LOCUS       NM_022415               3647 bp    mRNA    linear   ROD 17-SEP-2024
DEFINITION  Mus musculus prostaglandin E synthase (Ptges), mRNA.
ACCESSION   NM_022415
VERSION     NM_022415.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3647)
  AUTHORS   Taketomi,Y., Higashi,T., Kano,K., Miki,Y., Mochizuki,C.,
            Toyoshima,S., Okayama,Y., Nishito,Y., Nakae,S., Tanaka,S.,
            Tokuoka,S.M., Oda,Y., Shichino,S., Ueha,S., Matsushima,K.,
            Akahoshi,N., Ishii,S., Chun,J., Aoki,J. and Murakami,M.
  TITLE     Lipid-orchestrated paracrine circuit coordinates mast cell
            maturation and anaphylaxis through functional interaction with
            fibroblasts
  JOURNAL   Immunity 57 (8), 1828-1847 (2024)
   PUBMED   39002541
REFERENCE   2  (bases 1 to 3647)
  AUTHORS   Zhang,D., Deng,W., Jiang,T., Zhao,Y., Bai,D., Tian,Y., Kong,S.,
            Zhang,L., Wang,H., Gao,S. and Lu,Z.
  TITLE     Maternal Ezh1/2 deficiency impairs the function of mitochondria in
            mouse oocytes and early embryos
  JOURNAL   J Cell Physiol 239 (6), e31244 (2024)
   PUBMED   38529784
REFERENCE   3  (bases 1 to 3647)
  AUTHORS   Liu,H., Zhou,R., Li,S., Dong,J., Fang,Y., Luo,Y., Su,H., Lai,B.,
            Liang,L., Zhang,D., Zhang,Y., Shyy,J.Y., Zhou,B., Yuan,Z. and
            Wang,Y.
  TITLE     Epigenetic repression of Cend1 by lysine-specific demethylase 1 is
            essential for murine heart development
  JOURNAL   iScience 27 (1), 108722 (2023)
   PUBMED   38226173
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3647)
  AUTHORS   Zhang,Y., Steinmetz-Spah,J., Idborg,H., Zhu,L., Li,H., Rao,H.,
            Chen,Z., Guo,Z., Hu,L., Xu,C., Chen,H., Korotkova,M.,
            Jakobsson,P.J. and Wang,M.
  TITLE     Microsomal prostaglandin E synthase-1 inhibition prevents adverse
            cardiac remodelling after myocardial infarction in mice
  JOURNAL   Br J Pharmacol 180 (15), 1981-1998 (2023)
   PUBMED   36788645
  REMARK    GeneRIF: Microsomal prostaglandin E synthase-1 inhibition prevents
            adverse cardiac remodelling after myocardial infarction in mice.
REFERENCE   5  (bases 1 to 3647)
  AUTHORS   Yasmen,N., Sluter,M.N., Li,L., Yu,Y. and Jiang,J.
  TITLE     Transient inhibition of microsomal prostaglandin E synthase-1 after
            status epilepticus blunts brain inflammation and is neuroprotective
  JOURNAL   Mol Brain 16 (1), 14 (2023)
   PUBMED   36694204
  REMARK    GeneRIF: Transient inhibition of microsomal prostaglandin E
            synthase-1 after status epilepticus blunts brain inflammation and
            is neuroprotective.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3647)
  AUTHORS   Lazarus,M., Munday,C.J., Eguchi,N., Matsumoto,S., Killian,G.J.,
            Kubata,B.K. and Urade,Y.
  TITLE     Immunohistochemical localization of microsomal PGE synthase-1 and
            cyclooxygenases in male mouse reproductive organs
  JOURNAL   Endocrinology 143 (6), 2410-2419 (2002)
   PUBMED   12021206
REFERENCE   7  (bases 1 to 3647)
  AUTHORS   Lazarus,M., Kubata,B.K., Eguchi,N., Fujitani,Y., Urade,Y. and
            Hayaishi,O.
  TITLE     Biochemical characterization of mouse microsomal prostaglandin E
            synthase-1 and its colocalization with cyclooxygenase-2 in
            peritoneal macrophages
  JOURNAL   Arch Biochem Biophys 397 (2), 336-341 (2002)
   PUBMED   11795891
REFERENCE   8  (bases 1 to 3647)
  AUTHORS   Guan,Y., Zhang,Y., Schneider,A., Riendeau,D., Mancini,J.A.,
            Davis,L., Komhoff,M., Breyer,R.M. and Breyer,M.D.
  TITLE     Urogenital distribution of a mouse membrane-associated
            prostaglandin E(2) synthase
  JOURNAL   Am J Physiol Renal Physiol 281 (6), F1173-F1177 (2001)
   PUBMED   11704570
  REMARK    GeneRIF: localization of membrane form in the urogenital tract
REFERENCE   9  (bases 1 to 3647)
  AUTHORS   Murakami,M., Naraba,H., Tanioka,T., Semmyo,N., Nakatani,Y.,
            Kojima,F., Ikeda,T., Fueki,M., Ueno,A., Oh,S. and Kudo,I.
  TITLE     Regulation of prostaglandin E2 biosynthesis by inducible
            membrane-associated prostaglandin E2 synthase that acts in concert
            with cyclooxygenase-2
  JOURNAL   J Biol Chem 275 (42), 32783-32792 (2000)
   PUBMED   10869354
REFERENCE   10 (bases 1 to 3647)
  AUTHORS   Idell,S., James,K.K., Levin,E.G., Schwartz,B.S., Manchanda,N.,
            Maunder,R.J., Martin,T.R., McLarty,J. and Fair,D.S.
  TITLE     Local abnormalities in coagulation and fibrinolytic pathways
            predispose to alveolar fibrin deposition in the adult respiratory
            distress syndrome
  JOURNAL   J Clin Invest 84 (2), 695-705 (1989)
   PUBMED   2788176
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK080897.1, AK167015.1 and BY691798.1.
            
            On Sep 15, 2009 this sequence version replaced NM_022415.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK080897.1, AK150013.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849382, SAMN01164131
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-513               AK080897.1         6-518
            514-3641            AK167015.1         383-3510
            3642-3643           AK080897.1         3650-3651
            3644-3647           BY691798.1         383-386
FEATURES             Location/Qualifiers
     source          1..3647
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 21.75 cM"
     gene            1..3647
                     /gene="Ptges"
                     /gene_synonym="2410099E23Rik; D2Ertd369e; mPGES; mPGES-1;
                     Pges"
                     /note="prostaglandin E synthase"
                     /db_xref="GeneID:64292"
                     /db_xref="MGI:MGI:1927593"
     exon            1..208
                     /gene="Ptges"
                     /gene_synonym="2410099E23Rik; D2Ertd369e; mPGES; mPGES-1;
                     Pges"
                     /inference="alignment:Splign:2.1.0"
     exon            209..291
                     /gene="Ptges"
                     /gene_synonym="2410099E23Rik; D2Ertd369e; mPGES; mPGES-1;
                     Pges"
                     /inference="alignment:Splign:2.1.0"
     exon            292..3647
                     /gene="Ptges"
                     /gene_synonym="2410099E23Rik; D2Ertd369e; mPGES; mPGES-1;
                     Pges"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      2138
                     /gene="Ptges"
                     /gene_synonym="2410099E23Rik; D2Ertd369e; mPGES; mPGES-1;
                     Pges"
     regulatory      3625..3630
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ptges"
                     /gene_synonym="2410099E23Rik; D2Ertd369e; mPGES; mPGES-1;
                     Pges"
                     /note="hexamer: ATTAAA"
     polyA_site      3647
                     /gene="Ptges"
                     /gene_synonym="2410099E23Rik; D2Ertd369e; mPGES; mPGES-1;
                     Pges"
                     /note="major polyA site"
ORIGIN      
        1 ctctccataa gccgcctgtg ggacagtctc actctcagtc ccggtgtccc cgagttgaag
       61 tccaggccgg ctagccgaga tgccttcccc gggcctggtg atggagagcg gccaggtgct
      121 cccggccttt ctgctctgca gcacactgct ggtcatcaag atgtacgcgg tggctgtcat
      181 cacaggccag atgaggctgc ggaagaaggc ttttgccaac cccgaggatg cgctgaaacg
      241 tggaggcctc cagtattaca ggagtgaccc agatgtggag cgctgcctca gagcccaccg
      301 caacgacatg gagacaatct atcctttcct cttcctcggc ttcgtgtact cattcctggg
      361 acccaaccct ctgatcgcct ggatacattt cctcgttgtc ctcacaggcc gtgtggtaca
      421 caccgtggcc tacctgggca agctgaaccc acgccttcgc tccggggcct atgtcctggc
      481 ccagttctcc tgtttctcca tggccctgca gatcctctgg gaggtggccc accatctgtg
      541 accagcagct gaagcctcct cagctaccac agtggggaca gagccatgaa ggctgaactt
      601 gcggacttgg tgtctcttct agaataggga cggggtctgg tcctggggtc ctgggtaacc
      661 tgggcgagtg gatctcaggg cccaatgtgc acatgtgtgt ttcttagcct tttgggatgc
      721 tagatgaagt cccatttgga gccacttaca gatgagctgt caagatttga gaggacatcc
      781 ttcacctcac aaaatgcctt aaacatcaca ccacactccc tcttaaccat aaaataaagg
      841 acaggattga ccaacagagc catcatccca tataggacta agaatgaagg cttctcagac
      901 ctacctacaa ttctggccca gcccaaggag agccacctgg ctggtatgtg tccgaggaca
      961 tcctcacaag aggcccagca gtggccagct ccatgtggag gtagagtgct tgctattttt
     1021 agaggtgggc aggtcagagc atccctgtcc cctgttgata ccaccgtcct ttgagtgcct
     1081 taggtagcac aggctcaggg gggtgagaat gtccacagct cagcctcctt gtgcatggct
     1141 ttggctcctc caaagacgga aaggatgggc tttgaccaac ccctggaagg gaactttggc
     1201 ttcttcagca tctgtgaggt ttgaagatgc caaatgtcta ctcctgtgga aaatctcact
     1261 tgtgtgtgtg cagtgtccct ccagagtcct gagacctgtt taggtttagt cattaaacag
     1321 cagagtgtga cctgtgaatg ttcggtgtct aagacccatg ctgtgccagc cggcctggta
     1381 cctatgggag ttttcacgtt ccggtgtgtg tatgttttac ttttatgaga caaggtctca
     1441 cttagcccga gttggcctca aacttactct acagtcagga caaccttgag ctgacagcct
     1501 acctgtgcct cctaagtgct gggatcgccg gcctgcacca ccatagtgcc aagccagtac
     1561 aggcaacttc caccaggctg ctccagagaa gtccctgaca agatggtgtt tggcttggga
     1621 tccagagatg tccaaatcct gtcttccacg tggcgattct ttctgcagct ctgccacctt
     1681 gtagggtgct ggttttctgc tctacagacg gagacggaag tgactacctg aaggaaggca
     1741 tagggtgtgc tccagaacct gggacattca ggctcccagg cttcccacac aagcctagcc
     1801 acaccacttc tcctcccagc ggggcaagcc ctgtgcccca gacctgctct atggggttgg
     1861 ggagggggtt ttactggaaa gccctgctgg cctaggcttc agcctcacac agctggtgtt
     1921 ctgggagtga atagcactgc cctctggtgg tgagttgaaa cctttgctct tggaatgctc
     1981 atctgagaaa acaaaaactg tagaatgggg cccctcttga atgccagctg tcgctgaaca
     2041 ttaggctgga tgcgaccttc atctgtcatt gtcaccccaa ccccaatgcc ccagttaata
     2101 cttaaatttt agataagacc aggtgaattc agacaaaagc cttttttcct gcgttttaat
     2161 tttctgtgga tgggtgtttt gtatgaatgt ctgtctgtat cataggtgta cctggtgccc
     2221 atggagacca gaagaagttg ctggagctgg agttagagac attgtgagcc atcatgtgga
     2281 tactgggaat tgaacccggg ttctctgaag agcaaccagt gctcttaacc actgagccat
     2341 ttctccagac ccatttttag ataagggatt caaggatcca agaagacttg tcctgaattc
     2401 ctgagctagc atagtcaaaa actttgcaag atgggaccca ggagagagag gactggagag
     2461 tccatgcagg gcgtataaat actcatctac ttcagtcttt tcctctcagg aaggtgagat
     2521 tgtgagggcc aggtgtaaga acctgccagt tgcctgatgc agaccatgca ttgcccacaa
     2581 ggtctgcctg ctgtggggcc tgcgagatgg aggccagggc ccctcggagg gtctactcat
     2641 ttgtctttct tgcccatccc ctggcactgc agtgggaaag gcaccaagca agggacagtg
     2701 acagcctcat gtggggtaag aaggctcagt cctctgatcc ctgctgggca gggaggtgag
     2761 ttacgctaat gctggccagg atgtataaag aaattcaagt gtgcacacct tcaatccagc
     2821 acacaggcag gtggatagct gagttggaag ccagcctggt ctacccagtg agtccttgtc
     2881 tcaaaagcaa agaaatcagt acctgtgtgc catggtatga agttgaaatt ggaggggtgg
     2941 gaaatcgggg taagagggcc attaaggagg ccgaggtacc ctttctatgt tccaagcagg
     3001 agagaggtgg ggacagtggt ttcagcaggg tgtcactggg cagttggcag gagcagagac
     3061 aggacctagt ggcttgttct gatccagccc tcatgatagg gaatacaggg agtgatctcc
     3121 tggctgcaaa tctggactca agacaggtgg ctccaggcca cagcacagag caaagcactg
     3181 tccagggagg cagtgtggct ggtgccacct gccaatccag ccagaggctg caacacagca
     3241 cctgcagccc tcaagccctg ctaccacagc agcatctctt gcatctctcg attccttttt
     3301 ttttctgaca tggtctcttg tctgaggcca tttgtggtgg cttgaatagg aatggccccc
     3361 caataaactc atgtgtttga ctgcttagcc catagggagg agtggcatta ttaagaggtg
     3421 tggccttgtt ggaggtggtg tgtcactgtg aggtgggctt tggggtctca tatgctcaat
     3481 ctcagcctac tggggcagtc ccctgctgcc ttcagatcaa gttgtagaac tctgatctcc
     3541 ttctccagca ccatgtctgc cttcatgcca tgttcccacc atgatgataa aggactaaac
     3601 ctctgaacct gtaagtcagc cccaattaaa tgctttcctt tataaga
//
