LOCUS       NM_018809               1508 bp    mRNA    linear   ROD 10-FEB-2025
DEFINITION  Mus musculus pancreas specific transcription factor, 1a (Ptf1a),
            mRNA.
ACCESSION   NM_018809
VERSION     NM_018809.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1508)
  AUTHORS   Wutikeli,H., Yu,Y., Zhang,T., Cao,J., Nawy,S. and Shen,Y.
  TITLE     Role of Elavl-like RNA-binding protein in retinal development and
            signal transduction
  JOURNAL   Biochim Biophys Acta Mol Basis Dis 1871 (1), 167518 (2025)
   PUBMED   39307290
REFERENCE   2  (bases 1 to 1508)
  AUTHORS   Mercanoglu,B., Waschkowski,S.A., Neuburg,E., Schraps,N.,
            Giannou,A.D., Dreyer,B., Harder,S., Heine,M., Krebs,C.F.,
            Gungor,C., Schluter,H., Melling,N., Hackert,T., Bockhorn,M.,
            Wagener,C. and Wolters-Eisfeld,G.
  TITLE     GalNT2-mediated O-glycosylation affects pancreas development and
            function in mice
  JOURNAL   Sci Rep 14 (1), 29760 (2024)
   PUBMED   39613794
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1508)
  AUTHORS   Alvarez,S., Gupta,S., Mercado-Ayon,Y., Honeychurch,K.,
            Rodriguez,C., Kawaguchi,R. and Butler,S.J.
  TITLE     Netrin1 patterns the dorsal spinal cord through modulation of Bmp
            signaling
  JOURNAL   Cell Rep 43 (11), 114954 (2024)
   PUBMED   39547237
REFERENCE   4  (bases 1 to 1508)
  AUTHORS   Pryce,B.R., Oles,A., Talbert,E.E., Romeo,M.J., Vaena,S., Sharma,S.,
            Spadafora,V., Tolliver,L., Mahvi,D.A., Morgan,K.A., Lancaster,W.P.,
            Beal,E., Koren,N., Watts,B., Overstreet,M., Berto,S.,
            Subramanian,S., Calisir,K., Crawford,A., Neelon,B., Ostrowski,M.C.,
            Zimmers,T.A., Tidball,J.G., Wang,D.J. and Guttridge,D.C.
  TITLE     Muscle inflammation is regulated by NF-kappaB from multiple cells
            to control distinct states of wasting in cancer cachexia
  JOURNAL   Cell Rep 43 (11), 114925 (2024)
   PUBMED   39475511
REFERENCE   5  (bases 1 to 1508)
  AUTHORS   Lugani,F., Arora,R., Papeta,N., Patel,A., Zheng,Z., Sterken,R.,
            Singer,R.A., Caridi,G., Mendelsohn,C., Sussel,L., Papaioannou,V.E.
            and Gharavi,A.G.
  TITLE     A retrotransposon insertion in the 5' regulatory domain of Ptf1a
            results in ectopic gene expression and multiple congenital defects
            in Danforth's short tail mouse
  JOURNAL   PLoS Genet 9 (2), e1003206 (2013)
   PUBMED   23437001
  REMARK    GeneRIF: The Sd heterozygote phenotype was not ameliorated by Ptf1a
            haploinsufficiency, further suggesting that the developmental
            defects result from ectopic expression of Ptf1a.
REFERENCE   6  (bases 1 to 1508)
  AUTHORS   Beres,T.M., Masui,T., Swift,G.H., Shi,L., Henke,R.M. and
            MacDonald,R.J.
  TITLE     PTF1 is an organ-specific and Notch-independent basic
            helix-loop-helix complex containing the mammalian Suppressor of
            Hairless (RBP-J) or its paralogue, RBP-L
  JOURNAL   Mol Cell Biol 26 (1), 117-130 (2006)
   PUBMED   16354684
REFERENCE   7  (bases 1 to 1508)
  AUTHORS   Krapp,A., Knofler,M., Ledermann,B., Burki,K., Berney,C.,
            Zoerkler,N., Hagenbuchle,O. and Wellauer,P.K.
  TITLE     The bHLH protein PTF1-p48 is essential for the formation of the
            exocrine and the correct spatial organization of the endocrine
            pancreas
  JOURNAL   Genes Dev 12 (23), 3752-3763 (1998)
   PUBMED   9851981
REFERENCE   8  (bases 1 to 1508)
  AUTHORS   Krapp,A., Knofler,M., Frutiger,S., Hughes,G.J., Hagenbuchle,O. and
            Wellauer,P.K.
  TITLE     The p48 DNA-binding subunit of transcription factor PTF1 is a new
            exocrine pancreas-specific basic helix-loop-helix protein
  JOURNAL   EMBO J 15 (16), 4317-4329 (1996)
   PUBMED   8861960
REFERENCE   9  (bases 1 to 1508)
  AUTHORS   Samuelson,L.C., Wiebauer,K., Howard,G., Schmid,R.M., Koeplin,D. and
            Meisler,M.H.
  TITLE     Isolation of the murine ribonuclease gene Rib-1: structure and
            tissue specific expression in pancreas and parotid gland
  JOURNAL   Nucleic Acids Res 19 (24), 6935-6941 (1991)
   PUBMED   1840677
REFERENCE   10 (bases 1 to 1508)
  AUTHORS   Petrucco,S., Wellauer,P.K. and Hagenbuchle,O.
  TITLE     The DNA-binding activity of transcription factor PTF1 parallels the
            synthesis of pancreas-specific mRNAs during mouse development
  JOURNAL   Mol Cell Biol 10 (1), 254-264 (1990)
   PUBMED   2294404
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK007922.2 and AL928806.14.
            
            On Mar 13, 2009 this sequence version replaced NM_018809.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB035675.1, AK007922.2 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849376, SAMN00849377
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1504              AK007922.2         27-1530
            1505-1508           AL928806.14        129399-129402
FEATURES             Location/Qualifiers
     source          1..1508
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 13.37 cM"
     gene            1..1508
                     /gene="Ptf1a"
                     /gene_synonym="bHLHa29; PTF1-p48; PTF1p48"
                     /note="pancreas specific transcription factor, 1a"
                     /db_xref="GeneID:19213"
                     /db_xref="MGI:MGI:1328312"
     exon            1..973
                     /gene="Ptf1a"
                     /gene_synonym="bHLHa29; PTF1-p48; PTF1p48"
                     /inference="alignment:Splign:2.1.0"
     CDS             199..1173
                     /gene="Ptf1a"
                     /gene_synonym="bHLHa29; PTF1-p48; PTF1p48"
                     /note="pancreas transcription factor1 p48 subunit; bHLH
                     transcription factor p48; p48 DNA-binding subunit of
                     transcription factor PTF1"
                     /codon_start=1
                     /product="pancreas transcription factor 1 subunit alpha"
                     /protein_id="NP_061279.2"
                     /db_xref="CCDS:CCDS15715.1"
                     /db_xref="GeneID:19213"
                     /db_xref="MGI:MGI:1328312"
                     /translation="MDAVLLEHFPGGLDTFPSPYFDEEDFFTDQSSRDPLEDSDELLG
                     DEQAEVEFLSHQLHEYCYRDGACLLLQPAPSAAPHALAPPPLGDPGEPEDNVSYCCDA
                     GAPLAAFPYSPGSPPSCLAYPCAAVLSPGARLGGLNGAAAAAAARRRRRVRSEAELQQ
                     LRQAANVRERRRMQSINDAFEGLRSHIPTLPYEKRLSKVDTLRLAIGYINFLSELVQA
                     DLPLRGSGAGGCGGPGGSRHLGEDSPGNQAQKVIICHRGTRSPSPSDPDYGLPPLAGH
                     SLSWTDEKQLKEQNIIRTAKVWTPEDPRKLNSKSFDNIENEPPFEFVS"
     exon            974..1508
                     /gene="Ptf1a"
                     /gene_synonym="bHLHa29; PTF1-p48; PTF1p48"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1479..1484
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ptf1a"
                     /gene_synonym="bHLHa29; PTF1-p48; PTF1p48"
                     /note="hexamer: AATAAA"
     polyA_site      1505
                     /gene="Ptf1a"
                     /gene_synonym="bHLHa29; PTF1-p48; PTF1p48"
                     /note="major polyA site"
ORIGIN      
        1 tctccagtgc cagccagagc cagcggccgc gcgcactcca gggaggccct cgtgcgggga
       61 cccgcggcca cctttgcctt ccccaacccc aaccccacga gggaggggct gagggaccta
      121 cccgaattgc cacggatcac tcacaaagcg tcaccccgag cagcccattc gtccttccgg
      181 gcctcggcgg ccgagggcat ggacgccgta ctcctggagc acttccccgg gggcctggac
      241 accttcccat ccccttactt tgatgaggaa gatttcttca ccgaccagtc ctctcgggac
      301 ccgctggagg acagcgacga gctgctgggg gacgagcaag cagaagtaga gttcctcagc
      361 caccagctac acgaatactg ctaccgcgac ggggcgtgcc tgctgctgca acccgcgccc
      421 tcggccgccc cgcacgcgct cgccccgccg cctttggggg atcctggcga gcccgaggac
      481 aacgtcagct attgctgcga tgcaggggct cctctcgctg ccttccccta ctcgcctggc
      541 tcaccgccct cgtgcctcgc ctacccgtgt gccgcggtgc tgtcccccgg tgcgcggctc
      601 ggtggtttga acggggctgc ggcagcggcg gcagcaaggc ggcggcgacg cgtgcgctcc
      661 gaggcggagc tgcagcagct gcgacaagcc gctaatgtgc gagagcggcg ccgcatgcag
      721 tccatcaacg acgccttcga ggggctgcgt tcgcacatcc ccacgctacc ctacgaaaag
      781 cgcctctcca aagtagacac gctgcgcttg gccataggct acattaactt cctcagcgag
      841 ctggtgcaag ccgacctgcc gctgcgcggg agtggcgcag gtggttgcgg gggcccaggt
      901 ggcagccggc acctcggaga ggacagtccc ggtaaccagg cccagaaggt tatcatctgc
      961 catcgaggca cccgttcacc ctcccccagt gacccggatt atggtctccc tcctcttgca
     1021 gggcactctc tttcctggac tgatgaaaaa cagctcaaag aacaaaatat catccgtaca
     1081 gctaaagtgt ggaccccaga ggaccccaga aaactcaaca gtaaatcttt cgacaacata
     1141 gagaacgaac caccctttga gtttgtgtcc tgagacagct cacatcgggt tggccgcgtc
     1201 tttgtgcata ttgtacgtgt aaataaatac ctataatgta aatgtaattt aaagaccaca
     1261 tttttctaat ggcaatcaac tgtttgttat ttatctattt attattctgt cgagttaatg
     1321 aaatagattg tcttttaaaa tatataattt atataattta tcgtgatgtt ctataatatg
     1381 atttcctgaa gcacctttga cagaagaact ggaagaactc tgtccaggaa actccgtgct
     1441 tatttaatat cagaattggt ttatttctga gtgttgttaa taaatgttat tcacatgtgt
     1501 ttctataa
//
