LOCUS       NM_001305437            3706 bp    mRNA    linear   ROD 28-JAN-2025
DEFINITION  Mus musculus phosphotriesterase related (Pter), transcript variant
            1, mRNA.
ACCESSION   NM_001305437 XM_006497400
VERSION     NM_001305437.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3706)
  AUTHORS   Wei,W., Lyu,X., Markhard,A.L., Fu,S., Mardjuki,R.E., Cavanagh,P.E.,
            Zeng,X., Rajniak,J., Lu,N., Xiao,S., Zhao,M., Moya-Garzon,M.D.,
            Truong,S.D., Chou,J.C., Wat,L.W., Chidambaranathan-Reghupaty,S.,
            Coassolo,L., Xu,D., Shen,F., Huang,W., Ramirez,C.B., Jang,C.,
            Li,L., Svensson,K.J., Fischbach,M.A. and Long,J.Z.
  TITLE     PTER is a N-acetyltaurine hydrolase that regulates feeding and
            obesity
  JOURNAL   Nature 633 (8028), 182-188 (2024)
   PUBMED   39112712
  REMARK    GeneRIF: PTER is a N-acetyltaurine hydrolase that regulates feeding
            and obesity.
REFERENCE   2  (bases 1 to 3706)
  AUTHORS   Longtine,C., Eliason,C.M., Mishkind,D., Lee,C., Chiappone,M.,
            Goller,F., Love,J., Kingsley,E.P., Clarke,J.A. and Tabin,C.J.
  TITLE     Homology and the evolution of vocal folds in the novel avian voice
            box
  JOURNAL   Curr Biol 34 (3), 461-472 (2024)
   PUBMED   38183987
REFERENCE   3  (bases 1 to 3706)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3706)
  AUTHORS   Wang,Q., Chow,J., Hong,J., Smith,A.F., Moreno,C., Seaby,P.,
            Vrana,P., Miri,K., Tak,J., Chung,E.D., Mastromonaco,G., Caniggia,I.
            and Varmuza,S.
  TITLE     Recent acquisition of imprinting at the rodent Sfmbt2 locus
            correlates with insertion of a large block of miRNAs
  JOURNAL   BMC Genomics 12, 204 (2011)
   PUBMED   21510876
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3706)
  AUTHORS   Thiagarajan,R.D., Georgas,K.M., Rumballe,B.A., Lesieur,E.,
            Chiu,H.S., Taylor,D., Tang,D.T., Grimmond,S.M. and Little,M.H.
  TITLE     Identification of anchor genes during kidney development defines
            ontological relationships, molecular subcompartments and regulatory
            pathways
  JOURNAL   PLoS One 6 (2), e17286 (2011)
   PUBMED   21386911
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3706)
  AUTHORS   Hou,X., Maser,R.L., Magenheimer,B.S. and Calvet,J.P.
  TITLE     A mouse kidney- and liver-expressed cDNA having homology with a
            prokaryotic parathion hydrolase (phosphotriesterase)-encoding gene:
            abnormal expression in injured and polycystic kidneys
  JOURNAL   Gene 168 (2), 157-163 (1996)
   PUBMED   8654936
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BB868274.1, U28016.1, BB854955.1, AK075604.1, AL929209.17 and
            BY704600.1.
            
            On Mar 12, 2015 this sequence version replaced XM_006497400.1.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660811.47862.1, BU509969.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849380
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-89                BB868274.1         2-90
            90-158              U28016.1           7-75
            159-243             BB854955.1         126-210
            244-1865            U28016.1           76-1697
            1866-2177           AK075604.1         1719-2030
            2178-2558           AL929209.17        26775-27155
            2559-3450           AK075604.1         2410-3301
            3451-3706           BY704600.1         135-390             c
FEATURES             Location/Qualifiers
     source          1..3706
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 9.63 cM"
     gene            1..3706
                     /gene="Pter"
                     /gene_synonym="Mpr56-1"
                     /note="phosphotriesterase related"
                     /db_xref="GeneID:19212"
                     /db_xref="MGI:MGI:107372"
     exon            1..158
                     /gene="Pter"
                     /gene_synonym="Mpr56-1"
                     /inference="alignment:Splign:2.1.0"
     exon            159..243
                     /gene="Pter"
                     /gene_synonym="Mpr56-1"
                     /inference="alignment:Splign:2.1.0"
     CDS             234..1319
                     /gene="Pter"
                     /gene_synonym="Mpr56-1"
                     /note="isoform 1 is encoded by transcript variant 1;
                     phosphotriesterase-related protein; parathion hydrolase
                     (phosphotriesterase)-related protein; N-acetyltaurine
                     hydrolase"
                     /codon_start=1
                     /product="N-acetyltaurine hydrolase isoform 1"
                     /protein_id="NP_001292366.1"
                     /db_xref="GeneID:19212"
                     /db_xref="MGI:MGI:107372"
                     /translation="MSSKKIPETLSGMSSLSGKVQTVLGLVEPSQLGRTLTHEHLTMT
                     FDSFYCPPPPCHEVTSKEPIMMKNLFWIQKNPYSHRENLQLNQEVGAIREELLYFKAK
                     GGGALVENTTTGLSRDVHTLKWLAEQTGVHIIAGAGFYVDATHSAATRAMSVEQLTDV
                     LINEILHGADGTSIKCGVIGEIGCSWPLTDSERKILEATAHAQAQLGCPVIIHPGRNP
                     GAPFQIIRILQEAGADISKTVMSHLDRTIFDKKELLEFAQLGCYLEYDLFGTELLNYQ
                     LSPDIDMPDDNKRIRRVHFLVDEGYEDRILMAHDIHTKHRLMKYGGHGYSHILTNIVP
                     KMLLRGLTERVLDKILIENPKQWLTFK"
     exon            244..701
                     /gene="Pter"
                     /gene_synonym="Mpr56-1"
                     /inference="alignment:Splign:2.1.0"
     exon            702..967
                     /gene="Pter"
                     /gene_synonym="Mpr56-1"
                     /inference="alignment:Splign:2.1.0"
     exon            968..1108
                     /gene="Pter"
                     /gene_synonym="Mpr56-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1109..3706
                     /gene="Pter"
                     /gene_synonym="Mpr56-1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1845..1850
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Pter"
                     /gene_synonym="Mpr56-1"
                     /note="hexamer: AATAAA"
     polyA_site      1866
                     /gene="Pter"
                     /gene_synonym="Mpr56-1"
                     /note="major polyA site"
     regulatory      1899..1904
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Pter"
                     /gene_synonym="Mpr56-1"
                     /note="hexamer: AATATA"
     polyA_site      1919
                     /gene="Pter"
                     /gene_synonym="Mpr56-1"
     regulatory      3686..3691
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Pter"
                     /gene_synonym="Mpr56-1"
                     /note="hexamer: AATAAA"
     polyA_site      3705
                     /gene="Pter"
                     /gene_synonym="Mpr56-1"
ORIGIN      
        1 gatgcggtgg gggtgggggt ggaagagaga gacaacttcc caaagggagg ggaagccgac
       61 ctagctcaag tcaagttccc agggggagaa ggcggcgcac agcgcggaat gaaggaagcc
      121 ccggagctgg ttaagtagct gtggacctgg taggaaaggt ccagcaagac tagaagagca
      181 ggaagacata cctgtacttc tgaaacttga gagtctgagg caggaggatc accatgagtt
      241 caaagaaaat ccctgagaca ctatcaggaa tgtcttcctt aagtgggaaa gtacaaacag
      301 ttctgggcct tgtagaaccc agccaactgg gacgcaccct gacccacgag catctgacaa
      361 tgacctttga cagtttttac tgcccacctc ctccatgcca cgaagtcacc tccaaggaac
      421 ctatcatgat gaaaaatcta ttttggattc agaaaaaccc ctattcccat cgagagaacc
      481 ttcagttgaa tcaggaggta ggagccataa gagaagagct gttgtatttc aaggctaagg
      541 gcggaggagc cttggtggag aatacgacaa ctgggctcag cagggacgtg catacgctga
      601 agtggctggc agagcagact ggagtccaca tcatagctgg agctgggttt tatgttgatg
      661 caactcactc tgcagcaacc agagccatgt cagtggagca gcttacagat gtccttatta
      721 atgaaattct ccatggagct gatggcacca gcatcaagtg tggagttatt ggagaaattg
      781 gctgctcctg gcctttgact gacagcgaga gaaagatact tgaggctaca gctcacgccc
      841 aggctcagct tggctgtcct gtcatcatcc atcctggacg gaacccaggt gcaccattcc
      901 agataatccg tatactgcaa gaagcaggag cagacatctc caaaacagtc atgtcccacc
      961 ttgacaggac tatatttgat aagaaagagc tgctggagtt tgctcaactt ggctgctact
     1021 tggaatacga tctctttggt acggaactcc ttaattacca gttgagccca gatattgata
     1081 tgcctgatga taacaaaaga attagaaggg tccattttct agtggatgag ggctatgaag
     1141 atcggattct catggcacat gacatacaca caaagcatcg gttgatgaag tacggaggtc
     1201 acggctactc acacatcctt accaacattg ttcctaagat gctccttaga ggtctgactg
     1261 agagggtgct tgacaagata ctcatagaaa accctaaaca atggctgact tttaaatagg
     1321 atggctgttc acgaacccag acctggagga tacaatgagc agagaatagt tggtgatttc
     1381 aaatctactg gagacattaa tccagtctac atagaactgg tgaatggtca cttctctcct
     1441 atgagaagct ggataactac cacagggaca tctctggtgg gggccacagg gctcaagtga
     1501 gtcccattgt ctttccttaa taaaataaat attgataaaa gagcatgttt ccaaacagta
     1561 gtttaaaact atatccccta agaatcattt tggatgtctt ccccaaccct gactctgtga
     1621 tctgcactac ttgagaaaaa tgaaagtgtt tctagctaag ttgccccttc tggagcaacc
     1681 taatgtttct tgtaatattg atgatcctac taattatcct gctgttcttt aattaatgct
     1741 taatgaataa tatggcattt taaaatcact tttgcaacaa gggaagttaa attttgagac
     1801 attttttccc aaaggagact gcaataaaat taccaattca caacaataaa gaaatttcga
     1861 aggttaccta tgtgttttcc acttatttat gtaaacaaaa tatatcattt tttttctgac
     1921 tttggctttc tggtctccat ttttactgtt aactatgttg tgtttttgaa aatctatcaa
     1981 agaacatata acaatagtga attataaaaa atgcaattat aaaagtaaaa atatattaca
     2041 taatatagtt taatgaatca ttacagttat tataacaaag gccacaattt aattaattca
     2101 tgttataatg caaagaaaaa gagaaatgct tgccttatat atagtccttt tatttcatgt
     2161 accttttatt tctttttttc tccggcctaa acagagaaaa taatgcttac ttatctaaag
     2221 aaaaggtcag gtctattgga aatgacagtc tgtttgtaaa cactactctt tagaagagat
     2281 ccagccatga agttcttttc taataaagcc ttttcaaaat gttagttaaa atgcttaatt
     2341 gatgaacact gttgtttata agttaatcct ttgaatcctc gttatgtgat ttggtaccca
     2401 agacaaatct ttaatccctt gcttgcaatc cataagtata tgctgttaaa tagaagttaa
     2461 aagtgtagca attcattggt gaattacctt acatattaga agggccaaat cgaattagtc
     2521 actattcttg atgaatgatc taagtgtttt tatcatataa atcacgacag ttactcagac
     2581 caaggcattt aaatacagca aacaccacct ttagatggga acaccatgca taactcttgg
     2641 aaaagtcaag gtttgctaaa ctaaagctat ttctgttgat catagctgat caagctctct
     2701 gtatattaga acagaaagta ccaaagttga gtgagccaaa agaacagccc agttccttta
     2761 aaggttaaaa tgcaaatgtc cttccccagt aaaccaagca gagttttaaa tctctggctt
     2821 tgaaatctac ttgtcaaaga atgtttaaag gcaactgaaa ggggaacaga ttttccactg
     2881 taagaggggg aattgtgtgt gagtaggaca tgttcgtatg cattttgatc ttccccttac
     2941 accaaagaga tggctcttgg cagtgtgttg taactagcga gaatgggttc gcactacact
     3001 atcagcttca atccaacaga aagaaaaaaa taattggctg ctcaaatgtg tatgtttcat
     3061 taccattgta agagagagct acttgcttcc taaagtcctg taatagtcgt ctgccaaaga
     3121 atgcagatga agtatggatt gcatgtggaa cacagttacc atgggatcaa ctaggtctca
     3181 tgtgtgacat agggcactgg aatctactgt gatttgactt tctgaataac tcttaaagag
     3241 aagtcacctt tattattttg ctactctatg tattggtatc atctaaaata tattttgatc
     3301 taaaataagt cgaataattt gtgcatggtt ctgtgtgtat acatatatac tttttaaatt
     3361 catttttgag ctgtacagcc actgtgctta gtggactgaa gccatatata tatataatat
     3421 tttcatctaa catatatgta tataaataag tgtgtggcag atatttatat aaaatatata
     3481 cactttgttg tcatgtcggt tctatgtgaa actgttaatt ttgaaataac ctcaggctac
     3541 agatttgtgg taactgtttg aaggccttac ttagtgtccc cttggtgacg catgcagtag
     3601 ctcaagttaa acttttgtgc cttaggttat gaacgatctt ttgttccaaa gaaggcaaaa
     3661 gcctccatct gacttcatac caaagaataa atttctctga ctgttc
//
