LOCUS       NM_013782               2137 bp    mRNA    linear   ROD 06-NOV-2024
DEFINITION  Mus musculus phosphatidylserine synthase 2 (Ptdss2), transcript
            variant 1, mRNA.
ACCESSION   NM_013782
VERSION     NM_013782.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2137)
  AUTHORS   Kimura,A.K. and Kim,H.Y.
  TITLE     Phosphatidylserine synthase 2: high efficiency for synthesizing
            phosphatidylserine containing docosahexaenoic acid
  JOURNAL   J Lipid Res 54 (1), 214-222 (2013)
   PUBMED   23071296
  REMARK    GeneRIF: PSS2 may play a key role in PS accumulation in brain and
            testis through high activity toward DHA-containing substrates that
            are abundant in these tissues
REFERENCE   2  (bases 1 to 2137)
  AUTHORS   Arikketh,D., Nelson,R. and Vance,J.E.
  TITLE     Defining the importance of phosphatidylserine synthase-1 (PSS1):
            unexpected viability of PSS1-deficient mice
  JOURNAL   J Biol Chem 283 (19), 12888-12897 (2008)
   PUBMED   18343815
REFERENCE   3  (bases 1 to 2137)
  AUTHORS   Steenbergen,R., Nanowski,T.S., Nelson,R., Young,S.G. and Vance,J.E.
  TITLE     Phospholipid homeostasis in phosphatidylserine synthase-2-deficient
            mice
  JOURNAL   Biochim Biophys Acta 1761 (3), 313-323 (2006)
   PUBMED   16627002
REFERENCE   4  (bases 1 to 2137)
  AUTHORS   Lin,Q., Donahue,S.L., Moore-Jarrett,T., Cao,S., Osipovich,A.B. and
            Ruley,H.E.
  TITLE     Mutagenesis of diploid mammalian genes by gene entrapment
  JOURNAL   Nucleic Acids Res 34 (20), e139 (2006)
   PUBMED   17062627
REFERENCE   5  (bases 1 to 2137)
  AUTHORS   Taniwaki,T., Haruna,K., Nakamura,H., Sekimoto,T., Oike,Y.,
            Imaizumi,T., Saito,F., Muta,M., Soejima,Y., Utoh,A., Nakagata,N.,
            Araki,M., Yamamura,K. and Araki,K.
  TITLE     Characterization of an exchangeable gene trap using pU-17 carrying
            a stop codon-beta geo cassette
  JOURNAL   Dev Growth Differ 47 (3), 163-172 (2005)
   PUBMED   15840001
REFERENCE   6  (bases 1 to 2137)
  AUTHORS   Bergo,M.O., Gavino,B.J., Steenbergen,R., Sturbois,B., Parlow,A.F.,
            Sanan,D.A., Skarnes,W.C., Vance,J.E. and Young,S.G.
  TITLE     Defining the importance of phosphatidylserine synthase 2 in mice
  JOURNAL   J Biol Chem 277 (49), 47701-47708 (2002)
   PUBMED   12361952
  REMARK    GeneRIF: Pss2 is responsible for the majority of serine exchange
            activity in in vitro assays, but a deficiency in this enzyme does
            not cause perturbations in phospholipid content or severe
            developmental abnormalities
REFERENCE   7  (bases 1 to 2137)
  AUTHORS   Mitchell,K.J., Pinson,K.I., Kelly,O.G., Brennan,J., Zupicich,J.,
            Scherz,P., Leighton,P.A., Goodrich,L.V., Lu,X., Avery,B.J.,
            Tate,P., Dill,K., Pangilinan,E., Wakenight,P., Tessier-Lavigne,M.
            and Skarnes,W.C.
  TITLE     Functional analysis of secreted and transmembrane proteins critical
            to mouse development
  JOURNAL   Nat Genet 28 (3), 241-249 (2001)
   PUBMED   11431694
REFERENCE   8  (bases 1 to 2137)
  AUTHORS   Stone,S.J. and Vance,J.E.
  TITLE     Phosphatidylserine synthase-1 and -2 are localized to
            mitochondria-associated membranes
  JOURNAL   J Biol Chem 275 (44), 34534-34540 (2000)
   PUBMED   10938271
REFERENCE   9  (bases 1 to 2137)
  AUTHORS   Stone,S.J. and Vance,J.E.
  TITLE     Cloning and expression of murine liver phosphatidylserine synthase
            (PSS)-2: differential regulation of phospholipid metabolism by PSS1
            and PSS2
  JOURNAL   Biochem J 342 (Pt 1) (Pt 1), 57-64 (1999)
   PUBMED   10432300
REFERENCE   10 (bases 1 to 2137)
  AUTHORS   Araki,K., Imaizumi,T., Sekimoto,T., Yoshinobu,K., Yoshimuta,J.,
            Akizuki,M., Miura,K., Araki,M. and Yamamura,K.
  TITLE     Exchangeable gene trap using the Cre/mutated lox system
  JOURNAL   Cell Mol Biol (Noisy-le-grand) 45 (5), 737-750 (1999)
   PUBMED   10512203
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC109272.20 and AC108908.16.
            
            On Mar 21, 2023 this sequence version replaced NM_013782.4.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC053517.1, AK036368.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-197               AC109272.20        1718-1914           c
            198-299             AC108908.16        113869-113970       c
            300-382             AC108908.16        106104-106186       c
            383-450             AC108908.16        102131-102198       c
            451-585             AC108908.16        97495-97629         c
            586-636             AC108908.16        97037-97087         c
            637-750             AC108908.16        96391-96504         c
            751-869             AC108908.16        96186-96304         c
            870-984             AC108908.16        94812-94926         c
            985-1130            AC108908.16        94577-94722         c
            1131-1316           AC108908.16        94283-94468         c
            1317-2137           AC108908.16        93125-93945         c
FEATURES             Location/Qualifiers
     source          1..2137
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 86.39 cM"
     gene            1..2137
                     /gene="Ptdss2"
                     /gene_synonym="PSS2"
                     /note="phosphatidylserine synthase 2"
                     /db_xref="GeneID:27388"
                     /db_xref="MGI:MGI:1351664"
     exon            1..197
                     /gene="Ptdss2"
                     /gene_synonym="PSS2"
                     /inference="alignment:Splign:2.1.0"
     CDS             82..1503
                     /gene="Ptdss2"
                     /gene_synonym="PSS2"
                     /EC_number="2.7.8.29"
                     /note="isoform 1 is encoded by transcript variant 1;
                     PSS-2; ptdSer synthase 2; serine-exchange enzyme II"
                     /codon_start=1
                     /product="phosphatidylserine synthase 2 isoform 1"
                     /protein_id="NP_038810.2"
                     /db_xref="CCDS:CCDS22001.1"
                     /db_xref="GeneID:27388"
                     /db_xref="MGI:MGI:1351664"
                     /translation="MRRGERRVAGGSGSESPLLKGRRSTESEVYDDGTNTFFWRAHTL
                     TVLFILTCALGYVTLLEETPQDTAYNTKRGIVASILVFLCFGVTQAKDGPFSRPHPAY
                     WRFWLCVSVVYELFLIFILFQTVQDGRQFLKYVDPRLGVPLPERDYGGNCLIYDADNK
                     TDPFHNIWDKLDGFVPAHFIGWYLKTLMIRDWWMCMIISVMFEFLEYSLEHQLPNFSE
                     CWWDHWIMDVLVCNGLGIYCGMKTLEWLSLKTYKWQGLWNIPTYKGKMKRIAFQFTPY
                     SWVRFEWKPASSLHRWLAVCGIILVFLLAELNTFYLKFVLWMPPEHYLVLLRLVFFVN
                     VGGVAMREIYDFMDELKPHRKLGQQAWLVAAITVTELLIVVKYDPHTLTLSLPFYISQ
                     CWTLGSILVLTWTVWRFFLRDITMRYKETRRQKQQSHQARAVNNRDGHPGPDDDLLGT
                     GTAEEEGTTNDGVTAEEGTSAAS"
     exon            198..299
                     /gene="Ptdss2"
                     /gene_synonym="PSS2"
                     /inference="alignment:Splign:2.1.0"
     exon            300..382
                     /gene="Ptdss2"
                     /gene_synonym="PSS2"
                     /inference="alignment:Splign:2.1.0"
     exon            383..450
                     /gene="Ptdss2"
                     /gene_synonym="PSS2"
                     /inference="alignment:Splign:2.1.0"
     exon            451..585
                     /gene="Ptdss2"
                     /gene_synonym="PSS2"
                     /inference="alignment:Splign:2.1.0"
     exon            586..636
                     /gene="Ptdss2"
                     /gene_synonym="PSS2"
                     /inference="alignment:Splign:2.1.0"
     exon            637..750
                     /gene="Ptdss2"
                     /gene_synonym="PSS2"
                     /inference="alignment:Splign:2.1.0"
     exon            751..869
                     /gene="Ptdss2"
                     /gene_synonym="PSS2"
                     /inference="alignment:Splign:2.1.0"
     exon            870..984
                     /gene="Ptdss2"
                     /gene_synonym="PSS2"
                     /inference="alignment:Splign:2.1.0"
     exon            985..1130
                     /gene="Ptdss2"
                     /gene_synonym="PSS2"
                     /inference="alignment:Splign:2.1.0"
     exon            1131..1316
                     /gene="Ptdss2"
                     /gene_synonym="PSS2"
                     /inference="alignment:Splign:2.1.0"
     exon            1317..2137
                     /gene="Ptdss2"
                     /gene_synonym="PSS2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2117..2122
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ptdss2"
                     /gene_synonym="PSS2"
                     /note="hexamer: AATAAA"
     polyA_site      2137
                     /gene="Ptdss2"
                     /gene_synonym="PSS2"
                     /note="major polyA site"
ORIGIN      
        1 actcccgcgg agaccccgcc gggcagcact gcgaccccag cccaccgcct gcagcctact
       61 gggctgcgca ggccgggcgc catgcggagg ggcgagcgca gagtcgccgg aggctcggga
      121 tctgagtctc cgctgctcaa gggccgccgc agcaccgagt ctgaagtcta cgacgatggc
      181 actaacacct tcttttggcg tgcccacact ttaactgtgc tgttcatcct cacctgtgcg
      241 ctgggctacg tgactctcct agaagaaacc cctcaggata cagcctacaa caccaagaga
      301 ggtattgtgg ccagtatttt ggttttctta tgttttggag tcacacaagc taaagacggg
      361 ccattttcca gacctcatcc agcttactgg cggttttggc tgtgtgttag tgtggtctac
      421 gaattgtttc tcatcttcat ccttttccag acagtccagg atggccgaca gtttctgaag
      481 tatgtggatc ccaggctggg agtcccattg ccagagaggg actacggggg caactgcctc
      541 atctatgatg ctgacaacaa gactgaccct ttccacaaca tctgggacaa gctggatggc
      601 tttgttcctg cacacttcat tggctggtat ctgaagacgc tcatgatccg tgactggtgg
      661 atgtgcatga tcatcagtgt gatgttcgag ttcctggagt acagcctgga gcaccagctg
      721 cccaacttca gcgagtgctg gtgggaccat tggatcatgg acgtcctcgt ctgcaacggg
      781 ctgggcatct actgtggcat gaagaccctc gagtggctgt ccctgaagac atataagtgg
      841 cagggcctct ggaacattcc aacctacaag ggcaagatga agaggattgc ctttcagttc
      901 acgccttaca gctgggtacg ctttgagtgg aagccagcct ccagcctgca ccgctggctg
      961 gccgtgtgtg gcatcatcct ggtgttcctg ctggcagagc tgaacacctt ctacctgaag
     1021 tttgtgctat ggatgccccc tgaacactac ctggtccttc tgaggctggt cttcttcgtg
     1081 aacgtgggtg gtgtggccat gcgtgagatc tacgacttca tggatgaatt gaagccccac
     1141 aggaagctgg gccagcaggc ctggctggtg gcagccatca cagtcacaga gcttctcatc
     1201 gtggtgaagt atgacccgca cacactcacc ctgtcactgc ccttctacat ctcccagtgc
     1261 tggactcttg gctccatcct ggtgcttaca tggactgtct ggcgcttctt cctgcgggac
     1321 atcaccatga ggtacaagga gacccggcga cagaagcagc agagtcacca ggccagagcc
     1381 gtcaacaacc gggatgggca ccctgggcca gatgatgacc tgctagggac tggaactgca
     1441 gaagaagagg ggaccaccaa tgacggtgtg actgctgagg aggggacctc agccgcgtca
     1501 tgagcctcac cctcgtcact ggccttgtgc caaggggctg tcccatttct cccttcctcg
     1561 tgctccctgc ttcagaggca ggggtggggg gggcatccac actccaggag gggcacctga
     1621 gaatacatgt ttgtgtgcag gtaggtgtat gcacatattg gctcctgaca ctactttggg
     1681 gccatgagct gaacagtgag cctggaactt gctctagagc aagagtcctt tctacctggt
     1741 caacaaaggc cctggtccat ggtctccctt gtgctcaatc tcagcaccgg ctaggggagg
     1801 tatcttggta tctcggtact ctttctccac tctttatggg gtaggcagaa gccccatgag
     1861 accctgtggt cccacccact tacagcagca taagtgaagg atatcataat accaacatgt
     1921 ctgcaaagtg gtgggtctag agtcagcact gagccatttc ctttggagcc ttcctttaac
     1981 cacgcaggac tataaactga atggtgtata catgacagtc acagattggc cttttgcggc
     2041 cagagagccc aacttggaga cctgtacccc aggtgccagg gtgctgtcac catggctccc
     2101 ttgagcaaat ggaacaaata aagtgatgat gaaggtg
//
