LOCUS       NM_008966               4414 bp    mRNA    linear   ROD 17-SEP-2024
DEFINITION  Mus musculus prostaglandin F receptor (Ptgfr), mRNA.
ACCESSION   NM_008966
VERSION     NM_008966.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4414)
  AUTHORS   Taketomi,Y., Higashi,T., Kano,K., Miki,Y., Mochizuki,C.,
            Toyoshima,S., Okayama,Y., Nishito,Y., Nakae,S., Tanaka,S.,
            Tokuoka,S.M., Oda,Y., Shichino,S., Ueha,S., Matsushima,K.,
            Akahoshi,N., Ishii,S., Chun,J., Aoki,J. and Murakami,M.
  TITLE     Lipid-orchestrated paracrine circuit coordinates mast cell
            maturation and anaphylaxis through functional interaction with
            fibroblasts
  JOURNAL   Immunity 57 (8), 1828-1847 (2024)
   PUBMED   39002541
REFERENCE   2  (bases 1 to 4414)
  AUTHORS   Odom,M.R., Hughes,F.M. Jr., Pope,N., Jin,H. and Purves,J.T.
  TITLE     Female Type 1 Diabetic Akita Mice Demonstrate Increased Bladder
            Contractility via FP Receptor Activation due to NLRP3-Mediated
            Inflammation
  JOURNAL   Front Biosci (Landmark Ed) 29 (4), 154 (2024)
   PUBMED   38682210
  REMARK    GeneRIF: Female Type 1 Diabetic Akita Mice Demonstrate Increased
            Bladder Contractility via FP Receptor Activation due to
            NLRP3-Mediated Inflammation.
REFERENCE   3  (bases 1 to 4414)
  AUTHORS   Gradwell,M.A., Ozeri-Engelhard,N., Eisdorfer,J.T., Laflamme,O.D.,
            Gonzalez,M., Upadhyay,A., Medlock,L., Shrier,T., Patel,K.R.,
            Aoki,A., Gandhi,M., Abbas-Zadeh,G., Oputa,O., Thackray,J.K.,
            Ricci,M., George,A., Yusuf,N., Keating,J., Imtiaz,Z., Alomary,S.A.,
            Bohic,M., Haas,M., Hernandez,Y., Prescott,S.A., Akay,T. and
            Abraira,V.E.
  TITLE     Multimodal sensory control of motor performance by glycinergic
            interneurons of the mouse spinal cord deep dorsal horn
  JOURNAL   Neuron 112 (8), 1302-1327 (2024)
   PUBMED   38452762
REFERENCE   4  (bases 1 to 4414)
  AUTHORS   Zhao,Y., Lei,Y., Ning,H., Zhang,Y., Chen,G., Wang,C., Wan,Q.,
            Guo,S., Liu,Q., Xie,R., Zhuo,Y., Yan,S., Zhao,J., Wei,F., Wang,L.,
            Wang,X., Li,W., Yan,H. and Yu,Y.
  TITLE     PGF2alpha facilitates pathological retinal angiogenesis by
            modulating endothelial FOS-driven ELR+ CXC chemokine expression
  JOURNAL   EMBO Mol Med 15 (1), e16373 (2023)
   PUBMED   36511116
REFERENCE   5  (bases 1 to 4414)
  AUTHORS   Hu,B.A., Sai,W.W., Yuan,J., Lan,H.T., Qi,J., Wang,D., Zhang,W.,
            Wang,Z.H., Zhong,M. and Shang,Y.Y.
  TITLE     PGF2alpha-FP Receptor Ameliorates Senescence of VSMCs in Vascular
            Remodeling by Src/PAI-1 Signal Pathway
  JOURNAL   Oxid Med Cell Longev 2022, 2908261 (2022)
   PUBMED   35126810
  REMARK    GeneRIF: PGF2alpha-FP Receptor Ameliorates Senescence of VSMCs in
            Vascular Remodeling by Src/PAI-1 Signal Pathway.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4414)
  AUTHORS   Hasumoto,K., Sugimoto,Y., Yamasaki,A., Morimoto,K., Kakizuka,A.,
            Negishi,M. and Ichikawa,A.
  TITLE     Association of expression of mRNA encoding the PGF2 alpha receptor
            with luteal cell apoptosis in ovaries of pseudopregnant mice
  JOURNAL   J Reprod Fertil 109 (1), 45-51 (1997)
   PUBMED   9068412
REFERENCE   7  (bases 1 to 4414)
  AUTHORS   Sugatani,J., Masu,Y., Nishizawa,M., Sakamoto,K., Houtani,T.,
            Sugimoto,T. and Ito,S.
  TITLE     Hormonal regulation of prostaglandin F2 alpha receptor gene
            expression in mouse ovary
  JOURNAL   Am J Physiol 271 (4 Pt 1), E686-E693 (1996)
   PUBMED   8897856
REFERENCE   8  (bases 1 to 4414)
  AUTHORS   Ishikawa,T.O., Tamai,Y., Rochelle,J.M., Hirata,M., Namba,T.,
            Sugimoto,Y., Ichikawa,A., Narumiya,S., Taketo,M.M. and Seldin,M.F.
  TITLE     Mapping of the genes encoding mouse prostaglandin D, E, and F and
            prostacyclin receptors
  JOURNAL   Genomics 32 (2), 285-288 (1996)
   PUBMED   8833158
REFERENCE   9  (bases 1 to 4414)
  AUTHORS   Woodward,D.F. and Lawrence,R.A.
  TITLE     Identification of a single (FP) receptor associated with
            prostanoid-induced Ca2+ signals in Swiss 3T3 cells
  JOURNAL   Biochem Pharmacol 47 (9), 1567-1574 (1994)
   PUBMED   8185669
REFERENCE   10 (bases 1 to 4414)
  AUTHORS   Sugimoto,Y., Hasumoto,K., Namba,T., Irie,A., Katsuyama,M.,
            Negishi,M., Kakizuka,A., Narumiya,S. and Ichikawa,A.
  TITLE     Cloning and expression of a cDNA for mouse prostaglandin F receptor
  JOURNAL   J Biol Chem 269 (2), 1356-1360 (1994)
   PUBMED   8288601
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BB613784.1, AK141760.1, AK080620.1 and AK086563.1.
            
            On Mar 4, 2006 this sequence version replaced NM_008966.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK141760.1, AK087833.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-26                BB613784.1         104-129
            27-2604             AK141760.1         2-2579
            2605-3065           AK080620.1         1620-2080
            3066-4106           AK141760.1         3043-4083
            4107-4414           AK086563.1         349-656
FEATURES             Location/Qualifiers
     source          1..4414
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 76.96 cM"
     gene            1..4414
                     /gene="Ptgfr"
                     /gene_synonym="fp; PGF"
                     /note="prostaglandin F receptor"
                     /db_xref="GeneID:19220"
                     /db_xref="MGI:MGI:97796"
     exon            1..227
                     /gene="Ptgfr"
                     /gene_synonym="fp; PGF"
                     /inference="alignment:Splign:2.1.0"
     exon            228..1097
                     /gene="Ptgfr"
                     /gene_synonym="fp; PGF"
                     /inference="alignment:Splign:2.1.0"
     CDS             300..1400
                     /gene="Ptgfr"
                     /gene_synonym="fp; PGF"
                     /note="prostaglandin F2alpha receptor; PGF receptor;
                     PGF2-alpha receptor; prostanoid FP receptor"
                     /codon_start=1
                     /product="prostaglandin F2-alpha receptor"
                     /protein_id="NP_032992.1"
                     /db_xref="CCDS:CCDS17913.1"
                     /db_xref="GeneID:19220"
                     /db_xref="MGI:MGI:97796"
                     /translation="MSMNSSKQPVSPAAGLIANTTCQTENRLSVFFSIIFMTVGILSN
                     SLAIAILMKAYQRFRQKSKASFLLLASGLVITDFFGHLINGGIAVFVYASDKDWIRFD
                     QSNILCSIFGISMVFSGLCPLFLGSAMAIERCIGVTNPIFHSTKITSKHVKMILSGVC
                     MFAVFVAVLPILGHRDYQIQASRTWCFYNTEHIEDWEDRFYLLFFSFLGLLALGVSFS
                     CNAVTGVTLLRVKFRSQQHRQGRSHHLEMIIQLLAIMCVSCVCWSPFLVTMANIAING
                     NNSPVTCETTLFALRMATWNQILDPWVYILLRKAVLRNLYKLASRCCGVNIISLHIWE
                     LSSIKNSLKVAAISESPAAEKESQQASSEAGL"
     exon            1098..4414
                     /gene="Ptgfr"
                     /gene_synonym="fp; PGF"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1660..1665
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ptgfr"
                     /gene_synonym="fp; PGF"
                     /note="hexamer: AATAAA"
     polyA_site      1683
                     /gene="Ptgfr"
                     /gene_synonym="fp; PGF"
                     /note="major polyA site"
     regulatory      2232..2237
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ptgfr"
                     /gene_synonym="fp; PGF"
                     /note="hexamer: AATAAA"
     regulatory      2237..2242
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ptgfr"
                     /gene_synonym="fp; PGF"
                     /note="hexamer: AAGAAA"
     polyA_site      2244
                     /gene="Ptgfr"
                     /gene_synonym="fp; PGF"
                     /note="major polyA site"
     polyA_site      2263
                     /gene="Ptgfr"
                     /gene_synonym="fp; PGF"
ORIGIN      
        1 ggaggtcacc cagccctcca ccctgcagag gctgggagca tctctaggtg ctctggagtt
       61 caggacacaa taggtcctgc gggtgatcca gtgctcagaa gtgtcctagg gaggaaagag
      121 aggtggaacc cgaggttgcg gctgcgcagg gctggttgcg ccatggaaca ccgggctcag
      181 cgctcttctg ctccggacac aaccactcag tggctcagga tgccgagatg tctgcactcc
      241 gagactgcac agttgtgaca gagagatgac ttgaggggac agcttttacc tccacaacaa
      301 tgtctatgaa cagttccaag cagccagtgt ctcctgcagc tggactcatc gcaaacacaa
      361 cctgccagac ggagaaccgg ctttcagtat ttttttctat catcttcatg acagtgggga
      421 tcttatcgaa cagcctggcc atcgccattc tcatgaaggc ctaccagaga tttagacaga
      481 agtcaaaggc ttccttcctg cttttggcta gtggcctggt gatcacagac ttctttggcc
      541 accttatcaa cggaggcata gctgtctttg tatatgcttc tgataaagac tggatccgct
      601 ttgatcagtc aaacatcctg tgcagtattt ttggaatctc catggtcttt tctggcttgt
      661 gcccactttt tctaggcagt gcgatggcca tcgagaggtg tataggagtc accaatccta
      721 tatttcactc tacgaagatc acatctaaac acgtgaaaat gatcctgagt ggtgtgtgca
      781 tgtttgctgt gttcgtggct gtgctgccca tccttggaca ccgagattat caaatccaag
      841 cgtccagaac ctggtgtttc tacaacacag agcacatcga agactgggaa gacagatttt
      901 atctcctgtt cttttctttc ctcggactct tagctcttgg tgtttccttc tcgtgcaatg
      961 ccgtcacggg agtcacactc ttaagagtga agttcagaag ccagcagcat aggcaaggca
     1021 gatctcacca cctggagatg atcattcagc tcctggccat aatgtgcgtc tcctgcgtct
     1081 gctggagtcc ctttctggta acaatggcca acattgcaat aaatggaaat aattccccag
     1141 tgacctgtga aacgacactt tttgctctcc gcatggcaac gtggaatcag atcttagatc
     1201 cctgggtcta tattctgcta cggaaggctg tccttaggaa cctgtataaa cttgccagtc
     1261 gttgctgtgg agttaacatc atcagcttgc atatctggga actcagctcc atcaagaatt
     1321 ccttaaaggt tgctgctatt tctgagtcac cagctgcaga gaaggagagc cagcaagcat
     1381 cgagtgaagc tggactgtaa atcaatgcag tattagaaga aagtcacgga aacttctgaa
     1441 acatctcagt tgatccgact catcgtgtaa ctggaacatt tggacctctg tgtagtttgg
     1501 gagaacactg gtcagacaca ccttctgact tttgttaagc tgactgctgc atggttgtgt
     1561 atttcatttg tttgtgtcaa caggagatag acagatacaa tgtggtgtcc ttgagtagaa
     1621 cacacatttg agtttaatct gtgtggctta cgttcttgga ataaatgaat ctgttgaggc
     1681 ctagtgcctt tatttgacct atttttccaa gcaccttatg ctacttgcac tgtgacatgg
     1741 catttgagga tccctgactt acagacaaag cttaaaatga cacaagtcat tttttctgtt
     1801 tgcgtgtgcg gttctgctct gtttaccagt ccatgtgtcc tcaatcaata tctgcatgac
     1861 catgacatct gagactcacg gtgactttga tggccactgt gtaggttggc cagcctgata
     1921 ttgtgaggct gatgaggata atcattcttg tcacaactga caggtatgag tgcttgcatt
     1981 tgttgttatg aaggttaatt atttttccat atttgttatc ctcctataaa gtcataggtt
     2041 ttcagtgtct aagtaatctc cagttcctct gaaaattgta gagaaatgcc ggctttgtct
     2101 tagcacagat tcagctcatg acagcctatc atgagcccta ttatagacga tagaaacatt
     2161 ggaaacccac ttacacatgc caagaacatg gcaaacgttg ctttatctga gttgtccttt
     2221 ctgtgtcaga gaataaaaga aaaacaatca agacacattt gaagtctgtt tgcagctatt
     2281 ctgtttctgc cttacacaca cacacacaga cagaaggaag ttctgttaac agcaatttca
     2341 ctaaataagt tgaaccacac ttccaaaagc ctgtgttgtc agtgaggagt ggaaagatct
     2401 agaattagcc aggagtttgg ccccactgtt gcagttaacc tgaggctaag attctgttgc
     2461 caagtttccc aatcttaatt cacacttctc ctttgttttt ataatttaac acaaagatac
     2521 tcaatttcag taatcattct aaacattagg ttcagcactg attagggtta gtgattatgt
     2581 tttatatgga aatgtatttt catatttaaa atgtttcctt gcttccatca agtttggctt
     2641 catttaaaga ctattactag tttttgcagt gtgtatggat gttttacctg aatgcatttc
     2701 tgtgcatcat gtgcatcatc ccgaaaccat gtgaattcaa tagacttaaa atagtatctt
     2761 caacatgatt tctctgtcaa gagatcacat ccaaagacct tctaggtcta taagatccgg
     2821 ctggaatgca gacatgcctg gacctggcta taatatagat acacccttag tacacacatt
     2881 taattcctaa caatgaagat aaagttagtt tgtagaagga agtagtcact tttgaaagca
     2941 atgtccaatt gaggggcaga tggagtgatg aatcagagaa agttttgacc gaatgagtta
     3001 gagaaaggat atgcctaact cacatgggaa tagcacagga aagagaggat actgaggagc
     3061 agagtagaga gggagagagg agagaggaga gagagagaga gagagagaga gagagagaga
     3121 gagagagaga gagagagaga gagagaaagg ggctctggtg tgtgtttgtg tttatggcaa
     3181 ttttagtttt cccaggacag ttttacatag atcagctgca gagagaacaa gatgggtgca
     3241 ggtgaagaca gagtgaacca aagaatggga agaatccaga agagcagagc ttattgacaa
     3301 agttagtatg aggccaagca agcaatcagg cagaagtgga gagaagccag attgaatcgg
     3361 ttagtttgga agattagatt gtttggagag tagaagcttt taggcctagg cctaggggta
     3421 agtagaacag agaaaaaaat gctctgagct cagcctaagc tgtgtattta cacagctaga
     3481 gtatggcttt catctcatct ctttgtctga ggaaatgaga gcaccatttt caagcagctg
     3541 ccgttcttaa ctgctgagcc atcactccag cctttcaaaa ttgtttttat ctataaaaat
     3601 gacttcagat tctaggactc aaaatactat cttcaaaaac ttttgctttt gattggtagt
     3661 ttacactaga tatgattact gcttttggta aattctccta agtaaattga aagaaattaa
     3721 gctaatagct taatttgttt aagtcttgtt gaagacttaa aggaaattat ttatagtgat
     3781 tcgaaaggaa tacacactat tatgtgataa tcttaagaca agtgatcaat cgcacaactg
     3841 attcctatgt agagaatata tcagagaata gacaatgatt tttggtgtaa cttgagcacg
     3901 gagttgtaaa gagcatgcac aatttaaatt taagctgaca gctacatgct ggtttttgtg
     3961 atgtacatat gtatacatat atgtatgtgt gttcctgtgt gcatgcatgt gagtgtttat
     4021 gaatatgtgt gtatatgtat gtgcatgtac atgtagaatg catatgattg taaaaaggca
     4081 ttacaattta tgattactgt tgcattacat aagtgttatc atctttcatt tcaagagtac
     4141 tcaaagcttg gacaaacttt ccgacagttc acttactttc tgagcagatt tattttctac
     4201 agaaataaga tgttggcatc ttaaaaacag aggcatgaag aaccaagtct ctgtcttccc
     4261 taattatagt tggtaaaact ctgcagttaa catgaccatg catttcaact gaggaaaggc
     4321 actgagaagg gacttgtttc gaggctccag ggctctttat tgtgagcctc tgatatggac
     4381 acaattgttc ctctactgct gtgatgtcta caat
//
