LOCUS       NM_029049               3191 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus patched domain containing 3 (Ptchd3), mRNA.
ACCESSION   NM_029049 XM_109751 XM_912872
VERSION     NM_029049.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3191)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 3191)
  AUTHORS   Gonzalez Morales,S.R., Liu,C., Blankenship,H. and Zhu,G.Z.
  TITLE     Mouse Ptchd3 is a non-essential gene
  JOURNAL   Gene 763S, 100032 (2020)
   PUBMED   34493359
  REMARK    GeneRIF: Mouse Ptchd3 is a non-essential gene.
REFERENCE   3  (bases 1 to 3191)
  AUTHORS   Gonzalez Morales,S.R., Liu,C., Blankenship,H. and Zhu,G.Z.
  TITLE     Mouse Ptchd3 is a non-essential gene
  JOURNAL   Gene X 5, 100032 (2020)
   PUBMED   32550558
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3191)
  AUTHORS   Fan,J., Akabane,H., Zheng,X., Zhou,X., Zhang,L., Liu,Q.,
            Zhang,Y.L., Yang,J. and Zhu,G.Z.
  TITLE     Male germ cell-specific expression of a novel Patched-domain
            containing gene Ptchd3
  JOURNAL   Biochem Biophys Res Commun 363 (3), 757-761 (2007)
   PUBMED   17904097
  REMARK    GeneRIF: Results indicate that Ptchd3 is a novel male germ
            cell-specific gene and may be involved in the Hh signaling to
            regulate sperm development and/or sperm function.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL663041.6.
            
            On Jul 1, 2022 this sequence version replaced NM_029049.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB235902.1, AK015440.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849384, SAMN00849390
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1000              AL663041.6         80166-81165         c
            1001-1122           AL663041.6         79259-79380         c
            1123-1268           AL663041.6         74899-75044         c
            1269-3191           AL663041.6         67992-69914         c
FEATURES             Location/Qualifiers
     source          1..3191
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 87.9 cM"
     gene            1..3191
                     /gene="Ptchd3"
                     /gene_synonym="4930451E13Rik; 4933440L20Rik; RNDEu-3"
                     /note="patched domain containing 3"
                     /db_xref="GeneID:74675"
                     /db_xref="MGI:MGI:1921925"
     exon            1..1000
                     /gene="Ptchd3"
                     /gene_synonym="4930451E13Rik; 4933440L20Rik; RNDEu-3"
                     /inference="alignment:Splign:2.1.0"
     CDS             44..2764
                     /gene="Ptchd3"
                     /gene_synonym="4930451E13Rik; 4933440L20Rik; RNDEu-3"
                     /note="RND-type protein RNDEu-3"
                     /codon_start=1
                     /product="patched domain-containing protein 3"
                     /protein_id="NP_083325.1"
                     /db_xref="CCDS:CCDS49014.1"
                     /db_xref="GeneID:74675"
                     /db_xref="MGI:MGI:1921925"
                     /translation="MISSKVAPGEEEQGESPSKVELGEAEEQREAPLEGQLEAVPLDE
                     AGPSWTTGPPLERLPPLGQEAPPPRRCHTNCLEAPLSRGFQRFGATVGANPWLFLLGP
                     ALLTASLGTGLIFLPKEKENLEEQYTPIGSPAKAERRFVQGHFSTNDTYRFSASRTSS
                     ETNFASILVVSLANSLLEPEIFKEVSKLDQAVQALKVVQENGTQILYQEVCAKYKTLC
                     VPPNPLLFSWQHNSSLNLSDLTFPIHNTPTQLIYLAGFFGGNVLGQMTGKSQRLVESR
                     AMRLLYYLKTEDPEDSERSQAWLTHFLDHFNDMKSSLTLEEIEVVYFSSLSRQLEFEA
                     TSKTVIPLFHLAYILIILFAVVSCSRLDCIRNKMCVAVFGVFSVAMSVVSGFGLMLHL
                     GVPFVIIVANSPFLILGVGVDDMFIMISAWQKTSLSESIRERLSNSYSKVAVSITITT
                     ITNVLAFYTGITSSFRSVQYFCIYTGTTLLFCYFYSITCFGAVMALDGKREVAWSRWL
                     EKPDQKYSSLKKSCCVPFGSLIDKHGEDNHPMNLFFRDYFGPFLTTSKAKFIVVLLYI
                     FYIISSIYGCFQVQEGLDLRNLASDDSYITPYFNVEEDYFSDYGPRVMVIVTESVNYW
                     DNDVRQKLDKCMTQFEENEYVDKNLTEFWLEAYMQYMNSSGNNPNDKNTFMNNIAGFL
                     QFFPIFTYDINISSSNEITSSRGFIQIVDVSSSSNKKRMLLKLRSIAENCEVPLMVYN
                     QAFIYFDQYAAIIENTVRNVMIASTAMFIVSLLLIPHPVCSLWVTFAIASVIVGVTGF
                     MAFWNVNLDSISMINLVICIGFSFDFSAHISYAFVSSTEPSVNKKSIEALYLLGYPVL
                     QSAISTIIGVCVLSAAKAYIFRTFFKIMFLVMFFGAAHGLIFIPVFLTFF"
     exon            1001..1122
                     /gene="Ptchd3"
                     /gene_synonym="4930451E13Rik; 4933440L20Rik; RNDEu-3"
                     /inference="alignment:Splign:2.1.0"
     exon            1123..1268
                     /gene="Ptchd3"
                     /gene_synonym="4930451E13Rik; 4933440L20Rik; RNDEu-3"
                     /inference="alignment:Splign:2.1.0"
     exon            1269..3191
                     /gene="Ptchd3"
                     /gene_synonym="4930451E13Rik; 4933440L20Rik; RNDEu-3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3168..3173
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ptchd3"
                     /gene_synonym="4930451E13Rik; 4933440L20Rik; RNDEu-3"
                     /note="hexamer: ATTAAA"
     polyA_site      3191
                     /gene="Ptchd3"
                     /gene_synonym="4930451E13Rik; 4933440L20Rik; RNDEu-3"
                     /note="major polyA site"
ORIGIN      
        1 gaaaacagct ctgcagcagc tcctctgaac agctgtgggc aacatgatct cctccaaggt
       61 ggcgcccgga gaggaggagc agggggagtc accgtccaag gtggagctcg gagaggcgga
      121 ggagcagcgg gaggcaccgt tggaaggcca actggaagcc gtgccacttg atgaggcggg
      181 ccctagctgg accaccgggc cgccactgga gcgcttgcca ccgctgggtc aggaggcacc
      241 tccgccgcgt cgctgccaca ccaactgctt ggaagcaccg ctgtcgcggg gcttccaacg
      301 ctttggcgcc acagtgggcg cgaacccctg gctgtttttg ctcgggcctg cactgctgac
      361 ggcctccctg ggcaccggtc tcattttcct acccaaggaa aaggagaacc tggaggagca
      421 gtacacaccg attggcagcc cagccaaggc agagcggcgt tttgtgcagg gtcatttcag
      481 taccaatgac acttaccgct tctctgcctc caggaccagc tccgagacca actttgcatc
      541 catcttggtg gtgtccctcg ccaactcact gctggagcca gaaatattca aagaggtgag
      601 caagctggac caggcggtgc aggcgctgaa agttgtccag gaaaatggaa cgcagattct
      661 ataccaagag gtgtgtgcca agtacaagac gctgtgcgtg ccgcccaacc ctctgctgtt
      721 ttcctggcag cataactcgt cgttgaacct gtcggacctc accttcccta tccacaacac
      781 gcccacccag ctcatctact tagcgggctt ctttggggga aatgttttgg gtcaaatgac
      841 tggaaaaagt caacgactcg tggagtcccg agcaatgaga ctactgtact acctcaagac
      901 ggaggacccc gaagacagtg aacgtagcca ggcatggctg actcactttc ttgaccattt
      961 taatgacatg aagagcagtc tgaccctgga agagatagag gtggtctact tttcatccct
     1021 ttccaggcag ctggagtttg aggcaacctc caagaccgtg atccccctgt ttcacttggc
     1081 atacatttta atcatactct ttgcagttgt atcatgctcc aggttggact gtataagaaa
     1141 caagatgtgt gttgcagtct ttggagtgtt ttctgttgcc atgtcagtgg tgagtggctt
     1201 tggcctgatg ctgcaccttg gggtcccatt tgtgatcata gttgcaaatt caccatttct
     1261 tattcttggt gttggtgttg atgacatgtt tatcatgatt tctgcctggc agaagaccag
     1321 cctctcagag agcataagag aacgactctc caattcatat tcaaaggtgg cagtgtctat
     1381 tacaatcacc accatcacca atgtccttgc tttctataca ggaatcacca gctctttcag
     1441 atctgtacag tatttttgca tctatacagg aacaaccctg ctcttttgct atttttatag
     1501 tatcacctgt tttggagcag ttatggctct ggatggtaaa agagaagttg catggtcccg
     1561 ctggctggaa aagccagacc aaaaatattc ctcacttaaa aagtcctgct gtgtcccatt
     1621 cggttcattg atagacaaac atggagaaga taaccatcca atgaatttgt tctttagaga
     1681 ttattttggt ccttttctta ccacttccaa agccaagttt attgtggtgc tgctatacat
     1741 tttctatatc ataagcagta tatatgggtg cttccaagtg caagaagggt tagatcttcg
     1801 gaacctggca agtgatgatt cctatatcac cccctacttc aatgtagagg aagattactt
     1861 ttcagattat ggtccaagag ttatggtcat tgttactgaa agtgttaact actgggataa
     1921 cgacgtaaga cagaaactgg acaaatgtat gacacaattt gaagaaaatg agtatgtaga
     1981 taaaaatctc acagagtttt ggttggaggc atatatgcaa tacatgaata gcagcggaaa
     2041 taatcctaat gacaagaata cctttatgaa taatattgca ggctttttac aatttttccc
     2101 catttttaca tatgatatta atatctcctc atcaaatgaa atcacttctt cccgaggctt
     2161 tatccagatt gtagatgttt catcctcaag caataagaaa agaatgttat taaagttacg
     2221 aagtatagct gaaaactgtg aagttccctt aatggtatat aaccaagcat tcatatattt
     2281 tgatcagtat gctgcaataa tagaaaacac tgttcgaaat gtcatgattg catcaacagc
     2341 tatgttcatt gtttccttat tgttaattcc tcatccagtg tgttccctgt gggtcacttt
     2401 tgctattgct tctgtgattg tgggagtgac aggttttatg gcattctgga atgttaatct
     2461 tgattccata tccatgatta atcttgtaat ttgtataggg ttttcttttg atttttctgc
     2521 acacatctcc tatgcatttg tttccagtac tgagccttca gtcaacaaaa agtctattga
     2581 ggcattatat ctgttaggtt atccagtgtt gcaaagtgca atttcaacaa taataggggt
     2641 gtgtgtttta tctgcagcta aagcttacat tttcaggaca ttttttaaga ttatgtttct
     2701 tgttatgttt tttggggctg cccatggcct gatttttatt cctgtattct taaccttttt
     2761 ttgaaagttt gtttgaatac acagtaacaa ataacccgaa ccagttatac aattcctgat
     2821 ggcctgaatc cagtctgatt ataaaatgca ctaattaaga ttggtcagta gaaaaagata
     2881 gaaatgaaat tagaaaggtg attatggggt aagaagaagc aggggtaggg gtgagaggga
     2941 agggagggta atgtaggata taaacaaggc acattgtata catgtatgaa aatgtcttag
     3001 tgaaaaccat taacttgtcc aattggtata tgctaataaa atagaattaa tatattactg
     3061 aaagcacata gaaagtgtta aaaataaaaa tagccactgt ctactttaaa gacatttcct
     3121 tgacttggaa gtcccattaa attgttcttt aacatattct gagaaaaatt aaaacttctt
     3181 taccaaatta a
//
