LOCUS       NP_032983               1434 aa            linear   ROD 12-JUN-2025
DEFINITION  protein patched homolog 1 isoform a [Mus musculus].
ACCESSION   NP_032983
VERSION     NP_032983.1
DBSOURCE    REFSEQ: accession NM_008957.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 1434)
  AUTHORS   Rudat,C., Straube,P., Hegermann,J., Trowe,M.O., Thiesler,H.,
            Hildebrandt,H., Witt,L. and Kispert,A.
  TITLE     PPARG contributes to urothelial integrity in the murine ureter by
            activating the expression of Shh and superficial cell-specific
            genes
  JOURNAL   Development 152 (8) (2025)
   PUBMED   40167323
REFERENCE   2  (residues 1 to 1434)
  AUTHORS   Gao,Y., Sun,M., Fu,T., Wang,Z., Jiang,X., Yang,L., Liang,X.G.,
            Liu,G., Tian,Y., Yang,F., Li,J., Li,Z., Li,X., You,Y., Ding,C.,
            Wang,Y., Ma,T., Zhang,Z., Xu,Z., Chen,B. and Yang,Z.
  TITLE     NOTCH, ERK, and SHH signaling respectively control the fate
            determination of cortical glia and olfactory bulb interneurons
  JOURNAL   Proc Natl Acad Sci U S A 122 (9), e2416757122 (2025)
   PUBMED   39999176
REFERENCE   3  (residues 1 to 1434)
  AUTHORS   Zhu,X., Xu,M., Portal,C., Lin,Y., Ferdinand,A., Peng,T.,
            Morrisey,E.E., Dlugosz,A.A., Castellano,J.M., Lee,V., Seykora,J.T.,
            Wong,S.Y., Iomini,C. and Millar,S.E.
  TITLE     Identification of Meibomian gland stem cell populations and
            mechanisms of aging
  JOURNAL   Nat Commun 16 (1), 1663 (2025)
   PUBMED   39955307
  REMARK    Publication Status: Online-Only
REFERENCE   4  (residues 1 to 1434)
  AUTHORS   Desai,K., Wanggou,S., Luis,E., Whetstone,H., Yu,C., Vanner,R.J.,
            Selvadurai,H.J., Lee,L., Vijay,J., Jaramillo,J.E., Fan,J.,
            Guilhamon,P., Kushida,M., Li,X., Stein,G., Kesari,S., Simons,B.D.,
            Huang,X. and Dirks,P.B.
  TITLE     OLIG2 mediates a rare targetable stem cell fate transition in sonic
            hedgehog medulloblastoma
  JOURNAL   Nat Commun 16 (1), 1092 (2025)
   PUBMED   39904987
  REMARK    Publication Status: Online-Only
REFERENCE   5  (residues 1 to 1434)
  AUTHORS   Palacio,V., Pancho,A., Morabito,A., Malkmus,J., He,Z., Soussi,G.,
            Zeller,R., Treutlein,B. and Zuniga,A.
  TITLE     Single-cell profiling of penta- and tetradactyl mouse limb buds
            identifies mesenchymal progenitors controlling digit numbers and
            identities
  JOURNAL   Nat Commun 16 (1), 1226 (2025)
   PUBMED   39890843
  REMARK    Publication Status: Online-Only
REFERENCE   6  (residues 1 to 1434)
  AUTHORS   Epstein,D.J., Marti,E., Scott,M.P. and McMahon,A.P.
  TITLE     Antagonizing cAMP-dependent protein kinase A in the dorsal CNS
            activates a conserved Sonic hedgehog signaling pathway
  JOURNAL   Development 122 (9), 2885-2894 (1996)
   PUBMED   8787761
REFERENCE   7  (residues 1 to 1434)
  AUTHORS   Hahn,H., Wicking,C., Zaphiropoulous,P.G., Gailani,M.R., Shanley,S.,
            Chidambaram,A., Vorechovsky,I., Holmberg,E., Unden,A.B.,
            Gillies,S., Negus,K., Smyth,I., Pressman,C., Leffell,D.J.,
            Gerrard,B., Goldstein,A.M., Dean,M., Toftgard,R.,
            Chenevix-Trench,G., Wainwright,B. and Bale,A.E.
  TITLE     Mutations of the human homolog of Drosophila patched in the nevoid
            basal cell carcinoma syndrome
  JOURNAL   Cell 85 (6), 841-851 (1996)
   PUBMED   8681379
REFERENCE   8  (residues 1 to 1434)
  AUTHORS   Hahn,H., Christiansen,J., Wicking,C., Zaphiropoulos,P.G.,
            Chidambaram,A., Gerrard,B., Vorechovsky,I., Bale,A.E., Toftgard,R.,
            Dean,M. and Wainwright,B.
  TITLE     A mammalian patched homolog is expressed in target tissues of sonic
            hedgehog and maps to a region associated with developmental
            abnormalities
  JOURNAL   J Biol Chem 271 (21), 12125-12128 (1996)
   PUBMED   8647801
REFERENCE   9  (residues 1 to 1434)
  AUTHORS   Sweet,H.O., Bronson,R.T., Donahue,L.R. and Davisson,M.T.
  TITLE     Mesenchymal dysplasia: a recessive mutation on chromosome 13 of the
            mouse
  JOURNAL   J Hered 87 (2), 87-95 (1996)
   PUBMED   8830098
REFERENCE   10 (residues 1 to 1434)
  AUTHORS   Goodrich,L.V., Johnson,R.L., Milenkovic,L., McMahon,J.A. and
            Scott,M.P.
  TITLE     Conservation of the hedgehog/patched signaling pathway from flies
            to mice: induction of a mouse patched gene by Hedgehog
  JOURNAL   Genes Dev 10 (3), 301-312 (1996)
   PUBMED   8595881
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BF464755.1, AB164615.1, CK639136.1, AK138524.1, CF165613.1,
            CD545333.1, CK636036.1, CN531162.1, AK163736.1, CO433508.1,
            CB520013.1, AK147626.1 and BU700582.1.
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (a).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            CDS exon combination :: U46155.1 [ECO:0000331]
            RNAseq introns       :: single sample supports all introns
                                    SAMN01164139 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1434
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="13"
                     /map="13 32.8 cM"
     Protein         1..1434
                     /product="protein patched homolog 1 isoform a"
                     /note="protein patched homolog 1; Ptch1 protein +12b;
                     mesenchymal dysplasia"
                     /calculated_mol_wt=159143
     Region          1..34
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q61115.1)"
     Region          29..1192
                     /region_name="2A060602"
                     /note="The Eukaryotic (Putative) Sterol Transporter (EST)
                     Family; TIGR00918"
                     /db_xref="CDD:273338"
     Site            87..107
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q61115.1)"
     Site            127
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q61115.1)"
     Site            298
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q61115.1)"
     Site            335
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q61115.1)"
     Site            400
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q61115.1)"
     Site            423..443
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q61115.1)"
     Site            459..479
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q61115.1)"
     Site            488..508
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q61115.1)"
     Site            534..554
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q61115.1)"
     Site            564..584
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q61115.1)"
     Site            735..755
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q61115.1)"
     Site            861
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q61115.1)"
     Site            986
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q61115.1)"
     Site            1014..1034
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q61115.1)"
     Site            1040..1060
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q61115.1)"
     Site            1070..1090
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q61115.1)"
     Site            1108..1128
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q61115.1)"
     Site            1141..1161
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q61115.1)"
     Region          1175..1219
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q61115.1)"
     Site            1181
                     /site_type="phosphorylation"
                     /note="Phosphothreonine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q61115.1)"
     Site            1183
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q61115.1)"
     Region          1257..1348
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q61115.1)"
     Region          1368..1396
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q61115.1)"
     CDS             1..1434
                     /gene="Ptch1"
                     /gene_synonym="A230106A15Rik; mes; Ptc; Ptc1; Ptch; wig"
                     /coded_by="NM_008957.3:216..4520"
                     /note="isoform a is encoded by transcript variant 1"
                     /db_xref="CCDS:CCDS26592.1"
                     /db_xref="GeneID:19206"
                     /db_xref="MGI:MGI:105373"
ORIGIN      
        1 masagnaaga lgrqagggrr rrtggphraa pdrdylhrps ycdaafaleq iskgkatgrk
       61 aplwlrakfq rllfklgcyi qkncgkflvv gllifgafav glkaanletn veelwvevgg
      121 rvsrelnytr qkigeeamfn pqlmiqtpke eganvlttea llqhldsalq asrvhvymyn
      181 rqwklehlcy ksgelitetg ymdqiieyly pcliitpldc fwegaklqsg tayllgkppl
      241 rwtnfdplef leelkkinyq vdsweemlnk aevghgymdr pclnpadpdc patapnknst
      301 kpldvalvln ggcqglsrky mhwqeelivg gtvknatgkl vsahalqtmf qlmtpkqmye
      361 hfrgydyvsh inwnedraaa ileawqrtyv evvhqsvapn stqkvlpftt ttlddilksf
      421 sdvsvirvas gyllmlayac ltmlrwdcsk sqgavglagv llvalsvaag lglcsligis
      481 fnaattqvlp flalgvgvdd vfllahafse tgqnkripfe drtgeclkrt gasvaltsis
      541 nvtaffmaal ipipalrafs lqaavvvvfn famvllifpa ilsmdlyrre drrldifccf
      601 tspcvsrviq vepqayteph sntryspppp ytshsfahet hitmqstvql rteydphthv
      661 yyttaeprse isvqpvtvtq dnlscqspes tsstrdllsq fsdsslhcle ppctkwtlss
      721 faekhyapfl lkpkakvvvi llflgllgvs lygttrvrdg ldltdivpre treydfiaaq
      781 fkyfsfynmy ivtqkadypn iqhllydlhk sfsnvkyvml eenkqlpqmw lhyfrdwlqg
      841 lqdafdsdwe tgrimpnnyk ngsddgvlay kllvqtgsrd kpidisqltk qrlvdadgii
      901 npsafyiylt awvsndpvay aasqanirph rpewvhdkad ympetrlrip aaepieyaqf
      961 pfylnglrdt sdfveaiekv rvicnnytsl glssypngyp flfweqyisl rhwlllsisv
     1021 vlactflvca vfllnpwtag iivmvlalmt velfgmmgli giklsavpvv iliasvgigv
     1081 eftvhvalaf ltaigdknhr amlalehmfa pvldgavstl lgvlmlagse fdfivryffa
     1141 vlailtvlgv lnglvllpvl lsffgpcpev spanglnrlp tpspepppsv vrfavppght
     1201 nngsdssdse yssqttvsgi seelrqyeaq qgaggpahqv iveatenpvf arstvvhpds
     1261 rhqppltprq qphldsgsls pgrqgqqprr dppreglrpp pyrprrdafe isteghsgps
     1321 nrdrsgprga rshnprnpts tamgssvpsy cqpittvtas asvtvavhpp pgpgrnprgg
     1381 pcpgyesype tdhgvfedph vpfhvrcerr dskvevielq dveceerpwg sssn
//
