LOCUS       NM_001359745            2120 bp    mRNA    linear   ROD 14-JAN-2025
DEFINITION  Mus musculus prostaglandin E receptor 3 (subtype EP3) (Ptger3),
            transcript variant 1, mRNA.
ACCESSION   NM_001359745 XM_011240037
VERSION     NM_001359745.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2120)
  AUTHORS   Esteva-Font,C., Geurts,F., Hansen,T.P.K., Hoorn,E.J. and
            Fenton,R.A.
  TITLE     Inducible deletion of the prostaglandin EP3 receptor in kidney
            tubules of male and female mice has no major effect on water
            homeostasis
  JOURNAL   Am J Physiol Renal Physiol 327 (3), F504-F518 (2024)
   PUBMED   38961846
  REMARK    GeneRIF: Inducible deletion of the prostaglandin EP3 receptor in
            kidney tubules of male and female mice has no major effect on water
            homeostasis.
REFERENCE   2  (bases 1 to 2120)
  AUTHORS   Taketomi,Y., Higashi,T., Kano,K., Miki,Y., Mochizuki,C.,
            Toyoshima,S., Okayama,Y., Nishito,Y., Nakae,S., Tanaka,S.,
            Tokuoka,S.M., Oda,Y., Shichino,S., Ueha,S., Matsushima,K.,
            Akahoshi,N., Ishii,S., Chun,J., Aoki,J. and Murakami,M.
  TITLE     Lipid-orchestrated paracrine circuit coordinates mast cell
            maturation and anaphylaxis through functional interaction with
            fibroblasts
  JOURNAL   Immunity 57 (8), 1828-1847 (2024)
   PUBMED   39002541
REFERENCE   3  (bases 1 to 2120)
  AUTHORS   Zhang,Y., Pool,A.H., Wang,T., Liu,L., Kang,E., Zhang,B., Ding,L.,
            Frieda,K., Palmiter,R. and Oka,Y.
  TITLE     Parallel neural pathways control sodium consumption and taste
            valence
  JOURNAL   Cell 186 (26), 5751-5765 (2023)
   PUBMED   37989313
REFERENCE   4  (bases 1 to 2120)
  AUTHORS   Mukai,Y., Okubo,T.S., Lazarus,M., Ono,D., Tanaka,K.F. and
            Yamanaka,A.
  TITLE     Prostaglandin E2 Induces Long-Lasting Inhibition of Noradrenergic
            Neurons in the Locus Coeruleus and Moderates the Behavioral
            Response to Stressors
  JOURNAL   J Neurosci 43 (47), 7982-7999 (2023)
   PUBMED   37734949
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2120)
  AUTHORS   Matsuoka,T. and Narumiya,S.
  TITLE     Prostaglandin receptor signaling in disease
  JOURNAL   ScientificWorldJournal 7, 1329-1347 (2007)
   PUBMED   17767353
  REMARK    Review article
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2120)
  AUTHORS   Negishi,M., Sugimoto,Y., Namba,T., Irie,A., Narumiya,S. and
            Ichikawa,A.
  TITLE     Signal transductions of three isoforms of mouse prostaglandin E
            receptor EP3 subtype
  JOURNAL   Adv Prostaglandin Thromboxane Leukot Res 23, 255-257 (1995)
   PUBMED   7732847
REFERENCE   7  (bases 1 to 2120)
  AUTHORS   Taniguchi,S., Watanabe,T., Nakao,A., Seki,G., Uwatoko,S. and
            Kurokawa,K.
  TITLE     Detection and quantitation of EP3 prostaglandin E2 receptor mRNA
            along mouse nephron segments by RT-PCR
  JOURNAL   Am J Physiol 266 (5 Pt 1), C1453-C1458 (1994)
   PUBMED   7515568
REFERENCE   8  (bases 1 to 2120)
  AUTHORS   Taketo,M., Rochelle,J.M., Sugimoto,Y., Namba,T., Honda,A.,
            Negishi,M., Ichikawa,A., Narumiya,S. and Seldin,M.F.
  TITLE     Mapping of the genes encoding mouse thromboxane A2 receptor and
            prostaglandin E receptor subtypes EP2 and EP3
  JOURNAL   Genomics 19 (3), 585-588 (1994)
   PUBMED   7910583
REFERENCE   9  (bases 1 to 2120)
  AUTHORS   Sugimoto,Y., Namba,T., Honda,A., Hayashi,Y., Negishi,M.,
            Ichikawa,A. and Narumiya,S.
  TITLE     Cloning and expression of a cDNA for mouse prostaglandin E receptor
            EP3 subtype
  JOURNAL   J Biol Chem 267 (10), 6463-6466 (1992)
   PUBMED   1372606
REFERENCE   10 (bases 1 to 2120)
  AUTHORS   Idell,S., James,K.K., Levin,E.G., Schwartz,B.S., Manchanda,N.,
            Maunder,R.J., Martin,T.R., McLarty,J. and Fair,D.S.
  TITLE     Local abnormalities in coagulation and fibrinolytic pathways
            predispose to alveolar fibrin deposition in the adult respiratory
            distress syndrome
  JOURNAL   J Clin Invest 84 (2), 695-705 (1989)
   PUBMED   2788176
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC141480.4 and AC132240.3.
            
            On Dec 5, 2019 this sequence version replaced NM_001359745.1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: D10204.1, ERR3363658.2646334.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-970               AC141480.4         46338-47307         c
            971-1150            AC141480.4         9039-9218           c
            1151-1239           AC132240.3         50922-51010
            1240-2120           AC132240.3         53076-53956
FEATURES             Location/Qualifiers
     source          1..2120
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 81.32 cM"
     gene            1..2120
                     /gene="Ptger3"
                     /gene_synonym="EP3; Pgerep3; Ptgerep3"
                     /note="prostaglandin E receptor 3 (subtype EP3)"
                     /db_xref="GeneID:19218"
                     /db_xref="MGI:MGI:97795"
     exon            1..970
                     /gene="Ptger3"
                     /gene_synonym="EP3; Pgerep3; Ptgerep3"
                     /inference="alignment:Splign:2.1.0"
     CDS             143..1243
                     /gene="Ptger3"
                     /gene_synonym="EP3; Pgerep3; Ptgerep3"
                     /note="isoform 1 is encoded by transcript variant 1;
                     prostaglandin E2 receptor EP3 subtype; prostanoid EP3
                     receptor; PGE receptor EP3 subtype; PGE2 receptor EP3
                     subtype; prostaglandin E receptor EP3 subtype"
                     /codon_start=1
                     /product="prostaglandin E2 receptor EP3 subtype isoform 1"
                     /protein_id="NP_001346674.1"
                     /db_xref="CCDS:CCDS89716.1"
                     /db_xref="GeneID:19218"
                     /db_xref="MGI:MGI:97795"
                     /translation="MASMWAPEHSAEAHSNLSSTTDDCGSVSVAFPITMMVTGFVGNA
                     LAMLLVSRSYRRRESKRKKSFLLCIGWLALTDLVGQLLTSPVVILVYLSQRRWEQLDP
                     SGRLCTFFGLTMTVFGLSSLLVASAMAVERALAIRAPHWYASHMKTRATRAVLLGVWL
                     SVLAFALLPVLGVGRYSVQWPGTWCFISTGPAGNETDPAREPGSVAFASAFACLGLLA
                     LVVTFACNLATIKALVSRCRAKAAVSQSSAQWGRITTETAIQLMGIMCVLSVCWSPLL
                     IMMLKMIFNQMSVEQCKTQMGKEKECNSFLIAVRLASLNQILDPWVYLLLRKILLRKF
                     CQIRDHTNYASSSTSLPCPGSSALMWSDQLER"
     exon            971..1150
                     /gene="Ptger3"
                     /gene_synonym="EP3; Pgerep3; Ptgerep3"
                     /inference="alignment:Splign:2.1.0"
     exon            1151..1239
                     /gene="Ptger3"
                     /gene_synonym="EP3; Pgerep3; Ptgerep3"
                     /inference="alignment:Splign:2.1.0"
     exon            1240..2120
                     /gene="Ptger3"
                     /gene_synonym="EP3; Pgerep3; Ptgerep3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2094..2099
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ptger3"
                     /gene_synonym="EP3; Pgerep3; Ptgerep3"
                     /note="hexamer: AATAAA"
     polyA_site      2120
                     /gene="Ptger3"
                     /gene_synonym="EP3; Pgerep3; Ptgerep3"
                     /note="major polyA site"
ORIGIN      
        1 agtccccgca gcctagcgcg ggaggcggcg ggcgatggag agcagagcct gggctccggc
       61 tgtcccccag tgcactctgc tgctatcccg cagctgagcc gggaggctcc ggccccgtgc
      121 gccctaccgt ggccccgcca ctatggctag catgtgggcg ccggagcact ctgctgaagc
      181 gcacagcaac ctgtcaagta ctaccgacga ctgcggctcc gtgtccgtgg cctttcccat
      241 caccatgatg gtcactggct tcgtgggcaa cgcgctggcc atgctgctcg tgtcgcgcag
      301 ctaccggcgc cgcgagagca agcgcaagaa gtctttcctg ctgtgcattg gctggctggc
      361 gctcaccgac ttagtggggc agctcctgac cagcccggtg gtcatcctcg tgtacctgtc
      421 acagcgacgc tgggagcagc tcgacccatc ggggcgtctg tgcaccttct tcgggctaac
      481 catgacagtg ttcgggctat cctcgctcct ggtggccagc gccatggccg tggagcgcgc
      541 cctggccatc cgtgcgccgc actggtatgc cagccacatg aagactcgcg ccacgcgcgc
      601 ggtactgctg ggcgtgtggc tgtctgtgct cgccttcgcg ctgctgccgg tgctgggcgt
      661 gggccgctac agcgtgcagt ggccgggcac gtggtgcttc atcagcaccg ggccggcggg
      721 caacgagaca gaccctgcgc gcgagccggg cagcgtggcc tttgcctccg ccttcgcctg
      781 cttgggcttg ctggctctgg tggtgacctt tgcctgcaac ctggcgacca tcaaagccct
      841 ggtgtcccgc tgtcgggcca aagccgccgt ctcgcagtcc agcgcccagt ggggcagaat
      901 caccacggag acggccatcc agctcatggg gatcatgtgt gtgctgtccg tctgttggtc
      961 gccgctattg ataatgatgt tgaaaatgat cttcaatcag atgtcggttg agcaatgcaa
     1021 gacacagatg ggaaaggaga aggagtgcaa ttcctttcta attgcagttc gcctggcttc
     1081 gctgaaccag atcttggatc cctgggttta tctgctgcta agaaagatcc ttcttcggaa
     1141 gttctgccag atcagagacc acaccaacta tgcttccagc tccacctcct tgccctgccc
     1201 aggctcctca gccctgatgt ggagtgacca gctggaaaga tgatgaacaa cctgaagtgg
     1261 actttcattg cagtacctgt ttccctgggt ctgagaattt cttctcccag ggaaggatga
     1321 ctgagtattt tggattgtat cttcttttgg cctcaatttt aagttttcct tgccattaaa
     1381 cacaccgaga caagctttct taggataatc tgagagtctg gttgttagct ggttcctgtg
     1441 aaggactgaa gactctgcac ttgagacggg ggcaagacga cacagagcag catggagaga
     1501 ctcagtgcag aaatatctcc agcctcagaa cctttgtgga catggacacc ttcatgtatt
     1561 gatagtctga ctcttctaaa taggtctgaa aaagcagcat aagtttttaa acagtgaagc
     1621 atcaatgtgt tgagagcaaa tgttcatcta ataagccatg agccaaacaa gacaaaaaag
     1681 tctacatgag agggcaagag agattgtgca aagggtattt gtgccaagaa ggtatacagt
     1741 accacagagt tgtgtcctca gtgagagtgg gaaataagtt tctaatttaa ttctaattac
     1801 tggctcctca gtaattcagg aatcgtgcca tcatttccct gcttttaaag ggagaagttt
     1861 agctaaagac acattccagg tgtcactaac agttccaaag ctaggtgact aaatgttcag
     1921 ctagagctgt taaaaggaaa accagctaat tatcattcca gtccaatgct atttttgaat
     1981 tactatctac ttaagatttc tcataatttg tgctcaggca gcacaataaa aagggggggg
     2041 caaaattact aagtgacagt tattctgcat ctaagtctgt gactttttta tgaaataaaa
     2101 tgattttgtc tgtgttgaaa
//
