LOCUS       NM_008969               2881 bp    mRNA    linear   ROD 04-MAR-2025
DEFINITION  Mus musculus prostaglandin-endoperoxide synthase 1 (Ptgs1), mRNA.
ACCESSION   NM_008969
VERSION     NM_008969.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2881)
  AUTHORS   Aikawa,S., Matsuo,M., Akaeda,S., Sugimoto,Y., Arita,M., Isobe,Y.,
            Sugiura,Y., Taira,S., Maeda,R., Shimizu-Hirota,R., Takeda,N.,
            Hiratsuka,D., He,X., Ishizawa,C., Iida,R., Fukui,Y., Hiraoka,T.,
            Harada,M., Wada-Hiraike,O., Osuga,Y. and Hirota,Y.
  TITLE     Spatiotemporally distinct roles of cyclooxygenase-1 and
            cyclooxygenase-2 at fetomaternal interface in mice
  JOURNAL   JCI Insight 9 (19), e181865 (2024)
   PUBMED   39377223
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2881)
  AUTHORS   Abou Nader,N., Charrier,L., Meisnsohn,M.C., Banville,L.,
            Deffrennes,B., St-Jean,G., Boerboom,D., Zamberlam,G.,
            Brind'Amour,J., Pepin,D. and Boyer,A.
  TITLE     Lats1 and Lats2 regulate YAP and TAZ activity to control the
            development of mouse Sertoli cells
  JOURNAL   FASEB J 38 (9), e23633 (2024)
   PUBMED   38690712
REFERENCE   3  (bases 1 to 2881)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   4  (bases 1 to 2881)
  AUTHORS   Bruno,A., Contursi,A., Tacconelli,S., Sacco,A., Hofling,U.,
            Mucci,M., Lamolinara,A., Del Pizzo,F., Ballerini,P., Di
            Gregorio,P., Yu,Y. and Patrignani,P.
  TITLE     The specific deletion of cyclooxygenase-1 in
            megakaryocytes/platelets reduces intestinal polyposis in ApcMin/+
            mice
  JOURNAL   Pharmacol Res 185, 106506 (2022)
   PUBMED   36241001
  REMARK    GeneRIF: The specific deletion of cyclooxygenase-1 in
            megakaryocytes/platelets reduces intestinal polyposis in
            Apc<sup>Min/+</sup> mice.
REFERENCE   5  (bases 1 to 2881)
  AUTHORS   Shionoya,K., Eskilsson,A. and Blomqvist,A.
  TITLE     Prostaglandin production selectively in brain endothelial cells is
            both necessary and sufficient for eliciting fever
  JOURNAL   Proc Natl Acad Sci U S A 119 (43), e2122562119 (2022)
   PUBMED   36252026
REFERENCE   6  (bases 1 to 2881)
  AUTHORS   Picot,D., Loll,P.J. and Garavito,R.M.
  TITLE     The X-ray crystal structure of the membrane protein prostaglandin
            H2 synthase-1
  JOURNAL   Nature 367 (6460), 243-249 (1994)
   PUBMED   8121489
  REMARK    GeneRIF: Prostaglandin G/H synthase is a moonlighting protein that
            functions both as a peroxidase as well as a cyclooxygenase.
REFERENCE   7  (bases 1 to 2881)
  AUTHORS   Kraemer,S.A., Meade,E.A. and DeWitt,D.L.
  TITLE     Prostaglandin endoperoxide synthase gene structure: identification
            of the transcriptional start site and 5'-flanking regulatory
            sequences
  JOURNAL   Arch Biochem Biophys 293 (2), 391-400 (1992)
   PUBMED   1536575
REFERENCE   8  (bases 1 to 2881)
  AUTHORS   Kujubu,D.A., Fletcher,B.S., Varnum,B.C., Lim,R.W. and
            Herschman,H.R.
  TITLE     TIS10, a phorbol ester tumor promoter-inducible mRNA from Swiss 3T3
            cells, encodes a novel prostaglandin synthase/cyclooxygenase
            homologue
  JOURNAL   J Biol Chem 266 (20), 12866-12872 (1991)
   PUBMED   1712772
REFERENCE   9  (bases 1 to 2881)
  AUTHORS   Marshburn,P.B., Shabanowitz,R.B. and Clark,M.R.
  TITLE     Immunohistochemical localization of prostaglandin H synthase in the
            embryo and uterus of the mouse from ovulation through implantation
  JOURNAL   Mol Reprod Dev 25 (4), 309-316 (1990)
   PUBMED   2109618
REFERENCE   10 (bases 1 to 2881)
  AUTHORS   DeWitt,D.L., el-Harith,E.A., Kraemer,S.A., Andrews,M.J., Yao,E.F.,
            Armstrong,R.L. and Smith,W.L.
  TITLE     The aspirin and heme-binding sites of ovine and murine
            prostaglandin endoperoxide synthases
  JOURNAL   J Biol Chem 265 (9), 5192-5198 (1990)
   PUBMED   2108169
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK159907.1 and AW493573.1.
            
            On Feb 1, 2014 this sequence version replaced NM_008969.3.
            
            Summary: This is one of two genes encoding similar enzymes that
            catalyze the conversion of arachinodate to prostaglandin. The
            encoded protein regulates angiogenesis in endothelial cells, and is
            inhibited by nonsteroidal anti-inflammatory drugs such as aspirin.
            Based on its ability to function as both a cyclooxygenase and as a
            peroxidase, the encoded protein has been identified as a
            moonlighting protein. [provided by RefSeq, Jan 2014].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC005573.1, AK159907.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            multifunctional gene product(s) :: PMID: 8121489
            RefSeq Select criteria          :: based on conservation,
                                               expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2864              AK159907.1         2-2865
            2865-2881           AW493573.1         1-17                c
FEATURES             Location/Qualifiers
     source          1..2881
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 24.19 cM"
     gene            1..2881
                     /gene="Ptgs1"
                     /gene_synonym="Cox-1; Cox-3; COX1; PGHS-1; Pghs1; PHS 1"
                     /note="prostaglandin-endoperoxide synthase 1"
                     /db_xref="GeneID:19224"
                     /db_xref="MGI:MGI:97797"
     exon            1..144
                     /gene="Ptgs1"
                     /gene_synonym="Cox-1; Cox-3; COX1; PGHS-1; Pghs1; PHS 1"
                     /inference="alignment:Splign:2.1.0"
     CDS             138..1946
                     /gene="Ptgs1"
                     /gene_synonym="Cox-1; Cox-3; COX1; PGHS-1; Pghs1; PHS 1"
                     /EC_number="1.14.99.1"
                     /note="prostaglandin G/H synthase 1; PGH synthase 1;
                     cyclooxygenase-1; prostaglandin H2 synthase 1"
                     /codon_start=1
                     /product="prostaglandin G/H synthase 1 precursor"
                     /protein_id="NP_032995.1"
                     /db_xref="CCDS:CCDS15970.1"
                     /db_xref="GeneID:19224"
                     /db_xref="MGI:MGI:97797"
                     /translation="MSRRSLSLWFPLLLLLLLPPTPSVLLADPGVPSPVNPCCYYPCQ
                     NQGVCVRFGLDNYQCDCTRTGYSGPNCTIPEIWTWLRNSLRPSPSFTHFLLTHGYWLW
                     EFVNATFIREVLMRLVLTVRSNLIPSPPTYNSAHDYISWESFSNVSYYTRILPSVPKD
                     CPTPMGTKGKKQLPDVQLLAQQLLLRREFIPAPQGTNILFAFFAQHFTHQFFKTSGKM
                     GPGFTKALGHGVDLGHIYGDNLERQYHLRLFKDGKLKYQVLDGEVYPPSVEQASVLMR
                     YPPGVPPERQMAVGQEVFGLLPGLMLFSTIWLREHNRVCDLLKEEHPTWDDEQLFQTT
                     RLILIGETIKIVIEEYVQHLSGYFLQLKFDPELLFRAQFQYRNRIAMEFNHLYHWHPL
                     MPNSFQVGSQEYSYEQFLFNTSMLVDYGVEALVDAFSRQRAGRIGGGRNFDYHVLHVA
                     VDVIKESREMRLQPFNEYRKRFGLKPYTSFQELTGEKEMAAELEELYGDIDALEFYPG
                     LLLEKCQPNSIFGESMIEMGAPFSLKGLLGNPICSPEYWKPSTFGGDVGFNLVNTASL
                     KKLVCLNTKTCPYVSFRVPDYPGDDGSVLVRRSTEL"
     exon            145..240
                     /gene="Ptgs1"
                     /gene_synonym="Cox-1; Cox-3; COX1; PGHS-1; Pghs1; PHS 1"
                     /inference="alignment:Splign:2.1.0"
     exon            241..357
                     /gene="Ptgs1"
                     /gene_synonym="Cox-1; Cox-3; COX1; PGHS-1; Pghs1; PHS 1"
                     /inference="alignment:Splign:2.1.0"
     exon            358..498
                     /gene="Ptgs1"
                     /gene_synonym="Cox-1; Cox-3; COX1; PGHS-1; Pghs1; PHS 1"
                     /inference="alignment:Splign:2.1.0"
     exon            499..642
                     /gene="Ptgs1"
                     /gene_synonym="Cox-1; Cox-3; COX1; PGHS-1; Pghs1; PHS 1"
                     /inference="alignment:Splign:2.1.0"
     exon            643..824
                     /gene="Ptgs1"
                     /gene_synonym="Cox-1; Cox-3; COX1; PGHS-1; Pghs1; PHS 1"
                     /inference="alignment:Splign:2.1.0"
     exon            825..908
                     /gene="Ptgs1"
                     /gene_synonym="Cox-1; Cox-3; COX1; PGHS-1; Pghs1; PHS 1"
                     /inference="alignment:Splign:2.1.0"
     exon            909..1155
                     /gene="Ptgs1"
                     /gene_synonym="Cox-1; Cox-3; COX1; PGHS-1; Pghs1; PHS 1"
                     /inference="alignment:Splign:2.1.0"
     exon            1156..1442
                     /gene="Ptgs1"
                     /gene_synonym="Cox-1; Cox-3; COX1; PGHS-1; Pghs1; PHS 1"
                     /inference="alignment:Splign:2.1.0"
     exon            1443..1590
                     /gene="Ptgs1"
                     /gene_synonym="Cox-1; Cox-3; COX1; PGHS-1; Pghs1; PHS 1"
                     /inference="alignment:Splign:2.1.0"
     exon            1591..2867
                     /gene="Ptgs1"
                     /gene_synonym="Cox-1; Cox-3; COX1; PGHS-1; Pghs1; PHS 1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2848..2853
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ptgs1"
                     /gene_synonym="Cox-1; Cox-3; COX1; PGHS-1; Pghs1; PHS 1"
                     /note="hexamer: AATAAA"
     polyA_site      2867
                     /gene="Ptgs1"
                     /gene_synonym="Cox-1; Cox-3; COX1; PGHS-1; Pghs1; PHS 1"
                     /note="major polyA site"
ORIGIN      
        1 agaggtgaca actggaggga ggagtggggg tggagccgtg agatgggtgg gaggggacct
       61 gccagtgctg gggcagtgct ggagttgcac ccgaggagcc agccgttggc attgcacatc
      121 catccactcc cagagtcatg agtcgaagga gtctctcgct ctggtttccc ctgctgctgc
      181 tcctgctgct gccgccgaca ccctcggtcc tgctcgcaga tcctggggtg ccctcaccag
      241 tcaatccctg ttgttactat ccgtgccaga accagggtgt ctgtgtccgc tttggcctcg
      301 acaactacca gtgtgattgt actcgcacgg gctactcagg ccccaactgt accatccctg
      361 agatctggac ctggcttcgg aattctctgc ggcccagccc ctcgttcacc catttcctgc
      421 tgacacatgg atactggctc tgggaatttg tgaatgccac cttcatccga gaagtactca
      481 tgcgcctggt actcacagtg cggtccaacc ttatccccag ccctccgacc tacaactcag
      541 cgcatgacta catcagctgg gagtccttct ccaatgtgag ctactatact cgcattctgc
      601 cctctgtacc caaagactgc cccacaccca tggggaccaa agggaagaaa cagttaccag
      661 atgttcagct tctggcccaa cagctgctgc tgagaaggga gttcattcct gccccccagg
      721 gcaccaacat cctgtttgcc ttctttgcac aacacttcac ccaccagttc ttcaagacct
      781 ctggaaagat gggtcctggc tttaccaagg ccttaggcca cggggtagac cttggccaca
      841 tttatggaga taatctggaa cgacagtatc acctgcggct cttcaaggat gggaaactta
      901 agtaccaggt gctggacgga gaggtgtacc caccttccgt ggaacaggcg tccgtgttga
      961 tgcgctaccc accaggtgtc ccgcctgaaa ggcagatggc tgtgggccag gaggtgtttg
     1021 ggttgcttcc ggggctgatg ctcttctcca cgatctggct tcgtgaacat aaccgcgtgt
     1081 gcgacctgct gaaggaggag catcccacgt gggatgatga gcagctcttc cagaccactc
     1141 gcctcatcct tataggagaa accatcaaaa ttgtcattga ggagtatgtg cagcacttga
     1201 gtggctattt cctgcagctc aagtttgacc cggagctgct gttccgagcc cagttccaat
     1261 atcgaaaccg catcgccatg gaatttaacc atctctatca ctggcatcca ctcatgccca
     1321 actccttcca agtgggctca caagagtaca gctacgagca gtttttattt aacacttcta
     1381 tgctggtgga ctatggggtt gaggcactgg tggatgcctt ctctcgccag agggctggcc
     1441 ggattggtgg aggtaggaac tttgactatc atgttctgca tgtggctgtg gatgtcatca
     1501 aggagtcccg agagatgcgc ctacagccct tcaatgaata ccgaaagagg tttggcttga
     1561 agccttacac ctctttccag gagctcacag gagagaagga gatggctgct gagttggagg
     1621 agctgtacgg tgacatcgat gctttagagt tctacccggg gttgctgctg gagaagtgcc
     1681 agcccaactc catctttgga gaaagtatga tagagatggg ggctcccttt tccctcaagg
     1741 gcctcctagg gaatcccatc tgttccccag agtactggaa acccagcacg ttcggtggtg
     1801 acgtgggctt caaccttgtc aacacagcct cactgaagaa actggtctgc ctcaacacca
     1861 agacctgccc ctatgtttcc ttccgtgtgc cagattaccc tggagatgac gggtctgtct
     1921 tagtgagacg ctccactgag ctctgaggga gctggaaagc agcctctgga gggaggagtt
     1981 ttgttcctga tgaagacagt ccttgatgtg ggttttcgtg gcttggcatt gtgagagctg
     2041 atgctcacat ttgaaacttt gggtcttacc cttgcctaga atattgtgat tttgccactt
     2101 tcggatgttg aattctttgt taactaagaa agttagaagt ggttttgtct gcctcctcag
     2161 aacttggctc tttgttggca actcagaaag tcagatttct ggttgatttg gaatataggc
     2221 ttaaaacttt atattatagg gtagggtgtg gttgcacaca ccttaatccc agcacttgga
     2281 aggcagaggc agttggatct ctgggagttt gaggccagtt tggcctatat agtgagttct
     2341 aggccagcca tggatgcata gtgagactct ttctcaaaac aaacaaacaa acaaacaaac
     2401 aaacaacttt tagaatgtag aattccgtaa aaaaaaaaaa tcccttgaaa gttaatgggg
     2461 tcctcaattt tcttcctaga atttggaggc ctcttcagaa tgttgactat ctgacaggtg
     2521 actcagaagg tcctgttcct ggtcaatgat ctataacatg ggccaaaaca ttcccaactt
     2581 gaatgtctag aatgtggaat tggttcattt tcctgttcag tgaaatggac acagaacaaa
     2641 agaacccagt gtccagcaag aattgccttg cccaaaccta cgtctacgcc aaaggtcaag
     2701 gcagtaaggt gttcttggga gccacactta gactctttcc aaagatgtgg agggaacaga
     2761 tggactcatc tatgatcttg gttggaaacc accacagttc tatccccatc cagatctttg
     2821 cttgtggcag ctgtttctca tgaagctaat aaaattcttt ctccaaaaaa aaaaaaaaaa
     2881 a
//
