LOCUS       NP_035327                879 aa            linear   ROD 03-APR-2024
DEFINITION  prostaglandin F2 receptor negative regulator precursor [Mus
            musculus].
ACCESSION   NP_035327 XP_912809
VERSION     NP_035327.2
DBSOURCE    REFSEQ: accession NM_011197.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 879)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   2  (residues 1 to 879)
  AUTHORS   Gerber,H., Mosser,S., Boury-Jamot,B., Stumpe,M., Piersigilli,A.,
            Goepfert,C., Dengjel,J., Albrecht,U., Magara,F. and Fraering,P.C.
  TITLE     The APMAP interactome reveals new modulators of APP processing and
            beta-amyloid production that are altered in Alzheimer's disease
  JOURNAL   Acta Neuropathol Commun 7 (1), 13 (2019)
   PUBMED   30704515
  REMARK    Publication Status: Online-Only
REFERENCE   3  (residues 1 to 879)
  AUTHORS   Pan,Y., Zhang,L., Liu,Q., Li,Y., Guo,H., Peng,Y., Peng,H., Tang,B.,
            Hu,Z., Zhao,J., Xia,K. and Li,J.D.
  TITLE     Insertion of a knockout-first cassette in Ampd1 gene leads to
            neonatal death by disruption of neighboring genes expression
  JOURNAL   Sci Rep 6, 35970 (2016)
   PUBMED   27775065
  REMARK    Publication Status: Online-Only
REFERENCE   4  (residues 1 to 879)
  AUTHORS   Gu,Z., Imai,F., Kim,I.J., Fujita,H., Katayama,Ki., Mori,K.,
            Yoshihara,Y. and Yoshida,Y.
  TITLE     Expression of the immunoglobulin superfamily cell adhesion
            molecules in the developing spinal cord and dorsal root ganglion
  JOURNAL   PLoS One 10 (3), e0121550 (2015)
   PUBMED   25826454
  REMARK    Publication Status: Online-Only
REFERENCE   5  (residues 1 to 879)
  AUTHORS   Lodato,S., Molyneaux,B.J., Zuccaro,E., Goff,L.A., Chen,H.H.,
            Yuan,W., Meleski,A., Takahashi,E., Mahony,S., Rinn,J.L.,
            Gifford,D.K. and Arlotta,P.
  TITLE     Gene co-regulation by Fezf2 selects neurotransmitter identity and
            connectivity of corticospinal neurons
  JOURNAL   Nat Neurosci 17 (8), 1046-1054 (2014)
   PUBMED   24997765
REFERENCE   6  (residues 1 to 879)
  AUTHORS   Okazaki,N., F-Kikuno,R., Ohara,R., Inamoto,S., Koseki,H.,
            Hiraoka,S., Saga,Y., Seino,S., Nishimura,M., Kaisho,T., Hoshino,K.,
            Kitamura,H., Nagase,T., Ohara,O. and Koga,H.
  TITLE     Prediction of the coding sequences of mouse homologues of KIAA
            gene: IV. The complete nucleotide sequences of 500 mouse
            KIAA-homologous cDNAs identified by screening of terminal sequences
            of cDNA clones randomly sampled from size-fractionated libraries
  JOURNAL   DNA Res 11 (3), 205-218 (2004)
   PUBMED   15368895
REFERENCE   7  (residues 1 to 879)
  AUTHORS   Stipp,C.S., Kolesnikova,T.V. and Hemler,M.E.
  TITLE     EWI-2 is a major CD9 and CD81 partner and member of a novel Ig
            protein subfamily
  JOURNAL   J Biol Chem 276 (44), 40545-40554 (2001)
   PUBMED   11504738
REFERENCE   8  (residues 1 to 879)
  AUTHORS   Weng,L., Falla,N., Van den Heuvel,R., Raymackers,J., Karperien,M.,
            Van Bezooijen,R., Van Vlasselaer,P., Lowik,C. and Merregaert,J.
  TITLE     The monoclonal antibodies 18d7/91f2 recognize a receptor regulatory
            protein on mouse bone marrow stromal cells
  JOURNAL   J Bone Miner Res 15 (7), 1286-1300 (2000)
   PUBMED   10893677
REFERENCE   9  (residues 1 to 879)
  AUTHORS   Orlicky,D.J., Lieber,J.G., Morin,C.L. and Evans,R.M.
  TITLE     Synthesis and accumulation of a receptor regulatory protein
            associated with lipid droplet accumulation in 3T3-L1 cells
  JOURNAL   J Lipid Res 39 (6), 1152-1161 (1998)
   PUBMED   9643346
REFERENCE   10 (residues 1 to 879)
  AUTHORS   Orlicky,D.J. and Nordeen,S.K.
  TITLE     Cloning, sequencing and proposed structure for a prostaglandin F2
            alpha receptor regulatory protein
  JOURNAL   Prostaglandins Leukot Essent Fatty Acids 55 (4), 261-268 (1996)
   PUBMED   8951995
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL645930.15 and AL669872.8.
            
            On or before Dec 7, 2005 this sequence version replaced
            XP_912809.1, NP_035327.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF152344.1, SRR17784651.734416.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..879
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 43.93 cM"
     Protein         1..879
                     /product="prostaglandin F2 receptor negative regulator
                     precursor"
                     /note="prostaglandin F2-alpha receptor regulatory protein;
                     prostaglandin F2-alpha receptor-associated protein; CD9
                     partner 1; glu-Trp-Ile EWI motif-containing protein F"
                     /calculated_mol_wt=96535
     sig_peptide     1..21
                     /inference="COORDINATES: ab initio prediction:SignalP:6.0"
                     /calculated_mol_wt=2205
     mat_peptide     22..879
                     /product="Prostaglandin F2 receptor negative regulator.
                     /id=PRO_0000014763"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9WV91.2)"
                     /calculated_mol_wt=96535
     Region          39..121
                     /region_name="IGv"
                     /note="Immunoglobulin V-Type; smart00406"
                     /db_xref="CDD:214650"
     Site            44
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q9WV91.2)"
     Region          89..91
                     /region_name="Cell attachment site. /evidence=ECO:0000255"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9WV91.2)"
     Region          102..106
                     /region_name="Ig strand E"
                     /note="Ig strand E [structural motif]"
                     /db_xref="CDD:409353"
     Region          <104..140
                     /region_name="Ig"
                     /note="Immunoglobulin domain; cl11960"
                     /db_xref="CDD:472250"
     Region          116..121
                     /region_name="Ig strand F"
                     /note="Ig strand F [structural motif]"
                     /db_xref="CDD:409353"
     Region          134..137
                     /region_name="Ig strand G"
                     /note="Ig strand G [structural motif]"
                     /db_xref="CDD:409353"
     Region          153..254
                     /region_name="Ig"
                     /note="Immunoglobulin domain; cl11960"
                     /db_xref="CDD:472250"
     Region          165..169
                     /region_name="Ig strand B"
                     /note="Ig strand B [structural motif]"
                     /db_xref="CDD:409353"
     Region          182..186
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:409353"
     Region          230..234
                     /region_name="Ig strand E"
                     /note="Ig strand E [structural motif]"
                     /db_xref="CDD:409353"
     Region          244..249
                     /region_name="Ig strand F"
                     /note="Ig strand F [structural motif]"
                     /db_xref="CDD:409353"
     Site            271
                     /site_type="phosphorylation"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000250|UniProtKB:Q62786; propagated from
                     UniProtKB/Swiss-Prot (Q9WV91.2)"
     Region          283..373
                     /region_name="Ig"
                     /note="Immunoglobulin domain; cl11960"
                     /db_xref="CDD:472250"
     Site            300
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000269|PubMed:19349973; propagated from
                     UniProtKB/Swiss-Prot (Q9WV91.2)"
     Site            383
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q9WV91.2)"
     Site            413
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q9WV91.2)"
     Region          424..427
                     /region_name="Endoplasmic reticulum retention signal"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9WV91.2)"
     Site            525
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q9WV91.2)"
     Site            600
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000269|PubMed:19349973,
                     ECO:0000269|PubMed:19656770; propagated from
                     UniProtKB/Swiss-Prot (Q9WV91.2)"
     Site            618
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000269|PubMed:19349973,
                     ECO:0000269|PubMed:19656770; propagated from
                     UniProtKB/Swiss-Prot (Q9WV91.2)"
     Site            691
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000269|PubMed:19349973; propagated from
                     UniProtKB/Swiss-Prot (Q9WV91.2)"
     Region          703..705
                     /region_name="Cell attachment site. /evidence=ECO:0000255"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9WV91.2)"
     Site            833..853
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9WV91.2)"
     CDS             1..879
                     /gene="Ptgfrn"
                     /gene_synonym="4833445A08Rik; CD9P-1; EWI-F; FPRP; Trim45"
                     /coded_by="NM_011197.3:27..2666"
                     /db_xref="CCDS:CCDS17680.1"
                     /db_xref="GeneID:19221"
                     /db_xref="MGI:MGI:1277114"
ORIGIN      
        1 mgrpaprpll lallslavcr grvvrvpagt lvrvvgtelv ipcnvsdydg pseqnfdwsf
       61 sssgssfvel astwevgfpa qlyrerlqrg dillrrtand avelhiknvq psdqghykcs
      121 tpstdatvqg nyedtvqvkv ladalvvgps srpppglslr egepfelrci asttsplhth
      181 lalrwelhrg pvhrsilals hegrfhpgpg yeqryhsgdv rldtvgsday rlsvaralsa
      241 dqgsyrcvvs ewiteqgswq eiqekaveva tvviqptalq lavprtvsvt egkdldlscn
      301 ittdrvddvr pevtwyfkkt pdtsllashm larldrdslv hssphvalsh vdtrsyhllv
      361 rdvskensgy ylclvalwap ghnrswhkva eamsapsgvs vtwlepeyqv ylnaskvpgf
      421 sddptelqcr vidtkrleag vrltvswyyr mtrrnddvva sellavmdgd wtlrygersk
      481 qraqdgefif skehtdtfnf riqrtteedr gnyycvvsaw trqrnnswvk skdvfskpvn
      541 ifwasedsvl vvkarqpkpf faagntfemt ckvsskniks prysvlitae kpvgdlsspn
      601 etkyiisldq dsvvklenwt dasrvdgvvl ekvqedefry rmyqtqvsda glyrcmvtaw
      661 spiggslwre aatslsnpie idfqtsgptf nasvhsdtps vtrgdliklf civtvegavl
      721 dpddmafdvs wfavhsfgld kapvllssld rkgvvttgqr dwkstvsler vsvlefllqv
      781 hgsedqdfgn yycsvtpwvr sptgswqrea eihsrpifit vkmdvlnafk yplligvgls
      841 tvigllscli gycsshwcck kevretrrer rrlmsmemd
//
