LOCUS       NM_009962               2644 bp    mRNA    linear   ROD 09-FEB-2025
DEFINITION  Mus musculus prostaglandin D2 receptor 2 (Ptgdr2), mRNA.
ACCESSION   NM_009962
VERSION     NM_009962.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2644)
  AUTHORS   Pezzella-Ferreira,G.N., Pao,C.R.R., Bellas,I., Luna-Gomes,T.,
            Muniz,V.S., Paiva,L.A., Amorim,N.R.T., Canetti,C., Bozza,P.T.,
            Diaz,B.L. and Bandeira-Melo,C.
  TITLE     Endogenous PGD2 acting on DP2 receptor counter regulates
            Schistosoma mansoni infection-driven hepatic granulomatous fibrosis
  JOURNAL   PLoS Pathog 20 (8), e1011812 (2024)
   PUBMED   39173086
  REMARK    GeneRIF: Endogenous PGD2 acting on DP2 receptor counter regulates
            Schistosoma mansoni infection-driven hepatic granulomatous
            fibrosis.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2644)
  AUTHORS   Taketomi,Y., Higashi,T., Kano,K., Miki,Y., Mochizuki,C.,
            Toyoshima,S., Okayama,Y., Nishito,Y., Nakae,S., Tanaka,S.,
            Tokuoka,S.M., Oda,Y., Shichino,S., Ueha,S., Matsushima,K.,
            Akahoshi,N., Ishii,S., Chun,J., Aoki,J. and Murakami,M.
  TITLE     Lipid-orchestrated paracrine circuit coordinates mast cell
            maturation and anaphylaxis through functional interaction with
            fibroblasts
  JOURNAL   Immunity 57 (8), 1828-1847 (2024)
   PUBMED   39002541
REFERENCE   3  (bases 1 to 2644)
  AUTHORS   Horikami,D., Sekihachi,E., Omori,K., Kobayashi,Y., Kobayashi,K.,
            Nagata,N., Kurata,K., Uemura,A. and Murata,T.
  TITLE     Roles of lipocalin-type and hematopoietic prostaglandin D synthases
            in mouse retinal angiogenesis
  JOURNAL   J Lipid Res 64 (10), 100439 (2023)
   PUBMED   37666361
REFERENCE   4  (bases 1 to 2644)
  AUTHORS   Qian,F., Nettleford,S.K., Zhou,J., Arner,B.E., Hall,M.A.,
            Sharma,A., Annageldiyev,C., Rossi,R.M., Tukaramrao,D.B., Sarkar,D.,
            Hegde,S., Gandhi,U.H., Finch,E.R., Goodfield,L., Quickel,M.D.,
            Claxton,D.F., Paulson,R.F. and Prabhu,K.S.
  TITLE     Activation of GPR44 decreases severity of myeloid leukemia via
            specific targeting of leukemia initiating stem cells
  JOURNAL   Cell Rep 42 (7), 112794 (2023)
   PUBMED   37459233
REFERENCE   5  (bases 1 to 2644)
  AUTHORS   Zou,F., Li,Y., Zhang,S. and Zhang,J.
  TITLE     DP1 (Prostaglandin D2 Receptor 1) Activation Protects Against
            Vascular Remodeling and Vascular Smooth Muscle Cell Transition to
            Myofibroblasts in Angiotensin II-Induced Hypertension in Mice
  JOURNAL   Hypertension 79 (6), 1203-1215 (2022)
   PUBMED   35354317
  REMARK    GeneRIF: DP1 (Prostaglandin D2 Receptor 1) Activation Protects
            Against Vascular Remodeling and Vascular Smooth Muscle Cell
            Transition to Myofibroblasts in Angiotensin II-Induced Hypertension
            in Mice.
            Erratum:[Hypertension. 2022 Aug;79(8):e127. doi:
            10.1161/HYP.0000000000000218.. PMID: 35861754]
REFERENCE   6  (bases 1 to 2644)
  AUTHORS   Hata,A.N., Lybrand,T.P. and Breyer,R.M.
  TITLE     Identification of determinants of ligand binding affinity and
            selectivity in the prostaglandin D2 receptor CRTH2
  JOURNAL   J Biol Chem 280 (37), 32442-32451 (2005)
   PUBMED   16030019
  REMARK    GeneRIF: analysis of prostaglandin D2 receptor CRTH2 determinants
            of ligand binding affinity and selectivity
REFERENCE   7  (bases 1 to 2644)
  AUTHORS   Hata,A.N., Lybrand,T.P., Marnett,L.J. and Breyer,R.M.
  TITLE     Structural determinants of arylacetic acid nonsteroidal
            anti-inflammatory drugs necessary for binding and activation of the
            prostaglandin D2 receptor CRTH2
  JOURNAL   Mol Pharmacol 67 (3), 640-647 (2005)
   PUBMED   15563582
  REMARK    GeneRIF: CRTH2 can be activated by indomethacin, a nonselective
            cyclooxygenase inhibitor and widely used nonsteroidal
            anti-inflammatory drug (NSAID).
REFERENCE   8  (bases 1 to 2644)
  AUTHORS   Nagata,K.
  TITLE     CRTH2.
  JOURNAL   J Biol Regul Homeost Agents 17 (4), 334-337 (2003)
   PUBMED   15065763
  REMARK    GeneRIF: CRTH2 protein structure and expression (review)
            Review article
REFERENCE   9  (bases 1 to 2644)
  AUTHORS   Hirai,H., Abe,H., Tanaka,K., Takatsu,K., Sugamura,K., Nakamura,M.
            and Nagata,K.
  TITLE     Gene structure and functional properties of mouse CRTH2, a
            prostaglandin D2 receptor
  JOURNAL   Biochem Biophys Res Commun 307 (4), 797-802 (2003)
   PUBMED   12878180
  REMARK    GeneRIF: Gene structure and functional properties of CRTH2, a
            prostaglandin D2 receptor.
REFERENCE   10 (bases 1 to 2644)
  AUTHORS   Abe,H., Takeshita,T., Nagata,K., Arita,T., Endo,Y., Fujita,T.,
            Takayama,H., Kubo,M. and Sugamura,K.
  TITLE     Molecular cloning, chromosome mapping and characterization of the
            mouse CRTH2 gene, a putative member of the leukocyte
            chemoattractant receptor family
  JOURNAL   Gene 227 (1), 71-77 (1999)
   PUBMED   9931443
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC132402.3, AK041947.1 and AC148991.2.
            
            On Nov 3, 2012 this sequence version replaced NM_009962.2.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB109092.1, AK041947.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-3                 AC132402.3         4037-4039           c
            4-1141              AK041947.1         2-1139
            1142-1331           AC132402.3         1-190               c
            1332-2644           AC148991.2         111828-113140       c
FEATURES             Location/Qualifiers
     source          1..2644
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="19"
                     /map="19 7.4 cM"
     gene            1..2644
                     /gene="Ptgdr2"
                     /gene_synonym="Crth2; Gpr44; Grp45"
                     /note="prostaglandin D2 receptor 2"
                     /db_xref="GeneID:14764"
                     /db_xref="MGI:MGI:1330275"
     exon            1..102
                     /gene="Ptgdr2"
                     /gene_synonym="Crth2; Gpr44; Grp45"
                     /inference="alignment:Splign:2.1.0"
     exon            103..193
                     /gene="Ptgdr2"
                     /gene_synonym="Crth2; Gpr44; Grp45"
                     /inference="alignment:Splign:2.1.0"
     exon            194..2644
                     /gene="Ptgdr2"
                     /gene_synonym="Crth2; Gpr44; Grp45"
                     /inference="alignment:Splign:2.1.0"
     CDS             254..1402
                     /gene="Ptgdr2"
                     /gene_synonym="Crth2; Gpr44; Grp45"
                     /note="prostaglandin D2 receptor CRTH2; PGD2 receptor;
                     chemoattractant receptor-homologous molecule expressed on
                     TH2 cells; G-protein coupled receptor 44"
                     /codon_start=1
                     /product="prostaglandin D2 receptor 2"
                     /protein_id="NP_034092.1"
                     /db_xref="CCDS:CCDS29592.1"
                     /db_xref="GeneID:14764"
                     /db_xref="MGI:MGI:1330275"
                     /translation="MANVTLKPLCPLLEEMVQLPNHSNSSLRYIDHVSVLLHGLASLL
                     GLVENGLILFVVGCRMRQTVVTTWVLHLALSDLLAAASLPFFTYFLAVGHSWELGTTF
                     CKLHSSVFFLNMFASGFLLSAISLDRCLQVVRPVWAQNHRTVAVAHRVCLMLWALAVL
                     NTIPYFVFRDTIPRLDGRIMCYYNLLLWNPGPDRDTTCDYRQKALAVSKFLLAFMVPL
                     AIIASSHVAVSLRLHHRGRQRTGRFVRLVAAIVVAFVLCWGPYHIFSLLEARAHSVTT
                     LRQLASRGLPFVTSLAFFNSVVNPLLYVFTCPDMLYKLRRSLRAVLESVLVEDSDQSG
                     GLRNRRRRASSTATPASTLLLADRIPQLRPTRLIGWMRRGSAEVPQRV"
     regulatory      2612..2617
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ptgdr2"
                     /gene_synonym="Crth2; Gpr44; Grp45"
                     /note="hexamer: AATAAA"
     polyA_site      2632
                     /gene="Ptgdr2"
                     /gene_synonym="Crth2; Gpr44; Grp45"
                     /note="major polyA site"
ORIGIN      
        1 actctcctcc tgccactcgc ctggtgctca gtcctgctgc tttcagaagc tgccagcctt
       61 cacgactcaa ccctgtgctc actgtgttca ctgtgtggct cgaggaaggg ccagctcccc
      121 tggtctcaac caatcagcac acccgatcag tcactgaggc tgacaactgc tctctaggag
      181 gaactgcaga gaggctgcag gcttcttctg gttcctgggt gacaggctca gccctccttt
      241 cttccacctt gccatggcca acgtcacact gaagccgctc tgtccactct tggaggagat
      301 ggtccagctt ccaaaccaca gcaactctag cctccgctac atcgaccacg tgtcggtgct
      361 gttgcacggg ctggcctcgc tgctgggcct ggtggaaaac ggactcatcc tgtttgtggt
      421 gggctgtcgc atgcgccaga cagtggtcac cacctgggtg ctgcacctgg cgctatccga
      481 cttgttagcc gccgcctccc tgcctttctt cacctacttc ctggcagtgg gccactcgtg
      541 ggagctgggc actaccttct gcaagctaca ttcctcggtc ttcttcctca acatgtttgc
      601 cagcggcttc ctgctcagtg ccattagcct ggaccgctgc ctgcaggtgg tgaggccagt
      661 gtgggcacag aaccaccgca cggtggcggt cgcgcacaga gtctgcctga tgctctgggc
      721 tctggcggtg ctcaacacaa taccatattt cgtgttcaga gacaccatcc cgcggcttga
      781 tggccgcatc atgtgctact acaacttgct gctctggaat ccagggcctg accgcgacac
      841 cacgtgcgac taccgccaga aggccctggc ggtcagcaaa ttcctgctgg ccttcatggt
      901 acctctggcc ataattgcct cgagccacgt agccgtgagc ctgcgactgc accaccgtgg
      961 tcgccagagg acaggccgct ttgtgcgcct ggtggcggcc atcgtggttg ccttcgtgct
     1021 ctgctggggg ccctaccaca tcttcagtct gctggaggcg cgtgcccatt ctgtcaccac
     1081 gctacggcag ctcgcgtcac gtgggctgcc ctttgtcacc agcctggcct tcttcaacag
     1141 cgtggtcaac ccactgctct atgtgttcac atgccccgac atgttgtaca aactgcggcg
     1201 ctcgctacgc gcggtgcttg aaagcgtgct ggtagaagac agcgaccaga gtggtgggct
     1261 ccgcaatcgc cgtcgccgcg cctcctccac cgccacccca gcctctaccc tcctgctggc
     1321 tgaccgaatt ccccaactgc gtccaacccg cttgatcggc tggatgaggc gtggcagtgc
     1381 agaggtccca cagagggtct gagcggtccc tggagaaaca gggctcattg agctgtactt
     1441 tggattagac cggcacagcc cagatgacat gccaacatat cctgggtctc tctctcttga
     1501 aacccagtta aaaatgtaca tagccaatgc caggcccaag tcttggggag ggtccaggca
     1561 accagcttat ggaagtgtcc tgagtgactc aatctcccgg agcaaggtga attgaagcag
     1621 tccttttaaa acactttaat cttgcagtat ggacctggga gagcaacaag atgcaaaagt
     1681 agccatcgag gagttacctg gctcttgact gctggcctcc aggtttctac acatttaaga
     1741 gcaaaagtac ttaattgcct agggatcttg ctagggtaac tgataagggt cgggtaaaat
     1801 tttgtatttc tattaccttc ctggcagctc gcccaaggca cttgggaatc acacaggtta
     1861 agctcacagc ctgcatctca taactccctg ctttgtgaat gggacaaagg gagtcggcca
     1921 atcagtattt atgggggtca gtgagaggaa aagggttgag accagccaac tgccatcatt
     1981 tttaatcccc catttggcct gagacaggtg ctttaaccac accttgctag tcagcttgtt
     2041 attgttatat atggtgatat ggatgtgtca actcccacta gggattttca ctgcccagtt
     2101 ttagggctgc tgctgctggc tttcagcagc actggatcaa ttctaggcag agagaacaac
     2161 ctacccttat tagctgcctg gcagggagag ggcctggcag ccatcacttc caacctacag
     2221 gtaggagggg cacctgtgcc agtcatggac cttctatcac acatttcatg tcctccccat
     2281 catagactgc agggaagctg gctgattcct ctttaccttc taggggaagg ggagctgatg
     2341 tcagaaattg gtaaatatgg aacagggatg gggtagtctc aggatctcct gaaccacgca
     2401 aggccaggct ggttgtcagt tgtgttgagc aggcctcaag cctgtggcag gcgcttctca
     2461 aactggagag taaaatgtca ccaagtccct cctgctttac tcagtgtacc tgtcacacca
     2521 ttatttcaat ggtttattat gataatgaaa gccaagtggg gcaggggctt ctgtccttcg
     2581 gggagcccag agctgtactt atgcagatac caataaacac ctctgcaata gagcaggtag
     2641 gtat
//
