LOCUS       NM_133783               1969 bp    mRNA    linear   ROD 17-SEP-2024
DEFINITION  Mus musculus prostaglandin E synthase 2 (Ptges2), mRNA.
ACCESSION   NM_133783
VERSION     NM_133783.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1969)
  AUTHORS   Taketomi,Y., Higashi,T., Kano,K., Miki,Y., Mochizuki,C.,
            Toyoshima,S., Okayama,Y., Nishito,Y., Nakae,S., Tanaka,S.,
            Tokuoka,S.M., Oda,Y., Shichino,S., Ueha,S., Matsushima,K.,
            Akahoshi,N., Ishii,S., Chun,J., Aoki,J. and Murakami,M.
  TITLE     Lipid-orchestrated paracrine circuit coordinates mast cell
            maturation and anaphylaxis through functional interaction with
            fibroblasts
  JOURNAL   Immunity 57 (8), 1828-1847 (2024)
   PUBMED   39002541
REFERENCE   2  (bases 1 to 1969)
  AUTHORS   Zhong,D., Chen,J., Qiao,R., Song,C., Hao,C., Zou,Y., Bai,M., Su,W.,
            Yang,B., Sun,D., Jia,Z. and Sun,Y.
  TITLE     Genetic or pharmacologic blockade of mPGES-2 attenuates renal
            lipotoxicity and diabetic kidney disease by targeting
            Rev-Erbalpha/FABP5 signaling
  JOURNAL   Cell Rep 43 (4), 114075 (2024)
   PUBMED   38583151
  REMARK    GeneRIF: Genetic or pharmacologic blockade of mPGES-2 attenuates
            renal lipotoxicity and diabetic kidney disease by targeting
            Rev-Erbalpha/FABP5 signaling.
REFERENCE   3  (bases 1 to 1969)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   4  (bases 1 to 1969)
  AUTHORS   Zhong,D., Quan,L., Hao,C., Chen,J., Qiao,R., Lin,T., Ying,C.,
            Sun,D., Jia,Z. and Sun,Y.
  TITLE     Targeting mPGES-2 to protect against acute kidney injury via
            inhibition of ferroptosis dependent on p53
  JOURNAL   Cell Death Dis 14 (10), 710 (2023)
   PUBMED   37907523
  REMARK    GeneRIF: Targeting mPGES-2 to protect against acute kidney injury
            via inhibition of ferroptosis dependent on p53.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1969)
  AUTHORS   Zhong,D., Cai,J., Hu,C., Chen,J., Zhang,R., Fan,C., Li,S.,
            Zhang,H., Xu,Z., Jia,Z., Guo,D. and Sun,Y.
  TITLE     Inhibition of mPGES-2 ameliorates NASH by activating NR1D1 via heme
  JOURNAL   Hepatology 78 (2), 547-561 (2023)
   PUBMED   35839302
  REMARK    GeneRIF: Inhibition of mPGES-2 ameliorates NASH by activating NR1D1
            via heme.
REFERENCE   6  (bases 1 to 1969)
  AUTHORS   Meng,Q., Raha,A., Roy,S., Hu,J. and Kalvakolanu,D.V.
  TITLE     IFN-gamma-stimulated transcriptional activation by
            IFN-gamma-activated transcriptional element-binding factor 1 occurs
            via an inducible interaction with CAAAT/enhancer-binding
            protein-beta
  JOURNAL   J Immunol 174 (10), 6203-6211 (2005)
   PUBMED   15879117
  REMARK    GeneRIF: Transactivators GBF1 and CCAAT/enhancer-binding
            protein-beta physically interact to induce
            interferon-gamma-regulated transcription; a 37-aa long peptide
            derived from the GBF1 protein can associate with C/EBP-beta in an
            IFN-inducible manner.
REFERENCE   7  (bases 1 to 1969)
  AUTHORS   Bosetti,F., Langenbach,R. and Weerasinghe,G.R.
  TITLE     Prostaglandin E2 and microsomal prostaglandin E synthase-2
            expression are decreased in the cyclooxygenase-2-deficient mouse
            brain despite compensatory induction of cyclooxygenase-1 and
            Ca2+-dependent phospholipase A2
  JOURNAL   J Neurochem 91 (6), 1389-1397 (2004)
   PUBMED   15584915
REFERENCE   8  (bases 1 to 1969)
  AUTHORS   Engblom,D., Saha,S., Engstrom,L., Westman,M., Audoly,L.P.,
            Jakobsson,P.J. and Blomqvist,A.
  TITLE     Microsomal prostaglandin E synthase-1 is the central switch during
            immune-induced pyresis
  JOURNAL   Nat Neurosci 6 (11), 1137-1138 (2003)
   PUBMED   14566340
REFERENCE   9  (bases 1 to 1969)
  AUTHORS   Murakami,M., Nakashima,K., Kamei,D., Masuda,S., Ishikawa,Y.,
            Ishii,T., Ohmiya,Y., Watanabe,K. and Kudo,I.
  TITLE     Cellular prostaglandin E2 production by membrane-bound
            prostaglandin E synthase-2 via both cyclooxygenases-1 and -2
  JOURNAL   J Biol Chem 278 (39), 37937-37947 (2003)
   PUBMED   12835322
REFERENCE   10 (bases 1 to 1969)
  AUTHORS   Hu,J., Meng,Q., Roy,S.K., Raha,A., Hu,J., Zhang,J., Hashimoto,K.
            and Kalvakolanu,D.V.
  TITLE     A novel transactivating factor that regulates
            interferon-gamma-dependent gene expression
  JOURNAL   J Biol Chem 277 (33), 30253-30263 (2002)
   PUBMED   12050152
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from CX221758.1, AK050616.1 and
            BE956255.1.
            
            On Oct 8, 2009 this sequence version replaced NM_133783.1.
            
            Summary: The protein encoded by this gene is a Golgi
            membrane-associated prostaglandin E synthase candidate, which is
            capable of catalyzing the conversion of prostaglandin H2 to
            prostaglandin E2 in vitro. However, a study using mice deficient of
            this gene suggests that this enzyme does not contribute to
            prostaglandin E2 biosynthesis in vivo. This protein is synthesized
            as a Golgi membrane-bound protein, but its N-terminal hydrophobic
            region is cleaved off during protein maturation to produce the
            predominant soluble truncated form that still retains the enzyme
            activity. This soluble protein also has been shown to activate the
            transcription regulated by a gamma-interferon-activated
            transcription element (GATE), possibly via an interaction with
            CAAAT/enhancer-binding protein-beta. [provided by RefSeq, Oct
            2009].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC004846.1, AK050616.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-375               CX221758.1         1-375
            376-1949            AK050616.1         2-1575
            1950-1969           BE956255.1         1-20                c
FEATURES             Location/Qualifiers
     source          1..1969
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 22.09 cM"
     gene            1..1969
                     /gene="Ptges2"
                     /gene_synonym="0610038H10Rik; Gbf1; Mpges2; Pges2"
                     /note="prostaglandin E synthase 2"
                     /db_xref="GeneID:96979"
                     /db_xref="MGI:MGI:1917592"
     exon            1..661
                     /gene="Ptges2"
                     /gene_synonym="0610038H10Rik; Gbf1; Mpges2; Pges2"
                     /inference="alignment:Splign:2.1.0"
     exon            662..859
                     /gene="Ptges2"
                     /gene_synonym="0610038H10Rik; Gbf1; Mpges2; Pges2"
                     /inference="alignment:Splign:2.1.0"
     exon            860..918
                     /gene="Ptges2"
                     /gene_synonym="0610038H10Rik; Gbf1; Mpges2; Pges2"
                     /inference="alignment:Splign:2.1.0"
     exon            919..1068
                     /gene="Ptges2"
                     /gene_synonym="0610038H10Rik; Gbf1; Mpges2; Pges2"
                     /inference="alignment:Splign:2.1.0"
     exon            1069..1269
                     /gene="Ptges2"
                     /gene_synonym="0610038H10Rik; Gbf1; Mpges2; Pges2"
                     /inference="alignment:Splign:2.1.0"
     exon            1270..1387
                     /gene="Ptges2"
                     /gene_synonym="0610038H10Rik; Gbf1; Mpges2; Pges2"
                     /inference="alignment:Splign:2.1.0"
     exon            1388..1952
                     /gene="Ptges2"
                     /gene_synonym="0610038H10Rik; Gbf1; Mpges2; Pges2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1928..1933
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ptges2"
                     /gene_synonym="0610038H10Rik; Gbf1; Mpges2; Pges2"
                     /note="hexamer: AATAAA"
     polyA_site      1952
                     /gene="Ptges2"
                     /gene_synonym="0610038H10Rik; Gbf1; Mpges2; Pges2"
                     /note="major polyA site"
ORIGIN      
        1 gggagggcag agagagtctg agacaatgca gccacccact ggagaccgcg tcggaccttt
       61 tctggggagt gaatgggtcg gaagaccaat gttctccctg ccatcgtaga tgcacgatgt
      121 ggaaacgccc gaccacgagt tacaggtcat cattgtaccc tcagaagaca gcgacgccaa
      181 gccacttcct aagcccctgg ggtgtgcttc tgcctctcag acaggcatgc gctctcagat
      241 ccctcaagga ctctggtcct acttggcgtc atcgttaccc taggcaacac gcaggcccgg
      301 tactgtccct ttaaggaatc ctagagccgc cctggttggg ccattttggt tttgcgcgct
      361 cgcccgcagc gccggcagag cgaacatggc ccaggcggcg cgcctttcgt gggtgcttgt
      421 ctctagccgg tgcgccctga ctgaggggct gctcacacga ccctggcagc cgctctcggc
      481 acagagccgg gctggcttca ccagggtggc tgccggaagc cggggcgccg cggtccgcaa
      541 ggggagcccg cggttgctgg gggcggcggc gctggccctg ggcggcgcgc tggggctgta
      601 ccacaccgtg cggtggcacc agcgttccca ggacctccgc gcggagcgct cggctgcgca
      661 gctgcccctg tcgaacagcc tgcagctgac cctgtaccag tacaagacat gtcccttctg
      721 cagcaaagtc cgtgccttcc tcgacttcca ctccctgccc tatcaggtgg tggaggtgaa
      781 tcccgtgaga aggactgaga tcaaattctc ctcctacagg aaagtgccca tcttggtggc
      841 ccaggaagga gacagcttgc aacagctcaa tgactcctct gtcatcatta gtgccctcaa
      901 gacctacctg gtttcagggc agcccctgga agaggtcatc acttattacc cacccatgaa
      961 ggccatgaat gaccagggca aggaggtgac cgagttttgc aacaagtact ggctcatgct
     1021 ggacgagaag gaggcccagc agatgtatgg cgggaaggaa gccaggacgg aggagatgaa
     1081 gtggcggcag tgggcggatg actggctggt gcatctcatc tctcccaacg tgtaccgaac
     1141 acccgctgag gccttggctt ccttcgacta cattgtccgt gagggcaagt ttggggctgt
     1201 ggaggctgcc atggccaagt atgtgggcgc ggctgccatg tacctcatca gcaagcgcct
     1261 caaaagcagg caccacctgc aggatgatgt acgggtagac ctctatgaag cagccaacaa
     1321 gtgggtgaca gccgtgggta aagaccggcc attcatgggg ggtcagaagc ctaaccttgc
     1381 tgacctggca gtgtatggtg tgctgcgagt gatggagggt ctggaggcct tcgacgacct
     1441 gatgcgacac tcacacatcc agccttggta cctgcggatg gagcgggcca ttgaagaagc
     1501 cccctcggtg catcatgtca accctagctg caaagactag ttgctaggga cacaagacct
     1561 ggaccagccc ctggctgtgc tcacagaggg cagagtcatt ttgtctctgg tccacctagc
     1621 ccccagttct ctgcttctga tactggacat ttctagggcc cttgacgctg aggacaaggc
     1681 ccaaacttac agctgttctg tgggtaaagg gtctggggtc tcaaaggcct acccttcaac
     1741 cccagttcag aggcctggtc ccctaacagg gactcctttt caactctgct agggcccagt
     1801 cccttgttga cagggatcag actggctcct gccctggagg aggggaaggc agtgtgttaa
     1861 caaagccccg cccacatgcc tccaggtttc agctcttcga aggtgcccct gggactattg
     1921 tatttgtaat aaaggagagg tctgccaccc ccaaaaaaaa aaaaaaaaa
//
