LOCUS       NM_011195               1283 bp    mRNA    linear   ROD 04-AUG-2023
DEFINITION  Mus musculus pre T cell antigen receptor alpha (Ptcra), mRNA.
ACCESSION   NM_011195
VERSION     NM_011195.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1283)
  AUTHORS   Beckmann D, Langnaese K, Gottfried A, Hradsky J, Tedford K, Tiwari
            N, Thomas U, Fischer KD and Korthals M.
  TITLE     Ca2+ Homeostasis by Plasma Membrane Ca2+ ATPase (PMCA) 1 Is
            Essential for the Development of DP Thymocytes
  JOURNAL   Int J Mol Sci 24 (2), 1442 (2023)
   PUBMED   36674959
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1283)
  AUTHORS   Fahl SP, Sertori R, Zhang Y, Contreras AV, Harris B, Wang M,
            Perrigoue J, Balachandran S, Kennedy BK and Wiest DL.
  TITLE     Loss of Ribosomal Protein Paralog Rpl22-like1 Blocks Lymphoid
            Development without Affecting Protein Synthesis
  JOURNAL   J Immunol 208 (4), 870-880 (2022)
   PUBMED   35046107
REFERENCE   3  (bases 1 to 1283)
  AUTHORS   Fahl SP, Contreras AV, Verma A, Qiu X, Harly C, Radtke F,
            Zuniga-Pflucker JC, Murre C, Xue HH, Sen JM and Wiest DL.
  TITLE     The E protein-TCF1 axis controls gammadelta T cell development and
            effector fate
  JOURNAL   Cell Rep 34 (5), 108716 (2021)
   PUBMED   33535043
REFERENCE   4  (bases 1 to 1283)
  AUTHORS   Klein F, Mitrovic M, Roux J, Engdahl C, von Muenchow L,
            Alberti-Servera L, Fehling HJ, Pelczar P, Rolink A and Tsapogas P.
  TITLE     The transcription factor Duxbl mediates elimination of pre-T cells
            that fail beta-selection
  JOURNAL   J Exp Med 216 (3), 638-655 (2019)
   PUBMED   30765463
REFERENCE   5  (bases 1 to 1283)
  AUTHORS   Almeida FF, Tenno M, Brzostek J, Li JL, Allies G, Hoeffel G, See P,
            Ng LG, Fehling HJ, Gascoigne NR, Taniuchi I and Ginhoux F.
  TITLE     Identification of a novel lymphoid population in the murine
            epidermis
  JOURNAL   Sci Rep 5, 12554 (2015)
   PUBMED   26223192
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1283)
  AUTHORS   Del Porto P, Bruno L, Mattei MG, von Boehmer H and Saint-Ruf C.
  TITLE     Cloning and comparative analysis of the human pre-T-cell receptor
            alpha-chain gene
  JOURNAL   Proc Natl Acad Sci U S A 92 (26), 12105-12109 (1995)
   PUBMED   8618853
REFERENCE   7  (bases 1 to 1283)
  AUTHORS   Fehling HJ, Krotkova A, Saint-Ruf C and von Boehmer H.
  TITLE     Crucial role of the pre-T-cell receptor alpha gene in development
            of alpha beta but not gamma delta T cells
  JOURNAL   Nature 375 (6534), 795-798 (1995)
   PUBMED   7596413
  REMARK    Erratum:[Nature 1995 Nov 23;378(6555):419]
REFERENCE   8  (bases 1 to 1283)
  AUTHORS   Fehling HJ, Laplace C, Mattei MG, Saint-Ruf C and von Boehmer H.
  TITLE     Genomic structure and chromosomal location of the mouse pre-T-cell
            receptor alpha gene
  JOURNAL   Immunogenetics 42 (4), 275-281 (1995)
   PUBMED   7672822
REFERENCE   9  (bases 1 to 1283)
  AUTHORS   Saint-Ruf C, Ungewiss K, Groettrup M, Bruno L, Fehling HJ and von
            Boehmer H.
  TITLE     Analysis and expression of a cloned pre-T cell receptor gene
  JOURNAL   Science 266 (5188), 1208-1212 (1994)
   PUBMED   7973703
REFERENCE   10 (bases 1 to 1283)
  AUTHORS   Kishi H, Borgulya P, Scott B, Karjalainen K, Traunecker A, Kaufman
            J and von Boehmer H.
  TITLE     Surface expression of the beta T cell receptor (TCR) chain in the
            absence of other TCR or CD3 proteins on immature T cells
  JOURNAL   EMBO J 10 (1), 93-100 (1991)
   PUBMED   1703490
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            U16958.1 and BC119062.1.
            
            [WARNING] On Aug 11, 2023 this sequence was replaced by
            NM_011195.3.
            
            On Apr 18, 2009 this sequence version replaced NM_011195.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U16958.1, BC119062.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849383, SAMN00849384
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-897               U16958.1           1-897
            898-1161            BC119062.1         823-1086
            1162-1283           U16958.1           1162-1283
FEATURES             Location/Qualifiers
     source          1..1283
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 22.9 cM"
     gene            1..1283
                     /gene="Ptcra"
                     /gene_synonym="gp33; pT-alpha; pT-alpha-TCR; pTa; pTalpha;
                     pT[a]"
                     /note="pre T cell antigen receptor alpha"
                     /db_xref="GeneID:19208"
                     /db_xref="MGI:MGI:104857"
     exon            1..177
                     /gene="Ptcra"
                     /gene_synonym="gp33; pT-alpha; pT-alpha-TCR; pTa; pTalpha;
                     pT[a]"
                     /inference="alignment:Splign:2.1.0"
     CDS             99..719
                     /gene="Ptcra"
                     /gene_synonym="gp33; pT-alpha; pT-alpha-TCR; pTa; pTalpha;
                     pT[a]"
                     /codon_start=1
                     /product="pre T-cell antigen receptor alpha precursor"
                     /protein_id="NP_035325.1"
                     /db_xref="CCDS:CCDS28840.1"
                     /db_xref="GeneID:19208"
                     /db_xref="MGI:MGI:104857"
                     /translation="MLLHEWAMARTWLLLLLGVRCQALPSGIAGTPFPSLAPPITLLV
                     DGRQHMLVVCLVLDAAPPGLDNPVWFSAGNGSALDAFTYGPSLAPDGTWTSLAQLSLP
                     SEELEAWEPLVCHTRPGAGGQNRSTHPLQLSGESSTARSCFPEPLGGTQRQVLWLSLL
                     RLLLFKLLLLDVLLTCSHLRLHVLAGQHLQPPPSRKSLPPTHRIWT"
     exon            178..498
                     /gene="Ptcra"
                     /gene_synonym="gp33; pT-alpha; pT-alpha-TCR; pTa; pTalpha;
                     pT[a]"
                     /inference="alignment:Splign:2.1.0"
     exon            499..543
                     /gene="Ptcra"
                     /gene_synonym="gp33; pT-alpha; pT-alpha-TCR; pTa; pTalpha;
                     pT[a]"
                     /inference="alignment:Splign:2.1.0"
     exon            544..1283
                     /gene="Ptcra"
                     /gene_synonym="gp33; pT-alpha; pT-alpha-TCR; pTa; pTalpha;
                     pT[a]"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctagcccaca cctcagagct gcagctgggc ctgtggcctg ggaggcagac tagcagagcc
       61 tcctccccca acaggtagct cctggctgca actgggtcat gcttctccac gagtgggcca
      121 tggctaggac atggctgctg ctgcttctgg gcgtcaggtg tcaggctcta ccatcaggca
      181 tcgctggcac cccctttccg tctctggctc cacccatcac actgctggta gatggaaggc
      241 agcacatgct ggtggtttgc ctggtcctcg atgcggcacc ccctggcctt gacaaccctg
      301 tctggttctc agctggcaat ggcagtgccc tagacgcctt cacctatggg ccctctctgg
      361 caccggacgg cacctggact agcctggccc agctctcctt gccttctgaa gagctggaag
      421 cctgggagcc cttggtctgt cacaccaggc ctggggctgg gggacagaac cggagcacac
      481 accccctcca gctgtcaggg gaatcttcga cagccaggag ctgctttccg gagcctctcg
      541 gggggacaca gcggcaggta ctgtggctga gcctactgcg cctgctcctc ttcaaactgc
      601 ttctgctcga tgtgctcctg acctgcagcc acctccgcct ccatgtgctg gcgggccagc
      661 acctccagcc accaccctca cgcaagtccc tgcctcccac ccacagaatt tggacatagt
      721 tatgagtctc tgagcttaga tcttacccac ccctctgagc ccagggtggt ggtgatgctg
      781 gacactactg ctccctgggg ccaggaagaa caaagcccag gctgtgagga agccagctgg
      841 gcccagaact cacgatcccc cctcagtgct ccttgttcaa agtgggggtt tctttttgct
      901 ttttctgtat gtgatctgcc tcttgtaaat ggagctatcc tatcagagac tgggctcttg
      961 tctctcctat cagactgaga ctttgggaag aaaaggactg tgtctctgtc agacagggca
     1021 ggaggatgca cctggtaact gggcacaata caaaagtctt ataaaacaca ggcatgtcgg
     1081 gctggtgaga cggctcagtg gttaagagca ctgactactc ttccaaaggt cctgagttca
     1141 aatcccagca accacatggt ggctgacaac catccgtaac aagatctgat gccctcttct
     1201 ggtgtgtctg aagacagcta cattgtactt acatatagta aataaataaa tcttttaaaa
     1261 aaaacaaaaa acaacaacaa caa
//
