LOCUS       NM_008958               5119 bp    mRNA    linear   ROD 10-OCT-2024
DEFINITION  Mus musculus patched 2 (Ptch2), transcript variant 1, mRNA.
ACCESSION   NM_008958
VERSION     NM_008958.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5119)
  AUTHORS   Almubarak,A., Zhang,Q., Zhang,C.H., Abdelwahab,N., Kume,T.,
            Lassar,A.B. and Berry,F.B.
  TITLE     FOXC1 and FOXC2 regulate growth plate chondrocyte maturation
            towards hypertrophy in the embryonic mouse limb skeleton
  JOURNAL   Development 151 (16) (2024)
   PUBMED   39012257
REFERENCE   2  (bases 1 to 5119)
  AUTHORS   Lin,Y., Tang,W., Huang,P., Wang,Z., Duan,L., Jia,C., Sun,R., Liu,L.
            and Shen,J.
  TITLE     Denticleless E3 ubiquitin protein ligase (DTL) maintains the
            proliferation and differentiation of epidermis and hair follicles
            during skin development
  JOURNAL   Dev Dyn 253 (7), 635-647 (2024)
   PUBMED   38131461
REFERENCE   3  (bases 1 to 5119)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   4  (bases 1 to 5119)
  AUTHORS   Lee,J., Kim,Y., Ataliotis,P., Kim,H.G., Kim,D.W., Bennett,D.C.,
            Brown,N.A., Layman,L.C. and Kim,S.H.
  TITLE     Coordination of canonical and noncanonical Hedgehog signalling
            pathways mediated by WDR11 during primordial germ cell development
  JOURNAL   Sci Rep 13 (1), 12309 (2023)
   PUBMED   37516749
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 5119)
  AUTHORS   Yan,L., Yin,H., Mi,Y., Wu,Y. and Zheng,Y.
  TITLE     Deficiency of Wdr60 and Wdr34 cause distinct neural tube
            malformation phenotypes in early embryos
  JOURNAL   Front Cell Dev Biol 11, 1084245 (2023)
   PUBMED   37228654
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 5119)
  AUTHORS   Pepicelli,C.V., Lewis,P.M. and McMahon,A.P.
  TITLE     Sonic hedgehog regulates branching morphogenesis in the mammalian
            lung
  JOURNAL   Curr Biol 8 (19), 1083-1086 (1998)
   PUBMED   9768363
  REMARK    Review article
REFERENCE   7  (bases 1 to 5119)
  AUTHORS   St-Jacques,B., Dassule,H.R., Karavanova,I., Botchkarev,V.A., Li,J.,
            Danielian,P.S., McMahon,J.A., Lewis,P.M., Paus,R. and McMahon,A.P.
  TITLE     Sonic hedgehog signaling is essential for hair development
  JOURNAL   Curr Biol 8 (19), 1058-1068 (1998)
   PUBMED   9768360
REFERENCE   8  (bases 1 to 5119)
  AUTHORS   Yang,Y., Guillot,P., Boyd,Y., Lyon,M.F. and McMahon,A.P.
  TITLE     Evidence that preaxial polydactyly in the Doublefoot mutant is due
            to ectopic Indian Hedgehog signaling
  JOURNAL   Development 125 (16), 3123-3132 (1998)
   PUBMED   9671585
REFERENCE   9  (bases 1 to 5119)
  AUTHORS   Motoyama,J., Takabatake,T., Takeshima,K. and Hui,C.
  TITLE     Ptch2, a second mouse Patched gene is co-expressed with Sonic
            hedgehog
  JOURNAL   Nat Genet 18 (2), 104-106 (1998)
   PUBMED   9462734
REFERENCE   10 (bases 1 to 5119)
  AUTHORS   Takabatake,T., Ogawa,M., Takahashi,T.C., Mizuno,M., Okamoto,M. and
            Takeshima,K.
  TITLE     Hedgehog and patched gene expression in adult ocular tissues
  JOURNAL   FEBS Lett 410 (2-3), 485-489 (1997)
   PUBMED   9237688
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from CJ056518.1, BC058397.1,
            CF733501.1 and AK042653.1.
            
            On Aug 22, 2015 this sequence version replaced NM_008958.2.
            
            Summary: This gene encodes a member of the patched family of
            transmembrane receptor proteins. The encoded protein may be a
            functional receptor for the morphogen sonic hedgehog (Shh) and is
            reportedly involved in limb and skin development. Homozygous mutant
            mice for this gene exhibit hair loss and epidermal hyperplasia.
            Alternative splicing results in multiple transcript variants.
            [provided by RefSeq, Aug 2015].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB010833.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-40                CJ056518.1         2-41
            41-1235             BC058397.1         1-1195
            1236-1415           CF733501.1         429-608
            1416-4189           BC058397.1         1371-4144
            4190-5119           AK042653.1         1364-2293
FEATURES             Location/Qualifiers
     source          1..5119
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 53.41 cM"
     gene            1..5119
                     /gene="Ptch2"
                     /gene_synonym="ptc2"
                     /note="patched 2"
                     /db_xref="GeneID:19207"
                     /db_xref="MGI:MGI:1095405"
     exon            1..372
                     /gene="Ptch2"
                     /gene_synonym="ptc2"
                     /inference="alignment:Splign:2.1.0"
     CDS             301..3849
                     /gene="Ptch2"
                     /gene_synonym="ptc2"
                     /note="isoform 1 is encoded by transcript variant 1;
                     protein patched homolog 2"
                     /codon_start=1
                     /product="protein patched homolog 2 isoform 1"
                     /protein_id="NP_032984.1"
                     /db_xref="CCDS:CCDS18526.1"
                     /db_xref="GeneID:19207"
                     /db_xref="MGI:MGI:1095405"
                     /translation="MVRPLSLGELPPSYTPPARSSAPHILAGSLQAPLWLRAYFQGLL
                     FSLGCRIQKHCGKVLFLGLVAFGALALGLRVAVIETDLEQLWVEVGSRVSQELHYTKE
                     KLGEEAAYTSQMLIQTAHQEGGNVLTPEALDLHLQAALTASKVQVSLYGKSWDLNKIC
                     YKSGVPLIENGMIERMIEKLFPCVILTPLDCFWEGAKLQGGSAYLPGRPDIQWTNLDP
                     QQLLEELGPFASLEGFRELLDKAQVGQAYVGRPCLDPDDPHCPPSAPNRHSRQAPNVA
                     QELSGGCHGFSHKFMHWQEELLLGGTARDLQGQLLRAEALQSTFLLMSPRQLYEHFRG
                     DYQTHDIGWSEEQASMVLQAWQRRFVQLAQEALPANASQQIHAFSSTTLDDILRAFSE
                     VSTTRVVGGYLLMLAYACVTMLRWDCAQSQGAVGLAGVLLVALAVASGLGLCALLGIT
                     FNAATTQVLPFLALGIGVDDIFLLAHAFTKAPPDTPLPERMGECLRSTGTSVALTSVN
                     NMVAFFMAALVPIPALRAFSLQAAIVVGCNFAAVMLVFPAILSLDLRRRHRQRLDVLC
                     CFSSPCSAQVIQMLPQELGDRAVPVGIAHLTATVQAFTHCEASSQHVVTILPPQAHLL
                     SPASDPLGSELYSPGGSTRDLLSQEEGTGPQAACRPLLCAHWTLAHFARYQFAPLLLQ
                     TRAKALVLLFFGALLGLSLYGATLVQDGLALTDVVPRGTKEHAFLSAQLRYFSLYEVA
                     LVTQGGFDYAHSQRALFDLHQRFSSLKAVLPPPATQAPRTWLHYYRSWLQGIQAAFDQ
                     DWASGRITCHSYRNGSEDGALAYKLLIQTGNAQEPLDFSQLTTRKLVDKEGLIPPELF
                     YMGLTVWVSSDPLGLAASQANFYPPPPEWLHDKYDTTGENLRIPAAQPLEFAQFPFLL
                     HGLQKTADFVEAIEGARAACTEAGQAGVHAYPSGSPFLFWEQYLGLRRCFLLAVCILL
                     VCTFLVCALLLLSPWTAGLIVLVLAMMTVELFGIMGFLGIKLSAIPVVILVASIGIGV
                     EFTVHVALGFLTSHGSRNLRAASALEQTFAPVTDGAVSTLLGLLMLAGSNFDFIIRYF
                     FVVLTVLTLLGLLHGLLLLPVLLSILGPPPQVVQVYKESPQTLNSAAPQRGGLRWDRP
                     PTLPQSFARVTTSMTVALHPPPLPGAYVHPASEEPT"
     exon            373..565
                     /gene="Ptch2"
                     /gene_synonym="ptc2"
                     /inference="alignment:Splign:2.1.0"
     exon            566..755
                     /gene="Ptch2"
                     /gene_synonym="ptc2"
                     /inference="alignment:Splign:2.1.0"
     exon            756..825
                     /gene="Ptch2"
                     /gene_synonym="ptc2"
                     /inference="alignment:Splign:2.1.0"
     exon            826..917
                     /gene="Ptch2"
                     /gene_synonym="ptc2"
                     /inference="alignment:Splign:2.1.0"
     exon            918..1113
                     /gene="Ptch2"
                     /gene_synonym="ptc2"
                     /inference="alignment:Splign:2.1.0"
     exon            1114..1235
                     /gene="Ptch2"
                     /gene_synonym="ptc2"
                     /inference="alignment:Splign:2.1.0"
     exon            1236..1383
                     /gene="Ptch2"
                     /gene_synonym="ptc2"
                     /inference="alignment:Splign:2.1.0"
     exon            1384..1515
                     /gene="Ptch2"
                     /gene_synonym="ptc2"
                     /inference="alignment:Splign:2.1.0"
     exon            1516..1671
                     /gene="Ptch2"
                     /gene_synonym="ptc2"
                     /inference="alignment:Splign:2.1.0"
     exon            1672..1764
                     /gene="Ptch2"
                     /gene_synonym="ptc2"
                     /inference="alignment:Splign:2.1.0"
     exon            1765..1890
                     /gene="Ptch2"
                     /gene_synonym="ptc2"
                     /inference="alignment:Splign:2.1.0"
     exon            1891..2009
                     /gene="Ptch2"
                     /gene_synonym="ptc2"
                     /inference="alignment:Splign:2.1.0"
     exon            2010..2358
                     /gene="Ptch2"
                     /gene_synonym="ptc2"
                     /inference="alignment:Splign:2.1.0"
     exon            2359..2671
                     /gene="Ptch2"
                     /gene_synonym="ptc2"
                     /inference="alignment:Splign:2.1.0"
     exon            2672..2814
                     /gene="Ptch2"
                     /gene_synonym="ptc2"
                     /inference="alignment:Splign:2.1.0"
     exon            2815..2995
                     /gene="Ptch2"
                     /gene_synonym="ptc2"
                     /inference="alignment:Splign:2.1.0"
     exon            2996..3276
                     /gene="Ptch2"
                     /gene_synonym="ptc2"
                     /inference="alignment:Splign:2.1.0"
     exon            3277..3414
                     /gene="Ptch2"
                     /gene_synonym="ptc2"
                     /inference="alignment:Splign:2.1.0"
     exon            3415..3557
                     /gene="Ptch2"
                     /gene_synonym="ptc2"
                     /inference="alignment:Splign:2.1.0"
     exon            3558..3657
                     /gene="Ptch2"
                     /gene_synonym="ptc2"
                     /inference="alignment:Splign:2.1.0"
     exon            3658..5119
                     /gene="Ptch2"
                     /gene_synonym="ptc2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4381..4386
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ptch2"
                     /gene_synonym="ptc2"
                     /note="hexamer: AATATA"
     polyA_site      4401
                     /gene="Ptch2"
                     /gene_synonym="ptc2"
                     /note="major polyA site"
ORIGIN      
        1 gagatccaca gtcgccacct ttagctgtga ggtgcttcgc agccagtcgg gtccacccac
       61 acgcggagcc ctctttggac cacagcccac agatccagcg gggcttgggg ccaccacccc
      121 gcaccgccgc tgcgggctgc tcctgtgcat ctttacgcgc gcctcaccca ggaccgtatg
      181 gccgttcacg gcagctagga atcctcaggt gaagccgggc ggcacaaggc gccaagctag
      241 cctatggcag cgctcagata acgcaggttg ggggcgctcg cgccccccat cctcaccagc
      301 atggttcggc cactgtccct tggagagcta cctcccagct acacacctcc agctcggtcc
      361 tccgcacctc atatcctagc tgggagcctg caggctcctc tctggcttcg agcttacttc
      421 caaggtctac tcttctccct ggggtgcagg atccagaaac actgcggcaa agtgctcttc
      481 ctgggactgg tggcctttgg ggctctggca ctgggtctcc gagtggctgt aattgagaca
      541 gacctagaac agctctgggt agaagtgggc agcagggtga gccaggagct gcactacacc
      601 aaggagaagc tgggggaaga ggctgcgtac acctcccaga tgttgattca gactgcgcac
      661 caggaagggg gaaacgtcct cacccccgag gcacttgact tgcacctcca ggcggcgctc
      721 actgccagta aagtccaagt atcactctat gggaaatcct gggatttgaa caagatctgc
      781 tacaaatcag gggttcccct tattgaaaat gggatgatcg agcggatgat tgagaagctg
      841 tttccctgtg tgatcctcac cccgcttgac tgcttctggg aaggagccaa actccaaggg
      901 ggctctgcct acttgccggg ccgccctgat atccagtgga ccaacctgga ccctcagcag
      961 ctgctcgagg agctgggccc ctttgcctct ctggagggct tccgggaact gctagataag
     1021 gcacaggtgg gccaggccta tgtggggcga ccctgtctgg accctgatga cccccactgt
     1081 ccacctagtg ctcccaaccg gcacagcagg caggctccca atgtggctca ggagctgagt
     1141 gggggctgcc atggcttctc ccacaagttc atgcactggc aggaggaact gctactaggg
     1201 ggcacagcca gagatctcca aggacagctg ctgagggcag aggccttgca gagcaccttc
     1261 ctgctcatga gtccccgtca gctgtacgag cacttccggg gcgactacca gacacatgac
     1321 atcggctgga gcgaggagca ggccagcatg gtgctgcagg cctggcagag gcgctttgtg
     1381 cagctagccc aggaggctct gccggccaac gcgtcccagc agatccatgc cttctcctcc
     1441 accaccctgg atgacatcct gcgcgcgttc tctgaagtca gcaccacccg tgtggtagga
     1501 ggctatctgc ttatgctggc ctatgcctgc gtaacaatgc tgcggtggga ctgcgcccag
     1561 tcccagggtg ccgtaggtct tgctggggtg ttgctggtgg ccctggcggt ggcctcaggt
     1621 cttgggcttt gtgccctact tggcatcact ttcaatgctg ccactacaca ggtgctgccc
     1681 ttcttggctc tgggcattgg cgtggatgac atcttcctgc tggcgcatgc cttcacaaaa
     1741 gccccacctg acacccctct cccagagcgt atgggtgagt gtttgaggag cacgggcacc
     1801 agcgtggcac tcacatccgt caacaacatg gtcgcctttt tcatggctgc cctggttccc
     1861 attcctgcgc tgcgggcctt ctccctgcag gcagccatag tggtcggctg caactttgca
     1921 gcggtaatgc tcgtcttccc tgccatcctc agcctcgacc tgcgccggcg ccaccgccaa
     1981 cgcctggacg ttctctgctg cttttctagc ccctgctccg ctcaggtcat tcagatgctg
     2041 ccccaggagc taggggacag agcagtacca gtgggcattg cccacctgac tgccaccgtg
     2101 caagccttca cccactgcga agccagcagc cagcatgtag tcaccatttt gcctcctcaa
     2161 gcccacctgc tgtctccagc ttctgaccca ctgggctccg aactctatag ccctggaggg
     2221 tctacacggg accttctcag tcaggaggag gggacagggc cacaggcggc ctgcaggccc
     2281 ctgctctgtg cccactggac tctcgcccat tttgcccgct atcagtttgc acctttactg
     2341 ctccagacac gagccaaggc cctggtgttg ctgttctttg gggctctttt gggcctgagc
     2401 ctctatggag ccaccttggt acaagatggg ctggccctga cagatgtggt ccctaggggc
     2461 accaaggaac atgctttcct gagcgcccag ctcaggtact tctccctgta cgaggtggct
     2521 ctagtgacac agggtggctt tgactacgcc cactcccaac gcgccctctt tgatctgcac
     2581 cagcgcttca gctccctcaa ggctgtgctg cccccacctg ccacccaggc accccgcacc
     2641 tggcttcact actaccgcag ctggctacag ggtatccagg ctgcatttga ccaagactgg
     2701 gcttctgggc gcatcacctg ccactcttac cgcaacggct cagaagatgg cgccctggcc
     2761 tacaagctgc tcatccaaac cgggaatgcc caggagcctc tggatttcag ccagctgacc
     2821 acaaggaaac tggtggacaa ggagggactc attcccccag agctcttcta catggggcta
     2881 accgtgtggg tgagcagcga ccccctgggc ctcgcagcct ctcaggccaa cttctacccc
     2941 ccacctccag agtggcttca cgacaaatat gataccaccg gggagaacct tcgcatcccg
     3001 gcagcccagc ccttggagtt tgcccagttc cccttcctgc tgcatggact ccagaagact
     3061 gcagactttg tagaagccat cgaaggggcc agggcggcat gcacagaggc aggccaggca
     3121 ggggtgcatg cctaccccag tggctccccc ttcctcttct gggagcagta tctgggtctt
     3181 cggcgctgct tcctgctggc agtctgcatc ttgctggtgt gcaccttcct cgtctgtgcc
     3241 ctgcttctac tcagcccgtg gacagctggc ctcatagtgc tggtcctggc aatgatgact
     3301 gtggagctct ttggtatcat gggattcctg ggcatcaaac tgagtgccat ccccgtggta
     3361 atcctcgtgg cctctatagg cattggtgtt gaattcacag ttcacgtggc tctgggcttc
     3421 ctgaccagcc atggtagccg gaacctgcgg gctgctagcg ctctggaaca gacctttgcc
     3481 cctgtgactg atggagctgt ctccaccttg ctgggtctgc tcatgcttgc tggttctaac
     3541 tttgacttca tcataaggta tttctttgtg gtgctgacgg tgctgacact cttgggcctg
     3601 ctccatggac tcctgctgct gcctgtgctg ctctctatcc taggcccccc gccacaggtg
     3661 gtgcaggtat acaaggagag tccacagacc ctaaactccg ctgctccaca gagaggtggg
     3721 ctcaggtggg acaggccccc caccctgccc cagagttttg ccagagtgac tacctccatg
     3781 actgtggccc tccacccacc acctctgcct ggagcatacg tccacccagc ctccgaggag
     3841 cccacatagt ctcctgctgc cgccccagca caacctcagt tgtagaggac tgggtctagc
     3901 caccgagtga aagagtgtca gaaccacaga gacctgcagg gccatacaga gtcactggga
     3961 cgcaatgggt gaggtatgga gtgcaggatg gacccctgga gggccttatg ctgctgtctg
     4021 tatctcctcc cgactccaca cacctagctg acacccaaaa agaatagcta ctgcttggac
     4081 aagaggctcc cagcacatag ggactcacgg gagctcacgt ctgtatccag gttgggccga
     4141 gaggctccat tctggctgca gtgcagccct gtcctgttct gtcccacact gtcacctcag
     4201 tagatgaagc ctgagggttt ccagcacatt ctcccatccc tggcctttca ttgcttgatg
     4261 actcctaggg aggccctctg ttcccctccc tacctcctac catataaatt atttatatga
     4321 agatgtttat ttttgtatat agatgctatc actgctcaaa gttctatttt taaagagtga
     4381 aatatattct atacaaactc atctcagatg gctggagttt ttcttagatg acttttaggg
     4441 gagtgagcat cagaggtggc ttgtggggtg tcagggcctg gacttgtcta gttctgggtg
     4501 gggacgacct cagatgctga agttttatca aaataattgg gtcggcataa atgcttagta
     4561 taaggtgcta tgggagcctc aggtgaccgt gcaaacatgg ccaagtccaa gaaacaccac
     4621 acacaaccag tcctgaaaat gacacagaaa cgcaccaaga aacccctgtc acaaatctcc
     4681 caaggacacc taccccaagt gcccgaggag cctgtgcttt gccaagaagc acaagaattc
     4741 taggcctgaa gaagacacag gcaaaggcag tgcttgcgca cgcatcaaag cccctgtgaa
     4801 gcccaggtgc taaagacccc agctgcacac tcagacatct gcctttcatc atgacccccc
     4861 cacacacact tgggaagcat actcaaagct acatggctaa gagtcgtagg ctctgccaac
     4921 caaagcccaa ggttcaaacc aaagcagagg ctgcagctcc aggttgggct cccagaggtg
     4981 cacaggtccc tgtaaaggct ccatagaaaa ggcttctatc taccaatgtg agacaggtgg
     5041 actggtgtga cacagctaca cactgtttgc agatgaccag tgctctgtgc tgtttttaca
     5101 aataaactag aagcaaggt
//
