LOCUS       NM_133735               3219 bp    mRNA    linear   ROD 04-JUN-2024
DEFINITION  Mus musculus pentatricopeptide repeat domain 1 (Ptcd1), mRNA;
            nuclear gene for mitochondrial product.
ACCESSION   NM_133735
VERSION     NM_133735.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3219)
  AUTHORS   Richman,T.R., Ermer,J.A., Baker,J., Siira,S.J., Kile,B.T.,
            Linden,M.D., Rackham,O. and Filipovska,A.
  TITLE     Mitochondrial gene expression is required for platelet function and
            blood clotting
  JOURNAL   Cell Rep 42 (11), 113312 (2023)
   PUBMED   37889747
REFERENCE   2  (bases 1 to 3219)
  AUTHORS   Perks,K.L., Rossetti,G., Kuznetsova,I., Hughes,L.A., Ermer,J.A.,
            Ferreira,N., Busch,J.D., Rudler,D.L., Spahr,H., Schondorf,T.,
            Shearwood,A.J., Viola,H.M., Siira,S.J., Hool,L.C., Milenkovic,D.,
            Larsson,N.G., Rackham,O. and Filipovska,A.
  TITLE     PTCD1 Is Required for 16S rRNA Maturation Complex Stability and
            Mitochondrial Ribosome Assembly
  JOURNAL   Cell Rep 23 (1), 127-142 (2018)
   PUBMED   29617655
  REMARK    GeneRIF: PTCD1 is essential for 16s rRNA maturation complex
            stability and mitochondrial ribosome assembly.
REFERENCE   3  (bases 1 to 3219)
  AUTHORS   Perks,K.L., Ferreira,N., Richman,T.R., Ermer,J.A., Kuznetsova,I.,
            Shearwood,A.J., Lee,R.G., Viola,H.M., Johnstone,V.P.A.,
            Matthews,V., Hool,L.C., Rackham,O. and Filipovska,A.
  TITLE     Adult-onset obesity is triggered by impaired mitochondrial gene
            expression
  JOURNAL   Sci Adv 3 (8), e1700677 (2017)
   PUBMED   28835921
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3219)
  AUTHORS   McKee,A.E., Minet,E., Stern,C., Riahi,S., Stiles,C.D. and
            Silver,P.A.
  TITLE     A genome-wide in situ hybridization map of RNA-binding proteins
            reveals anatomically restricted expression in the developing mouse
            brain
  JOURNAL   BMC Dev Biol 5, 14 (2005)
   PUBMED   16033648
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3219)
  AUTHORS   Okazaki,N., F-Kikuno,R., Ohara,R., Inamoto,S., Koseki,H.,
            Hiraoka,S., Saga,Y., Seino,S., Nishimura,M., Kaisho,T., Hoshino,K.,
            Kitamura,H., Nagase,T., Ohara,O. and Koga,H.
  TITLE     Prediction of the coding sequences of mouse homologues of KIAA
            gene: IV. The complete nucleotide sequences of 500 mouse
            KIAA-homologous cDNAs identified by screening of terminal sequences
            of cDNA clones randomly sampled from size-fractionated libraries
  JOURNAL   DNA Res 11 (3), 205-218 (2004)
   PUBMED   15368895
REFERENCE   6  (bases 1 to 3219)
  AUTHORS   Piao,Y., Ko,N.T., Lim,M.K. and Ko,M.S.
  TITLE     Construction of long-transcript enriched cDNA libraries from
            submicrogram amounts of total RNAs by a universal PCR amplification
            method
  JOURNAL   Genome Res 11 (9), 1553-1558 (2001)
   PUBMED   11544199
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC127411.3 and BC083097.1.
            
            On Jul 23, 2009 this sequence version replaced NM_133735.1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC083097.1, AK150514.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164143 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: inferred from homology
            RefSeq Select criteria             :: based on conservation,
                                                  expression, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-53                AC127411.3         190699-190751
            54-3071             BC083097.1         13-3030
            3072-3219           AC127411.3         210278-210425
FEATURES             Location/Qualifiers
     source          1..3219
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 85.06 cM"
     gene            1..3219
                     /gene="Ptcd1"
                     /gene_synonym="1110069M14Rik"
                     /note="pentatricopeptide repeat domain 1"
                     /db_xref="GeneID:71799"
                     /db_xref="MGI:MGI:1919049"
     exon            1..151
                     /gene="Ptcd1"
                     /gene_synonym="1110069M14Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            152..624
                     /gene="Ptcd1"
                     /gene_synonym="1110069M14Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             178..2265
                     /gene="Ptcd1"
                     /gene_synonym="1110069M14Rik"
                     /codon_start=1
                     /product="pentatricopeptide repeat-containing protein 1,
                     mitochondrial"
                     /protein_id="NP_598496.3"
                     /db_xref="CCDS:CCDS19858.1"
                     /db_xref="GeneID:71799"
                     /db_xref="MGI:MGI:1919049"
                     /translation="MDLLRLSRLFSGPRPIGLSVLQHLDLVGSTRWTGGREGPARLRA
                     AFCGSSSPLPLGSGNQKEMSSLCSDSSKLSTVAPQEEAEEESFGSLSGKFSSRRIFHK
                     STAQLYNLQLKEQGGEEEELEPRPWRGRRNTQYWYFFQCKRLIKEGKLAEALDLFERQ
                     MLKEERLQPLECNYTVLIGGCGRVGYLKKAFRLFNDMKKRDLEPSDATYTALFNVCAE
                     SPWKDSALQSALKLRQQLQARNFQLNLKTYHALLKVAAKCADLRLCLDVFKEIIQRGH
                     AVTEETFCFLLVGCIQDKKTGFRQAMQVWRQMLSLGIKPSRHGYNLLLEAARDCGLGD
                     PEVASRLLLTSQEETILLPPPKGRHMAGRKVQAKTVHGVSLRHVEALERQLFLEPSQK
                     LEGPPALPEARVTSRTQPEVETTAEPGHTVALTPLASKPTHLELEVSLLSLGTLSPAV
                     VSFGTVATPADRLALMGGLEGFLGKMTEHGLQPDIKTLTLLAEVVEPGSTAESSLLSV
                     LDRHRVEADVTFFNTLIRKKSKLGDLEGAKALLPILAKKGIVPNLRTFCNLAIGCHRP
                     RDGMQLLADMKKSQVSPNIHIYSTLINAALKKLDYTYLISILKDMRQNSVPVNEVVVR
                     QLEFAAEYPPTFDRYKGKNTYLEKIDGFRAYYKQWLKAMPAEEAPHPWQEFQNKPVGD
                     QDTTDKAGGLRDG"
     exon            625..765
                     /gene="Ptcd1"
                     /gene_synonym="1110069M14Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            766..984
                     /gene="Ptcd1"
                     /gene_synonym="1110069M14Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            985..1086
                     /gene="Ptcd1"
                     /gene_synonym="1110069M14Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1087..1791
                     /gene="Ptcd1"
                     /gene_synonym="1110069M14Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1792..1908
                     /gene="Ptcd1"
                     /gene_synonym="1110069M14Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1909..2091
                     /gene="Ptcd1"
                     /gene_synonym="1110069M14Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2092..3219
                     /gene="Ptcd1"
                     /gene_synonym="1110069M14Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3049..3054
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ptcd1"
                     /gene_synonym="1110069M14Rik"
                     /note="hexamer: AATAAA"
     polyA_site      3071
                     /gene="Ptcd1"
                     /gene_synonym="1110069M14Rik"
                     /note="major polyA site"
ORIGIN      
        1 ggttctgtat cttacacaag aggcggcgac gcaagtgcgc ctgcgcggga tctccgtagt
       61 ctgtgctgag ggcaggaacg ctgtctctgg agccgcggtc cctcgactct gaggacgtct
      121 cactaggggc tcgccgctta gaacgctcag agctgcaggg gctcgaggca gccagcgatg
      181 gacctcctaa gactctcccg gctcttttcc ggtccccgcc ccataggact gtctgtcctt
      241 caacacctgg atcttgttgg atcaacccga tggacaggag gcagggaggg acctgcacgg
      301 ctgagagctg ccttctgcgg ctcctcctcc ccgctgcccc tgggcagcgg gaaccagaag
      361 gaaatgagca gcctctgctc tgactccagt aagctcagca ctgtggctcc ccaggaggag
      421 gcagaggaag agagcttcgg gagcctctct ggcaaattct cctcccggag gatattccac
      481 aagtcaacgg cccagctcta caacctgcag ctcaaggaac agggtggtga ggaggaagaa
      541 ctggagccca gaccgtggcg gggccggagg aacactcagt actggtactt ctttcagtgc
      601 aaacgtctga tcaaggaagg aaagcttgca gaggccctgg atctgtttga gaggcagatg
      661 ctgaaggaag agcgcttgca gcctctggag tgcaactaca cggtgctgat tgggggctgc
      721 gggcgcgtcg ggtacctgaa gaaggctttc agactcttca atgatatgaa gaagagagac
      781 ctggagccct cggatgccac atacacagct ctgttcaatg tctgtgcgga gtccccctgg
      841 aaggactctg ccctgcagag tgccctgaag ctccgacagc agctccaggc cagaaacttc
      901 cagctcaacc tgaaaacgta tcatgccctg ctgaaggtgg ccgccaagtg tgcagacctc
      961 aggctgtgcc tggatgtctt caaggaaatc atccaaaggg ggcatgcagt cacagaggag
     1021 accttctgtt ttctgcttgt gggctgcatc caggacaaga agacaggctt ccggcaagcc
     1081 atgcaggtgt ggcggcagat gctgagtctg gggatcaaac caagtaggca tggctacaac
     1141 ctcctgttgg aggcagctcg agactgtggt ctgggggacc cagaggttgc ctccaggctg
     1201 ctcctgacgt cccaggaaga gaccatcttg ctcccacccc caaagggcag gcatatggca
     1261 gggaggaaag tccaggccaa gacagtgcat ggtgtgtcac tcagacatgt ggaagcactg
     1321 gagaggcagc tgtttctgga accttctcag aaactcgagg ggccaccagc ccttcctgag
     1381 gccagggtaa caagcaggac ccagcctgag gtggaaacca cggcagaacc tggccacaca
     1441 gtagccctca ccccactggc ctcgaaacct acccacttgg agctggaagt cagtctccta
     1501 agtcttggaa ctctctcccc cgctgtggtc tcatttggga cagtggccac acctgctgat
     1561 aggctggcgt tgatgggggg cctggaaggc ttcctgggca agatgaccga acacgggctc
     1621 cagccagaca tcaaaaccct cactctgctg gctgaggtgg tggagcctgg gagcactgca
     1681 gaatcctcgc tgctttccgt cctggacagg catagggtgg aggccgacgt aaccttcttc
     1741 aacacgctga taaggaaaaa gagcaaactg ggagacctgg agggagccaa ggcactgttg
     1801 ccaatcctgg caaagaaggg aattgtcccc aatcttcgga ctttctgcaa tctggccatt
     1861 ggttgccatc ggcccaggga tggtatgcag ctgcttgcag acatgaagaa gtcccaggtg
     1921 agccctaaca tccacatcta cagcaccctt atcaacgcag ccctcaagaa gttggactac
     1981 acctatctca tcagcatcct gaaggacatg aggcagaaca gcgtcccagt aaacgaggtg
     2041 gtcgtccgcc agctggagtt tgcagccgag taccctccca cctttgaccg gtacaaagga
     2101 aaaaacacct acttggagaa gattgatggc tttcgggctt attacaagca gtggttgaaa
     2161 gccatgccag cagaggaagc cccccacccc tggcaggagt tccagaacaa gcctgttggg
     2221 gaccaagaca ccactgacaa ggctggcggc cttagggacg gatgacggag cacgcggcta
     2281 tgacaagtgc ccagccttca cactgctggg ggagcctggg agtcctttca acttcagagg
     2341 ccaagaatat tccagaggca ccacagcact ttacaggcaa atgctgggct cagggtgccc
     2401 agatcatagc aggtcccaca ccaggccaaa gcatcctgac aacgatcatg gtcacacagc
     2461 atctacaaca cagagccagg actaagccca tcccctggca ctcttaaaag aaagaatgta
     2521 gcgaggaggt ctaaaggttt tatttttaca gatctcagct ggtgaacact aaagtcgtca
     2581 cctgtacagc tcatgcttcc ccccctgggt cttttctctg agcaccactc tgagaagagt
     2641 tgcttcaggc agtggcccaa taagtcttaa gtccaaggtc caaagaccag gatgcagagg
     2701 agtcaagggt gtcagccaga gcaaccccgg cagccacagt gtgtgcactc gatgatgcga
     2761 ccctgaaaca gaagaagaac atttgaacac actgctacag ccctgcacac tcccttgcag
     2821 agcatctcta ctggacactt ctacttgggc gtctcagctc ctttgtgacg tggaacagtt
     2881 actaccaggc ggaagttagt gtctgtgtgt gattgctgta acaagacaca cttgtcactg
     2941 ccaagagggc gaaagccaga gttcctgagg ccactgggtg gggatggggg tcctggagca
     3001 atgctgtctt tacctccttt tctggaggcc acgagcccat tctaaacaaa taaagttctc
     3061 tggtaacgtt ctgttagttt taactgagtg cgtctcatat ataggatgac cctaattttc
     3121 tggtcctgcc aacagctgct gaatgctaga atgacagatg tacacttgca catctggctc
     3181 tatggggcac tggagatgga acctagggct tctagggct
//
