LOCUS       NM_008967               3305 bp    mRNA    linear   ROD 14-FEB-2025
DEFINITION  Mus musculus prostaglandin I receptor (IP) (Ptgir), transcript
            variant 1, mRNA.
ACCESSION   NM_008967
VERSION     NM_008967.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3305)
  AUTHORS   Taketomi,Y., Higashi,T., Kano,K., Miki,Y., Mochizuki,C.,
            Toyoshima,S., Okayama,Y., Nishito,Y., Nakae,S., Tanaka,S.,
            Tokuoka,S.M., Oda,Y., Shichino,S., Ueha,S., Matsushima,K.,
            Akahoshi,N., Ishii,S., Chun,J., Aoki,J. and Murakami,M.
  TITLE     Lipid-orchestrated paracrine circuit coordinates mast cell
            maturation and anaphylaxis through functional interaction with
            fibroblasts
  JOURNAL   Immunity 57 (8), 1828-1847 (2024)
   PUBMED   39002541
REFERENCE   2  (bases 1 to 3305)
  AUTHORS   Tang,S.Y., Meng,H., Anderson,S.T., Sarantopoulou,D., Ghosh,S.,
            Lahens,N.F., Theken,K.N., Ricciotti,E., Hennessy,E.J., Tu,V.,
            Bittinger,K., Weiljie,A.M., Grant,G.R. and FitzGerald,G.A.
  TITLE     Sex-dependent compensatory mechanisms preserve blood pressure
            homeostasis in prostacyclin receptor-deficient mice
  JOURNAL   J Clin Invest 131 (14) (2021)
   PUBMED   34101620
  REMARK    GeneRIF: Sex-dependent compensatory mechanisms preserve blood
            pressure homeostasis in prostacyclin receptor-deficient mice.
REFERENCE   3  (bases 1 to 3305)
  AUTHORS   Norlander,A.E., Bloodworth,M.H., Toki,S., Zhang,J., Zhou,W.,
            Boyd,K., Polosukhin,V.V., Cephus,J.Y., Ceneviva,Z.J., Gandhi,V.D.,
            Chowdhury,N.U., Charbonnier,L.M., Rogers,L.M., Wang,J.,
            Aronoff,D.M., Bastarache,L., Newcomb,D.C., Chatila,T.A. and
            Peebles,R.S. Jr.
  TITLE     Prostaglandin I2 signaling licenses Treg suppressive function and
            prevents pathogenic reprogramming
  JOURNAL   J Clin Invest 131 (7) (2021)
   PUBMED   33529171
REFERENCE   4  (bases 1 to 3305)
  AUTHORS   Inazumi,T., Yamada,K., Shirata,N., Sato,H., Taketomi,Y., Morita,K.,
            Hohjoh,H., Tsuchiya,S., Oniki,K., Watanabe,T., Sasaki,Y., Oike,Y.,
            Ogata,Y., Saruwatari,J., Murakami,M. and Sugimoto,Y.
  TITLE     Prostaglandin E2-EP4 Axis Promotes Lipolysis and Fibrosis in
            Adipose Tissue Leading to Ectopic Fat Deposition and Insulin
            Resistance
  JOURNAL   Cell Rep 33 (2), 108265 (2020)
   PUBMED   33053354
REFERENCE   5  (bases 1 to 3305)
  AUTHORS   Kirkby,N.S., Raouf,J., Ahmetaj-Shala,B., Liu,B., Mazi,S.I.,
            Edin,M.L., Chambers,M.G., Korotkova,M., Wang,X., Wahli,W.,
            Zeldin,D.C., Nusing,R., Zhou,Y., Jakobsson,P.J. and Mitchell,J.A.
  TITLE     Mechanistic definition of the cardiovascular mPGES-1/COX-2/ADMA
            axis
  JOURNAL   Cardiovasc Res 116 (12), 1972-1980 (2020)
   PUBMED   31688905
REFERENCE   6  (bases 1 to 3305)
  AUTHORS   Hayes,J.S., Lawler,O.A., Walsh,M.T. and Kinsella,B.T.
  TITLE     The prostacyclin receptor is isoprenylated. Isoprenylation is
            required for efficient receptor-effector coupling
  JOURNAL   J Biol Chem 274 (34), 23707-23718 (1999)
   PUBMED   10446129
REFERENCE   7  (bases 1 to 3305)
  AUTHORS   Lim,H., Gupta,R.A., Ma,W.G., Paria,B.C., Moller,D.E., Morrow,J.D.,
            DuBois,R.N., Trzaskos,J.M. and Dey,S.K.
  TITLE     Cyclo-oxygenase-2-derived prostacyclin mediates embryo implantation
            in the mouse via PPARdelta
  JOURNAL   Genes Dev 13 (12), 1561-1574 (1999)
   PUBMED   10385625
REFERENCE   8  (bases 1 to 3305)
  AUTHORS   Murata,T., Ushikubi,F., Matsuoka,T., Hirata,M., Yamasaki,A.,
            Sugimoto,Y., Ichikawa,A., Aze,Y., Tanaka,T., Yoshida,N., Ueno,A.,
            Oh-ishi,S. and Narumiya,S.
  TITLE     Altered pain perception and inflammatory response in mice lacking
            prostacyclin receptor
  JOURNAL   Nature 388 (6643), 678-682 (1997)
   PUBMED   9262402
REFERENCE   9  (bases 1 to 3305)
  AUTHORS   Ishikawa,T.O., Tamai,Y., Rochelle,J.M., Hirata,M., Namba,T.,
            Sugimoto,Y., Ichikawa,A., Narumiya,S., Taketo,M.M. and Seldin,M.F.
  TITLE     Mapping of the genes encoding mouse prostaglandin D, E, and F and
            prostacyclin receptors
  JOURNAL   Genomics 32 (2), 285-288 (1996)
   PUBMED   8833158
REFERENCE   10 (bases 1 to 3305)
  AUTHORS   Namba,T., Oida,H., Sugimoto,Y., Kakizuka,A., Negishi,M.,
            Ichikawa,A. and Narumiya,S.
  TITLE     cDNA cloning of a mouse prostacyclin receptor. Multiple signaling
            pathways and expression in thymic medulla
  JOURNAL   J Biol Chem 269 (13), 9986-9992 (1994)
   PUBMED   7511597
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC148981.7.
            
            On Feb 28, 2023 this sequence version replaced NM_008967.3.
            
            Sequence Note: An in-frame AUG is located 2 codons upstream of the
            annotated translation start site but is not being annotated as a
            start site since it is not conserved and is in a weak Kozak
            sequence context.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC094386.1, D26157.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            CDS uses downstream in-frame AUG :: upstream AUG and CDS extension
                                                is not conserved
            RefSeq Select criteria           :: based on conservation,
                                                expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1120              AC148981.7         3873-4992           c
            1121-3305           AC148981.7         606-2790            c
FEATURES             Location/Qualifiers
     source          1..3305
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 9.15 cM"
     gene            1..3305
                     /gene="Ptgir"
                     /gene_synonym="IP; PGI2"
                     /note="prostaglandin I receptor (IP)"
                     /db_xref="GeneID:19222"
                     /db_xref="MGI:MGI:99535"
     exon            1..1120
                     /gene="Ptgir"
                     /gene_synonym="IP; PGI2"
                     /inference="alignment:Splign:2.1.0"
     CDS             269..1516
                     /gene="Ptgir"
                     /gene_synonym="IP; PGI2"
                     /note="isoform 1 is encoded by transcript variant 1; PGI
                     receptor; PGI2 receptor; prostanoid IP receptor;
                     prostaglandin I2 receptor; prostacyclin receptor"
                     /codon_start=1
                     /product="prostacyclin receptor isoform 1"
                     /protein_id="NP_032993.2"
                     /db_xref="CCDS:CCDS20857.2"
                     /db_xref="GeneID:19222"
                     /db_xref="MGI:MGI:99535"
                     /translation="MMASDGHPGPPSVTPGSPLSAGGREWQGMAGSCWNITYVQDSVG
                     PATSTLMFVAGVVGNGLALGILGARRRSHPSAFAVLVTGLAVTDLLGTCFLSPAVFVA
                     YARNSSLLGLAHGGTMLCDTFAFAMTFFGLASTLILFAMAVERCLALSHPYLYAQLDG
                     PRCARFALPSIYAFCCLFCSLPLLGLGEHQQYCPGSWCFIRMRSAQPGGCAFSLAYAS
                     LMALLVTSIFFCNGSVTLSLYHMYRQQRRHHGSFVPTSRAREDEVYHLILLALMTVIM
                     AVCSLPLMIRGFTQAIAPDSREMGDLLAFRFNAFNPILDPWVFILFRKAVFQRLKFWL
                     CCLCARSVHGDLQAPLSRPASGRRDPPAPTSLQAKEGSWVPLSSWGTGQVAPLTAVPL
                     TGGDGCSVGMPSKSEAIAACSLC"
     exon            1121..3305
                     /gene="Ptgir"
                     /gene_synonym="IP; PGI2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3276..3281
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ptgir"
                     /gene_synonym="IP; PGI2"
                     /note="hexamer: AATAAA"
     polyA_site      3305
                     /gene="Ptgir"
                     /gene_synonym="IP; PGI2"
                     /note="major polyA site"
ORIGIN      
        1 agactcgcac acagacagga gagactgagg gacttcagaa ggcagaggtg ctggagggtc
       61 tagaaagcag aaatgtcaag gaggtgacag agaagtgtag aggaaagaac agggggtagg
      121 ggacagggaa cactgaggca caaagggaca aggacctgac agagaaggaa agaaacagga
      181 gagggacaga cacaggagaa gacagaaaca aaagacagaa acacacgggc aactgggaat
      241 tgactggcag atcccagatc ctatgaagat gatggccagc gatggacatc ctggaccccc
      301 ttctgtcact cctgggagcc ctctcagtgc aggtggcaga gagtggcagg gcatggcagg
      361 ctcctgctgg aatatcacct acgttcaaga ctcggtagga cctgccacca gcacgctgat
      421 gttcgtggct ggtgtagtgg gcaacgggct ggcattgggc atcctgggtg cccgacggag
      481 gtcacaccca tcggcctttg cggtgttggt cactgggctg gcggtgacgg atctgctggg
      541 cacgtgcttc ttgagccctg cagtgtttgt ggcctatgct cgaaacagct ctctgctggg
      601 cctggcccac ggtgggacga tgctgtgtga cactttcgcc ttcgccatga cgttcttcgg
      661 cctggcctcc acgctcatcc tctttgccat ggctgtggag cggtgcctgg cactcagtca
      721 cccctacctg tacgcccagc tggacgggcc gcgctgcgcc cgctttgcct tgccttccat
      781 ctacgctttc tgctgcctct tctgctcact gcccctgctg ggcctgggcg agcatcagca
      841 gtattgccca gggagctggt gcttcatccg catgcgttcc gcccagcctg gcggctgtgc
      901 cttctccctg gcctacgcca gtctcatggc cctgttggtg acctccatct tcttctgcaa
      961 cggctccgtc actctcagcc tctatcacat gtaccgccaa cagagacgcc accatggctc
     1021 gtttgtaccg acctctcggg cacgagagga tgaagtttac cacctgattc tgctggccct
     1081 catgaccgtc atcatggccg tgtgctccct gcctctcatg atccgaggct tcactcaggc
     1141 catcgcccca gacagcagag agatggggga cctcctcgcc ttccgcttca acgccttcaa
     1201 ccccatcctg gacccctggg tcttcatcct tttccgaaag gctgtcttcc aacgcctcaa
     1261 gttctggttg tgttgcctgt gtgcccgttc tgtccatggg gatttgcagg cgcccctttc
     1321 cagacctgca tcggggagaa gagacccacc ggctcctact tctctccagg ctaaggaagg
     1381 gagctgggtg cccctgtcgt cctggggcac gggacaggtg gcaccattga ctgctgtgcc
     1441 tctgactggt ggtgacggct gctctgtggg aatgccatcc aagtcagagg ccatcgctgc
     1501 ctgctccctc tgctgatatc tgagctggtc ctgcatgtca tcctaagccc gctgtcacag
     1561 gaccagaagc cagaagatca gggactcaac tgacggtagc agaaaccaca tatttgatcc
     1621 ccagagtctg ggggtgtctg ctgctgcttc tcctccttcg gtatggtggc tagaggcctt
     1681 ggaaagaggg tgagggatgc cgaaggttct atggctctca agaaggattc tctcaaaata
     1741 accagggcct gggcaggctg ctctggcccc tgggctcctc catccatctc tctgtctaaa
     1801 tatttaggga gcagaaaaat tcccagaggc ttctgtggac tcgagtctac tggggttaga
     1861 gtgtctgctc tcctcttcca ctgagggggc ccctggctgc ccaccccagg tccccagggg
     1921 acacaaggca ttccagcaac ttctgcagaa atgtgtctgc ctcccccatt tcccatcccc
     1981 tatctgactt ggaaatcttg aacccctaag aggaagtgag aagaaaggag ggccactgca
     2041 ctgcaggtga cattgctgga cacatgcctg gcacagaaat ggtctgagaa atgccacagc
     2101 tatcttgggg aactgcgctg tgtgaacttt ggaggagggc acagggacaa ggcggagatg
     2161 gtggtgatgt agcatgcaga ggctccaaag gacttcacag gcatgcttcc taggatgcat
     2221 gtcccaagcc tgtgccccca tcctggaaca acttactgcc acctttcaga actggaccac
     2281 aactcaccat ctttggaatc tccacaaaag tttccctcat tcattcaaca aactcccggg
     2341 ggaccctgaa gtcagcaggc actcactctt cctccctcgg atcagggtcg cagaaaagtc
     2401 ccaggcctcc aagcaaagaa tcctgggtgc gtggaaatga gctgcctggc atgaggggaa
     2461 gtgagtcagc tggagggccg ggctgcatgc gggagggcaa gccagtgctc ctgctgatgt
     2521 ttctcctggt tcctgtttct cagccactcc ggtcattcgt cctcccactc catctgctcg
     2581 gcagcatatt agcaaagcct ctccagagaa agtggaacca gggcccagag agggcaaagc
     2641 ccaagcttgg accacacagc agaactttct cacggcctct ctgtgcctca gtttcctcag
     2701 ctctaatctg acaggggtgt cttgaggagt aaaggactct ctcccaaaag aacactttaa
     2761 cacaggacct ggaaggaagc cacagagggt gttactgtta ctgctgtcaa tattgttatc
     2821 tgggcaaaca tagaaacaaa aaactagaaa ataaggcaag gatttctcct gagttttttt
     2881 ttttctccca agtaagtata tttccatcac actcagaaaa agcaaagaga atcgggagaa
     2941 gagaaaacag gcagaggtaa gctgggtgtg gaggtgtgtg ccacaacgcc tcggcccttc
     3001 ttcaggcagg aggtcagagt tcaaggtcat cctccactac atacagggtt caaggtcagc
     3061 ctggggtatt tgagactctc aaaaccaaat gacaacaaca gataaaacca caaaacaaac
     3121 cagtctgagt tgaccagtca gtcctcaggt actgaaagat actatctgat gccagttgct
     3181 gactttgtaa atgatccaaa taccactgaa tggataattt gctgtgaatg ataaatggtt
     3241 aaaatggtaa tttttattta cgggtatttt accacaataa aaaaaatgta atagtgaaaa
     3301 aataa
//
