LOCUS       NM_008959               3424 bp    mRNA    linear   ROD 29-JUL-2024
DEFINITION  Mus musculus phosphatidylserine synthase 1 (Ptdss1), mRNA.
ACCESSION   NM_008959 XM_909381 XM_921291
VERSION     NM_008959.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3424)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 3424)
  AUTHORS   Sekar,D., Dillmann,C., Sirait-Fischer,E., Fink,A.F., Zivkovic,A.,
            Baum,N., Strack,E., Klatt,S., Zukunft,S., Wallner,S., Descot,A.,
            Olesch,C., da Silva,P., von Knethen,A., Schmid,T., Grosch,S.,
            Savai,R., Ferreiros,N., Fleming,I., Ghosh,S., Rothlin,C.V.,
            Stark,H., Medyouf,H., Brune,B. and Weigert,A.
  TITLE     Phosphatidylserine Synthase PTDSS1 Shapes the Tumor Lipidome to
            Maintain Tumor-Promoting Inflammation
  JOURNAL   Cancer Res 82 (8), 1617-1632 (2022)
   PUBMED   35425959
  REMARK    GeneRIF: Phosphatidylserine Synthase PTDSS1 Shapes the Tumor
            Lipidome to Maintain Tumor-Promoting Inflammation.
REFERENCE   3  (bases 1 to 3424)
  AUTHORS   Dickinson,M.E., Flenniken,A.M., Ji,X., Teboul,L., Wong,M.D.,
            White,J.K., Meehan,T.F., Weninger,W.J., Westerberg,H., Adissu,H.,
            Baker,C.N., Bower,L., Brown,J.M., Caddle,L.B., Chiani,F., Clary,D.,
            Cleak,J., Daly,M.J., Denegre,J.M., Doe,B., Dolan,M.E., Edie,S.M.,
            Fuchs,H., Gailus-Durner,V., Galli,A., Gambadoro,A., Gallegos,J.,
            Guo,S., Horner,N.R., Hsu,C.W., Johnson,S.J., Kalaga,S., Keith,L.C.,
            Lanoue,L., Lawson,T.N., Lek,M., Mark,M., Marschall,S., Mason,J.,
            McElwee,M.L., Newbigging,S., Nutter,L.M., Peterson,K.A.,
            Ramirez-Solis,R., Rowland,D.J., Ryder,E., Samocha,K.E.,
            Seavitt,J.R., Selloum,M., Szoke-Kovacs,Z., Tamura,M., Trainor,A.G.,
            Tudose,I., Wakana,S., Warren,J., Wendling,O., West,D.B., Wong,L.,
            Yoshiki,A., MacArthur,D.G., Tocchini-Valentini,G.P., Gao,X.,
            Flicek,P., Bradley,A., Skarnes,W.C., Justice,M.J., Parkinson,H.E.,
            Moore,M., Wells,S., Braun,R.E., Svenson,K.L., de Angelis,M.H.,
            Herault,Y., Mohun,T., Mallon,A.M., Henkelman,R.M., Brown,S.D.,
            Adams,D.J., Lloyd,K.C., McKerlie,C., Beaudet,A.L., Bucan,M. and
            Murray,S.A.
  CONSRTM   International Mouse Phenotyping Consortium; Jackson Laboratory;
            Infrastructure Nationale PHENOMIN, Institut Clinique de la Souris
            (ICS); Charles River Laboratories; MRC Harwell; Toronto Centre for
            Phenogenomics; Wellcome Trust Sanger Institute; RIKEN BioResource
            Center
  TITLE     High-throughput discovery of novel developmental phenotypes
  JOURNAL   Nature 537 (7621), 508-514 (2016)
   PUBMED   27626380
  REMARK    Erratum:[Nature. 2017 Nov 16;551(7680):398. doi:
            10.1038/nature24643. PMID: 29144450]
REFERENCE   4  (bases 1 to 3424)
  AUTHORS   Tasseva,G., Cole,L. and Vance,J.E.
  TITLE     N-Myc and SP regulate phosphatidylserine synthase-1 expression in
            brain and glial cells
  JOURNAL   J Biol Chem 286 (2), 1061-1073 (2011)
   PUBMED   21068393
  REMARK    GeneRIF: Site-directed mutagenesis of binding sites within the Pss1
            promoter demonstrated that Sp and N-Myc synergistically activate
            Pss1 expression in astrocytes
REFERENCE   5  (bases 1 to 3424)
  AUTHORS   Hoffman,B.G., Zavaglia,B., Witzsche,J., Ruiz de Algara,T.,
            Beach,M., Hoodless,P.A., Jones,S.J., Marra,M.A. and Helgason,C.D.
  TITLE     Identification of transcripts with enriched expression in the
            developing and adult pancreas
  JOURNAL   Genome Biol 9 (6), R99 (2008)
   PUBMED   18554416
REFERENCE   6  (bases 1 to 3424)
  AUTHORS   Bergo,M.O., Gavino,B.J., Steenbergen,R., Sturbois,B., Parlow,A.F.,
            Sanan,D.A., Skarnes,W.C., Vance,J.E. and Young,S.G.
  TITLE     Defining the importance of phosphatidylserine synthase 2 in mice
  JOURNAL   J Biol Chem 277 (49), 47701-47708 (2002)
   PUBMED   12361952
REFERENCE   7  (bases 1 to 3424)
  AUTHORS   Sturbois-Balcerzak,B., Stone,S.J., Sreenivas,A. and Vance,J.E.
  TITLE     Structure and expression of the murine phosphatidylserine
            synthase-1 gene
  JOURNAL   J Biol Chem 276 (11), 8205-8212 (2001)
   PUBMED   11084049
REFERENCE   8  (bases 1 to 3424)
  AUTHORS   Stone,S.J. and Vance,J.E.
  TITLE     Phosphatidylserine synthase-1 and -2 are localized to
            mitochondria-associated membranes
  JOURNAL   J Biol Chem 275 (44), 34534-34540 (2000)
   PUBMED   10938271
REFERENCE   9  (bases 1 to 3424)
  AUTHORS   Stone,S.J. and Vance,J.E.
  TITLE     Cloning and expression of murine liver phosphatidylserine synthase
            (PSS)-2: differential regulation of phospholipid metabolism by PSS1
            and PSS2
  JOURNAL   Biochem J 342 (Pt 1) (Pt 1), 57-64 (1999)
   PUBMED   10432300
REFERENCE   10 (bases 1 to 3424)
  AUTHORS   Stone,S.J., Cui,Z. and Vance,J.E.
  TITLE     Cloning and expression of mouse liver phosphatidylserine synthase-1
            cDNA. Overexpression in rat hepatoma cells inhibits the
            CDP-ethanolamine pathway for phosphatidylethanolamine biosynthesis
  JOURNAL   J Biol Chem 273 (13), 7293-7302 (1998)
   PUBMED   9516423
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK085857.1 and AK054101.1.
            
            On Oct 21, 2009 this sequence version replaced NM_008959.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK085857.1, SRR1660821.85144.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-562               AK085857.1         1-562
            563-3012            AK054101.1         2-2451
            3013-3424           AK085857.1         3014-3425
FEATURES             Location/Qualifiers
     source          1..3424
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="13"
                     /map="13 34.54 cM"
     gene            1..3424
                     /gene="Ptdss1"
                     /gene_synonym="mKIAA0024; PSS-1"
                     /note="phosphatidylserine synthase 1"
                     /db_xref="GeneID:19210"
                     /db_xref="MGI:MGI:1276575"
     exon            1..857
                     /gene="Ptdss1"
                     /gene_synonym="mKIAA0024; PSS-1"
                     /inference="alignment:Splign:2.1.0"
     exon            858..949
                     /gene="Ptdss1"
                     /gene_synonym="mKIAA0024; PSS-1"
                     /inference="alignment:Splign:2.1.0"
     exon            950..994
                     /gene="Ptdss1"
                     /gene_synonym="mKIAA0024; PSS-1"
                     /inference="alignment:Splign:2.1.0"
     exon            995..1119
                     /gene="Ptdss1"
                     /gene_synonym="mKIAA0024; PSS-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1120..1278
                     /gene="Ptdss1"
                     /gene_synonym="mKIAA0024; PSS-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1279..1430
                     /gene="Ptdss1"
                     /gene_synonym="mKIAA0024; PSS-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1431..1572
                     /gene="Ptdss1"
                     /gene_synonym="mKIAA0024; PSS-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1573..1685
                     /gene="Ptdss1"
                     /gene_synonym="mKIAA0024; PSS-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1686..1751
                     /gene="Ptdss1"
                     /gene_synonym="mKIAA0024; PSS-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1752..1851
                     /gene="Ptdss1"
                     /gene_synonym="mKIAA0024; PSS-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1852..1920
                     /gene="Ptdss1"
                     /gene_synonym="mKIAA0024; PSS-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1921..1990
                     /gene="Ptdss1"
                     /gene_synonym="mKIAA0024; PSS-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1991..3424
                     /gene="Ptdss1"
                     /gene_synonym="mKIAA0024; PSS-1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3013..3018
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ptdss1"
                     /gene_synonym="mKIAA0024; PSS-1"
                     /note="hexamer: ATTAAA"
     polyA_site      3034
                     /gene="Ptdss1"
                     /gene_synonym="mKIAA0024; PSS-1"
                     /note="major polyA site"
     regulatory      3171..3176
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ptdss1"
                     /gene_synonym="mKIAA0024; PSS-1"
                     /note="hexamer: AATATA"
     polyA_site      3193
                     /gene="Ptdss1"
                     /gene_synonym="mKIAA0024; PSS-1"
ORIGIN      
        1 ggccttagtc tgaagctgat gaacaagccc ggcgacgttg ccaccacaag gtttaggtac
       61 cgaccgatcg agcccgaacc tcctctccgg gtcaccgata cctaccaagc cgcgaggctc
      121 ccggacgctg ctgggtacag gtaggccgga cagtaatccg gccgggcggc ggtctcgcgc
      181 tcctgcttca cagcgaccgt gcaacctacg ccggggatac ggtgcaccgt agcttcgcaa
      241 gccggcgatt cgccacgcta ggccggcacc gccccccacg tgggctgcgc tgcgaatggg
      301 cgagaccatc tgcggcggcg cgggaaggga cgccgcgggg gaccgggaca gagctggcct
      361 ggggtttgca ggccctggag ctggtcgccg cgttcccagg atcagtcact ccgccgtaat
      421 gtggggaggg tgagagctct acgatgtcgc cctactaggc tgcttcttca ggctgccttc
      481 tccccctgct ccgggacgcg gtggtggcgc cgcgaccccg ccctcgcgcg cgggtccttc
      541 cctgggctag cacccttctc agggtgccag accccgcccc agcgtcaggc accttcgctg
      601 ctgcggtccg tcgctgccgg ggtcccagcc ttctagggcc ggggcctccg gggccgcggc
      661 aggacgggga gaagaactat ggcgtcctgc gtggggagca ggactctgag caaggatgat
      721 gtgaactaca ggatgcattt ccgcatgatc aacgagcagc aagtggagga catcaccata
      781 gacttcttct accggccgca caccatcacc ctgctcagct tcaccatcat cagcctcatg
      841 tacttcgcct tcaccaggga tgactctgtt ccggaagaca acatctggag aggcatcctg
      901 tctgttatct tcttctttct catcatcagc gtgttagcat tccccaatgg tccatttact
      961 cgacctcatc cagccttatg gcgaatggtt tttggtctca gtgtgttgta tttcctcttc
     1021 ttggtattcc tccttttcct gaacttcgag caggttaaat ccctgatgta ttggctggat
     1081 cccaatcttc gatatgctac acgagaagcg gacatcatgg agtatgctgt gaactgtcat
     1141 gtgataacct gggagagaat cgttagtcac tttgatatat ttgcatttgg ccatttctgg
     1201 ggctgggcca tgaaggcctt gttgatccgt agttatgggc tttgctggac aatcagtatc
     1261 acctgggagc tgacagagct tttcttcatg catctcctgc ccaattttgc tgagtgctgg
     1321 tgggaccaag tcattctgga catcctgttg tgcaatggtg gtggaatctg gctgggcatg
     1381 gtcgtttgcc ggtttctgga gatgagaact taccactggg caagcttcaa ggacatccac
     1441 accaccacag ggaagatcaa gcgagctgtg ctgcagttca cccctgctag ctggacttac
     1501 gtcaggtggt ttgatcccaa gtcttccttt cagagagtgg ctggtatata cctcttcatg
     1561 atcatatggc agttgactga gttgaatacc ttcttcttga agcacatctt tgtgttccaa
     1621 gccagccatc ccttaagctg gggtagaatc ctcttcatcg gctgcattac ggctcccaca
     1681 gtgagacagt actatgccta cctcacggac acacagtgca agcgtgtagg gacacagtgc
     1741 tgggtgtttg gggtcattgg tttcctggaa gctattgttt gcataaaatt tggacaagat
     1801 ctcttttcta agacccagat actctatgtg atgctttggc ttctttgtgt ggccttcacc
     1861 acgttcctgt gtctgtacgg catggtttgg tatgcagagc actatggtca ccgggaaaag
     1921 acctattcag agtgtgaaga tggcacttac agtccagaga tctcctggca tcatgggaaa
     1981 ggctccaaag gttctgaaga cagcccaccg aagcattcaa gcaaccacga aagccattct
     2041 tccagaagaa ggaaccggca ttctaagtcc aaagtcacta atggagttgg aaagaaatga
     2101 aggaagctag ttaatgtcag atgttccaga gtgcctagac ccgagaggaa aacagcatat
     2161 ttggaccttc ctatgcagag atcataatgt acggaaagaa ccgagggagc ttaggggatc
     2221 gtgacttgag agtgtaagtc ttgtctccca tagacctgga cacacactag gctgaccatg
     2281 gctcggggtc ctttgccaac tggaagagtc tctaaacttc agcgtatggc ctgcattctc
     2341 tggtagcaat acagtgtgct ggaaggacag gatagctgtt tattcccagc tgccagcagt
     2401 ggctctctgc tggtgtgtct tgtggatgtt gtataaatgt cttcattcag atgttgactt
     2461 aactaactgg ctaatgaact ggtcgcttgg ttttattttt atgagtctgc ctgtccattt
     2521 gattgattgt ttaagttcag agagtctgct tttacttcat gtttttgagt taaatagctt
     2581 caaagcttcc agaatccact gctgaaattg ggggagggtt ccttctagag aaacaaaggg
     2641 tggaaggagc tttggtgtcc cagctaagca tactcagtcc ccagccacat ggcagatgac
     2701 cccagccgga gtgaagaggc tggctgctgg cactggagcc tcggcttcag attagaactg
     2761 ttttgttccc ttccagacac tgtccagact gagtgcacaa gaacgacctt gcgagcggat
     2821 ctgggacagt ggggctccct gccagggtcc ttttccatgt gcttggtttt tcctctgtga
     2881 tgttttgcct actctgtctt tctggctcat gtgaggtgct agtgggtatt aattaacttt
     2941 catctgtgcc atgttctact aaaacattct ccctgtctac cctggatcct tgttttaaat
     3001 atatcagttc acattaaaca gctcatcaat gatctgtctt tgttagaatg atgtttcttt
     3061 gtatcttatt agtcttttaa ctacttggag gcaagttcat attttgcagt tgaccttagg
     3121 ataatatgta tgtatgtgtg ttctatatgg taaagaaaga aaaaagaaaa aatatatttt
     3181 aaaggggctt acacatatat gtcctatctg aaccttccag agtgatccac agggaatgga
     3241 agtgtatgca ggggcattgt ctgtcactat ggtcttactt actaggttgg attttctttc
     3301 tcagacaagt gggctgtaaa acaaacttgc tacaaacaat cctgctgctc actcaccaaa
     3361 gcacgatgat ttctgtttct ttgcctcctt aaagggagtc tttgaactat aaaagttatg
     3421 tttt
//
