneRIF: PTH regulates osteogenesis and suppresses adipogenesis
            through Zfp467 in a feed-forward, PTH1R-cyclic AMP-dependent
            manner.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 717)
  AUTHORS   Seldin,M.F., Mattei,M.G. and Hendy,G.N.
  TITLE     Localization of mouse parathyroid hormone-like peptide gene (Pthlh)
            to distal chromosome 6 using interspecific backcross mice and in
            situ hybridization
  JOURNAL   Cytogenet Cell Genet 60 (3-4), 252-254 (1992)
   PUBMED   1354597
REFERENCE   7  (bases 1 to 717)
  AUTHORS   Levan,G., Szpirer,J., Szpirer,C., Klinga,K., Hanson,C. and
            Islam,M.Q.
  TITLE     The gene map of the Norway rat (Rattus norvegicus) and comparative
            mapping with mouse and man
  JOURNAL   Genomics 10 (3), 699-718 (1991)
   PUBMED   1889815
REFERENCE   8  (bases 1 to 717)
  AUTHORS   Saunders,A.M. and Seldin,M.F.
  TITLE     A molecular genetic linkage map of mouse chromosome 7
  JOURNAL   Genomics 8 (3), 525-535 (1990)
   PUBMED   1981054
REFERENCE   9  (bases 1 to 717)
  AUTHORS   Barton,D.E., Kwon,B.S. and Francke,U.
  TITLE     Human tyrosinase gene, mapped to chromosome 11 (q14----q21),
            defines second region of homology with mouse chromosome 7
  JOURNAL   Genomics 3 (1), 17-24 (1988)
   PUBMED   3146546
REFERENCE   10 (bases 1 to 717)
  AUTHORS   Lalley,P.A., Sakaguchi,A.Y., Eddy,R.L., Honey,N.H., Bell,G.I.,
            Shen,L.P., Rutter,W.J., Jacobs,J.W., Heinrich,G., Chin,W.W. et al.
  TITLE     Mapping polypeptide hormone genes in the mouse: somatostatin,
            glucagon, calcitonin, and parathyroid hormone
  JOURNAL   Cytogenet Cell Genet 44 (2-3), 92-97 (1987)
   PUBMED   2882956
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC156987.7 and AK138677.1.
            
            On Mar 23, 2007 this sequence version replaced NM_020623.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: CK788256.1, AK138677.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849383 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-3                 AC156987.7         174805-174807
            4-708               AK138677.1         2-706
            709-717             AC156987.7         177794-177802
FEATURES             Location/Qualifiers
     source          1..717
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 59.19 cM"
     gene            1..717
                     /gene="Pth"
                     /gene_synonym="Pthp"
                     /note="parathyroid hormone"
                     /db_xref="GeneID:19226"
                     /db_xref="MGI:MGI:97799"
     exon            1..123
                     /gene="Pth"
                     /gene_synonym="Pthp"
                     /inference="alignment:Splign:2.1.0"
     exon            124..214
                     /gene="Pth"
                     /gene_synonym="Pthp"
                     /inference="alignment:Splign:2.1.0"
     CDS             129..476
                     /gene="Pth"
                     /gene_synonym="Pthp"
                     /codon_start=1
                     /product="parathyroid hormone precursor"
                     /protein_id="NP_065648.1"
                     /db_xref="CCDS:CCDS21756.1"
                     /db_xref="GeneID:19226"
                     /db_xref="MGI:MGI:97799"
                     /translation="MMSANTVAKVMIIMLAVCLLTQTDGKPVRKRAVSEIQLMHNLGK
                     HLASMERMQWLRRKLQDMHNFVSLGVQMAARDGSHQKPTKKEENVLVDGNPKSLGEGD
                     KADVDVLVKSKSQ"
     exon            215..717
                     /gene="Pth"
                     /gene_synonym="Pthp"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      670
                     /gene="Pth"
                     /gene_synonym="Pthp"
                     /note="major polyA site"
     regulatory      691..696
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Pth"
                     /gene_synonym="Pthp"
                     /note="hexamer: AATAAA"
     polyA_site      714
                     /gene="Pth"
                     /gene_synonym="Pthp"
                     /note="major polyA site"
ORIGIN      
        1 cctgcatatg aaactcagac ttgaagaact gcagtccagt tcatcagctg tctggtttac
       61 tccagcttac tacagcatca gtttgtgcat ccccgaagga tcccctttga gagtcattgt
      121 atgtaaagat gatgtctgca aacaccgtgg ctaaagtgat gatcatcatg ctggcagtct
      181 gtcttcttac ccaaacggat gggaaacccg tgaggaagag agctgtcagt gaaatacagc
      241 ttatgcacaa cctgggcaaa cacctggcct ccatggagag gatgcaatgg ctgagaagga
      301 agctgcaaga tatgcacaat tttgttagtc ttggagtcca aatggctgcc agagatggca
      361 gtcaccagaa gcccaccaag aaggaggaaa atgtccttgt tgatggcaat ccaaaaagtc
      421 ttggtgaggg agacaaagct gatgtggatg tattagttaa atcaaaatct cagtaaatgc
      481 tgatttattc tagacagtgc agggcactga catatgctgc taccttttca agcttatgaa
      541 gatcaccaag tgctaatact tctactgtaa tgaaactttg gaattttttt gattacattt
      601 ttgctcattt aaggtctctt tcaatgattc catttcaata tgctcttctt tttaaagtac
      661 tactcatttc cacttctctc cttaaatata aataaagctt taatgctcat gaatcaa
//
