LOCUS       NM_008962               3187 bp    mRNA    linear   ROD 09-FEB-2025
DEFINITION  Mus musculus prostaglandin D receptor (Ptgdr), mRNA.
ACCESSION   NM_008962
VERSION     NM_008962.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3187)
  AUTHORS   Taketomi,Y., Higashi,T., Kano,K., Miki,Y., Mochizuki,C.,
            Toyoshima,S., Okayama,Y., Nishito,Y., Nakae,S., Tanaka,S.,
            Tokuoka,S.M., Oda,Y., Shichino,S., Ueha,S., Matsushima,K.,
            Akahoshi,N., Ishii,S., Chun,J., Aoki,J. and Murakami,M.
  TITLE     Lipid-orchestrated paracrine circuit coordinates mast cell
            maturation and anaphylaxis through functional interaction with
            fibroblasts
  JOURNAL   Immunity 57 (8), 1828-1847 (2024)
   PUBMED   39002541
REFERENCE   2  (bases 1 to 3187)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 3187)
  AUTHORS   Horikami,D., Sekihachi,E., Omori,K., Kobayashi,Y., Kobayashi,K.,
            Nagata,N., Kurata,K., Uemura,A. and Murata,T.
  TITLE     Roles of lipocalin-type and hematopoietic prostaglandin D synthases
            in mouse retinal angiogenesis
  JOURNAL   J Lipid Res 64 (10), 100439 (2023)
   PUBMED   37666361
REFERENCE   4  (bases 1 to 3187)
  AUTHORS   Verma,A.K., Zheng,J., Mack,M., Ginhoux,F. and Perlman,S.
  TITLE     Differential Effects of Prostaglandin D2 Signaling on Macrophages
            and Microglia in Murine Coronavirus Encephalomyelitis
  JOURNAL   mBio 12 (5), e0196921 (2021)
   PUBMED   34488442
REFERENCE   5  (bases 1 to 3187)
  AUTHORS   Duncan,K.D., Sun,X., Baker,E.S., Dey,S.K. and Lanekoff,I.
  TITLE     In situ imaging reveals disparity between prostaglandin
            localization and abundance of prostaglandin synthases
  JOURNAL   Commun Biol 4 (1), 966 (2021)
   PUBMED   34389796
  REMARK    Erratum:[Commun Biol. 2021 Aug 20;4(1):1010. doi:
            10.1038/s42003-021-02560-w.. PMID: 34417560]
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3187)
  AUTHORS   Matsuoka,T., Hirata,M., Tanaka,H., Takahashi,Y., Murata,T.,
            Kabashima,K., Sugimoto,Y., Kobayashi,T., Ushikubi,F., Aze,Y.,
            Eguchi,N., Urade,Y., Yoshida,N., Kimura,K., Mizoguchi,A., Honda,Y.,
            Nagai,H. and Narumiya,S.
  TITLE     Prostaglandin D2 as a mediator of allergic asthma
  JOURNAL   Science 287 (5460), 2013-2017 (2000)
   PUBMED   10720327
REFERENCE   7  (bases 1 to 3187)
  AUTHORS   Narumiya,S., Sugimoto,Y. and Ushikubi,F.
  TITLE     Prostanoid receptors: structures, properties, and functions
  JOURNAL   Physiol Rev 79 (4), 1193-1226 (1999)
   PUBMED   10508233
  REMARK    Review article
REFERENCE   8  (bases 1 to 3187)
  AUTHORS   Ashby,B.
  TITLE     Co-expression of prostaglandin receptors with opposite effects: a
            model for homeostatic control of autocrine and paracrine signaling
  JOURNAL   Biochem Pharmacol 55 (3), 239-246 (1998)
   PUBMED   9484788
  REMARK    Review article
REFERENCE   9  (bases 1 to 3187)
  AUTHORS   Ishikawa,T.O., Tamai,Y., Rochelle,J.M., Hirata,M., Namba,T.,
            Sugimoto,Y., Ichikawa,A., Narumiya,S., Taketo,M.M. and Seldin,M.F.
  TITLE     Mapping of the genes encoding mouse prostaglandin D, E, and F and
            prostacyclin receptors
  JOURNAL   Genomics 32 (2), 285-288 (1996)
   PUBMED   8833158
REFERENCE   10 (bases 1 to 3187)
  AUTHORS   Hirata,M., Kakizuka,A., Aizawa,M., Ushikubi,F. and Narumiya,S.
  TITLE     Molecular characterization of a mouse prostaglandin D receptor and
            functional expression of the cloned gene
  JOURNAL   Proc Natl Acad Sci U S A 91 (23), 11192-11196 (1994)
   PUBMED   7972033
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK032488.1 and BC132297.1.
            
            On Mar 21, 2009 this sequence version replaced NM_008962.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK032488.1, BC132297.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849377, SAMN00849378
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-346               AK032488.1         2-347
            347-1513            BC132297.1         326-1492
            1514-3187           AK032488.1         1517-3190
FEATURES             Location/Qualifiers
     source          1..3187
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="14"
                     /map="14 22.59 cM"
     gene            1..3187
                     /gene="Ptgdr"
                     /gene_synonym="DP; PGD"
                     /note="prostaglandin D receptor"
                     /db_xref="GeneID:19214"
                     /db_xref="MGI:MGI:102966"
     exon            1..965
                     /gene="Ptgdr"
                     /gene_synonym="DP; PGD"
                     /inference="alignment:Splign:2.1.0"
     CDS             123..1196
                     /gene="Ptgdr"
                     /gene_synonym="DP; PGD"
                     /note="PGD receptor; PGD2 receptor; prostanoid DP
                     receptor"
                     /codon_start=1
                     /product="prostaglandin D2 receptor"
                     /protein_id="NP_032988.3"
                     /db_xref="CCDS:CCDS26971.1"
                     /db_xref="GeneID:19214"
                     /db_xref="MGI:MGI:102966"
                     /translation="MNESYRCQTSTWVERGSSATMGAVLFGAGLLGNLLALVLLARSG
                     LGSCRPGPLHPPPSVFYVLVCGLTVTDLLGKCLISPMVLAAYAQNQSLKELLPASGNQ
                     LCETFAFLMSFFGLASTLQLLAMAVECWLSLGHPFFYQRHVTLRRGVLVAPVVAAFCL
                     AFCALPFAGFGKFVQYCPGTWCFIQMIHKERSFSVIGFSVLYSSLMALLVLATVVCNL
                     GAMYNLYDMHRRQRHYPHRCSRDRAQSGSDYRHGSLHPLEELDHFVLLALMTVLFTMC
                     SLPLIYRAYYGAFKLENKAEGDSEDLQALRFLSVISIVDPWIFIIFRTSVFRMLFHKV
                     FTRPLIYRNWSSHSQQSNVESTL"
     exon            966..3187
                     /gene="Ptgdr"
                     /gene_synonym="DP; PGD"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1682..1687
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ptgdr"
                     /gene_synonym="DP; PGD"
                     /note="hexamer: ATTAAA"
     polyA_site      1706
                     /gene="Ptgdr"
                     /gene_synonym="DP; PGD"
                     /note="major polyA site"
ORIGIN      
        1 gccaccagtg gagctctctc tgctgcacaa cctctgtgcc ttagctgcgc cctgagcagc
       61 ctggggctcc ttcacagcgg gcctggctgc agcctttctt ccagtcagac gggacaaggg
      121 ctatgaacga gtcctatcgc tgtcagacat ccacctgggt ggaaaggggc tcctcggcga
      181 cgatgggcgc tgtgctcttc ggtgcggggc ttctgggcaa tcttctggcg ctggtgctgc
      241 tggcgcgctc gggactgggg tcttgccggc cagggccact acacccgccg ccctcggtct
      301 tttatgtgct cgtgtgtggc ttgacggtca ccgacttgct gggcaagtgt ctgatcagcc
      361 cgatggtcct ggctgcctac gcgcaaaacc agagcctaaa ggaactgctg cctgcctcag
      421 gcaatcagtt atgcgaaacg ttcgccttcc tgatgtcctt ctttgggcta gcctcgacct
      481 tacagctgtt ggctatggcg gtggagtgct ggctgtctct gggacacccc ttcttctacc
      541 aaaggcacgt caccttgcgc cggggagtgc tggtggcacc ggtcgtggcc gccttctgct
      601 tggctttctg tgcgctcccc tttgctggtt ttgggaagtt cgtgcagtac tgtccaggca
      661 cctggtgttt catccagatg atccacaagg agcgttcatt ttcggtaata ggcttctctg
      721 tgctctactc cagcctcatg gcgctgctgg tcctcgcaac cgtggtgtgc aacctgggtg
      781 ccatgtacaa cctctatgac atgcacaggc gccagaggca ctatcctcac cgctgctcca
      841 gggaccgcgc ccagtcaggc tcagactaca ggcacgggtc cctgcatcct ttggaggagc
      901 tggaccactt tgtgctgctg gctctcatga cagtgctctt caccatgtgt tccctgcctt
      961 taatttatcg tgcgtactat ggagccttta aacttgagaa caaagctgaa ggagactcag
     1021 aagacctcca agccttgcgt ttcctgtctg tgatttccat agtggacccc tggatcttca
     1081 tcatcttcag gacttcagta ttccggatgt tatttcacaa ggttttcaca agacctctga
     1141 tctacagaaa ctggagcagc cattcccagc aaagtaacgt ggaatccact ttgtgagggc
     1201 tttgcgtgtt ctgataagct gaaaatacag cacacattca aagagccgtg cttggaaaag
     1261 ccttacaatt taaatcctta aaaactatct cccatgaaga gatggagaga gggatcagca
     1321 ctgaagatca tttacttctc ttccagagga cctgagtttg attcccagaa cccacaacag
     1381 gtgcctcaca ccactgtaag tccagctcca gggaatctta caccagtggc ctgcacggtc
     1441 acctgcactc atgtgcatat aaccacatgt gagcacacac acacacacac agtgagagag
     1501 agagagagag agagacagag agagagagac agagagagag ggagagagac ttaaaagtaa
     1561 taaaagctaa tttaaaatat ctcccataat taagacatct caaaggtaac caatttatat
     1621 gttgtcactc tgtatccata aacccttttg gtccatttaa aaaaatgtgc tattaacagc
     1681 aattaaactt tgtatgttat aaacaatgtt aacagtgcta tagcaatgat tttaattgtc
     1741 tcaacatttg tacctgatgg ttctaaatgt ttagggcaat cttgagaccc atgggttttt
     1801 aattgaaata tgatagaaac aacaccgtct cactgtaggc ttgtaatttt gtagtgggta
     1861 ttcttgaaca aacctagcaa catctcacac attgttacag taaagcttaa cttattttgt
     1921 atcattgttg ctcctttttg tggatggttt ggtttggttt gtttgtttgt ttttgtcaaa
     1981 tgacctaaga ataatctgaa ttgtagataa tatttaagag aaatgagttg ggaaaccaga
     2041 tcaggtaagg tatttggaga gaccatttcg ggggctacag gaaaagacct gcaagtccca
     2101 tgtagttaaa tgaaacaaga tataactagg gtcaacaact caaagtggaa aaaggaaact
     2161 gatcttttga agtctggtct ggaagcaggg atggcaaggg tagtcagtaa tttgcataat
     2221 gagtctaaga ttttcaattc aggaaacctt cattttcaca ttgatggact ctttaaagag
     2281 caggatttgt gtttcttggg aaaacactgg tgtatgactt accgaagagc tgtattatat
     2341 accaatttca gtcaactcac agggcattga gcacagtagg aggcccactc aggacatagc
     2401 ctctgtgaag ggtgatggca gtggcattca cacctgcctc ttacagcttc agtctgctgt
     2461 tagtagaggg aatgagatgt tacctgggac tgcagtgagc tgggctagct gaaccagagt
     2521 aaaaacagct ctgaaaggca ctgggaacac tttaattact cacttttgag gtcacacagg
     2581 ccagcaacac tataacctaa aaagaaaatg tgtggggtgt gcggtgggag atggggagta
     2641 cccctgcatt gggagagagc tggagctcac agcaagagct ttggacagct ataaagcagt
     2701 agatggggat aggagagagt ttccgagtcc ctgagcattc cgacactcag atgctggaat
     2761 ggacgcaagg tctgcagcag gcagttcctc tcaaagacaa gaggagctcc catatttctt
     2821 ggtcagcaga aaaccaattt tctcaactct cattttcctg agacctcaga gatggtatta
     2881 acttagctta tgtatctatg tatgtatgta tgtatgcatg tatgtacgta catagagcaa
     2941 aactgtgaaa aagccaaatt aggaataaag aaagtataaa ctgagagtat gacacaaaga
     3001 aaaatgtttt ggttttggtt taacttgtgt ttctatgttt aatgtgaatg atgatttttt
     3061 ttttcttttg gtctgaggag gtgcattttt ttcgtgtgtg tgtcctagtt ttagaaggta
     3121 tgctatggta actgtctaga gaatttgata aagtgccaga tgaatcaata aatgtgattt
     3181 ttataag
//
