LOCUS       NP_001292366             361 aa            linear   ROD 28-JAN-2025
DEFINITION  N-acetyltaurine hydrolase isoform 1 [Mus musculus].
ACCESSION   NP_001292366 XP_006497463
VERSION     NP_001292366.1
DBSOURCE    REFSEQ: accession NM_001305437.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 361)
  AUTHORS   Wei,W., Lyu,X., Markhard,A.L., Fu,S., Mardjuki,R.E., Cavanagh,P.E.,
            Zeng,X., Rajniak,J., Lu,N., Xiao,S., Zhao,M., Moya-Garzon,M.D.,
            Truong,S.D., Chou,J.C., Wat,L.W., Chidambaranathan-Reghupaty,S.,
            Coassolo,L., Xu,D., Shen,F., Huang,W., Ramirez,C.B., Jang,C.,
            Li,L., Svensson,K.J., Fischbach,M.A. and Long,J.Z.
  TITLE     PTER is a N-acetyltaurine hydrolase that regulates feeding and
            obesity
  JOURNAL   Nature 633 (8028), 182-188 (2024)
   PUBMED   39112712
  REMARK    GeneRIF: PTER is a N-acetyltaurine hydrolase that regulates feeding
            and obesity.
REFERENCE   2  (residues 1 to 361)
  AUTHORS   Longtine,C., Eliason,C.M., Mishkind,D., Lee,C., Chiappone,M.,
            Goller,F., Love,J., Kingsley,E.P., Clarke,J.A. and Tabin,C.J.
  TITLE     Homology and the evolution of vocal folds in the novel avian voice
            box
  JOURNAL   Curr Biol 34 (3), 461-472 (2024)
   PUBMED   38183987
REFERENCE   3  (residues 1 to 361)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   4  (residues 1 to 361)
  AUTHORS   Wang,Q., Chow,J., Hong,J., Smith,A.F., Moreno,C., Seaby,P.,
            Vrana,P., Miri,K., Tak,J., Chung,E.D., Mastromonaco,G., Caniggia,I.
            and Varmuza,S.
  TITLE     Recent acquisition of imprinting at the rodent Sfmbt2 locus
            correlates with insertion of a large block of miRNAs
  JOURNAL   BMC Genomics 12, 204 (2011)
   PUBMED   21510876
  REMARK    Publication Status: Online-Only
REFERENCE   5  (residues 1 to 361)
  AUTHORS   Thiagarajan,R.D., Georgas,K.M., Rumballe,B.A., Lesieur,E.,
            Chiu,H.S., Taylor,D., Tang,D.T., Grimmond,S.M. and Little,M.H.
  TITLE     Identification of anchor genes during kidney development defines
            ontological relationships, molecular subcompartments and regulatory
            pathways
  JOURNAL   PLoS One 6 (2), e17286 (2011)
   PUBMED   21386911
  REMARK    Publication Status: Online-Only
REFERENCE   6  (residues 1 to 361)
  AUTHORS   Hou,X., Maser,R.L., Magenheimer,B.S. and Calvet,J.P.
  TITLE     A mouse kidney- and liver-expressed cDNA having homology with a
            prokaryotic parathion hydrolase (phosphotriesterase)-encoding gene:
            abnormal expression in injured and polycystic kidneys
  JOURNAL   Gene 168 (2), 157-163 (1996)
   PUBMED   8654936
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BB868274.1, U28016.1, BB854955.1, AK075604.1, AL929209.17 and
            BY704600.1.
            
            On Mar 12, 2015 this sequence version replaced XP_006497463.1.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660811.47862.1, BU509969.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849380
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..361
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 9.63 cM"
     Protein         1..361
                     /product="N-acetyltaurine hydrolase isoform 1"
                     /note="phosphotriesterase-related protein; parathion
                     hydrolase (phosphotriesterase)-related protein;
                     N-acetyltaurine hydrolase"
                     /calculated_mol_wt=40347
     Region          27..359
                     /region_name="PTE"
                     /note="Phosphotriesterase family; pfam02126"
                     /db_xref="CDD:396618"
     Site            order(38,40,180,213,242,310)
                     /site_type="active"
                     /db_xref="CDD:238295"
     Site            order(40,140,213,310)
                     /site_type="other"
                     /note="substrate binding pocket [chemical binding]"
                     /db_xref="CDD:238295"
     Site            order(45,113,152,156,163,170)
                     /site_type="other"
                     /note="homodimer interaction site [polypeptide binding]"
                     /db_xref="CDD:238295"
     CDS             1..361
                     /gene="Pter"
                     /gene_synonym="Mpr56-1"
                     /coded_by="NM_001305437.1:234..1319"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /db_xref="GeneID:19212"
                     /db_xref="MGI:MGI:107372"
ORIGIN      
        1 msskkipetl sgmsslsgkv qtvlglveps qlgrtltheh ltmtfdsfyc ppppchevts
       61 kepimmknlf wiqknpyshr enlqlnqevg aireellyfk akgggalven tttglsrdvh
      121 tlkwlaeqtg vhiiagagfy vdathsaatr amsveqltdv lineilhgad gtsikcgvig
      181 eigcswpltd serkileata haqaqlgcpv iihpgrnpga pfqiirilqe agadisktvm
      241 shldrtifdk kellefaqlg cyleydlfgt ellnyqlspd idmpddnkri rrvhflvdeg
      301 yedrilmahd ihtkhrlmky gghgyshilt nivpkmllrg ltervldkil ienpkqwltf
      361 k
//
