LOCUS       NM_008963                805 bp    mRNA    linear   ROD 12-NOV-2024
DEFINITION  Mus musculus prostaglandin D2 synthase (brain) (Ptgds), transcript
            variant 1, mRNA.
ACCESSION   NM_008963 XM_974597
VERSION     NM_008963.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 805)
  AUTHORS   Pezzella-Ferreira,G.N., Pao,C.R.R., Bellas,I., Luna-Gomes,T.,
            Muniz,V.S., Paiva,L.A., Amorim,N.R.T., Canetti,C., Bozza,P.T.,
            Diaz,B.L. and Bandeira-Melo,C.
  TITLE     Endogenous PGD2 acting on DP2 receptor counter regulates
            Schistosoma mansoni infection-driven hepatic granulomatous fibrosis
  JOURNAL   PLoS Pathog 20 (8), e1011812 (2024)
   PUBMED   39173086
  REMARK    GeneRIF: Endogenous PGD2 acting on DP2 receptor counter regulates
            Schistosoma mansoni infection-driven hepatic granulomatous
            fibrosis.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 805)
  AUTHORS   Taketomi,Y., Higashi,T., Kano,K., Miki,Y., Mochizuki,C.,
            Toyoshima,S., Okayama,Y., Nishito,Y., Nakae,S., Tanaka,S.,
            Tokuoka,S.M., Oda,Y., Shichino,S., Ueha,S., Matsushima,K.,
            Akahoshi,N., Ishii,S., Chun,J., Aoki,J. and Murakami,M.
  TITLE     Lipid-orchestrated paracrine circuit coordinates mast cell
            maturation and anaphylaxis through functional interaction with
            fibroblasts
  JOURNAL   Immunity 57 (8), 1828-1847 (2024)
   PUBMED   39002541
REFERENCE   3  (bases 1 to 805)
  AUTHORS   Souali-Crespo,S., Condrea,D., Vernet,N., Feret,B., Klopfenstein,M.,
            Grandgirard,E., Alunni,V., Cerciat,M., Jung,M., Mayere,C., Nef,S.,
            Mark,M., Chalmel,F. and Ghyselinck,N.B.
  TITLE     Loss of NR5A1 in mouse Sertoli cells after sex determination
            changes cellular identity and induces cell death by anoikis
  JOURNAL   Development 150 (24) (2023)
   PUBMED   38078651
REFERENCE   4  (bases 1 to 805)
  AUTHORS   Horikami,D., Sekihachi,E., Omori,K., Kobayashi,Y., Kobayashi,K.,
            Nagata,N., Kurata,K., Uemura,A. and Murata,T.
  TITLE     Roles of lipocalin-type and hematopoietic prostaglandin D synthases
            in mouse retinal angiogenesis
  JOURNAL   J Lipid Res 64 (10), 100439 (2023)
   PUBMED   37666361
REFERENCE   5  (bases 1 to 805)
  AUTHORS   Qu,F., Li,W., Xu,J., Zhang,R., Ke,J., Ren,X., Meng,X., Qin,L.,
            Zhang,J., Lu,F., Zhou,X., Luo,X., Zhang,Z., Wang,M., Wu,G., Pei,D.,
            Chen,J., Cui,G., Suo,S. and Peng,G.
  TITLE     Three-dimensional molecular architecture of mouse organogenesis
  JOURNAL   Nat Commun 14 (1), 4599 (2023)
   PUBMED   37524711
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 805)
  AUTHORS   Bingham,C.O. 3rd, Murakami,M., Fujishima,H., Hunt,J.E., Austen,K.F.
            and Arm,J.P.
  TITLE     A heparin-sensitive phospholipase A2 and prostaglandin endoperoxide
            synthase-2 are functionally linked in the delayed phase of
            prostaglandin D2 generation in mouse bone marrow-derived mast cells
  JOURNAL   J Biol Chem 271 (42), 25936-25944 (1996)
   PUBMED   8824228
REFERENCE   7  (bases 1 to 805)
  AUTHORS   Pilz,A., Woodward,K., Povey,S. and Abbott,C.
  TITLE     Comparative mapping of 50 human chromosome 9 loci in the laboratory
            mouse
  JOURNAL   Genomics 25 (1), 139-149 (1995)
   PUBMED   7774911
REFERENCE   8  (bases 1 to 805)
  AUTHORS   Chan,P., Simon-Chazottes,D., Mattei,M.G., Guenet,J.L. and
            Salier,J.P.
  TITLE     Comparative mapping of lipocalin genes in human and mouse: the four
            genes for complement C8 gamma chain, prostaglandin-D-synthase,
            oncogene-24p3, and progestagen-associated endometrial protein map
            to HSA9 and MMU2
  JOURNAL   Genomics 23 (1), 145-150 (1994)
   PUBMED   7829063
REFERENCE   9  (bases 1 to 805)
  AUTHORS   Igarashi,M., Nagata,A., Toh,H., Urade,Y. and Hayaishi,O.
  TITLE     Structural organization of the gene for prostaglandin D synthase in
            the rat brain
  JOURNAL   Proc Natl Acad Sci U S A 89 (12), 5376-5380 (1992)
   PUBMED   1608945
REFERENCE   10 (bases 1 to 805)
  AUTHORS   Spies,T. and DeMars,R.
  TITLE     Restored expression of major histocompatibility class I molecules
            by gene transfer of a putative peptide transporter
  JOURNAL   Nature 351 (6324), 323-324 (1991)
   PUBMED   2034277
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL732557.4.
            
            On Aug 21, 2018 this sequence version replaced NM_008963.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK131859.1, AB006361.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849381, SAMN01164131
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-190               AL732557.4         142333-142522       c
            191-330             AL732557.4         141761-141900       c
            331-407             AL732557.4         141606-141682       c
            408-524             AL732557.4         140845-140961       c
            525-626             AL732557.4         140591-140692       c
            627-685             AL732557.4         140060-140118       c
            686-805             AL732557.4         139485-139604       c
FEATURES             Location/Qualifiers
     source          1..805
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 17.28 cM"
     gene            1..805
                     /gene="Ptgds"
                     /gene_synonym="21kDa; L-PGDS; PGD2; PGDS; PGDS2; Ptgs3"
                     /note="prostaglandin D2 synthase (brain)"
                     /db_xref="GeneID:19215"
                     /db_xref="MGI:MGI:99261"
     exon            1..190
                     /gene="Ptgds"
                     /gene_synonym="21kDa; L-PGDS; PGD2; PGDS; PGDS2; Ptgs3"
                     /inference="alignment:Splign:2.1.0"
     exon            191..330
                     /gene="Ptgds"
                     /gene_synonym="21kDa; L-PGDS; PGD2; PGDS; PGDS2; Ptgs3"
                     /inference="alignment:Splign:2.1.0"
     exon            331..407
                     /gene="Ptgds"
                     /gene_synonym="21kDa; L-PGDS; PGD2; PGDS; PGDS2; Ptgs3"
                     /inference="alignment:Splign:2.1.0"
     exon            408..524
                     /gene="Ptgds"
                     /gene_synonym="21kDa; L-PGDS; PGD2; PGDS; PGDS2; Ptgs3"
                     /inference="alignment:Splign:2.1.0"
     exon            525..626
                     /gene="Ptgds"
                     /gene_synonym="21kDa; L-PGDS; PGD2; PGDS; PGDS2; Ptgs3"
                     /inference="alignment:Splign:2.1.0"
     exon            627..685
                     /gene="Ptgds"
                     /gene_synonym="21kDa; L-PGDS; PGD2; PGDS; PGDS2; Ptgs3"
                     /inference="alignment:Splign:2.1.0"
     exon            686..805
                     /gene="Ptgds"
                     /gene_synonym="21kDa; L-PGDS; PGD2; PGDS; PGDS2; Ptgs3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gctccttctg cccagttttc cttgctttgt ccacattgct ggcatcaggc ccaggcacct
       61 gctctgctct gagcaaatgg ctgctcttcg catgctgtgg atgggtttgg tcctcctggg
      121 tctcttggga ttcccacaga ccccagccca gggccatgac acagtgcagc ccaactttca
      181 acaagacaag ttcctggggc gctggtacag cgcgggcctc gcctccaact caagctggtt
      241 ccgggagaag aaagctgtat tgtatatgtg caagacagtg gtagccccct ccacagaagg
      301 cggcctcaat ctcacctcta ccttcctcag gaaaaaccag tgtgagacca agatcatggt
      361 actgcagcct gcgggggctc ctggacacta cacctacagc agcccccact cgggcagcat
      421 ccactccgtg tcagtggtgg aggccaacta tgacgagtac gctctgctat tcagcagagg
      481 caccaagggc ccaggccagg acttccgcat ggccaccctc tacagcagaa cccagactct
      541 gaaggacgag ctgaaggaga aattcaccac ctttagcaag gcccagggcc tcacagagga
      601 ggacattgtt ttcctgcccc aaccggataa gtgcattcaa gagtaaacgc aggtgagaga
      661 agtcagtcag agggctggtc acatggtgac ctggcctcag gactcctttg ctctgtcact
      721 ctcaagatcc cagccctggc tccccaaagt acctctacac cctccagctt tgccttgaca
      781 aagaaataaa agtccaaagc aagtc
//
