LOCUS       NM_001310711            3361 bp    mRNA    linear   ROD 07-FEB-2024
DEFINITION  Mus musculus polypyrimidine tract binding protein 2 (Ptbp2),
            transcript variant 2, mRNA.
ACCESSION   NM_001310711 XM_006501733
VERSION     NM_001310711.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3361)
  AUTHORS   Salehi,S., Zare,A., Prezza,G., Bader,J., Schneider,C., Fischer,U.,
            Meissner,F., Mann,M., Briese,M. and Sendtner,M.
  TITLE     Cytosolic Ptbp2 modulates axon growth in motoneurons through axonal
            localization and translation of Hnrnpr
  JOURNAL   Nat Commun 14 (1), 4158 (2023)
   PUBMED   37438340
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3361)
  AUTHORS   Feng,S., Li,J., Wen,H., Liu,K., Gui,Y., Wen,Y., Wang,X. and Yuan,S.
  TITLE     hnRNPH1 recruits PTBP2 and SRSF3 to modulate alternative splicing
            in germ cells
  JOURNAL   Nat Commun 13 (1), 3588 (2022)
   PUBMED   35739118
  REMARK    GeneRIF: hnRNPH1 recruits PTBP2 and SRSF3 to modulate alternative
            splicing in germ cells.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3361)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3361)
  AUTHORS   Snider,P.L., Simmons,O. and Conway,S.J.
  TITLE     Cracd Marks the First Wave of Meiosis during Spermatogenesis and Is
            Mis-Expressed in Azoospermia Mice
  JOURNAL   J Dev Biol 8 (3), 21 (2020)
   PUBMED   32962040
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3361)
  AUTHORS   Monzon-Casanova,E., Matheson,L.S., Tabbada,K., Zarnack,K.,
            Smith,C.W. and Turner,M.
  TITLE     Polypyrimidine tract-binding proteins are essential for B cell
            development
  JOURNAL   Elife 9, e53557 (2020)
   PUBMED   32081131
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3361)
  AUTHORS   Rahman,L., Bliskovski,V., Reinhold,W. and Zajac-Kaye,M.
  TITLE     Alternative splicing of brain-specific PTB defines a
            tissue-specific isoform pattern that predicts distinct functional
            roles
  JOURNAL   Genomics 80 (3), 245-249 (2002)
   PUBMED   12213192
REFERENCE   7  (bases 1 to 3361)
  AUTHORS   Pilipenko,E.V., Viktorova,E.G., Guest,S.T., Agol,V.I. and Roos,R.P.
  TITLE     Cell-specific proteins regulate viral RNA translation and
            virus-induced disease
  JOURNAL   EMBO J 20 (23), 6899-6908 (2001)
   PUBMED   11726525
REFERENCE   8  (bases 1 to 3361)
  AUTHORS   Piao,Y., Ko,N.T., Lim,M.K. and Ko,M.S.
  TITLE     Construction of long-transcript enriched cDNA libraries from
            submicrogram amounts of total RNAs by a universal PCR amplification
            method
  JOURNAL   Genome Res 11 (9), 1553-1558 (2001)
   PUBMED   11544199
REFERENCE   9  (bases 1 to 3361)
  AUTHORS   Lillevali,K., Kulla,A. and Ord,T.
  TITLE     Comparative expression analysis of the genes encoding
            polypyrimidine tract binding protein (PTB) and its neural homologue
            (brPTB) in prenatal and postnatal mouse brain
  JOURNAL   Mech Dev 101 (1-2), 217-220 (2001)
   PUBMED   11231079
REFERENCE   10 (bases 1 to 3361)
  AUTHORS   Polydorides,A.D., Okano,H.J., Yang,Y.Y., Stefani,G. and
            Darnell,R.B.
  TITLE     A brain-enriched polypyrimidine tract-binding protein antagonizes
            the ability of Nova to regulate neuron-specific alternative
            splicing
  JOURNAL   Proc Natl Acad Sci U S A 97 (12), 6350-6355 (2000)
   PUBMED   10829067
  REMARK    GeneRIF: PTBP2 was identified as a brain-expressed protein that
            interacts with the paraneoplastic target antigen Nova1 by yeast
            2-hybrid, in vivo co-IP and co-localization in neurons.
            Functionally, the proteins antagonize each other in splicing
            assays.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK135738.1, AC111029.8, AK033964.1 and AK013734.1.
            
            [WARNING] On Mar 30, 2024 this sequence was replaced by
            NM_001310711.2.
            
            On Jul 18, 2015 this sequence version replaced XM_006501733.1.
            
            Transcript Variant: This variant (2) uses an alternate in-frame
            splice site in the 3' coding region compared to variant 1. The
            encoded isoform (2) is shorter than isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC010255.1, SRR10662774.2693966.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-501               AK135738.1         2-502
            502-720             AK135738.1         504-722
            721-721             AC111029.8         115792-115792
            722-842             AK135738.1         724-844
            843-1645            AK135738.1         846-1648
            1646-2435           AK033964.1         2053-2842
            2436-2879           AK013734.1         998-1441
            2880-3361           AK033964.1         3289-3770
FEATURES             Location/Qualifiers
     source          1..3361
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 52.18 cM"
     gene            1..3361
                     /gene="Ptbp2"
                     /gene_synonym="brPTB; nPTB; Ptb2"
                     /note="polypyrimidine tract binding protein 2"
                     /db_xref="GeneID:56195"
                     /db_xref="MGI:MGI:1860489"
     exon            1..187
                     /gene="Ptbp2"
                     /gene_synonym="brPTB; nPTB; Ptb2"
                     /inference="alignment:Splign:2.1.0"
     CDS             180..1775
                     /gene="Ptbp2"
                     /gene_synonym="brPTB; nPTB; Ptb2"
                     /note="isoform 2 is encoded by transcript variant 2;
                     brain-enriched PTB; RRM-type RNA-binding protein brPTB;
                     neural polypyrimidine tract-binding protein;
                     brain-enriched polypyrimidine tract-binding protein"
                     /codon_start=1
                     /product="polypyrimidine tract-binding protein 2 isoform
                     2"
                     /protein_id="NP_001297640.1"
                     /db_xref="CCDS:CCDS80010.1"
                     /db_xref="GeneID:56195"
                     /db_xref="MGI:MGI:1860489"
                     /translation="MDGIVTEVAVGVKRGSDELLSGSVLSSPNSNMSGMVVTANGNDS
                     KKFKGEDKMDGAPSRVLHIRKLPGEVTETEVIALGLPFGKVTNILMLKGKNQAFLELA
                     TEEAAITMVNYYSAVTPHLRNQPIYIQYSNHKELKTDNTLNQRAQVVLQAVTAVQTAN
                     TPLSGTTVSESAVTPAQSPVLRIIIDNMYYPVTLDVLHQIFSKFGAVLKIITFTKNNQ
                     FQALLQYGDPVNAQQAKLALDGQNIYNACCTLRIDFSKLVNLNVKYNNDKSRDYTRPD
                     LPSGDGQPALDPAIAAAFAKETSLLAVPGALSPLAIPNAAAAAAAAAAGRVGMPGVSA
                     GGNTVLLVSNLNEEMVTPQSLFTLFGVYGDVQRVKILYNKKDSALIQMADGNQSQLAM
                     NHLNGQKMYGKIIRVTLSKHQTVQLPREGLDDQGLTKDFGNSPLHRFKKPGSKNFQNI
                     FPPSATLHLSNIPPSVAEEDLRTLFANTGGTVKAFKFFQDHKMALLQMATVEEAIQAL
                     IDLHNYNLGENHHLRVSFSKSTI"
     exon            188..218
                     /gene="Ptbp2"
                     /gene_synonym="brPTB; nPTB; Ptb2"
                     /inference="alignment:Splign:2.1.0"
     exon            219..294
                     /gene="Ptbp2"
                     /gene_synonym="brPTB; nPTB; Ptb2"
                     /inference="alignment:Splign:2.1.0"
     exon            295..467
                     /gene="Ptbp2"
                     /gene_synonym="brPTB; nPTB; Ptb2"
                     /inference="alignment:Splign:2.1.0"
     exon            468..611
                     /gene="Ptbp2"
                     /gene_synonym="brPTB; nPTB; Ptb2"
                     /inference="alignment:Splign:2.1.0"
     exon            612..776
                     /gene="Ptbp2"
                     /gene_synonym="brPTB; nPTB; Ptb2"
                     /inference="alignment:Splign:2.1.0"
     exon            777..887
                     /gene="Ptbp2"
                     /gene_synonym="brPTB; nPTB; Ptb2"
                     /inference="alignment:Splign:2.1.0"
     exon            888..1083
                     /gene="Ptbp2"
                     /gene_synonym="brPTB; nPTB; Ptb2"
                     /inference="alignment:Splign:2.1.0"
     exon            1084..1223
                     /gene="Ptbp2"
                     /gene_synonym="brPTB; nPTB; Ptb2"
                     /inference="alignment:Splign:2.1.0"
     exon            1224..1257
                     /gene="Ptbp2"
                     /gene_synonym="brPTB; nPTB; Ptb2"
                     /inference="alignment:Splign:2.1.0"
     exon            1258..1350
                     /gene="Ptbp2"
                     /gene_synonym="brPTB; nPTB; Ptb2"
                     /inference="alignment:Splign:2.1.0"
     exon            1351..1567
                     /gene="Ptbp2"
                     /gene_synonym="brPTB; nPTB; Ptb2"
                     /inference="alignment:Splign:2.1.0"
     exon            1568..1645
                     /gene="Ptbp2"
                     /gene_synonym="brPTB; nPTB; Ptb2"
                     /inference="alignment:Splign:2.1.0"
     exon            1646..3361
                     /gene="Ptbp2"
                     /gene_synonym="brPTB; nPTB; Ptb2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtctcccgcc gccgccgggc gcccgcgcgc tcggctcttt ccgccgccgc gcgctgcccc
       61 gtgcgctccg gcaccttcgg caatttccgt cgggccctgg ccgccatttt ctcgccgctt
      121 gtgtggctcg ctggctgcgt ggctcggttc ttgggagcga agctttgtcc ggttcggcaa
      181 tggacggaat tgtcactgag gttgctgttg gtgtgaagag aggatctgac gagctactct
      241 caggcagtgt tctcagcagc cccaactcta atatgagtgg catggtagtt acagccaacg
      301 gtaacgatag taagaaattt aaaggagaag ataaaatgga tggggctccc tctcgtgtac
      361 ttcacattcg aaagttacct ggtgaagtga ctgaaacaga agttattgct ttaggtttac
      421 cttttggtaa ggtgactaac atccttatgc tgaaaggaaa aaaccaggca tttttggaac
      481 tggcaacaga ggaagcagct attactatgg ttaattacta ttctgctgtg acacctcatc
      541 ttcgtaacca accaatttac atccagtact ccaatcacaa agaactaaag acagataata
      601 cattaaacca acgtgcgcaa gtagttcttc aagctgtgac agcggtccag acagcaaata
      661 cacctcttag tggcaccaca gtcagtgaga gtgcggtgac tccagcccag agtccagtac
      721 ttagaataat tattgacaat atgtactacc ctgtaacact tgatgtcctt caccaaatat
      781 tttctaagtt tggtgctgta ttgaagataa tcacatttac aaaaaacaac cagtttcagg
      841 ctttgctcca gtatggtgat ccggtaaacg ctcaacaagc caagctagcc ctagatggtc
      901 aaaatattta taatgcttgc tgtaccctaa ggattgattt ttccaaactt gtgaatttga
      961 atgtaaaata caacaatgat aaaagtaggg attatactcg acctgatctg ccatctggag
     1021 acggccagcc tgcgttagac ccagccattg ctgcagcatt tgccaaggag acatccctac
     1081 tagctgttcc aggggctctc agtcctttgg ctattccaaa tgctgctgca gcagctgctg
     1141 ccgctgccgc tggccgagtg ggcatgcctg gagtctcagc tggtggcaat acagtcctgt
     1201 tggttagcaa tttaaatgaa gagatggtta cgccccaaag tctgtttacc ctcttcggtg
     1261 tttatggaga tgtgcagcgc gtgaagattc tgtacaataa gaaagacagt gctctgatac
     1321 agatggctga tgggaaccag tcccagctcg ccatgaatca tcttaatggg cagaagatgt
     1381 atggaaaaat tattcgtgtt actctctcta aacatcagac tgtgcaacta cctcgagagg
     1441 gacttgatga tcaagggcta acaaaagatt ttgggaattc accactgcac cgttttaaaa
     1501 aaccgggatc caaaaacttt cagaacattt tccctccttc tgctaccctt cacctgtcta
     1561 acatcccccc ttctgtagca gaagaggatc tgcgaactct gtttgccaac accgggggca
     1621 ctgtgaaagc atttaagttt tttcaagatc acaaaatggc tcttcttcag atggcaacag
     1681 tggaggaagc tattcaggct ttgattgatc ttcataatta taaccttgga gaaaaccatc
     1741 atctgagagt gtctttctcc aagtcaacaa tctaagcacg ggagatgaag atggcgggca
     1801 gatcccattg ttggtgtcat cacctattga ctgttcagaa aagtggggac cagagtttga
     1861 tttttttcat gctgttatca ttccttggtt ataaaatgaa atggcatatg taaaggcaga
     1921 gttgctaact gctgtgtttc atctgttcaa tagggaagcc atttttgtct gtttaaattt
     1981 ttagtttaat tttgcttttt tttttttttc caacttagtt gacatacgtg ccttacaaag
     2041 gaaaactagt gttgctattc tgcatttact aggaaaaagg aattggttgt ttagggcaca
     2101 tcgttatgtg ggaattaaaa tatgtttggg caggggtgtg tcaaaaggtt aagtttttat
     2161 ttctcctgct tggaactttc tttgaattat tggcttatca catttctttc tatttaatct
     2221 aataagatac ttgatactga gagtataaaa cagcattttt agtttttact atcttaggct
     2281 ttattgcttt tgaaaacatt ggccttttgt atctcacaaa tctggtctag attcagttat
     2341 gaatgtaggc attagttaaa attaacaaga tgcagagtat taatttctta agacaagtga
     2401 tttctgtaag tttgagccct atgtggaaag cattgtggaa ccttaacctt tttgtacaca
     2461 ctcttgtggg acgtgtcata taaatgtcag cactaagtaa tgtcttgttt gtggctgaat
     2521 atttttcgta gatgtttttg aagttgacat gacttacgtg catttaaata tatattgcca
     2581 tccttagttt gtaattaaga tttggaaaat ggttgtggat ttctgagcat gtgcagactg
     2641 gtctagctag ttcaggaact ggtgcatgta tttttcaaag acaaagaaag tgtactgcga
     2701 aaacttgcag gaagattaat tttgtggcag ttttctaaaa ctgacaacca ggtgggacca
     2761 aagtttatgt gcctttagtc ttaatttacc ttgcattgta atattcagtt ttaataaatc
     2821 ttcaaaatat tttgtattta ggaatagatc tgactttaat aaaaacatgg ctcagaatct
     2881 acaggtcaaa tttatttgaa cagttcttgt caatctgaat tgttgattct gttaaatgac
     2941 caatactttt tgaaattgat gtacttagtt tcaagattca tagattctgt tatctatgta
     3001 gacagaatgg tcatgtatat tttctattag ttgagttttt acatctttag aaatgtaaaa
     3061 ttcagtatag tttgaaagcg gcacaattaa aaattaattt tctaacaaag ttgggaggtt
     3121 tgatggttgt ttaatttcac tttgtgtgta ctctgcttac ctctgtagca tgctcaataa
     3181 acacttctgt agctctgtat tcaccttttc tgtctttctc tgctgccttt tctctctctc
     3241 ctttgttttc actccactgt gcttctgagt tcatgtttac tctgccaggg tgggaaagga
     3301 gtaatactat cacaatccta tggctttata ccataaataa atccagatgc tgtgaaaatg
     3361 c
//
