LOCUS       NM_025968               2104 bp    mRNA    linear   ROD 30-JUL-2024
DEFINITION  Mus musculus prostaglandin reductase 1 (Ptgr1), mRNA.
ACCESSION   NM_025968
VERSION     NM_025968.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2104)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2104)
  AUTHORS   Dickinson,M.E., Flenniken,A.M., Ji,X., Teboul,L., Wong,M.D.,
            White,J.K., Meehan,T.F., Weninger,W.J., Westerberg,H., Adissu,H.,
            Baker,C.N., Bower,L., Brown,J.M., Caddle,L.B., Chiani,F., Clary,D.,
            Cleak,J., Daly,M.J., Denegre,J.M., Doe,B., Dolan,M.E., Edie,S.M.,
            Fuchs,H., Gailus-Durner,V., Galli,A., Gambadoro,A., Gallegos,J.,
            Guo,S., Horner,N.R., Hsu,C.W., Johnson,S.J., Kalaga,S., Keith,L.C.,
            Lanoue,L., Lawson,T.N., Lek,M., Mark,M., Marschall,S., Mason,J.,
            McElwee,M.L., Newbigging,S., Nutter,L.M., Peterson,K.A.,
            Ramirez-Solis,R., Rowland,D.J., Ryder,E., Samocha,K.E.,
            Seavitt,J.R., Selloum,M., Szoke-Kovacs,Z., Tamura,M., Trainor,A.G.,
            Tudose,I., Wakana,S., Warren,J., Wendling,O., West,D.B., Wong,L.,
            Yoshiki,A., MacArthur,D.G., Tocchini-Valentini,G.P., Gao,X.,
            Flicek,P., Bradley,A., Skarnes,W.C., Justice,M.J., Parkinson,H.E.,
            Moore,M., Wells,S., Braun,R.E., Svenson,K.L., de Angelis,M.H.,
            Herault,Y., Mohun,T., Mallon,A.M., Henkelman,R.M., Brown,S.D.,
            Adams,D.J., Lloyd,K.C., McKerlie,C., Beaudet,A.L., Bucan,M. and
            Murray,S.A.
  CONSRTM   International Mouse Phenotyping Consortium; Jackson Laboratory;
            Infrastructure Nationale PHENOMIN, Institut Clinique de la Souris
            (ICS); Charles River Laboratories; MRC Harwell; Toronto Centre for
            Phenogenomics; Wellcome Trust Sanger Institute; RIKEN BioResource
            Center
  TITLE     High-throughput discovery of novel developmental phenotypes
  JOURNAL   Nature 537 (7621), 508-514 (2016)
   PUBMED   27626380
  REMARK    Erratum:[Nature. 2017 Nov 16;551(7680):398. doi:
            10.1038/nature24643. PMID: 29144450]
REFERENCE   3  (bases 1 to 2104)
  AUTHORS   Sakakibara,I., Wurmser,M., Dos Santos,M., Santolini,M.,
            Ducommun,S., Davaze,R., Guernec,A., Sakamoto,K. and Maire,P.
  TITLE     Six1 homeoprotein drives myofiber type IIA specialization in soleus
            muscle
  JOURNAL   Skelet Muscle 6 (1), 30 (2016)
   PUBMED   27597886
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2104)
  AUTHORS   Yu,Y.H., Chang,Y.C., Su,T.H., Nong,J.Y., Li,C.C. and Chuang,L.M.
  TITLE     Prostaglandin reductase-3 negatively modulates adipogenesis through
            regulation of PPARgamma activity
  JOURNAL   J Lipid Res 54 (9), 2391-2399 (2013)
   PUBMED   23821743
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AK035425.1.
            
            On Apr 5, 2007 this sequence version replaced NM_025968.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK035425.1, AK134440.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849380, SAMN01164134
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2104              AK035425.1         2-2105
FEATURES             Location/Qualifiers
     source          1..2104
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 32.36 cM"
     gene            1..2104
                     /gene="Ptgr1"
                     /gene_synonym="2510002C21Rik; DIG-1; Ltb4dh; Zadh3"
                     /note="prostaglandin reductase 1"
                     /db_xref="GeneID:67103"
                     /db_xref="MGI:MGI:1914353"
     exon            1..41
                     /gene="Ptgr1"
                     /gene_synonym="2510002C21Rik; DIG-1; Ltb4dh; Zadh3"
                     /inference="alignment:Splign:2.1.0"
     exon            42..157
                     /gene="Ptgr1"
                     /gene_synonym="2510002C21Rik; DIG-1; Ltb4dh; Zadh3"
                     /inference="alignment:Splign:2.1.0"
     exon            158..203
                     /gene="Ptgr1"
                     /gene_synonym="2510002C21Rik; DIG-1; Ltb4dh; Zadh3"
                     /inference="alignment:Splign:2.1.0"
     exon            204..260
                     /gene="Ptgr1"
                     /gene_synonym="2510002C21Rik; DIG-1; Ltb4dh; Zadh3"
                     /inference="alignment:Splign:2.1.0"
     exon            261..428
                     /gene="Ptgr1"
                     /gene_synonym="2510002C21Rik; DIG-1; Ltb4dh; Zadh3"
                     /inference="alignment:Splign:2.1.0"
     exon            429..546
                     /gene="Ptgr1"
                     /gene_synonym="2510002C21Rik; DIG-1; Ltb4dh; Zadh3"
                     /inference="alignment:Splign:2.1.0"
     exon            547..702
                     /gene="Ptgr1"
                     /gene_synonym="2510002C21Rik; DIG-1; Ltb4dh; Zadh3"
                     /inference="alignment:Splign:2.1.0"
     exon            703..811
                     /gene="Ptgr1"
                     /gene_synonym="2510002C21Rik; DIG-1; Ltb4dh; Zadh3"
                     /inference="alignment:Splign:2.1.0"
     exon            812..930
                     /gene="Ptgr1"
                     /gene_synonym="2510002C21Rik; DIG-1; Ltb4dh; Zadh3"
                     /inference="alignment:Splign:2.1.0"
     exon            931..2104
                     /gene="Ptgr1"
                     /gene_synonym="2510002C21Rik; DIG-1; Ltb4dh; Zadh3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1149..1154
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ptgr1"
                     /gene_synonym="2510002C21Rik; DIG-1; Ltb4dh; Zadh3"
                     /note="hexamer: AATAAA"
     polyA_site      1177
                     /gene="Ptgr1"
                     /gene_synonym="2510002C21Rik; DIG-1; Ltb4dh; Zadh3"
                     /note="major polyA site"
     regulatory      1190..1195
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ptgr1"
                     /gene_synonym="2510002C21Rik; DIG-1; Ltb4dh; Zadh3"
                     /note="hexamer: AATGAA"
     polyA_site      1209
                     /gene="Ptgr1"
                     /gene_synonym="2510002C21Rik; DIG-1; Ltb4dh; Zadh3"
     regulatory      1301..1306
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ptgr1"
                     /gene_synonym="2510002C21Rik; DIG-1; Ltb4dh; Zadh3"
                     /note="hexamer: AATGAA"
     polyA_site      1320
                     /gene="Ptgr1"
                     /gene_synonym="2510002C21Rik; DIG-1; Ltb4dh; Zadh3"
     regulatory      1999..2004
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ptgr1"
                     /gene_synonym="2510002C21Rik; DIG-1; Ltb4dh; Zadh3"
                     /note="hexamer: AGTAAA"
     polyA_site      2018
                     /gene="Ptgr1"
                     /gene_synonym="2510002C21Rik; DIG-1; Ltb4dh; Zadh3"
ORIGIN      
        1 attcagagcg gtctcccggg aaggagtttc tgtgagcttg tgtataccag gatggtgcag
       61 gccaagagct ggaccctgaa gaagcacttc gaaggcttcc ctacggacgg taacttcgag
      121 ttgaagacga ctgagctccc acccttaaat aatggagagg tcctgctgga agccctgttc
      181 ctctctgtgg atccttacat gagagttgca gccaaaaaac tgaaggaggg cgacaggatg
      241 atgggcgagc aagtggccag agtcgtggaa agtaaaaact cagccttccc aaaaggaacg
      301 attgtagcgg ctttattagg ttggacatca cattccattt ctgatgggaa tggactgaca
      361 aagctgcctg tagagtggcc ggacaagttg ccactgtctt tggcactggg gacagttggc
      421 atgccaggcc tcactgccta ctttggcctg cttgacatct gtggcgtgaa gggtggagaa
      481 accgtgatgg tcagcgcagc agcaggagca gtgggctctg ttgtggggca gatagctaag
      541 ctcaagggct gcaaagttgt tggtacagca gggtctgatg aaaaggttgc ctatcttaag
      601 aagcttggat tcgacgtggc ctttaactac aagacagtaa agtcactgga ggaagctttg
      661 aggacagcct ctcccgatgg ttatgattgc tattttgata atgtaggtgg agagttttca
      721 aacgctgtta tactccagat gaagacattt ggaaggattg ccatctgtgg tgccatctct
      781 caatacaacc gtactggacc atgtccccag ggcccagccc cagaggtggt tatctatcag
      841 caactccgca tggaggggtt catcgtgaat cggtggcaag gagaagtccg ccagaaggct
      901 ctgacagagt taatgaattg ggtctcagag ggtaaagtcc agtgtcatga atacgtcact
      961 gaaggatttg agaaaatgcc cgcagcattt atgggaatgt tgaaaggaga aaatctgggg
     1021 aagaccatag tgaaagcatg aaaataaaaa tggcccacgg atcgtccctg gagggttagc
     1081 tttttaccat tcagtgcaag tgtatactgt cctatgtaag atgtaacagc aatgcgtttg
     1141 acctagctaa taaaacatgt gtgttttttt ttccccatct gtgatagaga atgaaatcat
     1201 gacaaccaat gagcaggcat gtttctgcct acctcagctc ctcctgggtg accgtgacaa
     1261 atactgcctt tggtgtctgt tctgatttta tttctgttgt aatgaaagca atttagagga
     1321 ggaaagggtt ttcttgactt acactttcag gtcacaggtg tcaccaagag aaatgagggc
     1381 aggaacttga aggaaggcct gctttgtatt ctgttaacat tttctctaac ctgggaactc
     1441 agtaaccaag gacatacagc agaaaccacg gtggaggacg gtctgccagc tagctcgtgc
     1501 aggctggtgt tcagctaatg ttctcatata catagaggaa atggtaaccc actctatgag
     1561 gatggctaag cccactgtgg gaggtagcat ttcctgggtg cagtcacctg ccacaggggt
     1621 cttagcctcc tccactgtca caggccagcc cgaccgatgc gggtcttcag ttaaggctca
     1681 ccactcaggt gatttgtgag acatgccaag gcagaggtta aatctaacta agacagtgaa
     1741 cttggtgtaa tgtgaaggca aaagatttct cttccaactg tttatagata ctaggggggg
     1801 ggagccacat tgctgatcta tgcagttctc agggccagcc cgcactggtg tgctgtgtag
     1861 tgacgctaac agatcaaggg aggaatctgt cacttaccac agctgggact gaggagtgtt
     1921 aggggaagag acaaactgtt ctgtacactg gtaccttctg agtcctgaac attctggaaa
     1981 cattttgctg acaaatacag taaaaaacta atactctaca ggccggtcag agctgttaca
     2041 tagagaagcc ctgtctcgct ctccccccgc cactgaaaat taaacctttt aaagctttgg
     2101 gtcc
//
