LOCUS       NM_019766               1954 bp    mRNA    linear   ROD 01-OCT-2024
DEFINITION  Mus musculus prostaglandin E synthase 3 (Ptges3), mRNA.
ACCESSION   NM_019766
VERSION     NM_019766.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1954)
  AUTHORS   Kantarci,H., Elvira,P.D., Thottumkara,A.P., O'Connell,E.M.,
            Iyer,M., Donovan,L.J., Dugan,M.Q., Ambiel,N., Granados,A., Zeng,H.,
            Saw,N.L., Brosius Lutz,A., Sloan,S.A., Gray,E.E., Tran,K.V.,
            Vichare,A., Yeh,A.K., Munch,A.E., Huber,M., Agrawal,A., Morri,M.,
            Zhong,H., Shamloo,M., Anderson,T.A., Tawfik,V.L., Du Bois,J. and
            Zuchero,J.B.
  TITLE     Schwann cell-secreted PGE2 promotes sensory neuron excitability
            during development
  JOURNAL   Cell 187 (17), 4690-4712 (2024)
   PUBMED   39142281
REFERENCE   2  (bases 1 to 1954)
  AUTHORS   Madon-Simon,M., Grad,I., Bayo,P., Perez,P. and Picard,D.
  TITLE     Defective glucocorticoid receptor signaling and
            keratinocyte-autonomous defects contribute to skin phenotype of
            mouse embryos lacking the Hsp90 co-chaperone p23
  JOURNAL   PLoS One 12 (6), e0180035 (2017)
   PUBMED   28650975
  REMARK    GeneRIF: Skin differentiation is impaired, and both apoptosis and
            cell proliferation are augmented in the absence of p23; the
            consequences are a severe thinning of the stratum corneum and
            reduced numbers of hair follicles. Since the phenotype of p23-null
            embryos is strikingly similar to that of embryos lacking the
            glucocorticoid receptor, a paradigmatic Hsp90-p23 client protein,
            we investigated glucocorticoid signaling.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1954)
  AUTHORS   Liepelt,A., Naarmann-de Vries,I.S., Simons,N., Eichelbaum,K.,
            Fohr,S., Archer,S.K., Castello,A., Usadel,B., Krijgsveld,J.,
            Preiss,T., Marx,G., Hentze,M.W., Ostareck,D.H. and
            Ostareck-Lederer,A.
  TITLE     Identification of RNA-binding Proteins in Macrophages by
            Interactome Capture
  JOURNAL   Mol Cell Proteomics 15 (8), 2699-2714 (2016)
   PUBMED   27281784
  REMARK    GeneRIF: Results identified two proteins P23 and HCLS1, which were
            not known as RNA-binding proteins, exhibiting RNA-binding activity.
REFERENCE   4  (bases 1 to 1954)
  AUTHORS   Zhang,J., Spilman,P., Chen,S., Gorostiza,O., Matalis,A., Niazi,K.,
            Bredesen,D.E. and Rao,R.V.
  TITLE     The small co-chaperone p23 overexpressing transgenic mouse
  JOURNAL   J Neurosci Methods 212 (2), 190-194 (2013)
   PUBMED   23022695
  REMARK    GeneRIF: we report the generation of transgenic mouse lines that
            overexpress wild-type p23 or uncleavable p23
REFERENCE   5  (bases 1 to 1954)
  AUTHORS   Zelin,E., Zhang,Y., Toogun,O.A., Zhong,S. and Freeman,B.C.
  TITLE     The p23 molecular chaperone and GCN5 acetylase jointly modulate
            protein-DNA dynamics and open chromatin status
  JOURNAL   Mol Cell 48 (3), 459-470 (2012)
   PUBMED   23022381
  REMARK    GeneRIF: Data support a model in which p23 and GCN5 regulate
            diverse multistep pathways by controlling the longevity of
            protein-DNA complexes.
REFERENCE   6  (bases 1 to 1954)
  AUTHORS   Bush,J.O., Lan,Y. and Jiang,R.
  TITLE     The cleft lip and palate defects in Dancer mutant mice result from
            gain of function of the Tbx10 gene
  JOURNAL   Proc Natl Acad Sci U S A 101 (18), 7022-7027 (2004)
   PUBMED   15118109
REFERENCE   7  (bases 1 to 1954)
  AUTHORS   Zhang,Y., Schneider,A., Rao,R., Lu,W.J., Fan,X., Davis,L.,
            Breyer,R.M., Breyer,M.D. and Guan,Y.
  TITLE     Genomic structure and genitourinary expression of mouse cytosolic
            prostaglandin E(2) synthase gene
  JOURNAL   Biochim Biophys Acta 1634 (1-2), 15-23 (2003)
   PUBMED   14563409
REFERENCE   8  (bases 1 to 1954)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   9  (bases 1 to 1954)
  AUTHORS   Araki,K., Imaizumi,T., Sekimoto,T., Yoshinobu,K., Yoshimuta,J.,
            Akizuki,M., Miura,K., Araki,M. and Yamamura,K.
  TITLE     Exchangeable gene trap using the Cre/mutated lox system
  JOURNAL   Cell Mol Biol (Noisy-le-grand) 45 (5), 737-750 (1999)
   PUBMED   10512203
REFERENCE   10 (bases 1 to 1954)
  AUTHORS   Holt,S.E., Aisner,D.L., Baur,J., Tesmer,V.M., Dy,M., Ouellette,M.,
            Trager,J.B., Morin,G.B., Toft,D.O., Shay,J.W., Wright,W.E. and
            White,M.A.
  TITLE     Functional requirement of p23 and Hsp90 in telomerase complexes
  JOURNAL   Genes Dev 13 (7), 817-826 (1999)
   PUBMED   10197982
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AC131120.4.
            
            On Apr 29, 2007 this sequence version replaced NM_019766.3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK077538.1, BC085264.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849380
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-305               AC131120.4         179003-179307
            306-419             AC131120.4         188693-188806
            420-489             AC131120.4         189237-189306
            490-588             AC131120.4         190155-190253
            589-678             AC131120.4         192089-192178
            679-741             AC131120.4         194243-194305
            742-766             AC131120.4         195359-195383
            767-1954            AC131120.4         196088-197275
FEATURES             Location/Qualifiers
     source          1..1954
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="10"
                     /map="10 76.39 cM"
     gene            1..1954
                     /gene="Ptges3"
                     /gene_synonym="5730442A20Rik; cPGES; p23; Ptges; sid3177;
                     Tebp"
                     /note="prostaglandin E synthase 3"
                     /db_xref="GeneID:56351"
                     /db_xref="MGI:MGI:1929282"
     exon            1..305
                     /gene="Ptges3"
                     /gene_synonym="5730442A20Rik; cPGES; p23; Ptges; sid3177;
                     Tebp"
                     /inference="alignment:Splign:2.1.0"
     exon            306..419
                     /gene="Ptges3"
                     /gene_synonym="5730442A20Rik; cPGES; p23; Ptges; sid3177;
                     Tebp"
                     /inference="alignment:Splign:2.1.0"
     exon            420..489
                     /gene="Ptges3"
                     /gene_synonym="5730442A20Rik; cPGES; p23; Ptges; sid3177;
                     Tebp"
                     /inference="alignment:Splign:2.1.0"
     exon            490..588
                     /gene="Ptges3"
                     /gene_synonym="5730442A20Rik; cPGES; p23; Ptges; sid3177;
                     Tebp"
                     /inference="alignment:Splign:2.1.0"
     exon            589..678
                     /gene="Ptges3"
                     /gene_synonym="5730442A20Rik; cPGES; p23; Ptges; sid3177;
                     Tebp"
                     /inference="alignment:Splign:2.1.0"
     exon            679..741
                     /gene="Ptges3"
                     /gene_synonym="5730442A20Rik; cPGES; p23; Ptges; sid3177;
                     Tebp"
                     /inference="alignment:Splign:2.1.0"
     exon            742..766
                     /gene="Ptges3"
                     /gene_synonym="5730442A20Rik; cPGES; p23; Ptges; sid3177;
                     Tebp"
                     /inference="alignment:Splign:2.1.0"
     exon            767..1954
                     /gene="Ptges3"
                     /gene_synonym="5730442A20Rik; cPGES; p23; Ptges; sid3177;
                     Tebp"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcattttgct gcgtcaccag ccgccgcccg gcctcgccac ccctcgcgcg cacgcacgct
       61 ccttctccgt cctcgcgccc cttttcctac actttccttc tctcccgggt tgagggagcc
      121 gctctccgcg cggtgcattc tgggcatcga ggccgagccc gccgccgccg tcgcctaaga
      181 ggagcgagga gaggccgcga ccgggcagag accgccggag tcgccgccgg agaggagtcg
      241 actcgccagc cgccgccagc gaggcccgcc cacccgtttg tctggccctc tgccccgttc
      301 accatgcagc ctgcttctgc aaagtggtac gatcgaaggg actatgtatt cattgaattt
      361 tgtgttgaag acagtaaaga tgttaatgta aactttgaaa aatccaaact tactttcagt
      421 tgtcttggag gaagcgataa ttttaagcat ttaaatgaaa ttgatctttt tcattgtatc
      481 gatccaaatg attccaagca taaaagaaca gacagatcga ttttatgttg tttgcgaaaa
      541 ggagaatccg gccagtcatg gcctaggtta acaaaggaaa gggcaaagct taattggctc
      601 agtgtggact tcaataattg gaaagactgg gaggatgact cagatgaaga catgtcgaat
      661 tttgaccgtt tctctgagat gatggatcac atgggtggtg atgaggatgt agatttacca
      721 gaagtagatg gagcagatga tgattcacaa gacagtgatg atgaaaagat gccagatctg
      781 gagtaagggc tgttgtcatc gcctggattt tgagaaagga aaataacttc tgcaagattt
      841 cacaattgag aaaacccctg agtcgatagc tctaaaggca gatatgctgt acttgcctcc
      901 tctaacccag ttgtcaacct ttttttttct ttttcttttt tttctttttt tttttttttg
      961 aaaggcttca ctaagggttg attatgtacc attgtgtggg gcgatttaag tcagctaagg
     1021 cagtatcctt atgcatgaac atttcccatg attccatgag gcagttgatc ctaggcaact
     1081 gctccagcag ctcggacaaa taattgcatt tcatctaagt ctttcatcat aacacaatta
     1141 cttacacatt aggaaagctc tcagcttagg gaaagatgaa agttttagat cctagaccat
     1201 ggatttaaag gaggcggaaa caaattggct aataccttaa actgataacc tgccattctt
     1261 tcaggatacc tttcaaaatt attccactaa agtttatttt tcaaaaaaaa aaaatgtact
     1321 ttacatcatt gtatgtgatc acttgtcagt gttcaggtgt attttagcaa aaactagtgg
     1381 atgccctaac ttagatggtt tttgaagcct atacacttgg tattgtttgg cccttaagct
     1441 tttacatctc ttagcatgga ggacaaagaa agctgtacat tgttgcttga gagtatgtac
     1501 attttagacc agatttgtat ttgcacagtc agtatggcaa atgagtggac aatgttaaat
     1561 acactattgg atttttttta ttttctgttt tgatttcagc ttatgccctg gctggaaaac
     1621 ctcaatttat gttcatgaca gtggggattt ttttaaatgt ctacattctt tctaataaac
     1681 tgttggaaga tttcttggct gtccttttaa gtgtctgttt gctgtaattt catgtattta
     1741 ccccttactg gaatggagtt tggttttttt tttttttttg ttttgttttt ttgagggaaa
     1801 atttggactg gtcctgtttg aacaaagagg cttgctgtac tgtcacagga aaccctgtaa
     1861 agtgtgtctg taaatgggaa gctgtgggca cttggcagca gccagacaag tgttgtgact
     1921 tgactgaaat aaaagtgaat gtgttgtcct cctg
//
