LOCUS       NM_013641               2080 bp    mRNA    linear   ROD 11-FEB-2025
DEFINITION  Mus musculus prostaglandin E receptor 1 (subtype EP1) (Ptger1),
            mRNA.
ACCESSION   NM_013641
VERSION     NM_013641.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2080)
  AUTHORS   Taketomi,Y., Higashi,T., Kano,K., Miki,Y., Mochizuki,C.,
            Toyoshima,S., Okayama,Y., Nishito,Y., Nakae,S., Tanaka,S.,
            Tokuoka,S.M., Oda,Y., Shichino,S., Ueha,S., Matsushima,K.,
            Akahoshi,N., Ishii,S., Chun,J., Aoki,J. and Murakami,M.
  TITLE     Lipid-orchestrated paracrine circuit coordinates mast cell
            maturation and anaphylaxis through functional interaction with
            fibroblasts
  JOURNAL   Immunity 57 (8), 1828-1847 (2024)
   PUBMED   39002541
REFERENCE   2  (bases 1 to 2080)
  AUTHORS   Wang,B., Jin,Y., Liu,J., Liu,Q., Shen,Y., Zuo,S. and Yu,Y.
  TITLE     EP1 activation inhibits doxorubicin-cardiomyocyte ferroptosis via
            Nrf2
  JOURNAL   Redox Biol 65, 102825 (2023)
   PUBMED   37531930
  REMARK    GeneRIF: EP1 activation inhibits doxorubicin-cardiomyocyte
            ferroptosis via Nrf2.
REFERENCE   3  (bases 1 to 2080)
  AUTHORS   Fuchs,M.A.A., Schrankl,J., Leupold,C., Wagner,C., Kurtz,A. and
            Broeker,K.A.
  TITLE     Intact prostaglandin signaling through EP2 and EP4 receptors in
            stromal progenitor cells is required for normal development of the
            renal cortex in mice
  JOURNAL   Am J Physiol Renal Physiol 322 (3), F295-F307 (2022)
   PUBMED   35037469
REFERENCE   4  (bases 1 to 2080)
  AUTHORS   Eskilsson,A., Shionoya,K., Engblom,D. and Blomqvist,A.
  TITLE     Fever During Localized Inflammation in Mice Is Elicited by a
            Humoral Pathway and Depends on Brain Endothelial Interleukin-1 and
            Interleukin-6 Signaling and Central EP3 Receptors
  JOURNAL   J Neurosci 41 (24), 5206-5218 (2021)
   PUBMED   33941650
REFERENCE   5  (bases 1 to 2080)
  AUTHORS   Inazumi,T., Yamada,K., Shirata,N., Sato,H., Taketomi,Y., Morita,K.,
            Hohjoh,H., Tsuchiya,S., Oniki,K., Watanabe,T., Sasaki,Y., Oike,Y.,
            Ogata,Y., Saruwatari,J., Murakami,M. and Sugimoto,Y.
  TITLE     Prostaglandin E2-EP4 Axis Promotes Lipolysis and Fibrosis in
            Adipose Tissue Leading to Ectopic Fat Deposition and Insulin
            Resistance
  JOURNAL   Cell Rep 33 (2), 108265 (2020)
   PUBMED   33053354
REFERENCE   6  (bases 1 to 2080)
  AUTHORS   Batshake,B., Nilsson,C. and Sundelin,J.
  TITLE     Molecular characterization of the mouse prostanoid EP1 receptor
            gene
  JOURNAL   Eur J Biochem 231 (3), 809-814 (1995)
   PUBMED   7649181
REFERENCE   7  (bases 1 to 2080)
  AUTHORS   Brown,D.M. and Phipps,R.P.
  TITLE     Characterization and regulation of prostaglandin E2 receptors on
            normal and malignant murine B lymphocytes
  JOURNAL   Cell Immunol 161 (1), 79-87 (1995)
   PUBMED   7867087
REFERENCE   8  (bases 1 to 2080)
  AUTHORS   Takahashi,Y., Taketani,Y., Endo,T., Yamamoto,S. and Kumegawa,M.
  TITLE     Studies on the induction of cyclooxygenase isozymes by various
            prostaglandins in mouse osteoblastic cell line with reference to
            signal transduction pathways
  JOURNAL   Biochim Biophys Acta 1212 (2), 217-224 (1994)
   PUBMED   7514040
REFERENCE   9  (bases 1 to 2080)
  AUTHORS   Watabe,A., Sugimoto,Y., Honda,A., Irie,A., Namba,T., Negishi,M.,
            Ito,S., Narumiya,S. and Ichikawa,A.
  TITLE     Cloning and expression of cDNA for a mouse EP1 subtype of
            prostaglandin E receptor
  JOURNAL   J Biol Chem 268 (27), 20175-20178 (1993)
   PUBMED   7690750
REFERENCE   10 (bases 1 to 2080)
  AUTHORS   Idell,S., James,K.K., Levin,E.G., Schwartz,B.S., Manchanda,N.,
            Maunder,R.J., Martin,T.R., McLarty,J. and Fair,D.S.
  TITLE     Local abnormalities in coagulation and fibrinolytic pathways
            predispose to alveolar fibrin deposition in the adult respiratory
            distress syndrome
  JOURNAL   J Clin Invest 84 (2), 695-705 (1989)
   PUBMED   2788176
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC164432.3, AK164746.1 and AK053616.1.
            
            On Oct 21, 2017 this sequence version replaced NM_013641.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC138744.1, AK053616.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-189               AC164432.3         101697-101885       c
            190-1241            AK164746.1         2-1053
            1242-2080           AK053616.1         1021-1859
FEATURES             Location/Qualifiers
     source          1..2080
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 40.22 cM"
     gene            1..2080
                     /gene="Ptger1"
                     /gene_synonym="EP1; Ptgerep1"
                     /note="prostaglandin E receptor 1 (subtype EP1)"
                     /db_xref="GeneID:19216"
                     /db_xref="MGI:MGI:97793"
     exon            1..273
                     /gene="Ptger1"
                     /gene_synonym="EP1; Ptgerep1"
                     /inference="alignment:Splign:2.1.0"
     exon            274..1241
                     /gene="Ptger1"
                     /gene_synonym="EP1; Ptgerep1"
                     /inference="alignment:Splign:2.1.0"
     CDS             291..1508
                     /gene="Ptger1"
                     /gene_synonym="EP1; Ptgerep1"
                     /note="prostanoid EP1 receptor; PGE receptor EP1 subtype;
                     PGE2 receptor EP1 subtype"
                     /codon_start=1
                     /product="prostaglandin E2 receptor EP1 subtype"
                     /protein_id="NP_038669.1"
                     /db_xref="CCDS:CCDS22458.1"
                     /db_xref="GeneID:19216"
                     /db_xref="MGI:MGI:97793"
                     /translation="MSPCGLNLSLADEAATCATPRLPNTSVVLPTGDNGTSPALPIFS
                     MTLGAVSNVLALALLAQVAGRMRRRRSAATFLLFVASLLAIDLAGHVIPGALVLRLYT
                     AGRAPAGGACHFLGGCMVFFGLCPLLLGCGMAVERCVGVTQPLIHAARVSVARARLAL
                     AVLAAMALAVALLPLVHVGRYELQYPGTWCFISLGPRGGWRQALLAGLFAGLGLAALL
                     AALVCNTLSGLALLRARWRRRRSRRFRKTAGPDDRRRWGSRGPRLASASSASSITSAT
                     ATLRSSRGGGSARRVHAHDVEMVGQLVGIMVVSCICWSPLLVLVVLAIGGWNSNSLQR
                     PLFLAVRLASWNQILDPWVYILLRQAMLRQLLRLLPLRVSAKGGPTELGLTKSAWEAS
                     SLRSSRHSGFSHL"
     exon            1242..2080
                     /gene="Ptger1"
                     /gene_synonym="EP1; Ptgerep1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agagaacctc agtccttggc gggaaggagc tgggcccagt tgccctgact gttgccagca
       61 gttttgccca ctcaaggctc ccagccccag agagcagaca tgcatggggt ggagcagccc
      121 ctggaggcca gtgaagtgcg ggtggaggcg gcacggagcc gaggagccgc cccaggaaga
      181 gggagcggcc tgccgggagc cagggagtag ctggagcagg cagcaggagc caagttccag
      241 gccatgggga ccctgcatcc tgagcagcac tggccctctt ggccactgat atgagcccct
      301 gcgggcttaa cctgagccta gcggatgagg cagcaacgtg cgcaacaccc aggctcccca
      361 atacatctgt ggtgctgcca acaggcgata atggcacatc accagcgctg cctatcttct
      421 ccatgacgct gggtgctgtg tccaacgtgc tggcgctggc gctgctggcc caggttgcag
      481 gccgaatgcg gcggcgccgc tcggctgcca ccttcctgtt gttcgtcgcc agcctgcttg
      541 ccatcgacct agcaggccat gtgatcccgg gcgccctggt gcttcgcctg tatactgcgg
      601 ggcgtgcgcc tgctggaggg gcgtgtcatt tcctgggtgg ctgcatggtc ttcttcggcc
      661 tgtgcccact tttgcttggc tgtggcatgg ccgtagagcg ctgtgtgggt gtcacgcagc
      721 cactgatcca cgcggcgcgc gtatctgtgg cccgcgcacg cctggcacta gccgtgctgg
      781 ctgccatggc tttggcagtg gcgctgctgc cactggtaca cgtgggtcgc tacgagttac
      841 agtaccctgg cacctggtgt tttattagcc ttgggcctcg tggaggttgg cgccaggcgt
      901 tgcttgccgg cctcttcgcc ggccttggcc tggccgcgct ccttgcggca ttagtgtgca
      961 atacgctcag cggcctggcg ctcctccgtg cccgctggag acggcgtcgc tctcgacgat
     1021 tccgaaagac cgcaggtccc gatgatcgcc ggcgctgggg atctcgtgga ccccgcttgg
     1081 cctccgcctc gtctgcctca tccatcactt cagccacagc caccctccgc agctctcggg
     1141 gcggcggctc cgcgcgcagg gttcacgcac acgatgtgga aatggtgggc cagctcgtgg
     1201 gcatcatggt ggtgtcgtgc atctgctgga gccccctgct ggtgttggtg gtgttggcca
     1261 tcgggggctg gaactctaac tccctgcagc ggccactctt tctggctgta cgcctcgcat
     1321 cgtggaacca gatcctggac ccatgggtgt acatcctgct gcgccaggcc atgctgcgcc
     1381 aactgcttcg cctcctaccc ctgagggtca gtgccaaggg tggtccaacg gagctgggcc
     1441 taaccaagag tgcctgggaa gccagttcac tgcgtagttc ccggcacagt ggtttcagtc
     1501 acctctgaat gtgcccagaa gctaagtcaa accattctgg gctgggctca agggtataga
     1561 gtctcaaact cagtgtgcct agggcgctgc gtcctgtggg tccacaacac tgtcaccgca
     1621 caggggtgaa agaggctcca ctggggacga gtacagttct aacgatggtc acgcgatggc
     1681 ccagatacat gggatgctcg aaacaccaga ggtgggactc cccaggccaa cagcttgaag
     1741 agcatgcgca cagcgccgca accttagttc taagattcgg gctctccata aatagagcaa
     1801 agttttggat tcacttccca tctctgtcac caccccaata gactcttgca agcgtctatc
     1861 ccaaactatc ccaagaatct caacaccttc tacccacacg gccttaaaac cccaatgctc
     1921 tccaacatac ccctaagccc actactgcat gttcccatct tgacctttca aatgtgcccc
     1981 atcagtcctg cccccaagag tctgccttgc ctctgtcacc tgctccaagc acactccagt
     2041 ccagatgcac acagaggctg aaaatgcatg tatggagtaa
//
