LOCUS       NM_008964               3768 bp    mRNA    linear   ROD 17-SEP-2024
DEFINITION  Mus musculus prostaglandin E receptor 2 (subtype EP2) (Ptger2),
            mRNA.
ACCESSION   NM_008964
VERSION     NM_008964.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3768)
  AUTHORS   Taketomi,Y., Higashi,T., Kano,K., Miki,Y., Mochizuki,C.,
            Toyoshima,S., Okayama,Y., Nishito,Y., Nakae,S., Tanaka,S.,
            Tokuoka,S.M., Oda,Y., Shichino,S., Ueha,S., Matsushima,K.,
            Akahoshi,N., Ishii,S., Chun,J., Aoki,J. and Murakami,M.
  TITLE     Lipid-orchestrated paracrine circuit coordinates mast cell
            maturation and anaphylaxis through functional interaction with
            fibroblasts
  JOURNAL   Immunity 57 (8), 1828-1847 (2024)
   PUBMED   39002541
REFERENCE   2  (bases 1 to 3768)
  AUTHORS   Lacher,S.B., Dorr,J., de Almeida,G.P., Honninger,J., Bayerl,F.,
            Hirschberger,A., Pedde,A.M., Meiser,P., Ramsauer,L., Rudolph,T.J.,
            Spranger,N., Morotti,M., Grimm,A.J., Jarosch,S., Oner,A.,
            Gregor,L., Lesch,S., Michaelides,S., Fertig,L., Briukhovetska,D.,
            Majed,L., Stock,S., Busch,D.H., Buchholz,V.R., Knolle,P.A.,
            Zehn,D., Dangaj Laniti,D., Kobold,S. and Bottcher,J.P.
  TITLE     PGE2 limits effector expansion of tumour-infiltrating stem-like
            CD8+ T cells
  JOURNAL   Nature 629 (8011), 417-425 (2024)
   PUBMED   38658748
REFERENCE   3  (bases 1 to 3768)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   4  (bases 1 to 3768)
  AUTHORS   Kameyama,H., Dondapati,P., Simmons,R., Leslie,M., Langenheim,J.F.,
            Sun,Y., Yi,M., Rottschaefer,A., Pathak,R., Nuguri,S., Fung,K.M.,
            Tsaih,S.W., Chervoneva,I., Rui,H. and Tanaka,T.
  TITLE     Needle biopsy accelerates pro-metastatic changes and systemic
            dissemination in breast cancer: Implications for mortality by
            surgery delay
  JOURNAL   Cell Rep Med 4 (12), 101330 (2023)
   PUBMED   38118415
REFERENCE   5  (bases 1 to 3768)
  AUTHORS   Wang,Q., Xin,B., Wang,X., Li,F., Fu,H., Yan,Z. and Zhu,Y.
  TITLE     TT-10 may elevate YAP and repair mouse uterine damage resulting
            from the inhibition effect of ibuprofen on COX2-PGE2 and YAP
  JOURNAL   Toxicol Lett 383, 215-226 (2023)
   PUBMED   37453669
  REMARK    GeneRIF: TT-10 may elevate YAP and repair mouse uterine damage
            resulting from the inhibition effect of ibuprofen on COX2-PGE2 and
            YAP.
REFERENCE   6  (bases 1 to 3768)
  AUTHORS   Katsuyama,M., Nishigaki,N., Sugimoto,Y., Morimoto,K., Negishi,M.,
            Narumiya,S. and Ichikawa,A.
  TITLE     The mouse prostaglandin E receptor EP2 subtype: cloning,
            expression, and northern blot analysis
  JOURNAL   FEBS Lett 372 (2-3), 151-156 (1995)
   PUBMED   7556658
REFERENCE   7  (bases 1 to 3768)
  AUTHORS   Takahashi,Y., Taketani,Y., Endo,T., Yamamoto,S. and Kumegawa,M.
  TITLE     Studies on the induction of cyclooxygenase isozymes by various
            prostaglandins in mouse osteoblastic cell line with reference to
            signal transduction pathways
  JOURNAL   Biochim Biophys Acta 1212 (2), 217-224 (1994)
   PUBMED   7514040
REFERENCE   8  (bases 1 to 3768)
  AUTHORS   Taketo,M., Rochelle,J.M., Sugimoto,Y., Namba,T., Honda,A.,
            Negishi,M., Ichikawa,A., Narumiya,S. and Seldin,M.F.
  TITLE     Mapping of the genes encoding mouse thromboxane A2 receptor and
            prostaglandin E receptor subtypes EP2 and EP3
  JOURNAL   Genomics 19 (3), 585-588 (1994)
   PUBMED   7910583
REFERENCE   9  (bases 1 to 3768)
  AUTHORS   Idell,S., James,K.K., Levin,E.G., Schwartz,B.S., Manchanda,N.,
            Maunder,R.J., Martin,T.R., McLarty,J. and Fair,D.S.
  TITLE     Local abnormalities in coagulation and fibrinolytic pathways
            predispose to alveolar fibrin deposition in the adult respiratory
            distress syndrome
  JOURNAL   J Clin Invest 84 (2), 695-705 (1989)
   PUBMED   2788176
REFERENCE   10 (bases 1 to 3768)
  AUTHORS   Fuller,J.L., Brady-Wood,S. and Elias,M.F.
  TITLE     Effects of retinal degeneration and brain size upon spatial
            reversal learning in mice
  JOURNAL   Percept Mot Skills 36 (3), 947-950 (1973)
   PUBMED   4704351
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BG086577.2, AK054132.1 and AC154627.2.
            
            On Mar 21, 2009 this sequence version replaced NM_008964.3.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK136577.1, AK036531.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-480               BG086577.2         1-480
            481-3098            AK054132.1         2-2619
            3099-3768           AC154627.2         109879-110548       c
FEATURES             Location/Qualifiers
     source          1..3768
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="14"
                     /map="14 22.68 cM"
     gene            1..3768
                     /gene="Ptger2"
                     /gene_synonym="EP2; Ptgerep2"
                     /note="prostaglandin E receptor 2 (subtype EP2)"
                     /db_xref="GeneID:19217"
                     /db_xref="MGI:MGI:97794"
     exon            1..1697
                     /gene="Ptger2"
                     /gene_synonym="EP2; Ptgerep2"
                     /inference="alignment:Splign:2.1.0"
     CDS             855..1943
                     /gene="Ptger2"
                     /gene_synonym="EP2; Ptgerep2"
                     /note="prostaglandin E receptor EP2 subtype; prostaglandin
                     E receptor 2 (EP2 subtype); prostaglandin E receptor
                     subtype EP2; prostanoid EP2 receptor; PGE receptor EP2
                     subtype; PGE2 receptor EP2 subtype"
                     /codon_start=1
                     /product="prostaglandin E2 receptor EP2 subtype"
                     /protein_id="NP_032990.1"
                     /db_xref="CCDS:CCDS26972.1"
                     /db_xref="GeneID:19217"
                     /db_xref="MGI:MGI:97794"
                     /translation="MDNFLNDSKLMEDCKSRQWLLSGESPAISSVMFSAGVLGNLIAL
                     ALLARRWRGDTGCSAGSRTSISLFHVLVTELVLTDLLGTCLISPVVLASYSRNQTLVA
                     LAPESHACTYFAFTMTFFSLATMLMLFAMALERYLSIGYPYFYRRHLSRRGGLAVLPV
                     IYGASLLFCSLPLLNYGEYVQYCPGTWCFIRHGRTAYLQLYATMLLLLIVAVLACNIS
                     VILNLIRMHRRSRRSRCGLSGSSLRGPGSRRRGERTSMAEETDHLILLAIMTITFAIC
                     SLPFTIFAYMDETSSLKEKWDLRALRFLSVNSIIDPWVFAILRPPVLRLMRSVLCCRT
                     SLRTQEAQQTSCSTQSSASKQTDLCGQL"
     exon            1698..3768
                     /gene="Ptger2"
                     /gene_synonym="EP2; Ptgerep2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2599..2604
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ptger2"
                     /gene_synonym="EP2; Ptgerep2"
                     /note="hexamer: ATTAAA"
     polyA_site      2618
                     /gene="Ptger2"
                     /gene_synonym="EP2; Ptgerep2"
                     /note="major polyA site"
     regulatory      3078..3083
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ptger2"
                     /gene_synonym="EP2; Ptgerep2"
                     /note="hexamer: AATAAA"
     polyA_site      3101
                     /gene="Ptger2"
                     /gene_synonym="EP2; Ptgerep2"
ORIGIN      
        1 gaggattaca agaacagttc ctgttttgtt ttgttaggat tgcttaagca agtcgttgtt
       61 ataggaaggc aaaggccact ctgtggtgtg cacggttcca tttcttggat ggataggttt
      121 gcttttcagt tccttccagt ttttgtccca cctttgttgg gtatctttct ggatgttttg
      181 tgttttgttt tgttttaaag gaaaacaaca acctctctca tattcttact tcaagttgtc
      241 ttgatgtttt tgtgcctcct ccacacctca cagggctgga ctctcttaac ctcagtttgg
      301 tgagttcctg ttaccccagt cttattaaac tgtgctggtt cccagccttc tgctagggct
      361 aaaggcttca gagctgaagt cagaggcact gcaacttcca acccatagga aggaagacct
      421 tatgggccag ctcagggtga gcgctgggaa cgcccccagg tcccttctag agccctgtca
      481 gtgtgtgtct gccctgcctg gccccacggc agcagctcgc aagcaatcta aattgctttc
      541 ctggattcca ctactggact tgccccctga aggcgctgga gggagcagct gctctggcaa
      601 gcaccccctg ctagggcagg tgaggcacag aagcaccgag agcgaccgga tattgtagtg
      661 aagaggccac tgtacgtaca ggcaggagac ccaaacaagt ctgtccttgg tgcgagttgg
      721 gggccggaag ggagctctgg atttcggtcc ctcccctttt ccctgctctg tcttggagcc
      781 ctggggccat cagaccctcc gactgtctgg tacttgcctg gaagagatat catctctcct
      841 ccacaccctc caccatggac aattttctta atgactccaa gctaatggag gactgcaaga
      901 gtcgtcagtg gctcctttcg ggggaaagcc cagccatcag ctcggtgatg ttctcggccg
      961 gggttctggg gaatctcatc gcactggcac tgttggcgcg ccgctggcgt ggggacaccg
     1021 ggtgtagcgc cggcagcagg acctctatct ccttgtttca cgtgctggta acggaattgg
     1081 tgctcactga cctgctggga acctgcctca tcagcccggt ggtgctggct tcatattcaa
     1141 gaaaccagac cctggtggcc ctggctcccg aaagtcacgc gtgtacctat ttcgctttca
     1201 ctatgacctt ctttagtctg gccacgatgc tcatgctctt cgctatggcc ctggaacgct
     1261 acctctccat cgggtaccct tacttctaca ggcgccactt atcgcgccgc gggggtctgg
     1321 cggtgctgcc tgtcatctat ggggcctcct tgctcttctg ttccctgccg ctgctcaact
     1381 acggggagta cgtccagtac tgtcctggga catggtgctt tatccggcac gggaggactg
     1441 cataccttca gctgtacgcc acgatgctcc tgctgcttat cgtggctgtg ctcgcctgca
     1501 acatcagcgt tatcctcaac ctcattcgca tgcaccgtcg gagcagaaga agccgctgcg
     1561 gattgtctgg cagtagccta agaggccctg gatctcgcag gagaggagag aggacttcga
     1621 tggcagagga gacggaccac ctcattctcc tggccattat gaccatcacc ttcgccatat
     1681 gctccttgcc tttcacaatc tttgcctaca tggatgaaac ctcttcccta aaggaaaagt
     1741 gggacctccg agctcttcgg tttttatcag ttaactctat aattgaccct tgggtctttg
     1801 ccatacttag gccaccggtc ctgaggttaa tgcgctcagt cctctgttgt cggacttcac
     1861 tgagaacaca agaagctcag caaacatcct gttctaccca gtccagtgcc agtaaacaga
     1921 ctgacctttg tggacagttg tgaggatgcg cttcatgagg gaacctctga agaagtcttt
     1981 aaatggcctc attggagaag tgtaaggggc tggaatataa acagaataac cttgccctga
     2041 gaagcagatg aaacagactt tatgaggtag tttgggctgc agatgtgatg acagagccct
     2101 ttgtggaaag tgtcagagga tataaagttc acattatgtg acctttgaag gacaatcggc
     2161 tgcgtctaag acccagttga tttaagcttt cctgttgagt gacaaagcat gtggttttgt
     2221 aatttgtttt aaaatgctac atggttactg ttttaatttt gatgtcactg ctgttataaa
     2281 tgcaatcaga ccaaatgaaa ttcattctct aggaagtcaa ctcatgcaag cgatgaagca
     2341 accagagcag acaagttgct gtctcgtgat tgcttaatgg actctttatt tggaccatga
     2401 agttgaatgc cattggcccc ttttactgtg cgcgttcatg tgggagtcct ctctggtaac
     2461 gaaaggatgc actgatttgg ttaatgctag ttaatccttt aggagctctg tcatgttgtc
     2521 agattattta ttctgtcttg tctattgtga taaggctact gaagaaaact tcagaaattt
     2581 gcgtctcaca aaggaataat taaaaaaatc aattttaatt agtgttcttc agttttttta
     2641 tagaggaaga gttttcacag ttgtatctga gatcagattt taggatcaaa ctctgaaaat
     2701 tcaagtctat ttttcaggtt ctctagaatc cttctagtgt tggtactaga cataactaac
     2761 atacacatac actacaagat gtttgattgt gccacggcaa acgcttttgt ctgtattttt
     2821 attgagggaa catattttga ttcatacaac agaagaaatc atgtaactgt gagtcatatc
     2881 ttatatttcc aaacgtttgg catggtataa actcagcatt aaagtattcc agtgagcgtg
     2941 tacatttagt cagttatagt gtaaacacat ctgaaatgtt acaagctaaa ttataaaaca
     3001 aaaaagtaga agtcttcaat gaattaactc cccaaggaca gtttgcagtt aatgtagaca
     3061 tggcatcttt taggtaaaat aaaagttttt aaaaaatcaa ataatatttt ggcaaatttt
     3121 taaaatgtac agttgttata aattaaaatt ttaagatatc cagtggagtt cttgatattg
     3181 aaagagagtt ttgctatcag ttttcactct tctgacatgg tcattagaat aatataacca
     3241 tcgtatttga gagcagatag aattgtagga tggctgttaa ctttttaaat ctagttgttt
     3301 ctcatgcttc atgtttaccc agagctgttt tttatagtta gttatcattt agaaagactc
     3361 tgtgtaacta aatatctctg atacaaatta tgggagtcaa agcagctctt acttttacaa
     3421 gaatatataa ataagtggtt cgtgtttgta taaatttaag cagagcagac aaagtttaat
     3481 ttaactaaaa tctaggcagg tataaataaa tgccacctct tcacccggtg ttgcatgcca
     3541 agaaattaca ttcaggggga gaatgacact gaagcagaaa tttctggtta ctttgcacct
     3601 ggaattttga ttccttttat cagatgtcgt tgtaaaaatc tcagaatgaa aaaaaatatt
     3661 aactacagcc tctcattgca ccacactgtg cccctgcacc cattgagaac aatgcctgag
     3721 attttttaaa atggacatag taccctcagg agcataaaat atcagaac
//
