LOCUS       NM_029880               3121 bp    mRNA    linear   ROD 04-JUN-2024
DEFINITION  Mus musculus prostaglandin reductase 2 (Ptgr2), transcript variant
            1, mRNA.
ACCESSION   NM_029880
VERSION     NM_029880.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3121)
  AUTHORS   Yaguchi,H., Okumura,F., Takahashi,H., Kano,T., Kameda,H.,
            Uchigashima,M., Tanaka,S., Watanabe,M., Sasaki,H. and Hatakeyama,S.
  TITLE     TRIM67 protein negatively regulates Ras activity through
            degradation of 80K-H and induces neuritogenesis
  JOURNAL   J Biol Chem 287 (15), 12050-12059 (2012)
   PUBMED   22337885
REFERENCE   2  (bases 1 to 3121)
  AUTHORS   Chou,W.L., Chuang,L.M., Chou,C.C., Wang,A.H., Lawson,J.A.,
            FitzGerald,G.A. and Chang,Z.F.
  TITLE     Identification of a novel prostaglandin reductase reveals the
            involvement of prostaglandin E2 catabolism in regulation of
            peroxisome proliferator-activated receptor gamma activation
  JOURNAL   J Biol Chem 282 (25), 18162-18172 (2007)
   PUBMED   17449869
  REMARK    GeneRIF: 15-oxoprostaglandin-Delta13-reductase (PGR-2) catalyzes
            the reaction converting 15-keto-PGE2 to 13,14-dihydro-15-keto-PGE2
REFERENCE   3  (bases 1 to 3121)
  AUTHORS   Levin,I., Schwarzenbacher,R., McMullan,D., Abdubek,P., Ambing,E.,
            Biorac,T., Cambell,J., Canaves,J.M., Chiu,H.J., Dai,X.,
            Deacon,A.M., DiDonato,M., Elsliger,M.A., Godzik,A., Grittini,C.,
            Grzechnik,S.K., Hampton,E., Jaroszewski,L., Karlak,C., Klock,H.E.,
            Koesema,E., Kreusch,A., Kuhn,P., Lesley,S.A., McPhillips,T.M.,
            Miller,M.D., Morse,A., Moy,K., Ouyang,J., Page,R., Quijano,K.,
            Reyes,R., Robb,A., Sims,E., Spraggon,G., Stevens,R.C., van den
            Bedem,H., Velasquez,J., Vincent,J., von Delft,F., Wang,X., West,B.,
            Wolf,G., Xu,Q., Hodgson,K.O., Wooley,J. and Wilson,I.A.
  TITLE     Crystal structure of a putative NADPH-dependent oxidoreductase (GI:
            18204011) from mouse at 2.10 A resolution
  JOURNAL   Proteins 56 (3), 629-633 (2004)
   PUBMED   15229897
  REMARK    GeneRIF: This mouse gene encodes a putative NADPH-dependent
            oxidoreductase. We report the crystal structure of the putative
            oxidoreductase determined by the semi-automated high-throughput
            pipeline of the Joint Center for Structural Genomics
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CJ050177.1, AK159932.1 and CD742484.1.
            
            On Nov 22, 2011 this sequence version replaced NM_029880.2.
            
            Transcript Variant: This variant (1) is the predominant transcript
            and encodes the longer isoform (1). Variants 1 and 2 encode the
            same isoform.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660817.72886.1,
                                           SRR1660813.17254.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-106               CJ050177.1         2-107
            107-3103            AK159932.1         4-3000
            3104-3121           CD742484.1         1-18                c
FEATURES             Location/Qualifiers
     source          1..3121
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="12"
                     /map="12 39.14 cM"
     gene            1..3121
                     /gene="Ptgr2"
                     /gene_synonym="1810016I24Rik; 9130222H03Rik;
                     9630002F03Rik; B830026H24Rik; PGR-2; PRG-2; Zadh1"
                     /note="prostaglandin reductase 2"
                     /db_xref="GeneID:77219"
                     /db_xref="MGI:MGI:1916372"
     exon            1..181
                     /gene="Ptgr2"
                     /gene_synonym="1810016I24Rik; 9130222H03Rik;
                     9630002F03Rik; B830026H24Rik; PGR-2; PRG-2; Zadh1"
                     /inference="alignment:Splign:2.1.0"
     exon            182..266
                     /gene="Ptgr2"
                     /gene_synonym="1810016I24Rik; 9130222H03Rik;
                     9630002F03Rik; B830026H24Rik; PGR-2; PRG-2; Zadh1"
                     /inference="alignment:Splign:2.1.0"
     CDS             230..1285
                     /gene="Ptgr2"
                     /gene_synonym="1810016I24Rik; 9130222H03Rik;
                     9630002F03Rik; B830026H24Rik; PGR-2; PRG-2; Zadh1"
                     /EC_number="1.3.1.48"
                     /note="isoform 1 is encoded by transcript variant 1; zinc
                     binding alcohol dehydrogenase, domain containing 1;
                     15-oxoprostaglandin 13-reductase; zinc-binding alcohol
                     dehydrogenase domain-containing protein 1"
                     /codon_start=1
                     /product="prostaglandin reductase 2 isoform 1"
                     /protein_id="NP_084156.2"
                     /db_xref="CCDS:CCDS36490.1"
                     /db_xref="GeneID:77219"
                     /db_xref="MGI:MGI:1916372"
                     /translation="MIIQRVVLNSRPGKNGNPVAENFRVEEFSLPDALNEGQVQVRTL
                     YLSVDPYMRCKMNEDTGTDYLAPWQLAQVADGGGIGVVEESKHQKLTKGDFVTSFYWP
                     WQTKAILDGNGLEKVDPQLVDGHLSYFLGAIGMPGLTSLIGVQEKGHISAGSNQTMVV
                     SGAAGACGSLAGQIGHLLGCSRVVGICGTQEKCLFLTSELGFDAAVNYKTGNVAEQLR
                     EACPGGVDVYFDNVGGDISNAVISQMNENSHIILCGQISQYSNDVPYPPPLPPAVEAI
                     RKERNITRERFTVLNYKDKFEPGILQLSQWFKEGKLKVKETMAKGLENMGVAFQSMMT
                     GGNVGKQIVCISEDSSL"
     exon            267..385
                     /gene="Ptgr2"
                     /gene_synonym="1810016I24Rik; 9130222H03Rik;
                     9630002F03Rik; B830026H24Rik; PGR-2; PRG-2; Zadh1"
                     /inference="alignment:Splign:2.1.0"
     exon            386..577
                     /gene="Ptgr2"
                     /gene_synonym="1810016I24Rik; 9130222H03Rik;
                     9630002F03Rik; B830026H24Rik; PGR-2; PRG-2; Zadh1"
                     /inference="alignment:Splign:2.1.0"
     exon            578..748
                     /gene="Ptgr2"
                     /gene_synonym="1810016I24Rik; 9130222H03Rik;
                     9630002F03Rik; B830026H24Rik; PGR-2; PRG-2; Zadh1"
                     /inference="alignment:Splign:2.1.0"
     exon            749..958
                     /gene="Ptgr2"
                     /gene_synonym="1810016I24Rik; 9130222H03Rik;
                     9630002F03Rik; B830026H24Rik; PGR-2; PRG-2; Zadh1"
                     /inference="alignment:Splign:2.1.0"
     exon            959..1080
                     /gene="Ptgr2"
                     /gene_synonym="1810016I24Rik; 9130222H03Rik;
                     9630002F03Rik; B830026H24Rik; PGR-2; PRG-2; Zadh1"
                     /inference="alignment:Splign:2.1.0"
     exon            1081..1168
                     /gene="Ptgr2"
                     /gene_synonym="1810016I24Rik; 9130222H03Rik;
                     9630002F03Rik; B830026H24Rik; PGR-2; PRG-2; Zadh1"
                     /inference="alignment:Splign:2.1.0"
     exon            1169..1208
                     /gene="Ptgr2"
                     /gene_synonym="1810016I24Rik; 9130222H03Rik;
                     9630002F03Rik; B830026H24Rik; PGR-2; PRG-2; Zadh1"
                     /inference="alignment:Splign:2.1.0"
     exon            1209..3104
                     /gene="Ptgr2"
                     /gene_synonym="1810016I24Rik; 9130222H03Rik;
                     9630002F03Rik; B830026H24Rik; PGR-2; PRG-2; Zadh1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2108..2113
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ptgr2"
                     /gene_synonym="1810016I24Rik; 9130222H03Rik;
                     9630002F03Rik; B830026H24Rik; PGR-2; PRG-2; Zadh1"
                     /note="hexamer: AATAAA"
     polyA_site      2130
                     /gene="Ptgr2"
                     /gene_synonym="1810016I24Rik; 9130222H03Rik;
                     9630002F03Rik; B830026H24Rik; PGR-2; PRG-2; Zadh1"
     regulatory      3075..3080
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ptgr2"
                     /gene_synonym="1810016I24Rik; 9130222H03Rik;
                     9630002F03Rik; B830026H24Rik; PGR-2; PRG-2; Zadh1"
                     /note="hexamer: AATAAA"
     polyA_site      3101
                     /gene="Ptgr2"
                     /gene_synonym="1810016I24Rik; 9130222H03Rik;
                     9630002F03Rik; B830026H24Rik; PGR-2; PRG-2; Zadh1"
                     /note="major polyA site"
ORIGIN      
        1 gcgagatctc aaactgacag acacgcaggg gggccactgt atcgctgcac cggaagctgg
       61 attaagcccg cagaaaagga ggaagtgccg agccagggtg acctgtgggc gtcctcctcg
      121 agctccgggc gacaccggcg gtatagcttg ggacgctaga ctagggaatg ccccgtaaca
      181 ggaattattt tatatagaag tcttgtgaaa ccattgcaga attcaagtga tgatcataca
      241 aagagtggta ttgaattccc gacctgggaa aaatggaaat ccagtcgcag agaacttcag
      301 ggtggaagag ttcagtttac cggatgctct caatgaaggt caagttcaag tgaggactct
      361 ttatctctcg gtggatcctt acatgcgctg taagatgaac gaggacactg gcactgacta
      421 cttggcaccg tggcagctgg cgcaggtggc tgatggtgga ggaattggag ttgtagagga
      481 gagcaagcac cagaagttga ctaaaggcga ttttgtgact tcgttttact ggccctggca
      541 aactaaggca attctagatg ggaatggcct tgaaaaggta gacccacaac ttgtagatgg
      601 acacctttca tattttcttg gggctatagg tatgcctggc ttgacttcct tgattggggt
      661 acaggagaaa ggccatatat ctgctggatc taatcagaca atggttgtca gtggagcagc
      721 aggcgcctgt ggatctttgg ctgggcagat tggccacctg cttggctgtt ccagagtggt
      781 gggaatttgt ggaacgcagg agaaatgtct ctttttgacc tcagagctgg ggtttgatgc
      841 tgcagttaat tacaaaacag ggaatgtggc agagcagctg cgagaagcgt gcccgggcgg
      901 agtggatgtc tactttgaca atgttggagg tgacatcagc aacgcggtga taagtcagat
      961 gaatgagaac agccacatca tcctgtgtgg tcagatttct cagtacagta acgatgtgcc
     1021 ctaccctcct ccactgcccc ctgcagtaga agccatccgg aaggaacgaa acatcacaag
     1081 agagagattt acggtattaa attataaaga taaatttgag cctggaattc tacagctgag
     1141 tcagtggttt aaagaaggaa agctaaaggt caaggagacc atggcaaagg gcttggaaaa
     1201 catgggagtt gcattccagt ccatgatgac agggggcaac gtagggaaac agatcgtctg
     1261 catttcagaa gattcttctc tgtagtcttg gtgtgtcttc atcaaggaag ccctccattt
     1321 ttcacttccc acaaagattc ttaacatgca tttaaaaata atctttctgt acagatagtt
     1381 cttgattcta gtgtgataat attttctttg ttgtataacc actttatctt ccatatcata
     1441 ttcactctac atttaacatg tgattgcctg ccataataca ggagttctca agctgtgggt
     1501 tacggcccct ccggaggagt tacatatcag atatctcgca taacagatat ttacattatt
     1561 attcataaca gcaaaattac agttataagg taataaccga ataattttat ggttgggggt
     1621 caccacaaca tgagagactg tattaaaggg tgggtgtatt aggaaggttg agaaccaatg
     1681 ccacactaga ttgaagttag tattacttgt ttttctgtct tttttacttt gtttttgagg
     1741 caagatctct atatgacatc cacactggcc tccaacttgt gatcctgggg ctctgtctcc
     1801 taagtcctgg aattgtaggc atgtaccact atgcctgatt atttttctta taataactaa
     1861 taatattgtt ttggagatgg gtctgttagt ttagctcagg ctggactgac tcctcaggtc
     1921 tcccactgct gagcctgctg ggatgccagg cagctgtcac tcactaatat gtggctaatt
     1981 ttgtttgtga aaattaatat tacatatatt tgtatcaaat atttaaaaaa cctgggtggt
     2041 ttttaacccc aactattagt ggatcatata tatatatata tatatcttta aattactttt
     2101 agaactgaat aaacagtcta cgaattctaa ggtgagaagc agttaacatt tgttgaactg
     2161 gtaacatttt taccattctt aaactgagta ttagaattga gaaagccttt ccatattttt
     2221 gatgagagac tttaaaagtc tttacccgaa tgtttgtctg tacaccacat gcatgtctgg
     2281 tgcctacagt ggagagtggc tggagagggt attggggcat tggatcccct ggaactggag
     2341 agagtctgaa gccaccatgt gagtgctggg ttctagaatg cagatcctct ggtagagcag
     2401 gagatgctct tagtgttggc cacctctcca gcctgtctgt acttaatggc ataagtacat
     2461 aggatttcgg gcagcattgg gagtatttac agattgtgga acagtttggg gtaggacgtt
     2521 ttgggctggg agtggtctga gaagataaat gagtggttgg gagtctccag agacaaggtt
     2581 tacatccagg gatgatgttt gtgttctgcc aaacaactaa ttgagtagca agcctaacaa
     2641 cttactacgt gctgataaaa gcttgtgttt attttaggaa ttttttttta aagacaagag
     2701 tctgttaggt agcttgctat gtaatccagg ctggcctgga actcaaagat atccacttgg
     2761 ctgtctgcct ccgagtgcca gtgttaaagg cctgtatccc cattctgggc ttatactttg
     2821 gagaactaat agatataaac atcactaaga gtttcactga tgaaagtgag tcggagtggt
     2881 cagggcagaa cactgatcag tactctaggg gctctgaggt caatccccaa tggtaccttc
     2941 ccacaacaag ccccaagtaa tcaagctcca gaaagctata ggattaagta aattaaccaa
     3001 tggttataga catgactatt ccagatatac tgatgtatca catttgtttt cttaattttc
     3061 tcaaccttta gaaaaataaa actggagatg ttttctgagt atgaaaaaaa aaaaaaaaaa
     3121 a
//
